Clinical trials: Defects
Congenital Heart Disease, Pulmonary Hypertension
Early Postoperative Triple Targeted Therapy in Patients With CHD-PAH in the "Grey Zone"
The purpose of this study is to observe the efficacy of early application of triple targeted drug therapy, including trilostane, in patients with congenital heart disease who are in the "gray zone" of preoperative evaluation…
- Trial name
- NCT07844213
- Testing
- Control group (ambrisentan plus tadalafil or macitentan plus tadalafil), Treatment group (ambrisentan plus tadalafil plus treprostinil or macitentan plus tadalafil plus treprostinil)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China National Center for Cardiovascular Diseases
Hernias, Diaphragmatic, Congenital, Hernia; Diaphragm Defect, Congenital
Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia
Pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (CDH). The current care during the perinatal stabilisation period in infants born with this rare birth defect…
- Conditions
- Hernias, Diaphragmatic, Congenital, Hernia; Diaphragm Defect, Congenital, Pulmonary Hypertension
- Trial name
- PinC (NCT04373902)
- Testing
- Physiological-based cord clamping
- Where
- 9 sites in Australia, Austria and 5 more
- Volunteers
- 144 people
- Sponsor
- Erasmus Medical Center
Hypoxemia, Skin Pigment
Skin Pigment/Pulse Oximeter in Congenital Heart Disease (CHD)
Recent retrospective studies have demonstrated differences between pulse oximeter values (SpO2) and measured arterial oxygen saturation (SaO2) in patients identifying as Black or Hispanic.
- Conditions
- Hypoxemia, Skin Pigment, Congenital Heart Disease
- Trial name
- NCT06575270
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cesarean Scar Defect (Isthmococele)
Incision-Parallel Double-Layer Non-Locking Versus Single-Layer Locked Uterine Closure After Primary Caesarean Delivery: A Randomized Controlled Trial
This randomized controlled trial was conducted to compare two uterine closure techniques in women undergoing primary cesarean delivery.
- Trial name
- NCT07841028
- Testing
- Single-Layer Locked Uterine Closure, Double-Layer Incision-Parallel Nonlocking Uterine Closure
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Onur Karaaslan
Peridontal Disease, Furcation Defects
PRF Versus Emdogain for Class II Furcation Defects of Mandibular Molars
This study evaluated the regenerative potential of platelet-rich fibrin (PRF) compared with enamel matrix derivative (Emdogain®) in the surgical treatment of Class II (F2) furcation defects of mandibular molars.
- Trial name
- NCT07841301
- Testing
- Platelet rich fibrin, Emdogain
- Where
- Bulgaria
- Volunteers
- 21 people
- Sponsor
- Medical University of Sofia
Pediatric ALL, Cardiac Defect
Evaluating the Relationship Between Skin Color and Pulse Oximeter Accuracy in Children
This multisite study seeks to understand whether and how pulse oximeter accuracy varies across children with different skin colors in real world clinical settings.
- Trial name
- PACH (NCT06529575)
- Where
- 3 sites in United States
- Volunteers
- 650 people
- Sponsor
- University of Pennsylvania
Heart Defects, Congenital, Myocardial Reperfusion Injury
Morphine Versus Fentanyl for Myocardial Protection in Acyanotic Children Undergoing Congenital Open-Heart Surgery
This study compared two opioid pain medications - morphine and fentanyl - used during open-heart surgery in young children born with heart defects (congenital heart disease).
- Trial name
- MorphPed (NCT07839273)
- Testing
- Fentanyl (IV), morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Baskent University
Sensation Disorders, Sensation, Phantom
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
During breast surgery, sensory nerves are cut which may lead to reduced sensation and pain. Surgical reinnervation techniques have been developed with the aim of improving postoperative sensation by preserving the nerves and…
- Conditions
- Sensation Disorders, Sensation, Phantom, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06094257
- Testing
- Sensory testing
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Periodontal Intrabony Defects
Treating Intrabony Defect With MINST VS MINST Extended PRF
This study evaluates a minimally invasive non-surgical technique (MINST) for treating periodontal intrabony defects, with or without the addition of Extended Platelet-Rich Fibrin (e-PRF).
- Trial name
- MINST PRF (NCT07836231)
- Testing
- Extended Platelet-Rich Fibrin (e-PRF), Modified Minimally Invasive Non-Surgical Technique (MINST)
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Congenital Heart Defect, Heart Defects, Congenital
Fetal Cardiac Anomalies at Anomaly Scan: Detection and Pregnancy Outcomes - Assiut 2026
Congenital heart defects are among the most common congenital anomalies and cause significant perinatal morbidity and mortality. Prenatal detection allows counseling, multidisciplinary planning and optimization of delivery.
- Trial name
- NCT07832851
- Volunteers
- 200 people
- Sponsor
- Assiut University
Tetralogy of Fallot, Hypoplastic Left Heart Syndrome
Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart Disease
Positive intra-thoracic pressures induced by mechanical ventilation can negatively impact right heart hemodynamics by restricting systemic venous return and increasing right ventricular afterload.
- Conditions
- Tetralogy of Fallot, Hypoplastic Left Heart Syndrome, Univentricular Heart, Heart Defects, Congenital
- Trial name
- NCT04581668
- Testing
- Two ventilation periods with two different modes: conventional ventilation followed by NAVA.
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- St. Justine's Hospital
Patent Ductus Arteriosus, Congenital Heart Disease
PDA for Kidneys Study
The goal of this observational study is to gather more information on kidney oxygen levels in babies with a patent ductus arteriosus (PDA), and evaluate the relationships between kidney oxygen levels, PDA status and kidney…
- Trial name
- PDA4K (NCT06658496)
- Testing
- Near Infrared Spectroscopy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Wisconsin, Madison
Congenital Heart Disease, Unfractionated Heparin
Comparison of the Best Method for Measuring Anti-Xa Activity in Children Receiving Unfractionated Heparin in Cardiac Intensive Care (COMPAXE-HNF)
This study aims to compare the accuracy of two different blood sampling methods from a central venous catheter (CVC) for measuring anti-Xa activity in children receiving unfractionated heparin (UFH) from this CVC.
- Conditions
- Congenital Heart Disease, Unfractionated Heparin, Anti Xa Activity
- Trial name
- COMPAXE-HNF (NCT07365670)
- Testing
- blood sampling for measuring anti-Xa activity, measurement of anti-XA activity
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Dental Caries, Restoration Defects
Repair Versus Replacement of Failed Restorations in Primary Teeth
Dental caries affect approximately 573 million children globally, and the management of failed restorations is a frequent clinical issue in pediatric dentistry.
- Conditions
- Dental Caries, Restoration Defects, Primary Teeth
- Trial name
- NCT07813065
- Testing
- Repair of Failed Restoration, Replacement of Failed Restoration
- Where
- Brazil
- Volunteers
- 382 people
- Sponsor
- University of Sao Paulo
Congenital Heart Disease (CHD), Artifical Intelligence
AI-Assisted Versus Independent Heart Sound Screening for Congenital Heart Disease in Children
This is a prospective, school-based, cluster-randomized controlled trial conducted in Qinghai Province, China. The study will evaluate whether artificial intelligence (AI) can help primary care physicians identify congenital…
- Conditions
- Congenital Heart Disease (CHD), Artifical Intelligence, Screening, Cardiac Auscultation
- Trial name
- NCT07830251
- Testing
- AI-Assisted Cardiac Auscultation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Kun Sun
Mild Defects of the Lips
Post-Market Clinical Follow-up (PMCF) Study of Safety and Performance of 300-01 RefillHA Lips
A Post-Market Observational Study of the Safety and Efficacy of RefillHA Lips for Remodelling and Correction of Mild Defects of the Lips
- Trial name
- NCT07831213
- Where
- Israel
- Volunteers
- 87 people
- Sponsor
- Glyance
Atrial Fibrillation, Atrial Septal Defect
Utility of the Perclose ProGlide™ Suture-Mediated Closure Device After Cardiologic Procedures Via the Femoral Vein Approach (Eight-Clover)
The purpose of this study is to evaluate the clinical efficacy and safety of the Perclose ProStyle™ Suture-Mediated Closure Device in patients undergoing cardiologic procedures via a femoral vein approach using a sheath size of 8…
- Conditions
- Atrial Fibrillation, Atrial Septal Defect, Vascular Closure Device
- Trial name
- Eight-CLOVER (NCT07827287)
- Testing
- Perclose ProStyle™ Suture-Mediated Closure System, Conventional Hemostasis (Manual Compression or Figure-of-Eight Suture)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Adult Congenital Heart Disease, Heart Failure
Efficacy Of Sodium Glucose Transporter Inhibitor (SGLT2I) In Adult Patients With Congenital Heart Disease
The goal of the study is to investigate the feasibility and benefit of novel guideline-directed heart failure therapy drug Empagliflozin (Jardiance) for adult patients with congenital heart disease (ACHD).
- Trial name
- EmpaCHD (NCT06260059)
- Testing
- Empagliflozin 10 MG
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Anita Saraf
ASD2(Secundum Atrial Septal Defect)
Dapagliflozin and Right Heart Recovery After ASD Device Closure
The aim of this study is to evaluate the clinical and echocardiographic influence of dapagliflozin on right ventricular reverse remodeling in adult patients following successful transcatheter Atrial Septal Defect (ASD) device…
- Trial name
- NCT07823972
- Testing
- trans catheter device closure
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bone Defects
Endoscopic-Assisted Versus Conventional Crestal Sinus Lift
To compare Endoscopic-Assisted Versus Conventional Crestal Sinus Lift; bone grafting will be performed, followed by implant placement. Membrane perforation rates, surgical time, and bone density changes will be evaluated.
- Trial name
- sinus lift (NCT07824037)
- Testing
- Endoscopic-guided Sinus lift, non- endoscopic sinus lift
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Nahla Mahmoud Awad