Clinical trials: Macrosomia
Obesity, Gestational Diabetes
Impact of Diet and Exercise Activity on Pregnancy Outcomes
The general goal of the present study is to assess the impact of a community-based exercise and dietary intervention in pregnant women living in urban areas during and after their pregnancy on the reduction of the risks of both…
- Conditions
- Obesity, Gestational Diabetes, Type 2 Diabetes
- Trial name
- IDEA (NCT00486629)
- Testing
- Exercise and dietary education
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Gestational Diabetes, Pregnancy
Comparison of Two Screening Strategies for Gestational Diabetes (GDM2)
This is a single site blinded RCT of 920 pregnant women with singleton gestation designed to compare the Carpenter-Coustan and IADPSG criteria for diagnosing gestational diabetes.
- Conditions
- Gestational Diabetes, Pregnancy, Glucose Intolerance
- Trial name
- GDM2 (NCT02309138)
- Testing
- Gestational diabetes screening with fasting 3 hour 100 gm, Gestational diabetes screening with fasting 2 hour 75g
- Where
- United States
- Volunteers
- 921 people, healthy volunteers welcome
- Sponsor
- Esa M Davis, MD MPH FAAFP
Gestational Diabetes
The Use of Early Pregnancy HbA1c in Predicting Excessive Fetal Growth in Women at Risk of Glucose Intolerance
The association of hyperglycaemia in pregnancy (gestational diabetes mellitus; GDM) with adverse maternal and fetal outcomes is clearly recognised.
- Trial name
- SHAPE (NCT04858386)
- Where
- United Kingdom
- Volunteers
- 1,314 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Retardation, Fetal Growth, Macrosomia, Fetal
Antenatal Development Evaluated Prospectively
Fetal growth abnormalities is one of the most common problems faced in modern obstetrics. The association between low birth weight and perinatal death as well as severe morbidity is well known.
- Trial name
- ADEPT (NCT02478554)
- Testing
- Customized fetal growth curves
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Fetal Macrosomia, Intrauterine Growth Disorders (IUGR and Macrosomia)
Estimation of Fetal Weight by Measuring Abdominal Circumference, Abdominal Subcutaneous Soft Tissue Thickness, Femur Length and Mid-thigh Soft Tissue Thickness
Traditional methods for estimating fetal weight (EFW) often miss the mark because they focus on bone and circumference while ignoring fetal fat. This study proposes a more inclusive formula to fix that.
- Conditions
- Fetal Macrosomia, Intrauterine Growth Disorders (IUGR and Macrosomia), Intrauterine Growth Restriction (IUGR)
- Trial name
- NCT07575152
- Testing
- 3rd trimester ultrasound examination within 48-72 hours of delivery
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Fetal Macrosomia, Gestational Diabetes
Regulation Of Maternal Fuel Supply And Neonatal Adiposity
The purpose of this study is to determine whether unrecognized maternal hyperglycemia and postprandial lipemia early or late in gestation predicts excess neonatal adiposity.
- Trial name
- NCT00826904
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Fetal Macrosomia
Estimation of Fetal Weight by MR Imaging to PREdict Neonatal MACROsomia (PREMACRO Study)
Macrosomia and growth restriction are important causes of perinatal morbidity, at or near to term. However, clear identification of 'at risk' foetuses is difficult and clinical estimates of fetal weight are poor.
- Trial name
- NCT02713568
- Testing
- Ultrasound examination, Magnetic resonance examination
- Where
- Belgium
- Volunteers
- 2,413 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Fetal Macrosomia, Congenital Abnormality
Fish Oil Supplementation in Women With Gestational Diabetes
Gestational diabetes is the development of diabetes during pregnancy. Left untreated, gestational diabetes and preeclampsia can lead to serious -- or even fatal -- complications for both mother and child.
- Conditions
- Fetal Macrosomia, Congenital Abnormality, Other Respiratory Problems After Birth
- Trial name
- NCT02371343
- Testing
- Fish oil, Ocean plus, Sunflower Oil
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr. Sami Ulus Children's Hospital
Maternal Obesity Complicating Pregnancy, Birth,or Puerperium, Gestational Diabetes Mellitus
An Early-customized Low Glycaemic-index (GI) Diet Prevents LGA Babies in Overweight/Obese Pregnant Women
High pre-pregnancy body mass index (BMI) and excessive gestational weight gain (GWG) are associated with many unfavourable maternal and neonatal outcomes.
- Conditions
- Maternal Obesity Complicating Pregnancy, Birth,or Puerperium, Gestational Diabetes Mellitus, Birthweight, Large for Gestational Age (LGA)
- Trial name
- NCT02750774
- Testing
- Low-glycemic index group, Standard Care Group
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Gestational Diabetes
Active Patient GDM
Among women with GDM, the investigators will determine if a strategy of (1) a website-based information and motivational resource bank; (2) biosensor/ePlatform-based physical activity and GWG tracking; and/or (3) a health coach…
- Trial name
- NCT03802877
- Testing
- Resource bank, ePlatform, Health coach
- Where
- 6 sites in Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Overweight and Obesity, Weight Loss
PRE-Pregnancy Weight Loss And the Reducing Effect on CHILDhood Overweight - Aarhus
The study is a single site parallel randomized controlled study. The study will be assessing the effect of a 10% pre-conceptional weight loss intervention vs a control group among healthy couples where the prospective mother is…
- Conditions
- Overweight and Obesity, Weight Loss, Pregnancy Related, Child Nutrition Sciences
- Trial name
- PREPARE CHILD (NCT05798494)
- Testing
- Weight loss intervention
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ulla Kampmann Opstrup
Small for Gestational Age Infant, Large for Gestational Age Infant
"Fetal gRowth AbnorMality dEtection Trial"
The present trial intends to assess the diagnostic accuracy of symphysis fundal height (SFH) as opposed to SFH combined with point of care ultrasound to measure the fetal abdominal circumference (POC-US-AC) in identifying small…
- Conditions
- Small for Gestational Age Infant, Large for Gestational Age Infant, Oligohydramnios, Polyhydramnios
- Trial name
- FRAME (NCT05043753)
- Testing
- Point of care ultrasound to measure the fetal abdominal circumference (POC-US-AC)
- Where
- 3 sites in Italy
- Volunteers
- 1,566 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Fetal Growth Restriction, Gut Microbiota
Gut Microbiota, SCFAs and Glucolipid Metabolism in Pregnant Women With Abnormal Fetal Size and Their Newborns
Abnormal fetal size includes fetal growth restriction and fetal macrosomia. Onset is closely related to maternal nutrition metabolism.
- Conditions
- Fetal Growth Restriction, Gut Microbiota, Fetal Macrosomia, Glucolipid Metabolism
- Trial name
- NCT04399434
- Testing
- test gut microbiota, SCFAs and glucolipid metabolism and insulin sensitivity
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Large for Gestational Age Baby, Macrosomia, Fetal
A First Trimester Prediction Model for Large for Gestational Age Infants: a Preliminary Study
Large for gestational age infants (LGA) have increased risks of adverse short-term perinatal outcomes. This study aims to develop a multivariable prediction model for the risk of giving birth to a LGA baby, by using biochemical…
- Trial name
- PreMoLGA (NCT04838431)
- Testing
- Blood sample and ultrasound at first trimester
- Where
- Italy
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Accuracy of Sonographic Vs MRI Fetal Weight Estimation
Comparison of Sonographic and MRI Weight Estimation in Fetuses with Suspected Macrosomia
The goal of this clinical trial is to compare the accuracy of sonographic vs. magnetic resonance fetal weight estimation in suspected fetal macrosomia in term pregnancy.
- Trial name
- NCT06898892
- Testing
- Fetal MRI
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Small for Gestational Age at Delivery, Post-term Infant, Not Heavy-for-dates
Breast Milk Zinc Transfer to Appropriate- and Small-for-gestational-age Bangladeshi Infants
Data collected from this study will provide information on the breast milk zinc concentration, maternal and infant zinc status, and transfer of zinc from mothers breast milk to infants during first six months of life.
- Trial name
- NCT01728766
- Testing
- Small for gestational age at delivery, Post-term Infant, Not Heavy-for-dates
- Where
- Bangladesh
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pregnancy, Fetal Macrosomia
Correlation Between Placental Thickness in the Second and Third Trimester and Fetal Weight
The aim of this prospective longitudinal study was to investigate the relationship between placental thickness during the second and third trimesters and placental and birth weights.
- Conditions
- Pregnancy, Fetal Macrosomia, Intrauterine Growth Restriction
- Trial name
- NCT02473991
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Fetal Macrosomatia, Lipid Metabolism Disorders
Influence of TyG Index and TG/HDL-C Ratio on Fetal Macrosomia
Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus.
- Conditions
- Fetal Macrosomatia, Lipid Metabolism Disorders, Hyperlipidemias
- Trial name
- NCT06463990
- Testing
- TyG index
- Where
- Turkey (Türkiye)
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital