Clinical trials: In-hospital Cardiac Arrest
Cardiac Arrest
Cardiac Arrest and Intra Osseous Infusion
the international recommendations don't explain the place of the intraosseous infusion in the reanimation of adult cardiac arrest; the goal of this preliminary study is to inform the delay for obtaining a vascular access by…
- Trial name
- ACCIO (NCT01803971)
- Testing
- Obtention of vascular access in out-of-hospital cardiac arrest patients according to the current strategy
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bordeaux
Out-of-Hospital Cardiac Arrest, Death, Sudden, Cardiac
The Use of Mobile Phones in Out of Hospital Cardiac Arrest to Increase Bystander CPR
Death from cardiac disease is one of the most common causes of death in the western world. The majority of these deaths takes place outside hospital as sudden cardiac death.
- Conditions
- Out-of-Hospital Cardiac Arrest, Death, Sudden, Cardiac, Heart Diseases, Ventricular Fibrillation
- Trial name
- RUMBA (NCT01789554)
- Testing
- MLS dispatch for bystander CPR
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Karolinska Institutet
Out-Of-Hospital Cardiac Arrest
AMSA and Amiodarone Study in Cardiac Arrest
Investigators' aim is to assess whether the administration of amiodarone during resuscitation could cause a reduction of the values of the amplitude spectral area (AMSA).
- Trial name
- MOSAIC (NCT04997980)
- Testing
- Amiodarone Injection
- Where
- 4 sites in Italy, Norway and 1 more
- Volunteers
- 629 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Arrest Cardio Respiratory
Free Iron and Out of Hospital Cardiac Arrest
Out of hospital cardiac arrest is associated with a poor prognosis. The aim of this study is to provide a better understanding of perturbations of iron metabolism after cardiac arrest and to analyze the impact on clinical…
- Trial name
- DESFER (NCT03491670)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Brest
Cardiac Arrest, Ventricular Fibrillation
The OSIRIS ECPR Trial
The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal…
- Conditions
- Cardiac Arrest, Ventricular Fibrillation, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Arrest
- Trial name
- OSIRIS (NCT06805344)
- Testing
- Extracorporeal cardiopulmonary resuscitation based approach, Conventional cardiopulmonary resuscitation
- Volunteers
- 686 people
- Sponsor
- General University Hospital, Prague
Out of Hospital Cardiac Arrest
Out of Hospital Cardiac Arrest: Trial Assessing the Survival Impact of Phone Advice
Medical call center have no phone advice protocol within out of hospital cardiac arrest in France. The purpose of the present study is to compare a group of patients with protocol phone advice delivered by the dispatchers…
- Trial name
- CONTAC (NCT02934867)
- Testing
- Protocol phone advice, Usual phone advice
- Where
- 19 sites in France
- Volunteers
- 729 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
in Hospital Cardiac Arrest, in Situ Simulation
Clinical Audit of Cardio Pulmonary Resuscitation Management in Adults Patient Units of Care by in Situ Simulation
Clinical audit of in-hospital cardiac arrest management by in situ simulation Objectives: correct latent safety threats, knowledge gap, and crisis resource management (CRM) Design: clinical audit, observational sudy.
- Conditions
- in Hospital Cardiac Arrest, in Situ Simulation, Clinical Audit, Education
- Trial name
- SIMACRIS (NCT02065934)
- Testing
- cardio-pulmonary resuscitation
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Out-Of-Hospital Cardiac Arrest
Machine Learning Assisted Recognition of Out-of-Hospital Cardiac Arrest During Emergency Calls.
Emergency medical Services Copenhagen has developed a machine learning model that analyzes the calls to 1-1-2 (9-1-1) in real time. The model are able to recognize calls where a cardiac arrest is suspected.
- Trial name
- NCT04219306
- Testing
- Alert on dispatchers screen 'Suspect cardiac arrest'
- Where
- Denmark
- Volunteers
- 5,242 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Out-of-Hospital Cardiac Arrest (Simulated)
Simulation and Feasibility Study of Drone-Delivered AED for Out-of-Hospital Cardiac Arrest
Background: Survival after out-of-hospital cardiac arrest (OHCA) depends heavily on early defibrillation. Reducing the time from cardiac arrest to defibrillation is a key factor in improving survival.
- Trial name
- NCT07508774
- Testing
- Drone-Based AED Delivery System, Standard Ground Ambulance Response Pathway Simulation
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ye Sheng
Heart Arrest, Cardiac Arrest
Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest
The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest.
- Trial name
- NCT01968148
- Where
- 2 sites in Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Heart Arrest, Cardiac Arrest
Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiopulmonary Arrest, Out of Hospital Cardiac Arrest
- Trial name
- NCT02007499
- Testing
- Pre-Arrival Instructions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Medical College of Wisconsin
Out of Hospital Cardiac Arrest
I-Gel in Out-of-hospital Cardiac Arrest in Norway
The main objective of this trial is to compare the effectiveness of a newer supraglottic airway method (the i-Gel), compared to current airway management practice in out-of-hospital cardiac arrests treated by Norwegian ambulance…
- Trial name
- I-CAN (NCT02090218)
- Testing
- I-Gel, LTS, ETI or current airway management practice
- Where
- 4 sites in Norway
- Volunteers
- 550 people
- Sponsor
- Haukeland University Hospital
Heart Arrest, Out-Of-Hospital, Physical Activity
Physical Activity After Cardiac Arrest; a Sub-study in the Target Temperature Management Trial 2
The Target Temperature Management trial 2 (TTM2) is an international multi-center study, that randomize patients with OHCA of a presumed cardiac or unknown cause to target temperature management at 33°C or normothermia but…
- Trial name
- NCT03543332
- Testing
- Measures of physical activity and kinesiophobia
- Where
- 8 sites in Denmark, Sweden and 1 more
- Volunteers
- 109 people
- Sponsor
- Region Skane
Cardiac Death, Cardiac Arrest
Quality of Cardiopulmonary Resuscitation Pre- and Intra Hospital
The survival after intrahospital cardiac arrest has been reported to 15%. In Norway this varies between 16 and 23%.). Many factors are associated with survival after cardiac arrest, both intra- and prehospital.
- Conditions
- Cardiac Death, Cardiac Arrest, Cardiac Arrhythmia, Cardiac Disease
- Trial name
- NCT04295291
- Volunteers
- 300 people
- Sponsor
- Ostfold University College
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Cerebral Oximetry in Management of Post Cardiac Arrest
Resuscitation from a cardiac arrest is a common reason for admission to an intensive care unit (ICU). Because the brain is highly vulnerable to oxygen deprivation, severe brain damage often occurs during a cardiac arrest.
- Conditions
- Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury, Hypoxic-Ischemic Brain Injury
- Trial name
- COMPACT (NCT07829887)
- Testing
- Cerebral oximetry-guided treatment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Cardiac Arrest
RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems
RACE-CARS is a real-world cluster-randomized trial designed to evaluate a multifaceted community and health systems intervention aimed to improve outcomes of out-of-hospital cardiac arrest.
- Trial name
- NCT04660526
- Testing
- Rapid cardiac arrest recognition that triggers immediate priority EMS/first responder dispatch by 911 operators, Systematic bystander resuscitation instruction by 911 operators, Comprehensive community training of lay people in CPR and AED use.
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Duke University
Out-Of-Hospital Cardiac Arrest
Cardiac Arrest in Residential Areas With Mobile First-responder Activation
The study aims to increase proportions of bystander defibrillation during out-of-hospital cardiac arrest (hereof referred to as cardiac arrest) in residential areas with a high density of cardiac arrests.
- Trial name
- CARAMBA (NCT04446585)
- Testing
- Automated External Defibrillator (AED), Training in cardiopulmonary resuscitation and AED use, Activation of citizen responders
- Where
- Denmark
- Volunteers
- 260 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Out of Hospital Cardiac Arrest
Ambulance Clinicians' Experiences of Attending OHCA in Children
This research will explore ambulance clinicians' experiences of attending out of hospital cardiac arrest (OHCA) incidents involving children. OHCA occurs when the heart stops beating.
- Trial name
- NCT06922019
- Where
- United Kingdom
- Volunteers
- 2,137 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Cardiac Arrest
Phase 1 Study of HBN-1
Phase 1 First-in Human randomized, open-label, active control standard of care study of the safety of HBN-1 administered as pharmacologically induced hypothermia as an adjunct to standard of care targeted temperature management…
- Trial name
- NCT04094857
- Testing
- HBN-1
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Hibernaid, Inc