Clinical trials: Light
COVID-19 Respiratory Infection, Influenza
Light-based Immunomodulation for Guarding Against Human Respiratory Tract Infections
The purpose of trial is to determine if daily usage of a photobiomodulation device will decrease the incidence of upper respiratory tract infections (URI) due to COVID, influenza or other viruses.The RD-X10 device is handheld…
- Trial name
- LIGHT (NCT07610967)
- Testing
- RD-X19
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- David Moss
Regional Blood Flow, Ocular Physiology
Mechanisms of Choroidal Blood Flow Changes During Dark/Light Transitions
There is evidence from a variety of animal studies that choroidal blood flow is under neural control. By contrast, only little information is available from human studies.
- Trial name
- NCT00431392
- Testing
- Phenylephrine, NG-Monomethyl-L-Arginine, Propanolol
- Where
- Austria
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Breast Cancer
Effects of Bright Light on Co-occurring Cancer-related Symptoms in Breast Cancer Survivors
This study will implement therapeutic bright light that is tailored to the individual's circadian typology and will estimate its effects on circadian rhythms, 4 common cancer-associated symptoms, and impact on quality of life in…
- Trial name
- NCT03304587
- Testing
- Polysomnography (PSG), Rectal thermistor 400 Series, Bright blue-green light
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Dental Caries, Dental White Spot
Effect of Light Curable Resin Modified Glass Ionomer Varnish on Non-Cavitated Proximal Carious Lesions' Progression
The standard-of-care preventive measures to stop early tooth decay from becoming worse is by fluoride application, diet counseling, and oral hygiene instructions. This standard way is not always successful.
- Trial name
- NCT03685058
- Testing
- Light curable resin modified glass ionomer varnish, standard-of-care preventive measures
- Where
- Saudi Arabia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Orthodontic Retainer
Comparative Assessment of Failure Rate of Fixed Lingual Retainer Between Two Types of Light Cured Resin Composite
The study will be performed on human subjects with finished orthodontic treatment to see the failure rate(detachment) of fixed lingual retainer between two types of light cure resin composite
- Trial name
- NCT05660668
- Testing
- Transbond LR, Transbond XT
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Inflammatory Disease
Study of Intravenously Administered Anti-LIGHT Monoclonal Antibody CBS001 in Healthy Volunteers
A Phase 1, first in human (FIH), single-centre, double-blind, randomized, placebo-controlled, dose escalating trial to assess the safety and tolerability, pharmacokinetics (PK), immunogenicity and pharmacodynamics (PD) of CBS001…
- Trial name
- NCT05323110
- Testing
- CBS001
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Capella Bioscience Ltd
Peripheral Artery Disease (PAD)
Using Near-Infrared Light to Better Understand Peripheral Artery Disease
The goal of this study is to better understand how blood flows and how oxygen is utilized in the lower limbs of people who suffer from peripheral artery disease.
- Trial name
- NCT07313410
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Nanotechnology, Dental Materials, Composites
Nano Composites and Light Cure Composites - A Comparative Assessment of Bond Failure Rates
This randomized clinical trial is aimed to evaluate the bond failure rates of the brackets bonded with nano-hybrid composites (Filtek Z250) to that of conventional composites (Transbond XT)
- Trial name
- NCT05644860
- Testing
- Nanohybrid Compisite Group (Filtek Z250), Conventional Composite Group (Transbond XT)
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Non-visual Effects of Light, Chronic Variable Sleep Deficiency
Sleep, Light, Circadian, Central Oxidative Stress
Irregular sleep timing and sleep deficiency are pervasive in society despite evidence that sleep deficiency impairs cognition and is linked to neurodegenerative disease.
- Trial name
- NCT07471126
- Testing
- Chronic Variable Sleep Deficiency, Sleep- and Circadian-Informed Lighting, Dim Light
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Myopia, Progressive, Refractive Errors
Repeated Low-Level Red-Light Therapy and Orthokeratology in Fast-progressing Myopia Control
The purpose of this multicenter randomized clinical trial is to evaluate the adjunctive effect of repeated low-level red-light therapy (RLRL) and orthokeratology (ortho-k) on myopia control in ortho-k non-responders who have…
- Conditions
- Myopia, Progressive, Refractive Errors, Eye Diseases
- Trial name
- NCT04722874
- Testing
- Ortho-k lenses, RLRL
- Where
- 3 sites in China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Vitiligo, Dermatology/Skin - Other
Early Molecular Changes in Vitiligo After Narrowband Ultraviolet Therapy
Vitiligo is a chronic acquired cutaneous disease of pigmentation that affects patients' quality of life across all degrees of involvement and severity.
- Trial name
- NCT03270241
- Testing
- Phototherapy (NB-UVB) via the 3 Series PC & SP phototherapy cabinet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Light, Stress
Effect of Light Color Temperature Applied During Breastfeeding on Mother's Stress, Anxiety, Peace and Breastfeeding Motivation
Breastfeeding is an important condition for the health of the mother and the baby, which is the most difficult for mothers after birth.
- Conditions
- Light, Stress, Anxiety
- Trial name
- NCT06736886
- Testing
- Light application
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Osmaniye Korkut Ata University
Healthy Subjects
Shoulder Strength in Baseball Players
The purpose of this graduate student research study is to transform the existing concepts surrounding shoulder strength in baseball players, particularly in the context of retroverted shoulders.
- Trial name
- NCT07209423
- Testing
- Strength and Range of Motion
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Acne
Blue Light Therapy of C. Acnes
This proposal aims to investigate a novel light-based treatment to reduce morbidity in shoulder surgical patients. This has potential to improve outcomes and reduce health care utilization associated with infectious complications…
- Trial name
- NCT04300010
- Testing
- 5% Topical Benzoyl Peroxide Gel, Blue Light Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Skin Diseases, Keloid
Phase 1 Study of HF-LED-RL in Fitzpatrick Skin Types I to III
The goal of this study is to establish the safety of high fluence LED-RL at fluence of 480 J/cm2 and 640 J/cm2 in healthy non-Hispanic, Caucasian subjects.
- Conditions
- Skin Diseases, Keloid, Scar, Fibrosis
- Trial name
- NCT03433222
- Testing
- HF-LED-RL Phototherapy, Mock Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Northern California Health Care System
Musculoskeletal Pain, Fibromyalgia
Neural Mechanisms of Light Driven Analgesia
The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical…
- Conditions
- Musculoskeletal Pain, Fibromyalgia, Healthy Controls Group - Age and Sex-matched
- Trial name
- NCT07245303
- Testing
- S-cone modulating visual stimulus, Equal Energy White Visual Stimulus, Green light visual stimulus (S-OFF)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Peripheral Neuropathy
Effects of Light Emitting Diode Irradiation on the Conduction Parameters of the Superficial Radial Nerve
The introduction of light emitting diode (LED) devices as a novel treatment for pain relief in place of low-level laser warrants fundamental research on the effect of LED devices on one of the potential explanatory mechanisms…
- Trial name
- NCT01513148
- Testing
- Superluminous light diode
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Shenandoah University
Violence in Adolescence
Lights, Camera and Action Against Dating Violence (Lights4Violence)
Lights4Violence aims to promote adolescents' capabilities to improve their intimate relationships with peers through different participation approach activities.
- Trial name
- NCT03411564
- Testing
- Filming Together to See Ourselves in a New 'Present'
- Where
- Spain
- Volunteers
- 1,555 people, healthy volunteers welcome
- Sponsor
- University of Alicante
Algorithm Verification
mCVI® Lighting Conditions Clinical Study
This single center prospective clinical study is to verify the algorithm of mCVI® in 4 different lighting conditions to accurately capture pulse rate and respiratory rate in 10 healthy subjects in comparison to…
- Trial name
- NCT04811300
- Testing
- There is no intervention
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Intelomed, Inc.
Dental Caries, Dental Plaque
Orthodontic Varnish Microbiology Study
Orthodontic treatment is common in teenagers, which typically involve the attachment of metal brackets to the teeth. These brackets often impede proper oral hygiene, leading to plaque accumulation and the development of white…
- Conditions
- Dental Caries, Dental Plaque, Dental White Spot
- Trial name
- NCT04528134
- Testing
- Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles