Clinical trials: Memory Reactivation
Nightmares, REM-Sleep Type
Combined Treatment of Nightmares With Targeted Memory Reactivation and Imagery Rehearsal Therapy
With this protocol, investigators examine whether targeted memory reactivation (TMR), a technique used to strengthen memories, can accelerate remission of nightmare disorder.
- Trial name
- NCT05237778
- Testing
- Imagery Rehearsal Therapy and Targeted memory reactivation during REM sleep, Imagery Rehearsal Therapy
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University Hospital, Geneva
Sleep, Consolidation
Reactivating Specific Memories During Sleep in Conjunction with a Suppression Context
Forgetting is often perceived as the inability to retain information, but in fact at least some memory deterioration is due to active suppression processes, that are behaviorally adaptive.
- Trial name
- NCT04702750
- Testing
- Targeted memory reactivation (odors), Targeted memory reactivation (sounds)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Social Anxiety Disorder, Sleep
Targeted Memory Reactivation During REM Sleep in Patients With Social Anxiety Disorder
With this study, the investigators aim to use sleep and dreaming in order to enhance exposure therapy for social anxiety disorder (SAD), by pairing the positive feedback phase of exposure (public talk) to an auditory stimulus…
- Trial name
- NCT05261659
- Testing
- Exposure Therapy and Targeted memory reactivation during REM sleep, Exposure Therapy
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- University Hospital, Geneva
Nightmares, REM-Sleep Type, PTSD
Mental Imagery and Targeted Memory Reactivation in PTSD
With this protocol, investigators examine whether targeted memory reactivation (TMR), a technique used to strengthen memories, can accelerate remission of traumatic nightmares and post-traumatic stress disorder (PTSD)…
- Trial name
- NCT05933109
- Testing
- Imagery Rehearsal Therapy and Targeted memory reactivation during REM sleep, Imagery Rehearsal Therapy
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Geneva
Post-Traumatic Stress Disorder, PTSD
Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic Memories Using Propranolol
Post-traumatic stress disorder (PTSD) develops after life-threatening events, with domestic violence and sexual assault being major risk factors.
- Trial name
- VIOFEM (NCT07792122)
- Testing
- Propranolol, Psychotherapy
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Toulouse
Epilepsy, Memory Consolidation
Sleep and Rehearsal-Driven Memory in Epilepsy
Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning.
- Trial name
- CORESOM-EPI (NCT06967935)
- Testing
- Cognitive memory task on a computer, Eye tracking, Questionnaires on task-related fatigue
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Alcohol Use Disorder
Emotional Attention Bias Modification and Targeted Memory Reactivation in Alcohol Use Disorder
Through this protocol, researchers examine whether Targeted Memory Reactivation (TMR), a technique used to enhance memory, can augment the control of craving levels in patients with Alcohol Use Disorder by enhancing positive…
- Trial name
- NCT06457113
- Testing
- Emotional Attention Bias Modification and Targeted memory reactivation during REM sleep, Emotional Attention Bias Modification
- Volunteers
- 74 people
- Sponsor
- Shanghai Mental Health Center
Sleep, Consolidation
The Effects of Direct Context Reactivation During Sleep on Memory
The context in which memories are encoded is a major factor influencing how memories are organized. Individual memories are bound to the context (e.g., the location, time and state of mind in which they are encoded) and this…
- Trial name
- NCT04702152
- Testing
- Targeted memory reactivation (sounds)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Parkinson Disease, Aging
Role of Sleep on Motor Learning in Parkinson's Disease and Healthy Older Adults
People with Parkinson's disease (pwPD) often present difficulty consolidating newly learned skills into long-term memory. Sleep facilitates motor memory consolidation in healthy adults, especially in combination with targeted…
- Trial name
- TARGET-SLEEP (NCT04144283)
- Testing
- NAP, WAKE
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Sleep, Consolidation
Reinstatement of Context During Sleep and Its Subsequent Effect on Memory: an fMRI Study
Memory benefits from sleep and these benefits are putatively achieved through reactivation of the neural memory trace during sleep.
- Trial name
- NCT04702724
- Testing
- Targeted memory reactivation (sounds)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Phobia, Specific
Influence of Valproic Acid on Extinction-based Therapy in Patients With Fear of Spiders.
The purpose of this study is to evaluate whether valproic acid in combination with fear memory reactivation is useful to enhance treatment stability of exposure therapy for specific phobia.
- Trial name
- VALPRO (NCT02789813)
- Testing
- Valproic Acid, Fear reactivation, No fear reactivation
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Post-traumatic Stress Disorder (PTSD), Intrusive Memories of Traumatic Event(s)
Tetris Intervention Following Subliminal Reactivation for Intrusive Memories
Intrusive memories of traumatic events are a core feature of Post-Traumatic Stress Disorder (PTSD) and can cause substantial distress and functional impairment.
- Trial name
- NCT07495917
- Testing
- Subliminal Reactivation Followed by Visuospatial Interference, Computer-based Visuospatial Task (Tetris)
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Shaanxi Normal University
Posttraumatic Stress Disorder
A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
The consolidation of learning is enhanced by adrenalin and other stress hormones. This memory enhancing effect is opposed by propranolol.
- Trial name
- NCT00709735
- Testing
- Propranolol
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder
Emotional Memory Reactivation in Posttraumatic Stress Disorder
Converging lines of evidence have implicated the amygdala in the pathophysiology of posttraumatic stress disorder. The primary purpose of our study is to assess the effect of propanolol, a beta adrenergic antagonism, on amygdala…
- Trial name
- VIVITRAU (NCT01239173)
- Testing
- AVLOCARDYL
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Insomnia Disorder
Mental Imagery and Targeted Memory Reactivation in Insomnia
In this clinical trial, the investigators test whether mental Imagery Rescripting (IR), a technique where the individual is instructed to transform a negative memory or image into a positive one, and olfactory Targeted Memory…
- Trial name
- NCT06335784
- Testing
- Imagery Rescripting (IR), Imagery Rescripting (IR) and Targeted Memory Reactivation (TMR) during sleep, Sleep Hygiene
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University Hospital, Geneva
Claustrophobia, Obsessive-Compulsive Disorder
Efficacy of Targeted Memory Reactivation for Enhancing Exposure Therapy
This study evaluates whether a scent applied during exposure therapy and during subsequent sleep will increase the durability of treatment effects for individuals with fear of spiders, contamination, and enclosed spaces.
- Conditions
- Claustrophobia, Obsessive-Compulsive Disorder, Arachnophobia
- Trial name
- NCT04663672
- Testing
- Experimental Scent, Control Scent, No-Scent Control
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Texas at Austin
Stroke
Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke
This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors.
- Trial name
- NCT04312269
- Testing
- Targeted Memory Reactivation (TMR)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
PTSD
Treatment of Pediatric Post-traumatic Stress Disorder With Memory Reactivation Under the Influence of Propranolol
By age 18, roughly 8% of traumatized youth have met criteria for a diagnosis of PTSD, with numbers rising up to 40% in cases of sexual abuse and assault.
- Trial name
- PPP (NCT04985344)
- Testing
- Propranolol Oral Product, memory reactivation
- Where
- France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Toulouse
Memory Consolidation
The Impact of Reactivation During Sleep on the Consolidation of Abstract Information in Humans
In any given cognitive domain, representations of individual elements are not independent but are organized by means of structured relations.
- Trial name
- NCT05746299
- Testing
- Congruent vs. Incongruent, Immediate vs. Awake vs. Asleep, Targeted memory reactivation (TMR)
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Memory Reactivation, Memory Consolidation
Toward a Real-time Access to Sleepers' Mental Content
Sleep is crucial for global cognitive functioning, but its exact functions and mechanisms are still poorly understood. Cognitive studies of sleep typically rely on linking electrophysiological changes measured during sleep with…
- Conditions
- Memory Reactivation, Memory Consolidation, Sleepwalking
- Trial name
- SleepDance (NCT05452733)
- Testing
- differences of behavior between sleepwalking and non sleepwalking patient
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris