Clinical trials: Neuromodulation
Transcranial Direct Current Stimulation
Mechanism and Dosimetry Exploration in TES Magnetic Resonance Current Mapping Methods
In this study the investigators will explore dosimetry in transcranial electrical stimulation using a novel magnetic resonance imaging technique that can determine how electrical stimulation distributes within the brain.
- Trial name
- TES (NCT03772210)
- Testing
- tDCS
- Where
- 2 sites in United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Cerebellar Stroke, Autoimmune Cerebellar Disorders
Brain Stimulation to Improvement After Cerebellar Damage
The work will examine the mechanisms and potential therapeutic effects of transcranial magnetic stimulation on upper-limb sensorimotor function in individuals with cerebellar dysfunction, including those with damage due to stroke…
- Trial name
- NCT07838961
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- George Wittenberg
Aging
SMART Stimulation: Precision Neuromodulation of Cognition in Older Adults
The current study will investigate methods for enhancing cognitive training (CT) effects in healthy older adults by employing a combination of interventions facilitating neural plasticity and optimizing readiness for learning.
- Trial name
- NCT05377411
- Testing
- tDCS, cognitive training
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stroke
VNS-induced Corticospinal Plasticity
The goal of this study is to learn more about the connections between the brain, spinal cord, and muscles and how these connections can be strengthened after neurological injury.
- Trial name
- NCT04088565
- Testing
- Paired-Associative Stimulation (PAS), Vagus Nerve Stimulation (VNS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Language Development, Learning
Brain Stimulation Paired With Structured Language Learning in Adults
This study investigates whether transcranial electrical stimulation (tES) delivered during structured language-learning sessions affects the rate and quality of second-language acquisition in adults.
- Trial name
- NCT07762118
- Testing
- Active transcranial electrical stimulation (tES)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- General Neuro Inc.
Brain Concussion, Mild Traumatic Brain Injury
Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive Impairment
- Trial name
- CI-tDCS (NCT05762796)
- Testing
- tDCS in Youth with mild traumatic brain injury
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Overactive Bladder
Transcutaneous Posterior Tibial Nerve Electrostimulation With Low Dose Trospium Chloride in OAB in Females
This study was done to verify whether the combination of transcutaneous posterior tibial nerve stimulation (TPTNS) with low dose trospium chloride in the treatment of females with overactive bladder (OAB) would be more effective…
- Trial name
- NCT03104101
- Testing
- TPTNS+Drug, TPTNS
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Female Sexual Dysfunction, Female Sexual Dysfunction Due to Physical Condition
Effect of Peripheral Neuromodulation on Vaginal Blood Flow - Study 2
The overall purpose of this research is to improve sexual function in women with sexual dysfunction. The goal of this study is to see if either of two nerve stimulation interventions cause a short-term change in vaginal blood…
- Trial name
- NCT06999265
- Testing
- Transcutaneous electrical nerve stimulation - Tibial Nerve, Transcutaneous electrical nerve stimulation - Genital Nerve, Neutral and Erotic Film Clip Alternation
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Alzheimer Disease, Mild Cognitive Impairment
Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or…
- Trial name
- NCT05904132
- Testing
- tACS device
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Female Sexual Dysfunction, Spinal Cord Injuries
Effect of Peripheral Neuromodulation on Vaginal Blood Flow
The researchers want to see if nerve stimulation interventions cause a change in vaginal blood flow. This intervention was performed in women who have neurogenic (spinal cord injury) or non-neurogenic sexual dysfunction and…
- Trial name
- NCT04384172
- Testing
- Transcutaneous electrical nerve stimulation - Tibial Nerve, Transcutaneous electrical nerve stimulation - Genital Nerve
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Neuromodulation, Pain
Opinions of Healthcare Providers About Neuromodulation
The goal of this online survey is to gain further insight in the goals, expectations and definition of success for neuromodulation for pain, according to healthcare providers.
- Conditions
- Neuromodulation, Pain, Survey
- Trial name
- NCT05013840
- Testing
- Filling in an online survey
- Where
- Belgium
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Moens Maarten
Healthy Aging, Fatigue
Neuromodulation and Fatigue
In this project, we aim to determine any potential effects of a weak electrical current applied to the neck or thoracic area on functional capacity and muscle activation.
- Trial name
- NCT05487131
- Testing
- electrical stimulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
HTN-Hypertension, Blood Pressure Management
Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects
Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies.
- Trial name
- NCT06969846
- Testing
- CSN electrode was implanted around tissue including CSN branches
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Louis Stokes VA Medical Center
Female Sexual Dysfunction
Trial of Tibial Nerve Stimulation for Treating Sexual Dysfunction
The purpose of this study is to understand the efficacy of PTNS versus a placebo in the treatment of female sexual dysfunction syndrome.
- Trial name
- NCT04122703
- Testing
- percutaneous tibial nerve stimulation (PTNS)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Pain
Central Neuromodulation of Pain Through Music in Healthy Subjects
The present research aims to study the neuromodulatory effect of music on the sensory component of pain. The activation of pain control systems, through music, would pave the way for rehabilitation prospects for patients with a…
- Trial name
- DOUMU1 (NCT03914105)
- Testing
- Without music, With music
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Healthy
Neuromodulation-assisted Ego-disengagement: The NEURO-EGO Study Stage 1
The goal of this clinical trial is to learn whether brain stimulation technology can help people reach a meditative state quickly and easily without years of meditation training.
- Trial name
- NCT06601686
- Testing
- Transcranial electrical stimulation (TES), Transcranial electrical stimulation with temporal interference (TES-TI)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Schizophrenia, Nicotine Dependence
Network-Targeted Neuromodulation for Nicotine Dependence in Schizophrenia
The goal of this clinical trial is to compare two active types of transcranial magnetic stimulation in two nicotine-using populations: nicotine-using people with psychosis and nicotine-using people without a diagnosis of a…
- Trial name
- NCT06389266
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Thalamus
Neuromodulation of Conscious Perception: Investigating Thalamic Roles Through Ultrasonic Stimulation
The purpose of this study is to evaluate the role that the thalamus (the egg-shaped structure in the middle of your brain) plays in perception using a low-intensity ultrasound pulsation (LIFUP) device.
- Trial name
- NCT06083493
- Testing
- LIFUP excitation, LIFUP inhibition
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Temporal Perturbation, Virtual Lesion
Dynamic Causal Modeling of Neuromodulation of Action Speed Via Targeted TMS-EEG
Stroke is a major cause of long-term disability, with cognitive and motor deficits-especially action slowing and executive dysfunction-being strong predictors of poor recovery outcomes.
- Conditions
- Temporal Perturbation, Virtual Lesion, EEG, fNIRS
- Trial name
- NAS (NCT07468032)
- Testing
- Phase 1 functional MRI (fMRI), Phase 2 functional MRI (fMRI), Phase 3 functional MRI (fMRI)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Musical Performance, Neuromodulation
tDCS and Musical Performance in Young Orchestra Musicians
The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) can improve the technical, expressive, and stage aspects of musical performance in young orchestra musicians aged 18 to 30 years.
- Conditions
- Musical Performance, Neuromodulation, Performance Anxiety
- Trial name
- NCT06958081
- Testing
- Active transcranial direct current stimulation (tDCS)
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centro Universitário Augusto Motta