Clinical trials: Frailty in Aging
Aging, Muscle Mass and Strength
One Year of Velocity-based Resistance Training in Older People Living in Nursing Homes
This study is an exercise intervention assessing the efficacy of a velocity-based resistance training (VBRT) in institutionalized older adults.
- Conditions
- Aging, Muscle Mass and Strength, Muscle Power, Frailty Syndrome
- Trial name
- NCT07027397
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Sarcopenia
The Importance of Additional Protein to Benefit More From Training During and After Hospitalization
The purpose of the study is to investigate if an increased protein intake, in the form of a protein-enriched, milk-based supplement, can enhance the beneficial effect of resistance training, offered during hospitalization and 12…
- Trial name
- PEPOP (NCT02717819)
- Testing
- Protein, Resistance training, Vitamin D
- Where
- 3 sites in Denmark
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Forskningsenheden
Sarcopenia, Aging
STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging
The calf muscles (plantarflexors) are the most important muscles for walking, running and daily activities. Weakness of these muscles through aging and disease significantly impact a person's ability to walk and complete daily…
- Conditions
- Sarcopenia, Aging, Muscle Weakness or Atrophy, Frailty
- Trial name
- STRIDE (NCT07726498)
- Testing
- No intervention (observational study)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Frailty
Safety, Efficacy of FFP From Healthy Donors to Ameliorate Frailty and Enhance Immune Function in Older Individuals
1. Primary Objective To determine the safety and tolerability of 12 once monthly transfusions of GMFFP (Granulocyte - Colony Stimulating Factor (G-CSF) Mobilized Fresh Frozen Plasma harvested from young, healthy donors), given to…
- Trial name
- NCT03458429
- Testing
- GMFFP
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dipnarine Maharaj
Frailty, Frail Elderly Syndrome
Education for Prevention and Treatment of Frailty
Frailty is a condition with a high prevalence in older adults, leading to higher vulnerability and increasing the risk of adverse health outcomes and disabilities.
- Trial name
- FRAGSALUD (NCT05610605)
- Testing
- Health intervention programme: FRAGSALUD
- Where
- Spain
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Cardiovascular Diseases, Metabolic Diseases
Healthy Aging Longitudinal Study in Taiwan
The general aim of this study is to establish a longitudinal cohort of older persons in order to examine the physiological, environmental and genetic risk factors for physical disability, frailty, cardiovascular disease, and…
- Trial name
- HALST (NCT02677831)
- Volunteers
- 5,664 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Influenza
The Immune Response to Influenza Vaccinations in Elderly Individuals
The aim of this study is to characterize the immune profile of frail and healthy aged individuals and investigate their immune responsiveness including the response to influenza vaccine over an 18-month period.
- Trial name
- NCT03266237
- Testing
- Vaxigrip®
- Where
- 9 sites in Singapore
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Frailty at Older Adults, Mastication
Oral Function Intervention in Community-Dwelling Older Adults
Oral frailty is a potentially reversible condition associated with physical frailty and functional decline in older adults. Interventions targeting oral function may therefore improve broader physical health.
- Conditions
- Frailty at Older Adults, Mastication, Physical Functional Performance, Aging
- Trial name
- NCT07866781
- Testing
- Integrated Oral Function Intervention
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Frailty, Frailty Syndrome
Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
This project aims to address the impact of frailty on older adults, particularly its connection to cognitive impairments such as dementia.
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome, Pre-Frailty
- Trial name
- NCT05961319
- Testing
- Smart-Home Monitoring
- Where
- 2 sites in Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Healthy Ageing, Frailty
An Intrinsic Capacity Identification and Management Programme for Older Adults in Singapore's Primary Care
The IMPACTFrail program is an intrinsic capacity (IC) identification and management program for mildly frail older adults. Specifically, it delivers the three-tier approach recommended in the National Frailty Strategy Policy…
- Trial name
- IMPACTFrail (NCT06753643)
- Testing
- The IMPACTFrail programme
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Geriatric Education and Research Institute
Aging, Frailty
Knowledges and Use of Cannabidiol in Older Adults
The use of non-medical cannabidiol (CBD) has been growing recently in France and in the world, in young but also older adults. Few data are available on the use of cannabidiol in older adults.
- Trial name
- CBD-65 (NCT06094582)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Preventing Age-Related Muscle Loss: the Role of Exercise in Improving Strength, Function, and Well-being
Muscle Aging Evaluation
This study aims to assess the effects of physical activity in counteracting muscle aging. The increasing life expectancy worldwide has led to a rise in age-related muscle decline, which negatively impacts strength, function, and…
- Trial name
- NCT06845748
- Testing
- Physical activity Group
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Milan
Sarcopenia, Muscle Weakness
SARCOPEDIA - Sarcopenia Diagnostics in Aging Medicine
Musculoskeletal aging is one of the major responsibilities and challenges for public health. In particular, sarcopenia correlates with an increased risk of falls and increased morbidity and mortality.
- Conditions
- Sarcopenia, Muscle Weakness, Frailty
- Trial name
- SARCOPEDIA (NCT05263596)
- Testing
- dual x-ray absorptiometry, body impedance analysis, muscle strength measurements, ultrasound
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Department of Geriatric Medicine FELIX PLATTER
Quality of Life, Syndromes
Long-term Follow-up of the Helsinki Businessmen Study
The Helsinki Businessmen Study (HBS) is a clinico-epidemiological longitudinal study started in 1964. It also included a 5-year randomized, controlled multifactorial primary prevention trial of cardiovascular diseases between…
- Conditions
- Quality of Life, Syndromes, Aging, Cardiovascular Disease
- Trial name
- HBS (NCT02526082)
- Testing
- Intervention
- Volunteers
- 3,490 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Frailty
Intrinsic Capacity and Functional Ability Monitoring With an Integrated Data Eco-System for Healthy Ageing.
In this study, 120 older adults (aged 65 years or older) either patients undergoing rehabilitation or older nursing home residents will be provided with an Eforto® device and the eco-System for Healthy Ageing (ISHA) mobile…
- Trial name
- ISHA (NCT06270979)
- Testing
- ISHA
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prof. Ivan Bautmans
Healthy Aging, Frailty
Characterisation of Functional and Cognitive Responses Following Olfactory Stimulation and/or Functional Training in Older Adults.
This randomized controlled trial will evaluate the effects of olfactory stimulation and/or multicomponent physical training in adults aged 60 years and older.
- Conditions
- Healthy Aging, Frailty, Cognitive Decline, Olfactory Dysfunction
- Trial name
- INNOLFACT 2 (NCT07623122)
- Testing
- Olfactory stimulation, Multicomponent physical training, Combined olfactory stimulation and multicomponent physical training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Social Isolation, Quality of Life
A 3-month Cycle of Virtual Guided Tours to Promote Health in Older Community Members in a Context of COVID-19 Induced Social Isolation: a Pilot Study
Social isolation is defined as the objective and/or subjective reduction of number and quality of interpersonal contacts leading to a loss of an individual's social role and stigmatization.
- Conditions
- Social Isolation, Quality of Life, Well Aging, Frailty
- Trial name
- VGV (NCT04593433)
- Testing
- Museum virtual guided tours
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Frailty, Physical Inactivity
Effectiveness of Graded Training in the Vivifrail Exercise Program Among Long-Term Care Residents
This study evaluates the effectiveness of the Vivifrail multicomponent physical exercise program among elderly residents with different levels of frailty in long-term care centers.
- Conditions
- Frailty, Physical Inactivity, Aging
- Trial name
- NCT06975449
- Testing
- Multicomponent Physical Exercise Program (Vivifrail)
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Frailty, Age-Related Macular Degeneration
Visual Frailty in Ageing
The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known…
- Conditions
- Frailty, Age-Related Macular Degeneration, Functional Status, Mental Health
- Trial name
- VFiA (NCT06604104)
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh