Clinical trials: Knee Surgeries
Anterior Cruciate Ligament Rupture
Initial Graft Tension and ACL Surgery
The anterior cruciate ligament (ACL) is one of four strong ligaments connecting the bones of the knee joint. If overstretched, the ACL can tear. Reconstruction of a torn ACL is now a common surgical procedure.
- Trial name
- NCT00434837
- Testing
- Initial graft tension during ACL reconstruction surgery
- Where
- 2 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Postoperative Pain After Arthroscopic Knee Surgery
Adductor Canal Block Versus Parasartorial Compartment Block for Pain Relief and Recovery After Arthroscopic Knee Surgery
The goal of this clinical trial is to compare adductor canal block and parasartorial compartment block for pain relief and functional recovery in adults undergoing elective arthroscopic knee surgery.
- Trial name
- NCT07790393
- Testing
- Meperidine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Efficacy of Drugs in Pain Management
Dexamethasone Versus Dexmedetomidine in IPACK Block to Reduce Pain Post Arthroscopic Knee Surgeries
The investigators will test the effects of dexamethasone versus dexmedetomidine as adjuvant to bupivacaine in IPACK Block and it's direct effect in decreasing pain post operative following Arthroscopic knee surgeries
- Trial name
- NCT07024043
- Testing
- Dexamethasone versus Dexmedetomidine in IPACK Block to reduce pain post Arthroscopic knee surgeries, IPACK and multi-modal analgesic regimen
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anterior Cruciate Ligament Rupture
Comparison of Different Anterior Cruciate Ligament Surgery Techniques in Skeletally Immature Patients.
This cohort study compares to groups of patients with reconstruction of anterior cruciate ligament (ACL). Patients in group 1 had ACL-reconstruction in the years 2001-2010 with a transphyseal drilling technique.
- Trial name
- NCT04644497
- Testing
- ACL-reconstruction
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Knee Surgeries, Total Ankle Arthroplasty
Adductor Canal Block With IPACK Versus 4-in-1 Block for Postoperative Analgesia in Knee Surgery
This randomized interventional study compares the analgesic efficacy of Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) versus the 4-in-1 block technique in patients undergoing knee…
- Conditions
- Knee Surgeries, Total Ankle Arthroplasty, Anterior Cruciate Ligament (ACL) Tear, Posterior Cruciate Ligament Tear
- Trial name
- NCT07700797
- Testing
- Adductor canal block with IPACK, 4 in 1 block
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Hemodynamic Instability, Anesthesia
Hemodynamic Changes and Propofol Pharmacokinetic Variation During Anesthesia Induction and Knee-chest Positioning
Induction of anesthesia and the knee-chest position are associated with hemodynamic changes that may impact patient outcomes. Changes from baseline in cardiac output and other hemodynamic variables following induction of…
- Conditions
- Hemodynamic Instability, Anesthesia, Surgery
- Trial name
- NCT03961958
- Testing
- Propofol reduction
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Kinesiophobia
Kinesiophobia in Patients Undergoing Total Knee Replacement Surgery
Providing information to the patient before surgery has important effects on the patient's self-care skills regarding the treatment and care process, reducing stress and reducing fears in the postoperative period.
- Trial name
- NCT05950217
- Testing
- Education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Osteoarthritis, Knee
Technology and System for Minimally Invasive TKA Surgery Robot
Developed a robot for minimally invasive TKA surgery and prepare for the subsequent CFDA application of the minimally invasive total knee replacement robot system.
- Trial name
- NCT04953988
- Testing
- Robotic TKA, Manual operation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Postoperative Pain; Knee Arthroscopy; Acupuncture
Acupuncture for Pain Control After Ambulatory Knee Arthroscopy
Aim of the study: To investigate whether acupuncture with indwelling fixed needles reduces pain and analgesic requirement and foster mobilization in patients after arthroscopic knee surgery (AKS) Design: Prospective pilot…
- Trial name
- AcuK-Scope (NCT04134702)
- Testing
- Acupuncture
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Surgical Education, Clinical Competence
Mixed Reality vs. Traditional Arthroscopic Simulation
This randomized controlled trial evaluates and compares the educational effectiveness of two arthroscopic training platforms: a traditional physical bench-model simulator and an immersive Mixed Reality (MR) simulator.
- Trial name
- NCT07648056
- Testing
- Traditional Simulator Training, Mixed Reality Simulator Training
- Where
- Portugal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Arthroscopic Knee Surgery
Study to Find Optimal Dose of Local Spinal Anesthetic (Mepivacaine) Combined With Narcotic (Fentanyl) For Knee Surgery
Prolonged motor block and delayed ability to walk are limitations of spinal anesthesia in ambulatory (same-day) surgery. This can be improved by lowering the dose of local anesthetic (a medication that, when injected around…
- Trial name
- NCT01701102
- Testing
- Mepivacaine (24 mg) plus fentanyl, Mepivacaine (27 mg) plus fentanyl, Mepivacaine (30 mg) plus fentanyl
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Stress
Effect of Audio Book applıcatıon on patıents Blood Pressure, Pulse Rate and anxıety Levels Before Total Knee Replacement Surgery
Before the TDP surgery, the anxiety levels of the patients in the experimental group will be measured by listening to an audio book.
- Trial name
- NCT06905899
- Testing
- audiobook app
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Beyza Yilmaz
Anesthesia Morbidity, Osteoarthritis, Knee
Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System
The study is a retrospective cohort study of adult patients undergoing outpatient primary unilateral total knee or total hip replacement surgeries from 2017 to 2019 assessing for difference in anesthetic techniques and outcomes.
- Conditions
- Anesthesia Morbidity, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT04203732
- Testing
- Anesthesia Type
- Where
- United States
- Volunteers
- 12,466 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Knee Arthroplasty
Active Versus Passive Motion Device Following Knee Replacement Surgery
The purpose of this study is to determine how well an active motion device, Camoped, works compared to a continuous passive motion device, CPM, for rehabilitation after partial or total knee replacement.
- Trial name
- NCT02339831
- Testing
- CAMOPED, CPM passive motion device
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Total Knee Replacement, Wound Complication
Wound Healing in Primary TKA
Wound complications after total knee arthroplasty (TKA) can arise from many patient-specific factors, such as vascular or immune-related medical conditions, obesity, and smoking, among others.
- Trial name
- NCT06007599
- Testing
- Skin closure using skin adhesive, Skin closure without skin adhesive
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
ACL Injury, Hip Injuries
Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery
This study will utilize the Moxy wearable sensor to measure muscle oxygen saturation levels in athletes following lower extremity surgery (ACL or Hip arthroscopy) to evaluate their Return-to-Play.
- Trial name
- NCT05488054
- Testing
- Physical Therapy, Monitored Work-out, Moxy Oxygen Sensor Device
- Where
- 2 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Leg Injury, Arthroplasty, Replacement, Knee
Comparison of Ropivacaine With or Without Fentanyl in Spinal Anaesthesia for Lower Limb Surgeries
There has been a wide variety of use of anaesthetic agents along with adjuncts during subarachnoid block. The quest for attaining adequate analgesia and anaesthesia has always been shadowed by the concurrent deleterious effect of…
- Trial name
- NCT04199013
- Testing
- Ropivacaine 0.75% Injectable Solution, Fentanyl Citrate
- Where
- Nepal
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Arthritis Knee, Spine Fusion
Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery
The present study is a multi-center randomized prospective non-inferiority trial. The study's primary objective is to compare the coagulation profile upon using two different TXA administration strategies: empirical TXA…
- Conditions
- Arthritis Knee, Spine Fusion, Prostate Cancer, Arthritis of Hip
- Trial name
- NCT05957822
- Testing
- TXA, TEG6
- Where
- South Korea
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Anesthesia
Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service
A comparison of two anesthetic techniques for total knee replacements: (1) Peri-Articular Injection (PAI), local infiltration between the popliteal artery and capsule of the knee block (IPACK) and single-shot adductor canal block…
- Trial name
- EKAT-TeleTPS (NCT03747146)
- Testing
- Continuous Adductor Canal Catheter (ACC)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York