Clinical trials: Fracture of Shaft of Tibia
Tibial Shaft Fracture
Study of Tibial Shaft Fracture Fixation: Intramedullary Nailing Comparing With Dynamic Compression Plate
The purpose of this study is to determine which surgical approach is better for treatment of tibial shaft fracture
- Trial name
- NCT01190709
- Testing
- Dynamic Compression Plate, Unreamed intramedullary nailing
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Fracture of Shaft of Tibia
Focused Registry SmartFix
20 patients having received an AO large external fixator at the tibia will be equipped with a data logger device (AO Fracture Monitor) attached post-operation to a connection rod of the external fixator.
- Trial name
- FRSmartFix (NCT02094209)
- Testing
- SmartFix
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Tibial Shaft Fracture, Intramedullary Nail
RCT - Suprapatellar Approach Versus Lateral Parapatellar Approach in Tibial Shaft Fracture
This study aims to compare 2 surgical techniques for tibial shaft nailing (suprapatellar approach vs extra-articular lateral parapatellar approach). following peri-operative and postoperative outcomes
- Trial name
- ELPP (NCT07657559)
- Testing
- suprapatellar approach, extra-articular lateral parapatellar approach
- Volunteers
- 40 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Broken Leg
Suprapatellar Nailing of Tibial Shaft Fractures
To investigate the functional outcomes and prevalence and severity of knee pain for patients undergoing suprapatellar nailing of tibial shaft fractures.
- Trial name
- NCT02728362
- Volunteers
- 38 people
- Sponsor
- Corewell Health West
Tibial Fracture
SPRINT - Randomized Trial of Tibial Fracture Fixation
The purpose of this study is to determine if there is a difference in the rate of healing of a tibia fracture treated with an intramedullary nail based on whether or not the bone was reamed prior to nail insertion.
- Trial name
- NCT00038129
- Testing
- Intramedullary nail implant
- Where
- 16 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Minnesota
Nonunion of Fracture of Tibia (Diagnosis)
Risk Factors for Post-Operative Nonunion of Tibial Shaft Fractures Based on a Path Analysis Model
Tibial shaft fractures is common long tubular fracture that account for about 13.7% of all fractures. And the incidence of nonunion of tibial shaft fracture varied from 1% to 80%.
- Trial name
- NCT03928912
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Tibial Fractures, Fractures, Open
Percutaneous Autologous Bone-marrow Grafting for Open Tibial Shaft Fracture
The treatment of open tibial shaft fracture is often complicated by delayed union or non-union. The objective of this study is to evaluate the efficacy of autologous concentrated bone-marrow to accelerate healing of open tibial…
- Trial name
- IMOCA (NCT00512434)
- Testing
- Osteosynthesis
- Where
- 11 sites in France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Tours
Tibial Fractures
ACTiF- Assessment of Closed Tibial Fractures
The purpose of this study is to find out the good and bad effects of an investigational drug called CP-533,536 in patients with closed fracture of the tibial shaft undergoing internal fixation using reamed inter-locked IM nailing…
- Trial name
- NCT00533377
- Testing
- CP-533, 536, Standard of Care, CP-533,536
- Where
- 56 sites in United States, Australia and 9 more
- Volunteers
- 276 people
- Sponsor
- Pfizer
Femur Shaft Fracture, Tibia Fractures
Assessing Bone Fracture Healing Effect of Almonds
Femur and tibia shaft fractures are common after trauma with a burden of 5% and 20% respectively. Clinicians recommend costly bone strengthening drugs/supplements while treating bone fractures.
- Conditions
- Femur Shaft Fracture, Tibia Fractures, Vitamin D, Sweet Almonds
- Trial name
- AFHEA (NCT07153302)
- Testing
- Prunus dulcis (sweet almonds)
- Where
- Pakistan
- Volunteers
- 136 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Tibial Shaft Fractures in Children
Study of Tibial Shaft Fractures in Children
Tibial shaft fracture is one of the most common fractures in children and adolescents. It encompasses approximately 15 % of all long-bone fractures and is third behind only fractures of the femur and both bones of the forearm.
- Trial name
- NCT01238523
- Testing
- Long leg cast in full extension, Long leg cast with 45 degrees of flexion
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of California, Los Angeles
Tibia Fracture
Ilizarov Frame or Uni Planar External Fixator in the Cost-conscious Era
Tibial shaft fracture is a common injury worldwide. Their treatment, prognosis, and outcome are determined by the mechanism of injury, presence of communition, soft tissue injury and displacement.
- Trial name
- NCT03936972
- Testing
- ilizarov circular frame and uni-planarexternal fixator
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Tibial Shaft Fractures
Carbon Fiber Implants
The investigators will compare intramedullary nailing of open and closed tibia shaft fractures with carbon fiber implant versus titanium implant in a Level I trauma setting.
- Trial name
- NCT03382041
- Testing
- Carbon Fiber Implant, Titanium Implant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Broken Leg
Tibial Shaft Nailing Treated With Suprapatellar Nailing
The goal of this project is to determine the incidence of intra-articular knee pathology following tibial shaft fractures as evaluated by intraoperative knee aspiration and physical exam, and to evaluate for chondral injuries…
- Trial name
- NCT02510339
- Testing
- Observation
- Volunteers
- 16 people
- Sponsor
- Orlando Health, Inc.
Closed Transverse Fracture of Shaft of Tibia
Union Rate of Transverse Tibia Fracture
The investigators will compare the three methods of seating a tibial nail - Backslapping or Backslapping with Dynamic Locking or Internal Compression.
- Trial name
- NCT03042533
- Testing
- Conventional Compression, Standard Backslapping, Dynamic Locking with Backslapping
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Washington
Fracture of Tibia
Conservative Versus Intramedullary Nailing for Pediatric Tibial Shaft Fractures
Tibial shaft fracture is a common fracture in the pediatric and adolescent population. The outcomes of both conservative and operative treatment are not clear and to date there is no randomized prospective trial comparing…
- Trial name
- CINPED (NCT05501496)
- Testing
- intramedullary nailing, casting
- Where
- 2 sites in Finland
- Volunteers
- 66 people
- Sponsor
- Turku University Hospital
Fracture Non Union, Fracture Healing
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union).
- Conditions
- Fracture Non Union, Fracture Healing, Long Bone Delayed-Union Fracture, Humerus Shaft Fracture
- Trial name
- BioBone (NCT06658379)
- Testing
- CD8+TEMRA
- Where
- 7 sites in Germany
- Volunteers
- 640 people
- Sponsor
- Charite University, Berlin, Germany
Tibial Fractures, Surgery
Clinical Validation of the C-Arm Rotational View (CARV) to Avoid Rotational Malalignment After Intramedullary Nailing of Tibial Shaft Fractures.
Tibia shaft fractures are common long bone fractures in the field of Orthopaedic Trauma. In the USA, a total of 492.000 tibial fractures were reported per year by the National Center of Health Statistics (NCHS).
- Conditions
- Tibial Fractures, Surgery, Complication,Postoperative
- Trial name
- NCT05459038
- Testing
- C-Arm Rotational View (CARV)
- Where
- 2 sites in Australia, Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Lower Extremity Fractures
Feasibility of Structured Resistance Training After Lower Extremity Fracture
Adults recovering from surgically managed diaphyseal femur or tibia fractures often experience persistent weakness, pain, and functional limitations despite successful fracture healing.
- Trial name
- NCT07629180
- Testing
- Structured Supervised Resistance Training and Coaching Program
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Femoral Shaft Fracture, Tibial Shaft Fracture
MAGIK for Femoral/Tibial Shaft Fractures
The purpose of this phase 2 randomized control trial will be to evaluate the effect of glucose-insulin-potassium (GIK) therapy in the setting of lower extremity trauma to reduce short- and long-term muscle damage, acute…
- Trial name
- MAGIK (NCT05627479)
- Testing
- GIK solution, Isotonic Normal Saline Solution
- Where
- United States
- Sponsor
- NYU Langone Health