Clinical trials: Distal Bile Duct Obstruction
Malignant Biliary Stricture
Endoscopic Biliary Drainage in Malignant High Grade Biliary Stricture
Biliary drainage is the mainstay of the palliative treatment in patients with inoperable malignant bile duct stricture. Endoscopic retrograde cholangiopancreatography (ERCP) is the cornerstone of biliary drainage method in these…
- Trial name
- NCT03530527
- Testing
- ERCP with biliary stenting, EUS guided biliary drainage
- Where
- 2 sites in Thailand
- Volunteers
- 10 people
- Sponsor
- Prince of Songkla University
Pancreatic Cancer Non-resectable, Bile Duct Cancer
Treatment of Distal Malignant Biliary Obstruction by Uncovered, Partially Covered, or Fully Covered Metal Stents
The goal of this randomized controlled trial is to compare uncovered, partially covered, and fully covered self-expandable metal stents (SEMS) in the palliative treatment of distal malignant biliary obstruction in a Swedish…
- Conditions
- Pancreatic Cancer Non-resectable, Bile Duct Cancer, Papillary Carcinoma, Duodenal Cancer
- Trial name
- NCT06453590
- Testing
- Randomization to uncovered SEMS treating jaundice due to distal malignant biliary obstruction., Randomization to partially covered SEMS treating jaundice due to distal malignant biliary obstruction., Randomization to fully covered SEMS treating jaundice due to distal malignant biliary obstruction.
- Where
- 12 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Region Stockholm
Extrahepatic Bile Duct Cancer, Pancreatic Cancer
Two-in-one Covered and Uncovered Metal Stent
Endoscopic placement of a self-expandable metal stent (SEMS) is the principle method for palliation of inoperable malignant distal biliary obstruction.
- Conditions
- Extrahepatic Bile Duct Cancer, Pancreatic Cancer, Lymph Node Metastases, Gallbladder Cancer
- Trial name
- NCT04337333
- Testing
- Two-in-one stent
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Ajou University School of Medicine
Cholangiocarcinoma, Pancreatic Cancer
T-EUS for Gastrointestinal Disorders: A Multicenter Registry
The purpose of this registry is to record information and evaluate the impact of Endoscopic Ultrasound (EUS) Guided Endoscopic retrograde cholangiopancreatography (ERCP) on the management of pancreatico-biliary disorders.
- Conditions
- Cholangiocarcinoma, Pancreatic Cancer, Bile Duct Cancer, Biliary Stricture
- Trial name
- EUSERCPReg (NCT01522573)
- Testing
- EUS guided ERCP
- Where
- 2 sites in United States, Brazil
- Volunteers
- 1,000 people
- Sponsor
- Weill Medical College of Cornell University
Biliary Disease, Pancreatic Disease
Comparison of Duodenoscope With Single-use Distal Cover and the Conventional Reusable Duodenoscope
The purpose of the study is to compare the success rates of procedure success and complication rates in patients undergoing Endoscopic retrograde cholangiopancreatography (ERCP) using two types of currently available endoscopes.
- Conditions
- Biliary Disease, Pancreatic Disease, Choledocholithiasis, Biliary Obstruction
- Trial name
- NCT05429203
- Testing
- Duodenoscope with single-use distal cover, Conventional duodenoscope
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Stanford University
Bile Duct Obstruction, Pancreatic Cancer
Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction
The primary purpose is to compare patency of two different types of biliary metal stents, i.e. covered versus uncovered Nitinella metal stent. Secondary purposes are to determine frequency of complications in the two groups, e.g.
- Conditions
- Bile Duct Obstruction, Pancreatic Cancer, Gallbladder Cancer, Bile Duct Cancer
- Trial name
- NCT00280709
- Testing
- "Nitinella" ; SX-ELLA Stent Biliary (biliary metal stent)
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- University Hospital, Linkoeping
Distal Bile Duct Obstruction
Covered vs Uncovered Metal Stents for Palliative Biliary Decompression in Inoperable Malignant Distal Bile Duct Obstruction
The purpose of this study is to compare the rate of long-term stent failure, defined as need for repeat biliary intervention following placement of C-SEMS vs U-SEMS for palliation of inoperable malignant distal bile duct…
- Trial name
- NCT01905384
- Testing
- Covered Self-expanding metal biliary stents (C-SEMS), Uncovered Self-expanding metal biliary stents (U-SEMS)
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center
Biliary Stasis, Extrahepatic
The Effect of Aspirin on Patency of Metal Stent in Malignant Distal Bile Duct Obstruction
The aim of this study is to determine whether administration of aspirin can help maintain the patency of metallic stents for distal malignant common bile duct obstruction.
- Trial name
- NCT03279809
- Testing
- Aspirin
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Woo Hyun Paik
Malignant Biliary Obstruction
EUS - Guided Choledocho-duodenostomy Versus ERCP With Covered Metallic Stents in Patients With Unresectable Malignant Distal Common Bile Duct Strictures
EUS - guided choledocho-duodenostomy (ECDS) is an established option for bile duct drainage in unresectable malignant distal CBD strictures when endoscopic retrograde cholangiopancreatography (ERCP) fails.
- Trial name
- DRAMBO (NCT03000855)
- Testing
- EUS-guided choledocho-duodenostomy, Endoscopic retrograde cholangiopancreatography with covered metallic stent
- Where
- 6 sites in Australia, Belgium and 3 more
- Volunteers
- 77 people
- Sponsor
- Chinese University of Hong Kong
Bile Duct Obstruction, Extrahepatic
Ultrasound-guided Percutaneous Biliary Drainage Versus Endoscopic Ultrasound-guided Biliary Drainage
Prospective multi-site study of ultrasound-guided percutaneous biliary drainage and endoscopic ultrasound-guided biliary drainage with implantation of a self-expanding metal stent in patients with malignant, distal bile duct…
- Trial name
- PUMa (NCT03546049)
- Testing
- US-guided percutaneous biliary drainage, EUS-guided biliary drainage
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas
Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction
A randomised clinical trial to compare the clinical efficacy of multiple plastic stents to fully covered self expanding metal stents in the palliation of distal malignant biliary obstruction in patients with irresectable tumours.
- Conditions
- Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas, Cancer of the Bile Duct, Biliary Stricture
- Trial name
- NCT03821025
- Testing
- Biliary stent
- Where
- South Africa
- Volunteers
- 150 people
- Sponsor
- University of Cape Town
Biliary Tract Neoplasms, Jaundice, Obstructive
Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents
Endoscopic retrograde biliary drainage (ERBD) is now widely accepted as the standard intervention for the relief of obstructive jaundice in patients with unresectable malignant biliary obstruction.
- Trial name
- NCT01315522
- Testing
- ComVi stent, Uncovered SEMS
- Where
- 3 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Bile Duct Obstruction
A Study Comparing Sems Placement With and and Without Biliary Sphincterectomy in Patients With Malignant Biliary Obstruction
Background and rationale Placement of biliary self expanding metal stent (SEMS) is indicated when malignant common bile duct obstruction is encountered.
- Trial name
- NCT03628001
- Testing
- ERCP
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Istituto Clinico Humanitas
Stricture, Obstruction
Patency of a Prototype Large Plastic Biliary Stent in the Palliation of Malignant Distal Biliary Strictures.
Plastic biliary stents which are a new larger size will remain free of obstructions for a longer period of time than currently used 10 French stents in cancer in the common bile duct.
- Conditions
- Stricture, Obstruction, Cancer
- Trial name
- NCT01590394
- Testing
- Large plastic biliary stent
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Periampullary Cancer, Complications of Surgical Procedures or Medical Care
Comparison Between Fully Covered Metal Stents and Plastic Stents in Preoperative Biliary Drainage
This study is a prospective, randomized study to compare of outcome of fully covered metal stents with that of plastic stents for preoperative biliary drainage in distal common bile duct cancer, pancreas head cancer or ampullary…
- Conditions
- Periampullary Cancer, Complications of Surgical Procedures or Medical Care, Disorder of Bile Duct Stent
- Trial name
- NCT01789502
- Testing
- Fully covered metal stents, Plastic stents
- Where
- 3 sites in South Korea
- Volunteers
- 86 people
- Sponsor
- Inje University
Plastic Stent Occlusion
Single Versus Multiple Plastic Stents in Malignant Distal Bile Duct Obstruction
Endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent placement is crucial for palliative treatment in patients with malignant bile duct obstruction who cannot perform surgery due to advanced diseases or…
- Trial name
- NCT03849859
- Testing
- Single plastic stent, Multiple plastic stents
- Where
- 2 sites in Thailand
- Volunteers
- 9 people
- Sponsor
- Prince of Songkla University
Malignant Tumor of Extrahepatic Bile Duct
Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction
Strictures in the bile duct cause a blockage of flow of bile. This leads to potential problems including jaundice, itch and infection in the bile duct.
- Trial name
- NCT01514214
- Testing
- WInged perimeter biliary stent insertion (Viaduct), traditional polyethylene stent insertion (Cotton Huibregtse)
- Where
- 2 sites in Canada
- Volunteers
- 58 people
- Sponsor
- University of British Columbia