Clinical trials: Inter-individual Variability
Experimental Pain in Healthy Human Subjects
Intra- and Inter-individual Differences of Pain
Pain is a highly subjective and variable phenomenon. Different persons perceive objectively identical nociceptive stimuli differently.
- Trial name
- NCT05616091
- Testing
- painful stimulation by using a laser device (DEKA Stimul 1340, Calenzano, Italy)
- Where
- Germany
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Inter-individual Variability
Using Electroencephalography (EEG) and Transcranial Current Stimulation (tCS) to Study and Modulate Cognition Study
Inter-individual variability in responsiveness to interventions poses great challenges for translational neuroscience, and health care in general.
- Trial name
- NCT03293316
- Testing
- Transcranial Random Noise Stimulation
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Exercise, Healthy Participants
Inter- and Intraindividual Variability of the Acute Glucose Response to Exercise in Healthy Adults and People Living With Type 1 Diabetes: A Cross-over Replicate Trial
The goal of this clinical trial is to investigate if blood glucose responses are similar between and within individuals in response to standardized exercise in adults with and without Type 1 diabetes.
- Conditions
- Exercise, Healthy Participants, Glucose Variability, Type 1 Diabetes (T1D)
- Trial name
- NCT07209930
- Testing
- Exercise, Rest
- Where
- Ireland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Healthy Young Adults, Physical Activity Levels
Differences in Autonomic Recovery Between Physically Active and Inactive Women Following an Automated Massage Chair Intervention
The goal of this study is to investigate whether an automated massage chair can improve the body's recovery system in healthy young women (aged 19-26 years) who are either physically active or inactive.
- Conditions
- Healthy Young Adults, Physical Activity Levels, Inactive People
- Trial name
- NCT07529678
- Testing
- Massage chair
- Where
- Malaysia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Hyperglycemia, Insulin Sensitivity
Investigating Inter-individual Variability in Glycemic and Insulin Responses
This study aims to test the following hypothesis in healthy lean young men: There are differences in glycemic response (GR) and insulin response (IR) between Chinese, Malay and Asian-Indian There are differences in GI values to…
- Trial name
- NCT01804738
- Testing
- Jasmine rice, Parboiled basmati rice
- Where
- Singapore
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Polymorphosis, Cognitive Function
Effect of Gene Polymorphism on Cognitive Function
The goal of this observational study is to study the effect of gene polymorphism on cognitive improvement in response to exercise in healthy participants.
- Trial name
- NCT05879341
- Testing
- High intensitiy interval training
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Non Dependant 60 to 75 Year-old Men and Women
Multidimensional Phenotyping Towards Personalized Preventive Nutritional Support for Elderly People
There is high inter-individual variability in the response to feeding, which is determined by multiple interacting factors such as age, sex, genotype, gut microbiota, eating behaviors, physical activity or even socio-demographic…
- Trial name
- MetabotypAGE (NCT06163794)
- Testing
- Nutritional postprandial test
- Where
- 3 sites in France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Obesity
Inter Individual Variation in Weight Loss Response to Exercise
The identification and characterization of individuals who vary in their response to exercise-induced weight loss is important. Weight loss in response to exercise is variable and it remains unknown who will succeed, why, and…
- Trial name
- NCT00773214
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Diet, Food, and Nutrition, Dietary Supplements
Bioavailability of Green Tea and Coffee Polyphenols
There is little information on the dietary intake, absorption, metabolism and bioavailability (degree to which a substance becomes available to the target tissues upon administration) of polyphenols (natural substances present in…
- Trial name
- POBAS (NCT03248115)
- Testing
- Green tea and green coffee extract tablets
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- MRC Human Nutrition Research
Individual Variability in (Poly)Phenol Metabolism, Cardiometabolic Health
Precision Nutrition to Improve Cardiometabolic Health With Dietary (Poly)Phenols
This chronic study aims at assessing whether the effects of a personalized, plant-based diet rich in (poly)phenols on cardiometabolic health depend on the capability to metabolize dietary (poly)phenols, creating predictive models…
- Conditions
- Individual Variability in (Poly)Phenol Metabolism, Cardiometabolic Health, Personalized Dietary Intervention, Obesity
- Trial name
- PRE-CARE-DIET (NCT06347094)
- Testing
- Personalized Dietary Plan, Oral (Poly)phenol Challenge Test (OPCT), General Dietary Advice
- Where
- 2 sites in Italy
- Volunteers
- 330 people
- Sponsor
- University of Parma
Healthy
Inter- and Intra-individual Variation in Acute Responses to Two Different Warm-up Types.
The goal is to assess inter- and intraindividual variation in response to different warm-up protocols in a randomized, cross-over study with U16 and U17 Portuguese soccer players.
- Trial name
- NCT04738617
- Testing
- Inter and intra-individual variation in acute responses to two different warm-up types
- Where
- Portugal
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidade do Porto
Infection, Bacterial
Plasma Concentrations of Amoxicillin Administered in High-doses During the First Week of Treatment (MAX-AMOX)
Amoxicillin is the most prescribed antibiotic in France. High dose intravenous amoxicillin, (dosage greater than or equal to 150 mg / kg / day or 12 g per day for patients over 80 kg) is used in the treatment, in particular, of…
- Trial name
- MAX-AMOX (NCT04070469)
- Testing
- Amoxicillin
- Where
- France
- Volunteers
- 142 people
- Sponsor
- University Hospital, Clermont-Ferrand
Heart Rate Variability (HRV), Intracranial Pressure Change
Correlation Between the R-R Interval of the Electrocardiogram and the Intracranial Pulse Wave Interval Assessed by a Noninvasive Method in Healthy People
Heart rate variability (HRV) is a well-established cardiovascular and autonomic health metric in the medical literature. However, its applicability is limited by the difficulty of analysis and interpretation in clinical practice.
- Conditions
- Heart Rate Variability (HRV), Intracranial Pressure Change, Pulse Rate, Autonomic Nervous System Activity
- Trial name
- NCT07616674
- Testing
- Evaluate the correlation between R-R interval and R-R equivalent on the noninvasive intracranial compliance monitor (BRV) and evaluate their correspondence considering the Time domain (HR, NN, NN50, R
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Individual Variability in (Poly)Phenol Metabolism, Cardiometabolic Health
Aggregate Metabolic Phenotypes for (Poly)Phenols: Development of an Oral (Poly)Phenol Challenge Test (OPCT)
The study is a single-dose acute clinical trial aiming at identifying aggregate metabolic phenotypes for the main dietary (poly)phenols and assessing the factors associated with their formation.
- Trial name
- OPCT (NCT05414084)
- Testing
- Oral (poly)phenol challenge test (OPCT)
- Where
- 2 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Parma
Overweight and Obesity
Interindividual Variation in Response to Green Coffee
The study is a multifaceted approach to investigate the effects of regular consumption of green coffee rich in polyphenols (hydroxycinnamic acids) on weight, body composition, cardiometabolic and inflammatory biomarkers in a…
- Trial name
- GREENCOF (NCT06204445)
- Testing
- Green coffee, Roasted coffee
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto de Ciencia y Tecnología de Alimentos y Nutrición
Non Valvular Atrial Fibrillation
Apixaban Versus Rivaroxaban in Non Valvular Atrial Fibrillation
The investigators will first measure the maximum concentration (after 2 hours of intake) and the residual concentration (just before the next intake) after at least 15 consecutive days of treatment.
- Trial name
- APIXA-Xa (NCT06862726)
- Testing
- Anti Xa dosage, Dosage of PT-INR
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Iodine Deficiency
Variability of Daily Iodine Intake: The Effects of Intra- and Inter-individual Variability in Iodine Nutrition Studies
Iodine status in populations is assessed using urinary iodine concentration (UIC) measured in spot urine samples. The iodine intake is classified as deficient, sufficient, or excessive iodine based on the median UIC (mUIC).
- Trial name
- VIOLET (NCT03731312)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Motor Activity
The Reliability of the Box and Block Test in People After Stroke
The main aim of the pilot project is to establish inter-rater reliability, internal variability and variability of results got in Box and Block Test administered according to the new Czech extended version of its manual.
- Trial name
- NCT05009121
- Testing
- Box and Block Test
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Charles University, Czech Republic
Healthy
Anthropometric Normalization in Inter-Individual Variability of Comprehensive Isokinetic Strength Assessment
Accurate normalization of peak torque (PT) is critical for comparing muscle strength across individuals of varying body composition.
- Trial name
- PT (NCT07508150)
- Testing
- effects of BW versus BMI normalization on inter-individual variability of trunk, hip, and knee muscle strength in healthy female
- Where
- Egypt
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diet-induced Thermogenesis
Inter-Individual Variability in Early Diet-Induced Thermogenesis After a Standardized Meal
This study aims to characterize how individuals differ in their metabolic response to food intake, specifically focusing on early diet-induced thermogenesis (DIT).
- Trial name
- NCT07610759
- Testing
- Standardized Liquid Meal
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University