Clinical trials: Major Abdominal Surgeries
Perioperative Care, Fluid Therapy
Paired Comparison of SVV and PVI Accuracy
This study will compare two operating-room monitors-stroke volume variation (SVV, from the arterial line) and the Pleth Variability Index (PVI, from the pulse oximeter)-to see which one more accurately predicts whether giving a…
- Conditions
- Perioperative Care, Fluid Therapy, Monitoring, Physiologic, Hemodynamics
- Trial name
- NCT07260890
- Testing
- Stroke Volume Variation (SVV) monitoring, Pleth Variability Index (PVI) monitoring
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Frailty
Effectıvenes Of Frail Scale And Daily Lıfe Activity Assesment For Major Abdominal Surgery Patients
The effectiveness of assessing postoperative outcomes in eldely patients undergoing major abdominal surgery through the Frailty Scale and Katz Activities of Daily Living evaluation is investigated in individuals aged 65-85.
- Trial name
- NCT06182228
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Uludag University
Pain, Postoperative, Opioid Use
Therapeutic Efficacy of Intravenous Lidocaine Infusion Compared With Epidural Analgesia for Postoperative Pain Control in Adult Patients Undergoing Major Abdominal Surgery: Non-Inferiority Clinical Trial
Major abdominal surgery continues is one of the most performed surgical procedures in the world, both electively and urgently. One of the main problems of this type of intervention is postoperative pain.
- Trial name
- NCT04017013
- Testing
- Epidural Analgesia, Lidocaine Infusion
- Where
- Colombia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
To Compare Efficacy of Dexmedetomidine in Bilateral Quadratus Lumborum vs Lumbar Epidural Blocks on Analgesia After Major Lower Abdominal Surgery
Clinical Efficacy and Safety of Dexmedetomidine as an Adjuvant in Quadratus Lumborum Versus Epidural Block in Postoperative Lower Abdominal Cancer Surgeries
Clinical efficacy and safety of dexmedetomidine as an adjuvant in quadratus lumborum versus epidural block in postoperative patients
- Trial name
- NCT06130670
- Testing
- nerve block
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pain
Postoperative Pain Relief After Major Abdominal Gynecological Surgery
The aim of our study was to compare the effects of Lomber Epidural Analgesia (LEA), Transversus Abdominis Plane (TAP) block and Local Anesthetic Infiltration (LAI) on postoperative morphine consumption, time to first recue…
- Trial name
- NCT05845385
- Testing
- lumbar epidural analgesia with bupivacaine, transversus abdominis plane block with bupivacaine, wound infiltration with bupivacaine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Surgery, Critical Illness
Predictive Ability of PEEP Induced Changes in CVP to Predict Volume Responsiveness in Mechanically Ventilated Patients After Major Abdominal Surgery
Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major…
- Conditions
- Surgery, Critical Illness, Cardiac Output, Low
- Trial name
- NCT04191408
- Testing
- PEEP increase
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Dubrava
Postoperative Complications, Cancer
Predictive Value of Ariscat Index In The Development of Pulmonary Complication After Major Abdominal Cancer Surgery
The term postoperative pulmonary complication is the development of any complications affecting the respiratory system after anesthetic and surgery procedures.
- Conditions
- Postoperative Complications, Cancer, Pulmonary Complication, Atelectasis
- Trial name
- NCT04663958
- Testing
- Detection / Screening
- Where
- Turkey (Türkiye)
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Hypotension
Norepinephrine and Phenylephrine, Which Better for Elderly?
this is a prospective, double-blinded and single-center study. this study is based on the Stroke volume variation fluid guided therapy, to compare the effects of norepinephrine and phenylephrine in treating perioperative…
- Trial name
- NCT04067817
- Testing
- norepinephrine, Phenylephrine
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Electrical Cardiometry VS Esophageal Doppler
Hemodynamic Monitoring and Correlation Between Electrical Cardiometry and Esophageal Doppler in Patients Undergoing Major Abdominal Surgery
The aim of this study is to correlate hemodynamic monitoring between noninvasive Electrical Cardiometry and minimally invasive Esophageal Doppler in patients undergoing major abdominal surgery
- Trial name
- NCT04255550
- Testing
- Esophageal doppler
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dyspnea, Pain
Effectiveness of I COUGH Program to Dyspnea, Respiratory Parameters, Mobility and Pain After Major Abdominal Surgery
The purpose of the current study was to investigate the effect of the I COUGH care program following major abdominal surgery dyspnea, oxygen saturation, pulmonary function, mobility, and pain after major abdominal surgery (MAS)…
- Conditions
- Dyspnea, Pain, Respiratory Insufficiency, Mobility Limitation
- Trial name
- NCT06255327
- Testing
- I COUGH care program
- Where
- 3 sites in Libya
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Bowel Disease, Liver Diseases
The Impact of an Epidural Anesthetic on the Consumption of Sevoflurane in Major Abdominal Surgery
Major abdominal surgery - like non-laparoscopic bowel resection, liver, gastric, or pancreas surgery - is performed under general anesthesia.
- Conditions
- Bowel Disease, Liver Diseases, Pancreas Disease, Anesthesia; Functional
- Trial name
- NCT04021264
- Testing
- Ropivacaine-Sufentanil, Dextrose 5
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Complication, Postoperative, Perioperative/Postoperative Complications
The Impact of Prehabilitation Bundle on Perioperative Outcome for Frail Elderly Patients Undergoing Major Abdominal Surgery
This study aims to study the efficacy of a preoperative "bundle" of interventions, which consists of preoperative physiotherapy, nutritional support and cognitive exercises on elderly frail patients undergoing major abdominal…
- Trial name
- NCT02921932
- Testing
- Ensure, Resource 2.0 and Glucerna, Cognitive Training, Memory Card Game, 'Threshold' Inspiratory Muscle Trainer, Respironics of New Jersey Inc
- Where
- Singapore
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Major Upper or Lower Abdominal Surgery
A Multicenter, Randomized, Placebo-Controlled Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-F01 Sublingual Sufentanil in Patients Undergoing Major Abdominal Surgery
The purpose of this study is to evaluate dosages of ARX-F01 (opioid pain medication) versus a placebo (or sugar pill) for the treatment of post-operative pain in subjects following abdominal surgery.
- Trial name
- NCT00718081
- Testing
- Oral sufentanil
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Talphera, Inc
Intra-abdominal and Intrapelvic Surgery
Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction
Post-operative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon. Most patients will receive general anesthesia during surgery. Two groups of general anesthetics are used for this purpose.
- Trial name
- NCT01809041
- Testing
- Sevoflurane, propofol, remifentanil
- Where
- China
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Pain, Postoperative, Opioid Use
Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.
The goal of this clinical trial is to determine whether treating pain after surgery with ketamine is more effective when administered intravenously as a continuous infusion or through a patient-controlled analgesia (PCA) pump.
- Conditions
- Pain, Postoperative, Opioid Use, Major Surgery
- Trial name
- NCT06774274
- Testing
- Ketamine infusion, PCA Ketamine
- Where
- Colombia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Anesthesia
Impact of NOL Intraoperative Guided Fentanyl Analgesia vs SCC for Elective Major Abdominal Surgery
Recently, a newly developed index, the Nociceptive Level (NOL) index, was validated and showed superiority over heart rate and blood pressure for recognition and grading of intense and mild nociceptive stimuli during surgery…
- Trial name
- NCT03970291
- Testing
- PMD-200
- Where
- Israel
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Medasense Biometrics Ltd
Abdominal Cancer
Efficacy of Transverses Abdominis -Plane Block With Bupivacaine Versus Bupivacaine With Morphine Postoperatively
This study aims to compare the analgesic efficacy of transversus abdominis-plane block with bupivicaine versus bupivacaine with morphine in patients undergoing major abdominal cancer surgery.
- Trial name
- NCT02566096
- Testing
- transversus abdominis-plane block with local anesthetic 20 ml of bupivacaine 0.5% + 10 mg morphine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Prehabilitation
Prehabilitation for Elective Major Abdominal Surgery
Prehabilitation is a concept that challenges the traditional models of recovery by initiating the recovery process preoperatively.
- Trial name
- PISO (NCT02953119)
- Testing
- Prehabilitation
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nicolas DEMARTINES
Postoperative Complications
Development and Validation of a Morbidity Index for Complications in Minor and Major Abdominal Surgery
The aim is to develop and validate a morbidity index for postoperative complications in patients undergoing visceral surgery.
- Trial name
- NCT00782704
- Where
- Switzerland
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypovolemia, Surgery
Focused Assessed Echocardiography to Predict Fluid Responsiveness
The aims of the study are: 1. To evaluate the feasibility of echocardiography monitoring in postoperative unit; 2. To assess diagnostic value of different focussed echocardiography parameters to define fluid responsiveness for…
- Conditions
- Hypovolemia, Surgery, Hypotension
- Trial name
- fluidres (NCT03044405)
- Testing
- Fluid challenge, Focused transthoracic echocardiography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences