Clinical trials: Defects
Congenital Heart Disease
The Co-Op @ HeartWorks
This protocol is a research study involving human subjects diagnosed with Congenital Heart Defects/Disease (CHD). The Co-Op @ HeartWorks is a cooperative between the research platform at HeartWorks and members of the CHD…
- Trial name
- NCT06469918
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- HeartWorks, Inc.
Maxillary Augmentation in Horizontal Bone Defect
Radiographic and Histomorphometric Assessment of Anterior Horizontal Maxillary Bone Augmentation Using Autogenous and Bovine Sticky Bone Versus Autogenous and Bovine Bone Shell Technique (Khoury): A Randomized Comparative Clinical Trial
This clinical trial aims to compare two bone augmentation techniques for patients with anterior horizontal maxillary bone defects: Autogenous and Bovine Sticky Bone Technique using S1 Bovine Bone Graft Autogenous and Bovine Bone…
- Trial name
- RCT (NCT07210385)
- Testing
- anterior horizontal maxillary bone augmentation using autogenous and bovine sticky bone, anterior horizontal maxillary bone augmentation using autogenous and bovine bone shell technique (khoury)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Rectal Cancer, Defect of Floor of Lesser Pelvis
Collagen Implant (Biological Mesh) Versus GM Flap for Reconstruction of Pelvic Floor After ELAPE in Rectal Cancer
The trial compares two different techniques for reconstruction of the lesser pelvic floor after an extended abdominoperineal excision for locally advanced rectal cancer.
- Trial name
- NEAPE (NCT01347697)
- Testing
- Reconstruction with an acellular porcine dermal collagen implant (biological mesh), Reconstruction with a gluteus maximus myocutaneous flap
- Where
- 8 sites in Finland, Sweden
- Volunteers
- 91 people
- Sponsor
- Umeå University
Sickle Cell Disease, Thalassaemia
Integrative Diagnosis for SCD and Other RADs
INTEGRA aims at enabling personalized medicine for RHADs patients by the establishment of an integrative diagnostic approach based on deep phenotypic and genetic characterization through combining new generation methodologies.
- Conditions
- Sickle Cell Disease, Thalassaemia, Congenital Dyserythropoietic Anemia (CDA), Enzyme Disorder; Anemia
- Trial name
- INTEGRA (NCT07206095)
- Testing
- Analysis of genetic modifiers, Disease phenotyping
- Where
- 9 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Root Canal Infection, Tooth Defect
Clinical Trial of Modified Endocrown and Personalized Post-core and Crown for Large-area Tooth Defects After Root Canal Treatment
This study intends to adopt a multicenter, randomized controlled, single-blind, non-inferiority clinical trial design. 246 premolars that meet the inclusion criteria after complete root canal treatment will be selected from the…
- Conditions
- Root Canal Infection, Tooth Defect, Post and Core Technique
- Trial name
- NCT07206108
- Testing
- modified endocrown
- Where
- China
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Individuals With Eye Refraction Defects
The Effect of Eye Exercises in Individuals With Eye Refractive Defects
According to the World Health Organization's statement published in 2014, 43% of visual impairment is overhauled by uncorrected refractive errors.
- Trial name
- NCT05999552
- Testing
- Eye exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Anxiety Disorder of Adolescence
RCT of CBT Based C.A.T Project for Pakistani Adolescents With Anxiety Disorders.
Anxiety Disorders are the most prevalent mental health conditions among adolescents. The current randomized control trial aims to assess the efficacy of the C.A.T Project protocol among adolescents aged 14 to 17 years diagnosed…
- Trial name
- NCT07202715
- Testing
- CBT Based C.A.T Project- Intervention for Anxious Adolescents.
- Where
- 3 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- National University of Science and Technology
Congenital Heart Disease (CHD), Chromosomal Abnormalities
Chromosomal Abnormalities in Patients With Congenital Heart Disease at Assiut University Children's Hospital
Congenital heart disease (CHD) is one of the most common birth defects and an important cause of infant morbidity and mortality.
- Trial name
- NCT07204509
- Testing
- Conventional Karyotyping
- Volunteers
- 138 people
- Sponsor
- Assiut University
Acquired Visual Field Defects
Rehabilitation For Acquired Visual Field Defects: Development Of A Bottom-Up Approach
Cortical Visual Field Defects (CFVD) are common after acquired brain injury. They often cause problems with reading and visual exploration which impact on patients' quality of life.
- Trial name
- VISIOTRAIN (NCT01730560)
- Testing
- Treatment A, Treatment B
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Hospices Civils de Lyon
Furcation Defects, Periodontitis
Non-surgical vs. Surgical Therapy for Periodontal Furcations
Periodontitis is an inflammatory disease of the tooth-supporting apparatus, which leads to attachment and bone loss and eventually to tooth loss if treatment is not provided.
- Conditions
- Furcation Defects, Periodontitis, Surgical Procedure, Unspecified
- Trial name
- NCT05237401
- Testing
- Non-Surgical Periodontal treatment (NSPT), Surgical Periodontal treatment/ Open Flap Debridement (OFD)
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- King's College London
Pulmonary Valve Insufficiency
Feasibility Study to Evaluate the Safety of the Autologous GrOwnValve Transcatheter Pulmonary Heart Valve
Aim of this study is to investigate the clinical safety of a novel pediatric heart valve.
- Trial name
- GECT (NCT05809856)
- Testing
- GrOwnValve - novel heart valve replacement approach
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Charite University, Berlin, Germany
Heart Defects, Congenital, Mental Health Issue
Mind the Heart - Mental Health in Children and Adolescents With Congenital Heart Defects
The aim of the Mind the Heart study is to document the feasibility of an online parent/child administered screening model for mental disorders (MDs) in Danish children and adolescents with congenital heart disease (CHD).
- Trial name
- Mind the Heart (NCT05709470)
- Testing
- No-intervention
- Where
- Denmark
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ventilatory Defect, COVID-19
Visualizing Regional Lung Ventilation in Patients With Postacute-COVID-19
There is a lack of data of spontaneous breathing patients with post-COVID-19 syndrome (PCS) examined by Electrical impedance tomography (EIT). We compare 100 patients with PCS with 50 healthy probands.
- Conditions
- Ventilatory Defect, COVID-19, Post-acute COVID-19 Syndrome, Electric Impedance Tomography
- Trial name
- ViReVentPoCov (NCT05441657)
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jan-Christoph Lewejohann
Congenital Heart Disease in Children, Neurodevelopmental Disorders
Feasibility and Efficiency of Screening for Neurodevelopmental Disorders by an Advanced Practice Nurse in Children With Congenital Heart Disease
Feasibility and efficiency of Screening for Neurodevelopmental Disorders by an Advanced Practice Nurse in Children aged 1 to 5 with Congenital Heart Disease
- Trial name
- NEURODEV-IPA (NCT06431269)
- Testing
- Screening for neurodevelopmental disorders by an advanced practice nurse
- Where
- 3 sites in France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Montpellier
CNS Lesion, Blood Brain Barrier Defect
Efficacy and Safety of Gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)
This trial aimed to evaluate the Efficacy and Safety of gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)
- Trial name
- PICTURE (NCT03996447)
- Testing
- gadopiclenol, Gadobutrol 1Mmol/mL Solution for Injection Vial
- Where
- 33 sites in United States, Belgium and 9 more
- Volunteers
- 260 people
- Sponsor
- Guerbet
Congenital Heart Disease, Tetrology of Fallot
The Medtronic Harmony™ Transcatheter Pulmonary Valve Clinical Study
The purpose of this study is to further evaluate the safety and effectiveness of the Harmony™ TPV system. The Pivotal/CAS phases of the study have transitioned into a post-approval study to confirm the long-term functionality of…
- Conditions
- Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
- Trial name
- NCT02979587
- Testing
- Harmony TPV System
- Where
- 12 sites in United States, Canada and 1 more
- Volunteers
- 86 people
- Sponsor
- Medtronic Heart Valves
Heart Disease Congenital
Support Tool for Families of High-Risk Children With Heart Disease During Hospital Admission and After Discharge
The goal of this study is to pilot the "support tool" in the Nemours Cardiac Center to assess acceptability and feasibility. This tool will be offered to 5 high-risk families, and they will be asked to complete a survey.
- Trial name
- NCT05926661
- Testing
- NCC Support Toolkit
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Cranial Defect
Study on the Effect of Ultra-early Autologous Cranioplasty on Neurological Function Recovery
To compare the neurological recovery and complication rate of autogenous cranioplasty(CP) within 6 weeks after decompressive craniectomy (DC) with that of autogenous cranioplasty within 3~6 months after DC.
- Trial name
- FAST-ECP (NCT07183540)
- Testing
- operation opportunity-within 6 weeks after the DC operation., operation opportunity-within 90 to 180 days after the DC operation.
- Where
- 7 sites in China
- Volunteers
- 582 people
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
Uterine Caesarean Scar Defect
Enhanced Reproductive Efficiency: Shorter Time to Pregnancy After Hysteroscopic-Assisted Novel Transvaginal Repair
To investigate whether a novel hysteroscopic-assisted transvaginal repair technique results in a shorter time to pregnancy and superior fertility outcomes compared to traditional transvaginal repair.
- Trial name
- NCT07169435
- Where
- China
- Volunteers
- 120 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Congenital Heart Disease
The Effects of Telerehabilitation and Exercise Training in Pediatric Arrhythmia Patients With Pacemakers
There is no study evaluating online exercise training and results in children with pacemakers. This study investigates the effects of group exercise training performed via computer online videoconferencing in pediatric arrhythmia…
- Trial name
- NCT05454501
- Testing
- Exercise Training, Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Hacettepe University