Clinical trials: Metabolic Adaptation
Hypoxia, Erythropoiesis
Effects of Intermittent Hypoxia Training With Iron Supplementation on Red Blood Cells and Iron Levels in Trained Athletes
This study investigates how training under conditions of reduced oxygen (intermittent hypoxia) affects the body's ability to produce red blood cells and manage iron levels, compared to training under normal oxygen conditions.
- Conditions
- Hypoxia, Erythropoiesis, Iron Metabolism Disorders
- Trial name
- IHIT-IRON (NCT07720960)
- Testing
- Control group (CG), Hypoxia group (HG): trained at simulated altitudes between 4,450 and 5,850 m
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Néstor Vicente-Salar
Overweight
Evaluation of SODB® in Metabolic Adaptations in Overweight Women
The objective of this study is to evaluate the influence of a 3 months SODB® supplementation in adipose tissue modulations of overweight women, in comparison to a placebo.
- Trial name
- SORESCAL (NCT02667691)
- Testing
- SODB Dimpless, caloric restriction
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Robertet SA
Childhood Obesity
The ADAPT Trial: Adapting Evidence-Based Obesity Interventions in Community Settings
Evidence-based obesity treatment is inaccessible to most children in the United States. This lack of access is a source of health inequity, whereby children from rural and minority communities, who have the highest rates of…
- Trial name
- NCT06546696
- Testing
- Competency Based Approaches to Community Health (COACH)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Chronic Obstructive Pulmonary Disease (COPD)
Oral β-Alanine Supplementation in Patients With COPD
Preliminary evidence suggest that patients with chronic obstructive pulmonary disease (COPD) suffer from lower-limb muscle dysfunction.
- Trial name
- BACOPD (NCT02770417)
- Testing
- beta-alanine, control
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Overweight and Obese Adults, Physical Inactivity
A 12-week Field Trial of the Movámonos Physical Activity Support Program
The objective of this study is to design and refine an activity support program, called Movámonos, for adults with overweight or obesity who speak Spanish.
- Trial name
- Movámonos (NCT07561996)
- Testing
- Movámonos Physical Activity Support Program
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity, Overweight and Obesity
Physical Exercise in Obesity for Health and Quality of Life.
This project aims to develop an intervention on healthy habits based on physical exercise and nutritional education in people with obesity. It is accepted that exercise and nutrition are keys to controlling body weight.
- Conditions
- Obesity, Overweight and Obesity, Overweight or Obesity
- Trial name
- OBEFYSA (NCT05713461)
- Testing
- exercise training program, Feeding training
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Pablo de Olavide
Gut Microbiota, Metabolic Syndrome
Effect of Mango on Gut Microbiota and Metabolic Health
Mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. Polyphenols accumulate in the gut where they can positively modulate the microbiota.
- Trial name
- NCT03825276
- Testing
- Mango consumption
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Laval University
Ketogenic Diet, Weight Loss
Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.
This project will be a three-group controlled 6-wk feeding study where all meals are prepared and provided to obese participants. All participants will be fed a 25% energy-restricted diet.
- Trial name
- STAK (NCT06449287)
- Testing
- Diet, Blood Draw, Ketone/Glucose Monitoring
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Vitamin A Deficiency, Low Serum Retinol
Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children
The purpose of this cluster-randomized trial is to examine whether daily consumption of β-carotene biofortified maize flour can reduce the prevalence of vitamin A deficiency and improve the vitamin A status and among 4-8 year old…
- Trial name
- NCT01695148
- Testing
- β-Carotene Biofortified Maize Flour, White Maize Flour
- Where
- Zambia
- Volunteers
- 1,228 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Obesity, Physical Inactivity
Effects of Short Isokinetic Eccentric Resistance Training on Neuromuscular Induced Adaptations
The study compares the impact of isokinetic resistance training (RT) -induced neuromuscular adaptation following an 8-week short ECC ISO RT and CON ISO RT among obese, untrained women. The main question it aims to answer is: 1.
- Trial name
- NCT07407621
- Testing
- ECC ISO, CON ISO
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Obesity & Overweight
Long-term Adaptations of Skeletal Muscle After Hybrid Training
Obesity is a major challenge for public health and renders it imperative to reduce its prevalence. High intensity interval training (HIIT) is a form of exercise training that can efficiently induce weight loss in adults with…
- Trial name
- NCT07341711
- Testing
- Exercise training, Control group
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Magnetic Resonance Spectroscopy
Non-Invasive Monitoring Of Metabolite Levels Using Novel And Adapted MR Spectroscopy Techniques
This Swiss National Science Foundation (SNF) funded project and the linked European project aim to improve magnetic resonance (MR) methods, specifically MR spectroscopy and metabolic imaging (making them more sensitive and…
- Trial name
- NIMM_MRS (NCT05165537)
- Testing
- NIMM_MRS
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Bone Loss
Prosthetic Modality and MBL
The present study will test the effect of different prosthetic modalities on conical and internal hex connection implants, assessing the radiographic MBL changes after one year.
- Trial name
- NCT07156110
- Testing
- Traditional prosthetic procedure, one abutment-one time
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo
Mitochondrial Biogenesis, Inflammation
EFFECTS OF PYRROLOQUINOLINE QUINONE (PQQ) SUPPLEMENTATION ON NON-ENDURANCE TRAINED ATHLETES
The aim of this study was to investigate the effects of six weeks of PQQ supplementation in non-endurance-trained individuals on: 1. physiological and metabolic response during a FATmax-VO₂peak exercise test 2.
- Trial name
- NCT07148726
- Testing
- Pyrrole Quinoline Quinone (PQQ)
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Padova
Overweight, Obesity
Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese
The main purpose of our study is to examine the physiological adaptations in oxygen transport chain for high-intensity exercise and moderate exercise in overweight and obese humans. The main goals are: 1.
- Trial name
- TRENO (NCT01453972)
- Testing
- Long distanse moderate training, Long interval training, Short interval training
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Obesity
ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss…
- Trial name
- NCT06174389
- Testing
- Behavioral Weight Loss Program
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy, Healthy Participants
Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation
- Trial name
- NCT07364149
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Diabetes
Sustainable Culturally Adapted Nutrition (SCAN) Program
The purpose of the study is to determine the impact of an enhanced, food incentive program [called the sustainable culturally adapted nutrition (SCAN) program], which is integrated with the Diabetes Prevention Program (DPP) and a…
- Trial name
- NCT07220057
- Testing
- Live instructional video sessions, Links to educational videos, Diabetes Prevention Program (DPP)
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetes Mellitus, Type 2, Obesity
Culturally Adapted Dietary Clinical Trial in PR
This project will determine whether a diet culturally adapted to adults in Puerto Rico can effectively decrease cardiometabolic risk factors.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- PRECISION (NCT05962372)
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Cardiovascular Diseases
Impact of Statin Therapy on Adaptations to Aerobic Exercise
The purpose of this study is to determine how different doses of a statin affect muscle health and exercise.
- Trial name
- NCT03360916
- Testing
- Lipitor 20Mg Tablet, Lipitor 80Mg Tablet, Exercise Program
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center