Clinical trials: Muscular Hypertrophy
Healthy Nutrition
Effect of Ketogenic Diet on Muscle Hypertrophy
The purpose of this study is to investigate the effects of 4 weeks of carbohydrate deprivation (through a ketogenic diet) on hypertrophy signalling after a single bout of exercise in healthy trained male subjects, and the impact…
- Trial name
- NCT05897567
- Testing
- resistance training, ketogenic diet, western diet
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Padova
Resistance Training, Blood Flow Restriction (BFR) Training Effects
Strength Training With and Without Blood Flow Restriction on Shoulder Muscle Strength in Healthy Adults
The goal of this clinical trial is to compare two types of shoulder strength training: low-load training with blood-flow restriction (BFR) and high-load training without BFR. The study includes healthy adults.
- Trial name
- NCT07186231
- Testing
- Low-load resistance training with Blood flow Restriction, High-load resistance training.
- Where
- Portugal
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Alice Maria da Costa Carvalhais
Aortic Regurgitation
Diastolic Dysfunction in Aortic Regurgitation
Follow-up study in patients with severe aortic regurgitation after successful valve replacement. Systolic and diastolic function were assessed and persistent diastolic dysfunction was observed late (7-10 years) after operation.
- Trial name
- NCT00976625
- Testing
- Aortic Valve Replacement
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bern
Muscle Hypertrophy, Muscle Strength
Hip Thrust Versus Back Squat Training in Untrained Adults
This study compared the effects of two lower-body resistance training exercises - the barbell back squat and the barbell hip thrust - on muscle growth and strength in untrained young adults.
- Trial name
- HTS (NCT07760220)
- Testing
- Resistance training
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Auburn University
Supplement, Resistance Training Adaptation
Skeletal Muscle Adaptations to Peptide-Supplemented Resistance Exercise Training
Skeletal muscle size, an important metabolic tissue, is governed by the balance between two opposing processes, muscle protein synthesis and muscle protein breakdown.
- Trial name
- NCT07773142
- Testing
- Resistance Exercise Training with or without daily supplementation, Dual Energy X-Ray Absorptiometry (DEXA) Scan, Muscle Sampling
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Aging, Muscular Atrophy
Maximizing Mechanisms of Muscle Hypertrophy to Combat Sarcopenia in Older Adults
Resistance training has shown the most promise among interventions aimed to combat aging muscle atrophy as it enhances strength, power, and mobility function, but induces varying degrees of skeletal muscle hypertrophy as the…
- Trial name
- NCT02442479
- Testing
- resistance training
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Muscle Hypotrophy, Exercise Performance
Resistance Training Adaptations and Caffeine Intake
This parallel-group, randomized, double-blind, placebo-controlled trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 120 caffeine-naive, inactive…
- Conditions
- Muscle Hypotrophy, Exercise Performance, Muscle Strength, Adaptation
- Trial name
- NCT07410195
- Testing
- Caffeine (Constant Daily Dose), Caffeine (Escalating Dose), Caffeine (Training Days Only)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Muscular Hypertrophy
Resistance Training and Milk Supplementation
Post-resistance training high protein milk supplementation may be a viable method to elicit muscular gains. The investigators hypothesis is that high protein milk supplementation would improve skeletal regulatory markers…
- Trial name
- NCT04509297
- Testing
- high protein milk
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marymount University
Cardiomyopathy, Hypertrophic, Coronary Disease
Analysis of Heart Muscle Function in Patients With Heart Disease and Normal Volunteers
Myocardial ischemia is a heart condition in which not enough blood supply and oxygen reaches the heart muscle. Damage to the major blood vessels of the heart (coronary artery disease), minor blood vessels of the heart…
- Conditions
- Cardiomyopathy, Hypertrophic, Coronary Disease, Healthy, Myocardial Ischemia
- Trial name
- NCT00001459
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Resistance Training
The Effects of Leucine Metabolites in Performance, Body Composition and Biochemical Markers of Muscle Damage
This study aimed to conduct a double-blind randomized pragmatic trial to evaluate the effects of off-the-shelf leucine metabolite supplements HMB-FA, HMB-Ca, alfa-HICA, on resistance training-induced changes in body composition…
- Trial name
- LMET2IMPROVE (NCT03511092)
- Testing
- HMB-FA, HMB-Ca, alfa-HICA
- Where
- Portugal
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Muscle Strength, Hypertrophy
Effect of Cross-Education in Blood Flow Restriction Resistance Training on Lower Limbs in Older Women
Unilateral resistance training has been shown to promote strength adaptations in the directly trained limb and also improve strength in the contralateral limb, a phenomenon known as cross-education (CE), with more pronounced…
- Trial name
- NCT07155967
- Testing
- Blood Flow Restriction Cuff
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Paulista University
Healthy
Plant-based Dietary Protein and Resistance-training Adaptations
Dietary protein consumption maximizes the anabolic response during resistance training (RT) by triggering muscle protein synthesis and providing the indispensable amino acids for a net positive protein balance.
- Trial name
- NCT03907059
- Testing
- whey protein, soy protein
- Where
- Brazil
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Investigating the Effects of Power Training in the Elderly
Effects of Different Power Training Intensities in Older Adults
Power (strength × velocity) is a crucial component for maintaining independence during aging. Therefore, investigating interventions aimed at improving this physical capacity is essential for this population.
- Trial name
- NCT07023146
- Testing
- Moderate to high intensity (PTMH; 65-80% of 1-repetition maximum [1RM]) ), low to moderate intensity (PTLM; 40-60% of 1-repetition maximum [1RM])
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Sarcopenia, Muscular Atrophy
Exercise and Nutrition Interventions in Age-related Sarcopenia
This project will investigate the synergistic effects of Aerobic and Resistance type Exercise, in combination with Protein Supplementation, on; Body Composition, Musculoskeletal Functioning, Nutritional Status and Quality of Life…
- Trial name
- NCT02912130
- Testing
- Protein Supplementation, Aerobic Exercise, Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Liverpool Hope University
Muscle Strength, Muscle Hypertrophy
Effects of BFR Training on Muscle Strength, Thickness, and Motivation in National Adolescent Male Canoe Athletes
The aim of this study is to evaluate the effects of blood flow restriction (BFR) exercises on lower extremity muscle strength, muscle thickness, and sport-specific motivation in adolescent elite male canoe athletes.
- Conditions
- Muscle Strength, Muscle Hypertrophy, Sport Performance
- Trial name
- BRAVE-CAN (NCT06912867)
- Testing
- Blood Flow Restriction (BFR) Exercise Program
- Where
- Cyprus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Healthy
Individual Response to Different Volumes of Resistance Training
The literature is not clear as to which training volume to employ during initial phases of resistance training programs to ensure optimal muscular adaptations.
- Trial name
- NCT02179307
- Testing
- 12-week progressive strength training protocol
- Where
- Norway
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Inland Norway University of Applied Sciences
Muscle Hypertrophy, Muscular Strength
The Effect of Peak Force At Long and Short Muscle Lengths and the Impact on Muscle Growth and Strength
The goal of this clinical trial is to learn the effect of applying peak force/resistance to skeletal muscles during resistance exercise training in young and healthy adults.
- Trial name
- SLML (NCT06666127)
- Testing
- LONG and SHORT Resistance Training, Maximal Isotonic Strength Testing (1RM), Isokinetic Strength Testing
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiomyopathy, Hypertrophic, Dilated Cardiomyopathy
UTSW HP [13-C] Pyruvate Injection in HCM
The study objective is to identify the earliest changes in energy substrate metabolism in patients with cardiomyopathies (CMP). To achieve this objective, we plan first to test the hypothesis that patients with CMP present focal…
- Conditions
- Cardiomyopathy, Hypertrophic, Dilated Cardiomyopathy, Duchenne Muscular Dystrophy, Cardiac Sarcoidosis
- Trial name
- HPHCM (NCT03057002)
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Becker Muscular Dystrophy, Limb-Girdle Muscular Dystrophy Type 2I
Muscle MRI in Becker Muscular Dystrophy and in Limb-girdle Muscular Dystrophy Type 2I
The purpose of this study is to investigate the paradoxical muscle enlargement in the calves and tongue seen in patients affected by Becker muscular dystrophy and Limb-girdle muscular dystrophy type 2I.
- Trial name
- NCT02165358
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sarcopenia, Muscle Hypotrophy
Systemic Hormones and Muscle Protein Synthesis
This study evaluates the effect of increase in testosterone levels in older males and the effects of decrease in testosterone levels in young males on muscle protein synthesis.
- Conditions
- Sarcopenia, Muscle Hypotrophy, Muscle Atrophy
- Trial name
- NCT03054168
- Testing
- Sustanon 250, Zoladex
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nottingham