Clinical trials: Low Grade
Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm
Artificial Intelligence-powered Low-Dose Computed Tomography for Screening of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with early diagnosis crucial for improving survival. Due to the absence of effective screening methods, most patients are diagnosed at advanced stages.
- Conditions
- Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, High-grade Pancreatic Intraepithelial Neoplasia, PDAC - Pancreatic Ductal Adenocarcinoma
- Trial name
- AI-LDCT-PC (NCT07117045)
- Testing
- Diagnostic Evaluation for Positive AI Findings
- Where
- 5 sites in China
- Volunteers
- 400,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Overweight or Obesity, Healthy
Anti-inflammatory Effect and Associated Mechanisms of Mango Consumption
The primary objective of this project is to provide new knowledge through a comprehensive set of analyses that investigate the complex interplay between regular mango intake, gut microbial structure/ function, mechanisms of…
- Trial name
- MG2 (NCT04726293)
- Testing
- Mango, Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Immune Senescence, Low-grade Inflammation
Immune Benefits of Coffee
This study will assess whether coffee consumption: increases immune responses decreases inflammatory status
- Trial name
- NCT00860197
- Testing
- Fully torrefied coffee, Partially torrefied coffee
- Where
- Chile
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Chile
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
The LINFU® U.S. Registry for the in the General Population Without Risk Factors
Adenocyte has developed LINFU®, (Low Intensity Non-Focused Ultrasound excitation of the pancreas) as a method of identifying early, asymptomatic pancreatic cancer and its noninvasive precancerous lesions..
- Conditions
- Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, Pancreatic Dysplasia
- Trial name
- NCT06276803
- Testing
- LINFU®
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Adenocyte, LLC
Periodontal Diseases, Periodontal Attachment Loss
Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal Treatment
The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Periodontal Disease, AVDC Stage 3, Periodontal Inflammation
- Trial name
- NCT05233501
- Testing
- low level laser therapy, non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Beykent
Overweight
The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.
A randomized, double-blind, crossover dietary intervention trial will test the effects of 4 weeks of daily honey-flavored yogurt intake on markers of inflammation (Th17 cytokines) and oxidative stress (NOX2, UA, RSNO) and…
- Trial name
- NCT04248127
- Testing
- Honey sweetened yogurt, Sugar sweetened yogurt
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Poly Cystic Ovarian Syndrome, Polycystic Ovary Syndrome (PCOS)
Biomechanical Changes in Females with Poly Cystic Ovarian Syndrome
Polycystic ovarian syndrome (PCOS) is a prevalent endocrine disorder that causes an inversion of the normal luteinizing hormone (LH) to follicle-stimulating hormone (FSH) ratio.
- Trial name
- NCT06673901
- Testing
- Measurments
- Where
- Egypt
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Cairo University
Depressive Disorder, Major
Dopamine Modulation of Motivation and Motor Function in Major Depression & Inflammation
A large body of evidence on depression heterogeneity point to an "immunometabolic" subtype characterized by the clustering of immunometabolic dysregulations with atypical behavioral symptoms related to energy homeostasis.
- Trial name
- MOTIVADE (NCT05909267)
- Testing
- L-dopa/Carbidopa
- Where
- Germany
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
HPV-16/18, Photodynamic Therapy (PDT)
Multicenter Prospective Non-randomized Controlled Study of ALA-PDT for LSIL With HPV16/18 Infection
This multicenter, prospective trial assesses ALA-PDT versus observation for efficacy and safety in treating cervical LSIL with HPV16/18 infection.
- Conditions
- HPV-16/18, Photodynamic Therapy (PDT), LSIL, Low Grade Squamous Intraepithelial Lesion
- Trial name
- ALA-PDT-LSIL (NCT07306247)
- Testing
- ALA-PDT
- Where
- 5 sites in China
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Anemia
Inflammation, Iron Deficiency and Anaemia Study 1
Investigator have previously shown that hepcidin is up-regulated even by low levels of inflammation and, according to our prior stable isotope studies, is predicted to block iron absorption.
- Trial name
- NCT04097639
- Where
- The Gambia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Psychology, Social, Inflammation
Body and Social Behavior
This randomized, double-blind, placebo-controlled study of the influenza vaccine will shed important light on how the immune system responds to different positive and negative social experiences.
- Conditions
- Psychology, Social, Inflammation, Defeat, Social, Interaction, Social
- Trial name
- BSB (NCT05654441)
- Testing
- Influenza vaccine
- Where
- 2 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Multiple Myeloma, Low-Grade Lymphoma
64Cu-LLP2A for Imaging Hematologic Malignancies
This phase of the protocol (protocol part B), seeks to evaluate the new formulation in healthy normal volunteers to confirm the new formulation provides comparable human dosimetry to which was seen and published in protocol part…
- Conditions
- Multiple Myeloma, Low-Grade Lymphoma, Follicular Lymphoma, Marginal Zone Lymphoma
- Trial name
- NCT06636175
- Testing
- 64Cu-LLP2A, PET/CT
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Glucose Regulation, Low-grade Inflammation
Effect of Milk Ingredients on Glucose Regulation and Inflammation
Background: Recent advances in science have established a fundamental role for low grade chronic inflammation in mediating all stages of most of the non-communicable diseases associated with ageing.
- Trial name
- NCT02011672
- Testing
- nutrient-enriched milk, regular milk
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Furcation Defects, Periodontal Diseases
Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade III Furcation Defects (FURC-III-OST)
Teeth with furcation grade III defects will be treated with open flap debridement, with or without osteoplasty. The study is designed to examine the effect of osteoplasty in the treatment of teeth with furcation grade III defects…
- Trial name
- FURC-III-OST (NCT04017429)
- Testing
- Open flap debridement with osteoplasty, Open flap debridement without osteoplasty
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oslo
Keto Diet, Aerobic Exercise
Comparative Effects of Aerobic Exercise and Keto Diet on Obesity-Related Biomarkers in Obese Women With High (WHR)
the aim of this study is to compare between aerobic exercise and keto diet in their effect on obesity related biomarkers (testosterone, TNF alpha, IL6, HMW, BMI, WHR) in 120 obese women with high WHR.
- Conditions
- Keto Diet, Aerobic Exercise, Obesity (Disorder)
- Trial name
- NCT07834099
- Testing
- Keto diet, Aerobic exercise, Aerobic exercise + keto diet
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Atherosclerosis
Observational Study of Early Metabolic and Vascular Changes in Obesity
To work against the increasing burden of obesity, the STYJOBS / EDECTA (STYrian Juvenile OBesity Study / Early DetECtion of Atherosclerosis) project was started at the Medical University of Graz in 2003.
- Conditions
- Obesity, Atherosclerosis, Inflammation, Adiponectin Deficiency
- Trial name
- STYJOBS (NCT00482924)
- Testing
- Lifestyle intervention
- Where
- Austria
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Medulloblastoma, Childhood, Healthy Volunteers
Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition
One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized…
- Conditions
- Medulloblastoma, Childhood, Healthy Volunteers, Fossa Posterior Tumor, Low-grade Glioma
- Trial name
- CervIRM (NCT04174820)
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- 5 sites in France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Vaginal Flora Imbalance, ASC-US
"Lactobacillus Crispatus M247, LSIL and Microbiota"
Patients affected by ASC-US/ low-grade HPV cervical lesions will be randomly assigned to treatment arm vs control arm. The treatment arm will include the characterization of the vaginal microbiota at enrollment (T0), 4 months of…
- Conditions
- Vaginal Flora Imbalance, ASC-US, LSIL, HPV Infection
- Trial name
- NCT05808816
- Testing
- Lactobacillus Crispatus M247
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Anesthesia, Local
Intraligamental Local Anesthesia Versus Infiltration Technique for Extraction of Grade II Mobility Maxillary Molars
The study aims to assess the use of intraligamental local anesthetic injection compared to buccal infiltration for extraction of maxillary molars suffering grade II mobility in terms of pain control and extraction duration.
- Trial name
- NCT05875350
- Testing
- Intraligamental local anesthetic injection
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Metabolic Syndrome, Impaired Glucose Tolerance
The Health Effect of Diet Rich in Nordic Berries
Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures.
- Conditions
- Metabolic Syndrome, Impaired Glucose Tolerance, Low-grade Inflammation, Dyslipidemia
- Trial name
- Berry (NCT01414647)
- Testing
- 300 g of strawberry, raspberry and cloudberry, 400 g of bilberry, Control diet
- Where
- Finland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen