Clinical trials: Muscle Wasting
Intervertebral Disc Compression, Muscle Atrophy
50% Body Weight Reverses Stature, Lumbar Disc Expansion and Vertebral Compliance by Hyper-Buoyancy Floatation.
Study with the aim to see the effect on a space ground analogue , Hyper-Buoyancy Floatation (HBF) on lumbar column and the effect of a supplementary 50% of an axial load.
- Conditions
- Intervertebral Disc Compression, Muscle Atrophy, Spine Injury
- Trial name
- NCT05590754
- Testing
- Hyper-buoyancy Floatation (HBF), Axial Load after 4h of HBF
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Cancer Patients With Cachexia
Evaluation of the Effects of a Mixture of Amino Acids (Amixea) on Lean Body Mass and Muscle Strengh of Patients With Unresectable Advanced Non-small Cell Lung Cancer
The primary objectives of this study are to evaluate the effects of an amino acid mixture (Amixea) on the body composition as assessed by DXA, and on QMVC as assessed by strain gauge, in advanced NSCLC patients, compared to…
- Trial name
- NCT02877966
- Testing
- Amixea
- Where
- 3 sites in Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Helsinn Healthcare SA
Quadriceps Tendon Rupture, Quadriceps Strained Tendon
The Effect of the Reverse Nordic Curl Exercise on Quadriceps Femoris Muscles Injury Rate Among Soccer Players
The reverse Nordic curl is a body-weight exercise which mainly works the quadriceps and hip flexors. It has a large eccentric component, meaning the muscles are working whilst lengthening.
- Conditions
- Quadriceps Tendon Rupture, Quadriceps Strained Tendon, Quadriceps Muscle Atrophy
- Trial name
- NCT04674072
- Testing
- Reverse Nordic curl exercise, Usual warm up
- Where
- Saudi Arabia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Umm Al-Qura University
Sarcopenia
Assessment of the Intervention Effectiveness of Branched-chain Amino Acids(BCAA) Combined With Medium-chain Fatty Acid(MCFA) Products in Sarcopenia Among Middle-aged and Elderly Individuals
Taiwan entered an aging society in 2018 and is expected to transition into a super-aged society by 2025. With the increasing elderly population, age-related diseases pose urgent challenges to modern society.
- Trial name
- NCT06376266
- Testing
- nutritional supplements
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Spinal and Bulbar Muscular Atrophy, Healthy Subjects
High Intensity Training in Patients With Spinal and Bulbar Muscular Atrophy
We want investigate if high intensity training can increase daily functionality without causing muscle damage in patients Spinal and Bulbar Muscular Atrophy .
- Trial name
- HIT in Kennedy (NCT02156141)
- Testing
- Supervised high intensity training, Optional training, Control period
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karen Brorup Heje Pedersen
Sarcopenia
Effects of Graded Protein Intake on Body Composition in Older Adults
This clinical trial is intended to evaluate the effects of protein intake graded to resistance training volume over a 10-week period on macroscopic skeletal muscle adaptations and body composition.
- Trial name
- GPI (NCT04845282)
- Testing
- Graded Protein plus Resistance Training, RDA Protein plus Resistance Training
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Frailty, Sarcopenia
Study of The Effects of Testosterone in Frail Elderly Men
The study aims to determine the effects of testosterone on muscle function, mobility, activities of daily living and overall quality of life
- Trial name
- NCT00190060
- Testing
- Transdermal testosterone gel (Testogel 1% )
- Where
- United Kingdom
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Sarcopenia
Exercise Intermittent Isometric Handgrip and Blood Flow Restriction
Isometric handgrip exercises are used to explain the effects of fatigue on the strength and activation of the muscles involved. Blood flow available at the time of exercise can influence this fatigue process, as some studies…
- Trial name
- NCT02384161
- Testing
- Isometric exercise Intermittent
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Muscle Loss
Plyometric Exercises Versus Isometric Exercises With Theraband Elastic Band in Water Polo Players
Introduction: The improvement of strength affects muscle volume, dynamic stability and sports performance in water polo athletes.
- Trial name
- NCT03872076
- Testing
- Experimental, Control
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Sarcopenia
Passive Heat Treatment and Skeletal Muscle Reconditioning Older Adults
Rationale: Aging is accompanied by impairments in the sensitivity of skeletal muscle tissue to respond to the anabolic properties of protein feeding, which is suggested to result in age-related loss in muscle mass.
- Trial name
- Sauna (NCT05129995)
- Testing
- Passive heat treatment
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Sarcopenic Obesity
Sarcopenic Obesity as a Risk of Premature Aging
Recently, numerous signaling proteins derived from adipose tissue and/or skeletal muscle have been described and are involved in the pathogenesis of obesity and the pathophysiology of aging.
- Conditions
- Obesity, Sarcopenic Obesity, Aging
- Trial name
- SARCOBEAGING (NCT05443711)
- Testing
- No intervention, observational study
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospital de Leon
Sarcopenia
Middle Age muScle Krill Study
This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults.
- Trial name
- MASK (NCT06005064)
- Testing
- Krill oil, Vegetable oil
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Frailty, Obesity
Slow Gait Speed as an Indicator of Overweight, Dynapenic Obesity and Sarcopenic Obesity in Elderly People in the Community
The goal of this observational study is to evaluate the relationship of gait speed with dynapenic or sarcopenic obesity in community-dwelling older people.
- Conditions
- Frailty, Obesity, Sarcopenia, Sarcopenic Obesity
- Trial name
- SGSF (NCT06413030)
- Testing
- 10 Meter Walk Test
- Where
- Chile
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- University of Americas - Chili
Muscle Atrophy, Aging
The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults.
In healthy middle-aged men and women, what is the effect of dietary energy restriction and energy surplus on daily muscle protein synthesis rates and muscle morphology, compared to energy balance, during free-living and…
- Conditions
- Muscle Atrophy, Aging, Energy Malnutrition Protein
- Trial name
- PIE (NCT04900701)
- Testing
- Energy status
- Where
- 2 sites in United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Atrophy, Myotonia
Electromyostimulation (EMS) of Astronauts in Spaceflight (Easymotion-2)
This is a prospective spaceflight study involving an investigational non-risk device called the EasyMotionSkin for whole body electric muscle (myo) stimulation (WB-EMS) onboard the International Space Station (ISS).
- Conditions
- Muscle Atrophy, Myotonia, Stiffness; Spine, Exercise Overtraining
- Trial name
- Easymotion-2 (NCT06492057)
- Testing
- Electromyostimulation (EMS), Myoton, Electromyography (EMG)
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Sarcopenia
Effect of Nutrition Supplementation Combined With Resistance Exercise in Elderly With Sarcopenia.
The purpose of this study was determine whether milk or soy milk supplements combined with resistance exercise improved sarcopenia in the elderly.
- Trial name
- NCT05035121
- Testing
- milk supplement, soy milk supplement, resistance exercise
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Learning; Lack of (Specific), Depression
Nano-Learning for Improving Compliance Among Older Adults With Sarcopenia
Empirical evidence suggests that the use of short videos is associated with decreased feelings of loneliness and social isolation, thereby reducing depression among older adults .
- Conditions
- Learning; Lack of (Specific), Depression, Older Adults, Sarcopenia
- Trial name
- NCT07185763
- Testing
- Nano-Learning interventional program
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Muscle Weakness
The Effect of Alfacalcidol on Muscle Strength in Elderly Indonesian Women : A Randomized Controlled Trial
The age-related increase in falls is strongly associated with a decline in muscle strength by the mechanism of sarcopenia. There has been great interest in developing approaches to counteract the effects of sarcopenia, and…
- Trial name
- NCT02327091
- Testing
- alfacalcidol
- Where
- Indonesia
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Ageing
Effect of Strength Training and Protein Supplementation on Muscles in the Very-old
Three months intervention study, investigating the effect of nutrient supplementation (including 20g of milk protein) twice daily with or without additional heavy resistance exercise three times weekly on muscle size, structure…
- Trial name
- 83+ (NCT01997320)
- Testing
- Heavy resistance exercise and nutrition, Nutrition supplement
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Muscle Weakness, Muscle Atrophy
Effect of Neuromuscular Electrical Stimulation Combined With Blood Flow Restriction on Muscular and Cardiovascular Function
Neuromuscular electrical stimulation (NMES) has recently been combined with blood flow restriction (BFR) in controlled trials and has shown increased muscular strength and size compared with NMES and BFR on their own.
- Trial name
- NCT03662555
- Testing
- Neuromuscular electrical stimulation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham