Clinical trials: Keratoconus
Keratoconus
Familial Analysis of Keratoconus Risk
The principal objective of this study is to evaluate the frequency of KC inside family of patients with confirmed KC. It's a familial, epidemiological, prospective, single-center study.
- Trial name
- AFRIK (NCT02812563)
- Testing
- genetic
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Myopia, Keratoconus
Assessment of Corneal Biomechanical Properties Using Corvis ST and ECD Following LASIK, PRK, CXL, Veriflex IOL and Implantable Collamer Lens
To evaluate corneal biomechanical changes using the Corvis ST and ECD in patients who have under-gone LASIK, PRK, corneal cross-linking (CXL), Veriflex IOL and ICL.
- Conditions
- Myopia, Keratoconus, Refractive Surgery
- Trial name
- NCT06818461
- Testing
- Corvis St Before and after lasik, PRK, CXL, Veriflex IOL and ICL
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Keratoconus
Management of Patients With Keratoconus With Intacs
Purpose To evaluate long-term follow up of Intacs microthin prescription inserts (Addition Technology Inc, Fremont, Calif) for the management of keratoconus. Design A long-term (five years) retrospective, follow-up study
- Trial name
- NCT00384501
- Testing
- Intacs
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital of Crete
Keratoconus
Treatment of Keratoconus With Advanced Corneal Crosslinking
The purpose of this study was to determine whether mechanical compression of the cornea during corneal crosslinking for keratoconus using a sutured rigid contact lens can improve the optical outcomes of the treatment.
- Trial name
- NCT02425150
- Testing
- Corneal reshaping/crosslinking (CRXL), Corneal Crosslinking (CXL)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Umeå University
Elasticum, Incomplete Pseudoxanthoma
The Characteristics of Backscattering With Depth in the Progression of Keratoconus
To investigate the variation in backscattering with depth between forme fruste keratoconus (FFKC), keratoconus, and normal eyes; to determine the backscattering changes in the characteristics of keratoconus progression; and to…
- Trial name
- NCT06050629
- Where
- China
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Keratoconus
Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus
The purpose of this study is to determine which surgical method makes less corneal haze
- Trial name
- NCT01809977
- Testing
- collagen cross-linking procedure (total removal), collagen cross-linking procedure (partial removal)
- Where
- Iran
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Keratoconus
INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia
To join established study put on by Addition Technologies, Inc. in the surgical implantation of asymmetrical INTACS segments to treat myopia and astigmatism in patients with keratoconus.
- Trial name
- INTACS (NCT02512432)
- Testing
- INTACS
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pregnancy
The Influence of Hormonal Changes During Pregnancy on Corneal Biomechanics in Humans
The intraocular pressure in the human bulbus requires that the "wall" of the eye shows a certain (bio)mechanical strength. The human cornea represents the anterior portion of this wall.
- Trial name
- NCT01629264
- Testing
- Ocular Response Analyzer, Scheimpflug measurement, Blood sample
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Keratoconus
Comparative Analysis of the Visual Performance After TICL Implantation in Patients With Stable Keratoconus
To report on 4-year postoperative safety, efficacy, stability and predictability outcomes(to evaluate the visual, refractive, contrast sensitivity, defocus curve and aberrometric data preoperation, and compare with a similar…
- Trial name
- TICL (NCT02833649)
- Testing
- Toric Implantable collamer Lens
- Where
- Iran
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Keratoconus, Corneal Opacity
OCT in Diagnosis of Irregular Corneas
This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions.
- Conditions
- Keratoconus, Corneal Opacity, Corneal Dystrophy
- Trial name
- NCT03504800
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Corneal Topography, Dry Eye Syndromes
Performance Evaluation of the OCUTOP Hand-held Corneal Topographer
The OCUTOP is a new hand-held camera that photographs the front of the eye to map the shape of the cornea and to assess the tear film.
- Conditions
- Corneal Topography, Dry Eye Syndromes, Keratoconus, Healthy Volunteers
- Trial name
- OCUTOP (NCT07895849)
- Testing
- OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment)
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Keratoconus in One or Two Eyes for Case, Good Visual Acuity for Control
Influence of Keratoconus on Stress at Work
Keratoconus is a progressive disorder in which central and paracentral corneal stromal thinning occurs. No studies evaluated the influence of keratoconus on stress at work, nor the influence of treatments of keratoconus on stress…
- Trial name
- KERATOSTRESS (NCT04789707)
- Testing
- auto-questionnaire
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Keratoconus, Astigmatism
Corneal Epithelial and Stromal Thickness Distribution in Keratoconus
The purpose of the study was to identify corneal epithelial- and stromal-thickness distribution patterns in keratoconic eyes using spectral-domain-optical coherence tomography (SD-OCT).
- Trial name
- NCT02023619
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- SynsLaser Kirurgi AS
Accommodation Disorder, Keratoconus
Clinical Investigation for a Multifunction Ophthalmic Measurement Device
The purpose of this clinical investigation is to evaluate the clinical utility of a multifunctional measuring device for Ophtalmology.
- Conditions
- Accommodation Disorder, Keratoconus, Dry Eye, Refractive Errors
- Trial name
- NCT06565091
- Testing
- Measurements of physiological parameters of the anterior chamber, Measurements of the Axial biometry
- Where
- France
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Essilor International
Cataract, Keratoconus
Clinical Study - ES 900 - 2020-2
The EYESTAR 900 with software version i9.5.1.0 includes new analysis functionality. Since its clinical performance cannot be assessed based solely on clinical literature as found in the Clinical Evaluation Report, further data…
- Trial name
- NCT04392349
- Testing
- Haag-Streit EYESTAR 900, Tomey CASIA 2, Oculus PENTACAM HR
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Haag-Streit AG
Keratoconus, Healthy Controls
Corneal Thickness Changes With Scleral Contact Lenses
The purpose of this study is to investigate changes in the corneal thickness of scleral contact lens wearers in a keratoconic (KC) population and compare to age-matched controls.
- Trial name
- NCT03249233
- Testing
- ZenLens™, Zen™ RC
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Keratoconus, Intraocular Pressure
Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT
To evaluate the changes that occur in the intraocular pressure before and after corneal cross linking using Corvis CT.
- Trial name
- NCT07599020
- Testing
- Corvis Machine
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Tanta University
Keratoconus
Distinguishing Healthy and Keratoconic Eyes Using Ultrahigh-Resolution OCT
The OCT used in this trial offers the advantage of both a non-contact method and a very high axial resolution. Determined parameters with the highest potential of diagnostic discrimination between eyes with Keratoconus and…
- Trial name
- NCT03184610
- Testing
- OCT-scanning
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna