Clinical trials: Metastases, CNS
Postdural Puncture Headache (PDPH), Treatment Adherence and Compliance
Brochure-Supported Telemedicine Management of Postdural Puncture Headache
This study evaluates whether brochure-supported structured telemedicine counseling improves the management of postdural puncture headache after cesarean delivery under spinal anesthesia.
- Conditions
- Postdural Puncture Headache (PDPH), Treatment Adherence and Compliance, Cesarean Delivery Procedures
- Trial name
- Brochure-Suppo (NCT07708701)
- Testing
- Standard Information and Standard Telephone Follow-up, Brochure-Supported Structured Telemedicine Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Yuzuncu Yil University
Brain Tumor
MRI-Guided LITT for Treatment Metastatic Brain Tumors
The Methodist Hospital Neurological Institute is conducting a clinical trial for patients suffering from Metastatic brain tumors.
- Trial name
- NCT01736722
- Testing
- Visualase®
- Where
- United States
- Sponsor
- The Methodist Hospital Research Institute
Non Small Cell Lung Cancer Metastatic
Value of Screening MRI Brain in Stage IV Non-small Cell Lung Cancer
Patients with newly diagnosed stage IV non-oncogene addicted NSCLC, who are fit for systemic treatment and don't have any symptoms of brain disease will undergo an MRI of the brain to screen for brain disease.
- Trial name
- VULCAN (NCT05864794)
- Testing
- MRI
- Where
- 3 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- University Medical Center Groningen
Brain Metastases
Preoperative SRS/SRT vs Postoperative SRS/SRT for Brain Metastases
This pilot study is a randomized, open-label, 2-arm active-controlled phase II clinical trial conducted at a single study site (UAMS).
- Trial name
- NCT04422639
- Testing
- SRS/SRT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Arkansas
Bladder Cancer, Brain and Central Nervous System Tumors
High-dose ICE With Amifostine
The purpose of the study is to evaluate the combination of amifostine and high dose chemotherapy with blood stem cell support. Amifostine is a druf developed to protect normal tissues against the toxicities of chemotherapy and…
- Conditions
- Bladder Cancer, Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary, Extragonadal Germ Cell Tumor
- Trial name
- NCT00003657
- Testing
- filgrastim, Amifostine, Carboplatin
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Dana-Farber Cancer Institute
Cervicogenic Headache
Is Chiropractic Spinal Manipulative Therapy an Efficient Treatment Option in Cervicogenic Headache
This study will highlight and validate chiropractic spinal manipulative therapy (CSMT) for cervicogenic headache (CEH). If the method proves to be effective, it will provide a new non-pharmacological treatment option for CEH.
- Trial name
- NCT01687881
- Testing
- Chiropractic
- Where
- Norway
- Volunteers
- 19 people
- Sponsor
- University Hospital, Akershus
Non Small Cell Lung Cancer
Furmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLC
The goal of this clinical trial is to evaluate the clinical efficacy and safety of Furmonertinib in EGFR mutated NSCLC patients with leptomeningeal metastasis and to explore the feasibility of CSF ctDNA detection for efficacy…
- Trial name
- NCT05813522
- Testing
- Furmonertinib Mesilate Tablets
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Brain and Central Nervous System Tumors, Neuroblastoma
Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer
The purpose of this study is to test the feasibility and toxicity of administering intrathecal immunotherapy for patients with central nervous system/leptomeningeal (CNS/LM) malignancies.
- Conditions
- Brain and Central Nervous System Tumors, Neuroblastoma, Sarcoma
- Trial name
- NCT00089245
- Testing
- Iodine I 131 MOAB 8H9
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Y-mAbs Therapeutics
Post Traumatic Headache, Cervicogenic Headache
Comparative Effects of Post Isometric Relaxation and Reciprocal Inhibition in Individuals With Cervicogenic Headache.
This study aims to compare the effects of Post Isometric Relaxation (PIR) and Reciprocal Inhibition (RI) in individuals with cervicogenic headache, a secondary headache originating from dysfunction of the cervical spine…
- Trial name
- NCT07838545
- Testing
- Post Isometric Relaxation, Reciprocal Inhibition
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Foundation University Islamabad
Spinal Cord Injury (=3 Years), Sublesional Bone Loss Secondary to SCI
Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI
Treatment for sublesional bone loss (osteoporosis) in persons with chronic, motor-complete spinal cord injury (SCI) has been limited and unsuccessful to date.
- Trial name
- Chronic Romo (NCT04232657)
- Testing
- Romosozumab, Denosumab
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Lung Cancer, Metastatic Cancer
Everolimus and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastasis From Non-Small Cell Lung Cancer
RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00892801
- Testing
- RAD001, whole-brain radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Brain Metastases
Elective Simultaneous Modulated Accelerated Brain Radiation Therapy for NSCLCs With Limited Brain Metastases
Brain metastases are the most common intracranial tumors in adults. Whole-brain radiation therapy (WBI) increases the median survival of patients with brain metastases up to 3-6 months, but WBI can lead to the decline of…
- Trial name
- SMART-Brain (NCT03414944)
- Testing
- SMART-Brain
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shandong Cancer Hospital and Institute
Postdural Puncture Headache
Lumbar Spine Ultrasound of Patients With Previous Accidental Dural Puncture During Labour Epidural
Accidental dural puncture is a potential complication of epidural analgesia for labour and delivery. When it happens, it may cause debilitating headaches and other symptoms that prevent mothers from talking care of their…
- Trial name
- NCT00465166
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy
This observational, prospective, non-interventional study will include cancer patients who need a treatment for hyponatraemia secondary to SIADH.
- Conditions
- Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion, Cancer
- Trial name
- ASSERT (NCT02573077)
- Where
- 20 sites in Italy
- Volunteers
- 69 people
- Sponsor
- Otsuka Pharmaceutical Europe Ltd
Carcinoma, Non-Small-Cell Lung, Brain Neoplasms
Bevacizumab and Erlotinib in Lung Cancer With Brain Metastases, a Phase II Trial
This is an open-label, randomized, multicenter phase II study conducting in 3 medical centers in Asia. Patients will receive erlotinib in combination with bevacizumab or erlotinib alone.
- Trial name
- BRILLIANT (NCT02655536)
- Testing
- Bevacizumab plus erlotinib, Erlotinib
- Where
- Taiwan
- Volunteers
- 109 people
- Sponsor
- National Taiwan University Hospital
Cervicogenic Headache, Cervicogenic Headaches
Comparison of Myofascial Release and Mulligan Concept Techniques in Patients With Cervicogenic Headache
The International Headache Society classifies cervicogenic headache as a secondary headache caused by a disorder of the cervical spine and its components.
- Trial name
- NCT06690411
- Testing
- Mulligan Concept, Myofascial Release Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Medipol University Hospital
Tumors Metastatic to Brain, Unspecified Adult Solid Tumor, Protocol Specific
Quantitative MRI in Assessing Disease in Patients With Brain Tumors
This pilot clinical trial studies quantitative magnetic resonance imaging (MRI) at 3 Tesla in assessing disease in patients with tumors that have spread to the brain (brain metastases).
- Trial name
- NCT02269111
- Testing
- diffusion-weighted magnetic resonance imaging, chemical exchange saturation transfer magnetic resonance imaging, dynamic contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Migraine, Medication Overuse Headache
A Study of Eptinezumab in Participants With Migraine and Medication Overuse Headache
Medication overuse headache (MOH) is a type of headache caused by excessive use of acute headache or migraine medications (medications used to treat a headache or migraine once it begins).
- Trial name
- RESOLUTION (NCT05452239)
- Testing
- Eptinezumab
- Where
- 76 sites in United States, Australia and 9 more
- Volunteers
- 608 people
- Sponsor
- H. Lundbeck A/S
Central Nervous System Cancer, Brain Metastases
Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1
Adult patients with primary or secondary central nervous system malignancies will be invited to undergo a baseline [C-11]-CS1P1 PET scan and a follow-up scan within 24 months of the baseline scan (preferably within 6-months…
- Trial name
- NCT07462507
- Testing
- [C-11]-CS1P1, Brain MRI
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Washington University School of Medicine
Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis
PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF
This is a study of PIPE-791, an investigational study drug to treat progressive multiple sclerosis (MS) and idiopathic pulmonary fibrosis (IPF).
- Conditions
- Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis, Multiple Sclerosis, Multiple Sclerosis, MS
- Trial name
- NCT06683612
- Testing
- PIPE-791
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.