Clinical trials: Labor, Obstetric
Preterm Birth
Comparative Study Between Vaginal Progesterone Alone or Combined With Aspirin in Prevention of Recurrent Preterm Birth
This is a double blinded randomized placebo controlled clinical trial to detect the efficacy and safety of vaginal progesterone alone or combined with aspirin in prevention of recurrent PTB.
- Trial name
- prematurity (NCT05319834)
- Testing
- Aspirin tablet
- Where
- Egypt
- Volunteers
- 256 people
- Sponsor
- Menoufia University
Premature; Infant, Light-for-dates
Re-feeding Gastric Residuals in Preterm Infants
The purpose of this study is to determine whether re-feeding of gastric residuals reduces the time needed to establish full enteral feedings in premature infants.
- Trial name
- NCT01420263
- Testing
- Re-feeding residuals, Fresh Feeding Breastmilk or Formula only
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Alabama at Birmingham
Breast Milk, Digestion
The Effect of Breast Milk Smell on Nutrition in Preterms
The study was planned to determine the effect of breast milk odor applied during gavage feeding on early feeding cues of preterm newborns, the transition time to oral feeding and abdominal perfusion.
- Conditions
- Breast Milk, Digestion, Nutrition, Smell Stimulation
- Trial name
- NCT04843293
- Testing
- Olfactory stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Postpartum Hemorrhage Treated With Sulprostone
Emotional and Cardiac Impact of Postpartum Haemorrhage
To assess the impact and to identify the main risk factors for psychological and cardiac morbidity (post-traumatic stress disorder, anxiety and depression) in case of postpartum hemorrhage
- Trial name
- HELP-MOM (NCT02118038)
- Where
- France
- Volunteers
- 329 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Placenta Accreta
Placenta Accreta; Total Lower Uterine Segmentectomy With Cervico-corporeal Anastomosis
To study feasibility and safety of Total lower uterine segmentectomy with cervico-corporeal anastomosis in conservative management of placenta accreta
- Trial name
- NCT05419804
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Assiut University
Labor Pain, Obstetric Pain
Color Doppler Ultrasound to Locate Needle in Labor Epidural
Color Flow Doppler (CFD) utilizes Doppler information obtained from signals sent to and received from a transducer. This information is color-encoded and then displayed as color on an overlay of the two-dimensional image.
- Trial name
- NCT03596333
- Testing
- Retrospective chart review
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Augusta University
Intestinal Disease, Feeding Disorder Neonatal
Lactated Ringer's Solution in Neonates With Feeding Intolerance
The objective of this study is determining if enteral administration of Lactated Ringer's solution (LR) in preterm infants with feeding intolerance enables for faster advancement of milk feeding than fasting.
- Trial name
- LR (NCT01236833)
- Testing
- Lactated Ringer's Solution
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Placenta Praevia, Vaginismus
Transperineal Ultrasound to Assess the Progress of Labour
This is a prospective observational study of transperineal ultrasound between 24-42 weeks gestation and a prospective longitudinal observational study in all term (37-42 weeks) labouring women.
- Trial name
- NCT02430038
- Where
- United Kingdom
- Volunteers
- 584 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Shock
Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period
Haemodynamic insufficiency after birth is seen commonly in babies born prematurely and is associated with adverse outcomes. In current clinical practice, a combination of blood pressure and clinical signs is used to guide…
- Trial name
- NeoCirc-001 (NCT03311178)
- Testing
- Dobutamine
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Necrotizing Enterocolitis, Premature Birth
Role of Epidermal Growth Factor (EGF) in Development of Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is a serious gastrointestinal disorder that primarily affects preterm infants. About 10% of babies less than 32 weeks gestation at birth will develop it.
- Trial name
- NCT00059449
- Where
- 3 sites in United States
- Volunteers
- 372 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Placenta Accreta, Third Trimester
Magnetic Resonance Imaging (MRI ) Versus Ultrasound in Placenta Accreta Diagnosis
This study aim to assess the accuracy of magnetic resonance imaging (MRI) compared to gray-scale and colour Doppler ultrasound (US) for the prenatal diagnosis of placenta accreta.
- Trial name
- NCT03813212
- Testing
- MRI
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
PPH - Postpartum Hemorrhage, Eclampsia
Comparing Simulated Patients and Manikin Based Simulation in Obstetrics
The aim of this randomized study is to compare a live, trained simulated patient with a high-fidelity manikin in obstetric emergency team training using two standardized scenarios.
- Trial name
- NCT07857551
- Testing
- Trained, standardized patient, MamaAnne Patient Simulator
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Premature, Neonatal Intensive Care Unit
The Effect of Gentle Human Touch and Stimulus Reduction on Pain and Comfort During Heel Blood Collection in Premature Newborns
Premature infants frequently experience painful procedures during their admission to neonatal intensive care units; this can lead to acute adverse events, imbalances, and long-term neurodevelopmental implications.
- Conditions
- Premature, Neonatal Intensive Care Unit, Touch, Nursing Care
- Trial name
- NCT07715682
- Testing
- Gentle Human Touch, Environmental Modification
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kubra Nur Kabakcı Sarıdağ
Postpartum Hemorrhage, Uterine Atony
Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial
The aim of this study is to evaluate in a randomized fashion the comparative efficacy of two second-line medications, methylergonovine and carboprost for treating atonic postpartum hemorrhage (PPH).
- Trial name
- NCT03584854
- Testing
- 15-methyl prostaglandin F2α, Methylergonovine Maleate
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Severe Postpartum Haemorrhage
Clinical Outcomes of NovoSeven® Treatment in Severe Postpartum Haemorrhage - a Study at the University Hospital of Bern
This non-interventional study will compare the clinical outcomes in women with an event of severe postpartum haemorrhage treated with NovoSeven® to clinical outcomes in women with an event of severe postpartum haemorrhage not…
- Trial name
- NCT04444856
- Testing
- Eptacog alfa (activated), Standard of care
- Where
- Switzerland
- Volunteers
- 225 people
- Sponsor
- Novo Nordisk A/S
Preterm Birth
Maternal and Fetal/Neonatal Pharmacokinetics and - Dynamics of Corticosteroids During Pregnancy
Improving pregnancy outcome is essential in improving health of both parents and their offspring during the life course. Preterm birth (PTB) occurs in 10-15% of all pregnancies, is the leading cause of perinatal mortality and…
- Trial name
- MaDyCo (NCT06264973)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Prematurity
The Effect of Lipid Emulsions on Free Fatty Acids and Free Bilirubin in Premature Newborns
The goal of this research study is to compare the levels of free fatty acids and free bilirubin between two intravenous lipid emulsion products in premature newborns.
- Trial name
- NCT03857646
- Testing
- Intralipid, 20% Intravenous Emulsion, Soybean oil Medium-chain triglycerides Olive oil Fish Oil (SMOF) lipid
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- The University of Texas Health Science Center, Houston
Premature Infant, Breast Milk Expression
Growth and Nutritional Status of Very Low Birth Weight Infants Fed a High Protein Exclusive Human Milk Diet
The purpose of this two-arm investigation is to determine if growth patterns of very low birth weight infants (VLBW) (birth weight 750-1500 grams) fed human milk (maternal or donor) supplemented with a human milk-based fortifier…
- Trial name
- MedolacHMF (NCT03839173)
- Testing
- Human milk based human milk fortifier
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Augusta University
Preterm Labor
Cyclin-dependent Kinase Inhibitor 2A (Placental Senescence Marker) on Labor-related Signals
Onset of labor in human is initiated by progesterone withdrawal. Over many decades researchers had proposed hypotheses to explain the functional withdrawal of progesterone.
- Trial name
- NCT05864066
- Volunteers
- 81 people
- Sponsor
- Assiut University
Labor, Obstetric, Pain
Estimation of Pain During Epidural Analgesia During Labor
Epidural regional anesthesia is a technique to eliminate or lessen pain during obstetric labor and childbirth. It consists in establishing a catheter into the epidural space and to block the transmission of pain sensations by…
- Trial name
- PERIDANS (NCT02551354)
- Testing
- Portable video pupillometer
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
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