Clinical trials: Knee Osteoarthritis
Osteoarthritis, Knee
Effects of Multicomponent Exercise on Subchondral Bone and Cartilage in Postmenopausal Women With Knee Osteoarthritis
Today, osteoarthritis (OA) is considered a whole-organ disease that is amenable to prevention and treatment in the early stages.
- Trial name
- LuRu2 (NCT06173193)
- Testing
- Multicomponent exercise regimen, Standard rehabilitative management
- Where
- Finland
- Volunteers
- 103 people
- Sponsor
- University of Jyvaskyla
Pain, Physical Function
Osteoarthritis Outcomes in Different Ages
We aim to study if there are differences in outcomes between different age groups for persons with knee or hip osteoarthritis during treatment in digitally delivered exercise and education treatment.
- Conditions
- Pain, Physical Function, Age
- Trial name
- NCT05208463
- Testing
- Joint Academy
- Where
- Sweden
- Volunteers
- 14,610 people
- Sponsor
- Joint Academy
Knee Osteoarthritis (Knee OA)
Effects of Core Stabilization Exercises in Female Patients With Gonarthrosis
Osteoarthritis (OA) is a non-inflammatory degenerative disease characterized by progressive deterioration of cartilage tissue, synovial membrane, and joint capsule, primarily affecting weight-bearing joints.
- Trial name
- NCT07482332
- Testing
- 10 days of conventional physiotherapy (Hot Pack, TENS, Ultrasound) and 6 weeks of routine knee exercises, Six weeks of core stabilization exercises.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cumhuriyet University
Bilateral Knee Osteoarthritis
Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA
This is a randomized, open-label, parallel group study to compare systemic exposure of triamcinolone acetonide following administration into both knees of either FX006 or TAcs.
- Trial name
- NCT03378076
- Testing
- FX006 32 mg, TAcs 40 mg
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Amputation, Osteo Arthritis Knee
Femoral Cartilage Thickness In Patients With Lower Limb Amputation
The aim of the study to investigate any relation with functional parameters and femoral cartilage thickness evaluation by ultrasonography in lower extremity amputate individuals.
- Trial name
- NCT04422717
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Osteoarthritis, Mindfulness
A Mindfulness Program (MBSR) in the Management of Symptomatic Hip and Knee Osteoarthritis
Symptomatic osteoarthritis (OA) is the most common joint disease and the leading cause of disability in industrialized countries.
- Conditions
- Osteoarthritis, Mindfulness, MBSR
- Trial name
- MINDFULNESS_OA (NCT03644615)
- Testing
- Mindfluness and usual care, Usual care
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Osteoarthritis Pain
Evaluate the Efficacy and Safety of ACP-044 in Subjects With Pain Associated With Osteoarthritis of the Knee
To evaluate the efficacy of ACP-044 compared with placebo in the treatment of pain associated with osteoarthritis of the knee
- Trial name
- NCT05008835
- Testing
- ACP-044 Dose A, ACP-044 Dose B
- Where
- 34 sites in United States
- Volunteers
- 61 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Osteoarthritis, Knee
Prospective Post-Market Data Collection on Patients With Knee OA and Treated With nSTRIDE APS
This study will document treatment effects, changes in quality of life, procedure complications, adverse events, healthcare resource utilization, and further needed intervention(s) following treatment with nSTRIDE autologous…
- Trial name
- PROGRESS III (NCT02580643)
- Testing
- APS
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Zimmer Biomet
Osteoarthritis (OA) of the Knee
Kinesio Taping After Platelet-Rich Plasma Treatment in Individuals With Knee Osteoarthritis
This randomized controlled study evaluated whether kinesio taping provided additional benefits compared with sham taping in women with knee osteoarthritis who had received platelet-rich plasma (PRP) treatment as part of routine…
- Trial name
- NCT07773324
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Agri Ibrahim Cecen University
Osteoarthritis
Total Knee Arthroplasty Comparing Cementless to Cemented Fixation
The purpose of this study is to determine if there are any clinical or radiographic differences in cemented and cementless fixation in total knee replacement.
- Trial name
- NCT01335438
- Testing
- Cementless (Nexgen), Cemented (Nexgen)
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Young Hoo Kim
Knee Osteoarthritis, Task Performance and Analysis
Knee Osteoarthritis, Motor Control, Risk of Falls and Virtual Reality
The goal of this clinical trial is to learn about knee osteoarthritis, functionality, and risk of falls in community-dwelling adults aged 60 years and older.
- Conditions
- Knee Osteoarthritis, Task Performance and Analysis, Accidental Falls, Virtual Reality
- Trial name
- NCT06362785
- Testing
- Virtual Reality, Therapeutic exercise
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Knee Osteoarthritis
Autologous Adipose Stem Cells and Platelet Rich Plasma Therapy for Patients With Knee Osteoarthritis
Adipose stem cells and platelet rich plasma can regenerate the injured cartilage.
- Trial name
- NCT02142842
- Testing
- Autologous adipose tissue stromal vascular fraction and platelet rich plasma
- Where
- 3 sites in Vietnam
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Science Ho Chi Minh City
Degenerative Joint Disease, Osteoarthritis
PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.
The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade 4.0 during total knee replacement; to monitor and record post-operative pain, activity level, narcotic consumption, adverse…
- Trial name
- PRECISE (NCT01081886)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Medtronic Surgical Technologies
Knee Osteoarthritis
Taping Versus Conventional Physiotherapy in Knee Osteoarthritis
The purpose of this study is to determine the effects of kinesio taping versus conventional physiotherapy in women with knee osteoarthritis.
- Trial name
- NCT05606354
- Testing
- Intervention group
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Dow University of Health Sciences
Osteoarthritis, Knee
Efficacy and Safety Study of Transdermal Therapeutic System (TTS) Fentanyl in Participants With Osteoarthritis Knee Pain
The purpose of this study is to evaluate the efficacy and safety of Transdermal therapeutic system (TTS) fentanyl patches (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01742897
- Testing
- TTS-fentanyl
- Where
- Thailand
- Volunteers
- 35 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Knee Osteoarthritis
Wearable Sensor-based Balance Training for Patients With Knee Osteoarthritis
Knee osteoarthritis (KOA) is one of the leading causes of lower limb disability among the elderly and can cause loss of knee joint proprioception that contributes towards deterioration of postural balance.
- Trial name
- NCT02620462
- Testing
- Wearable sensor-based exercise training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Arizona
Osteoarthritis, Knee
Multiple Ascending Doses (MAD) of Anti-A Disintegrin and Metalloproteinase With Thrombospondin Motifs-5 (Anti-ADAMTS-5) Nanobody in Participants With Knee Osteoarthritis (OA)
The study will be conducted in participants with symptomatic knee OA to explore the safety, tolerability, immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD) of MAD of M6495.
- Trial name
- NCT03583346
- Testing
- M6495
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Knee Osteoarthritis, Umbilical Cord Bleeding
The Maximum Tolerated Dose of Mesenchymal Stem Cells From Umbilical Cord
The aim of this study was to evaluate the maximum tolerated dose of Mesenchymal Stem Cells (MSCs) from umbilical cord in the treatment of human knee OA
- Trial name
- NCT03357770
- Testing
- mesenchymal stem cells
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Osteoarthritis, Joint Diseases
Knee Stability Training for Knee Osteoarthritis (OA)
People with knee osteoarthritis (OA) frequently complain of knee instability. This study will test whether certain exercises can improve knee stability, reduce pain, and improve physical function in people with knee OA.
- Trial name
- NCT00078624
- Testing
- Traditional exercise therapy for knee osteoarthritis, Knee stability training
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- University of Pittsburgh
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