Clinical trials: Muscle Protein Synthesis
Sarcopenia
Habitual Protein Intake and Muscle Protein Synthesis
Protein intake stimulates muscle protein synthesis. From the standpoint of maintaining skeletal muscle mass with aging, it is important to optimize the adaptive response to food intake.
- Trial name
- Pro-Hab (NCT01986842)
- Testing
- Protein diet
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis, Whole-body Protein Balance
Essential Amino Acids and Protein Kinetics During Caloric Deprivation
The amount of essential amino acids (EAA) necessary to maximally stimulate muscle protein synthesis and optimize whole-body net protein balance during caloric deprivation has not been determined.
- Trial name
- NCT03372928
- Testing
- Standard EAA, High EAA
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Muscle Damage, Healthy
Exploring Muscle Breakdown During Exercise Recovery
This study will allow researchers to explore how muscle responds to heavy exercise. The researchers will characterise rates of muscle protein breakdown and synthesis 24hours after heavy exercise with a post exercise protein…
- Trial name
- EMBER (NCT04841772)
- Testing
- Recover Vegan Protein Supplement
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Healthy Volunteers, Female
Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS)
The goal of this clinical trial is to learn if micronized progesterone (PROMETRIUM®) influences the muscle-building response to resistance exercise in healthy premenopausal women aged 18-30 years.
- Conditions
- Healthy Volunteers, Female, Progesterone, Premenopausal
- Trial name
- MP4 MPS (NCT07173361)
- Testing
- Micronized progesterone (oral capsules)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Metabolism, Exercise
The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise
Plant-based proteins contain several amino acids that are essential to signal growth, reconditioning, maintenance and preservation of skeletal muscle mass.
- Conditions
- Metabolism, Exercise, Dietary Supplements
- Trial name
- NCT05020808
- Testing
- NEAA, PPI
- Where
- Ireland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Sedentary Lifestyle
Influence of Sedentary Time on Skeletal Muscle Protein Metabolism
This study will investigate the influence of increased sedentary time on long-term measures of muscle protein synthesis and metabolic health.
- Trial name
- NCT02624011
- Testing
- 7 days of habitual physical activity followed by 7 days of reduced physical activity
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Muscle Synthesis
Protein Supply in Elderly
Stimulating overnight muscle protein synthesis, might augment muscle hypertrophy, increase mitochondrial mass, and/or improve muscle tissue repair.
- Trial name
- NCT01317511
- Testing
- Protein
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Old Age; Debility, Muscle Weakness
Probiotic-Muscle Study
This study will examine the effect of probiotic supplementation (Bacillus coagulans) on muscle protein synthesis in older adults in response to a plant-based diet.
- Conditions
- Old Age; Debility, Muscle Weakness, Protein Deregulation, Protein Deposition
- Trial name
- NCT04297111
- Testing
- Probiotic
- Where
- Ireland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Rotator Cuff Tear
Load-induced Changes in Glenohumeral Translation in Patients With Rotator Cuff Tear
The study is to investigate the dose-response relationship between load-induced muscle activation (liMA) and load-induced glenohumeral translation (liTr) in patients with rotator cuff tears and asymptomatic control subjects.
- Trial name
- LiTrans (NCT04819724)
- Testing
- 3D motion analysis, isometric shoulder strength by dynamometer, fluoroscopic images of each shoulder
- Where
- Switzerland
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Aging
Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women
Using stable isotope methodology, investigators will determine the postabsorptive and postprandial muscle protein synthetic response in 60 female adults (Age 50-79, BMI: <30 kg/m2) immediately after an acute bout of resistance…
- Trial name
- NCT02918981
- Testing
- Resistance Exercise, 14 g Whey protein, 6.6 g Whey protein + 1.25 g leucine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Diet, Healthy, Protein Deficiency
Protein and Performance (PROPER) in Endurance Athletes
The present study is a parallel group design with randomised allocation to either a 1) reduced protein diet (RP) or a 2) normal protein diet (NP).
- Trial name
- PROPER (NCT05426447)
- Testing
- Dietary intervention of reduced protein intake, Dietary intervention of normal protein intake
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Nutrition, Healthy
The Impact of Plant-based Blends on Skeletal Muscle Protein Synthesis Rates in Older Adults
Lifestyle interventions such as physical activity and dietary habits are the most effective non-pharmacological strategies to combat the loss of muscle mass and the development of mobility limitations with aging.
- Trial name
- NCT05917223
- Testing
- Milk protein ingestion, Cron protein ingestion, Corn+Pea protein ingestion
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Protein Synthesis
The Anabolic Properties of a Lipid-rich Pork Matrix
The amount and quality of skeletal muscle mass determines physical performance, but also a significant contributor to metabolic health.
- Trial name
- NCT05876299
- Testing
- 95.1% Lean Pork, 81.16% Lean Pork, Carbohydrate Beverage
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Resistance Exercise
Skeletal Muscle Protein Synthesis: Traditional and Cluster Sets
Traditionally, when performing resistance exercise, repetitions are performed in a continuous manner resulting in a decrease in velocity, and thus power output.
- Trial name
- NCT04028726
- Testing
- Back-squat exercise
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Nutrition, Healthy
Aminoacidemia and Protein Kinetics in Response to the Ingestion of Plant-based Protein Blends
The present investigation aims to study a novel plant based protein isolate blend to determine if it results in similar muscle building responses compared to whey protein isolate.
- Trial name
- PBP (NCT05139160)
- Testing
- Protein quality
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia
Protein Synthesis in Midthigh Muscles PET/CT
The purpose of this study is to test a new imaging technique to help scientists study sarcopenia, the process by which muscle becomes weaker with age.
- Trial name
- NCT01008839
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ketosis, Muscle Protein Synthesis
Exogenous Ketosis and Muscle Protein Synthesis During Exercise Recovery
An acute bout of resistance exercise stimulates muscle protein synthesis (MPS) rates for up to 24-48 hours, supporting muscle growth and repair.
- Conditions
- Ketosis, Muscle Protein Synthesis, Dietary Proteins, Resistance Exercise
- Trial name
- NCT06769100
- Testing
- Ketone Monoester (KET), Ketone Monoester + Whey Protein (KET+PRO), Whey Protein (PRO)
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- McGill University
Time Restricted Feeding
Prolonged Overnight Fast, Energy Metabolism and Skeletal Muscle Anabolic Sensitivity
Recent research shows that timing of nutritional intake and daily periods of fasting may have important health effects. In humans, limiting daily food intake to a narrow window (typically ~8 hours) can bring about some beneficial…
- Trial name
- NCT05420181
- Testing
- Short 10hr fast, Long 16h fast
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham