Clinical trials: Nitrates
High Intensity Intermittent Sports Performance
Nitrate for High Intensity Intermittent Exercise
The objective of the current study is to assess the effect of 6-day dietary nitrate ingestion on high intensity intermittent sports performance in recreational soccer players.
- Trial name
- NITR-ITE (NCT02436629)
- Testing
- Nitrate-rich concentrated beetroot juice, Nitrate-depleted concentrated red beetroot juice
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cardiovascular Disease
Effects of Growth Hormone on the Nitric Oxide Pathway
The purpose of the study is to determine whether the treatment with growth hormone has an influence on the nitric oxide pathway in healthy males.
- Trial name
- NCT00470002
- Testing
- Somatropin
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Nitrate, Placebo - Control
Beetroot Juice and Neuromuscular Performance in Female Basketball Players
A randomized, double-blind, placebo-controlled study investigates the effects of 5 days of nitrate-rich beetroot juice supplementation (70 mL·day-¹; 6.4 mmol NO₃-·day-¹) on physical performance in female basketball players.
- Trial name
- BASKET_BEET (NCT07833579)
- Testing
- Beetroot juice supplementation
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Aging, Aging Well
Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments to compromise intrinsic capacity and healthspan.
- Conditions
- Aging, Aging Well, Healthy Aging
- Trial name
- BOOST-X (NCT07572266)
- Testing
- Nitrate enriched beetroot juice, Nitrate depleted beetroot juice, 12 week of combined exercise training
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
Pilot Study of Nitrate-rich Beetroot Juice Supplementation in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Idiopathic pulmonary fibrosis (IPF) is a type of scarring (fibrotic) lung disease. Reduced exercise capacity is a key symptom experienced by patients.
- Trial name
- BEET-IPF (NCT06488638)
- Testing
- nitrate-rich beetroot juice (70ml with approx. 400 mg nitrate) twice a day for 3 days
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Pulp Disease, Dental
Potassium Nitrate in Polycarboxylate as a Direct Pulp Capping
The study aimed to compare potassium nitrate in polycarboxylate cement to mineral trioxide aggregate as a direct pulp capping material of young permanent teeth in patients from 7 to 10 ears
- Trial name
- NCT05912907
- Testing
- potassium nitrate in polycarboxilate cement
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Minia University
Blood Plasma Nitrite
Nitrate and Power Output After Two Beetroot Juice Drinks
The main aim of this study is to determine and compare the optimal time to achieve peak concentration of blood plasma nitrite after ingestion of beetroot juice (BR) and isotonic beetroot juice (ISO-CB), respectively.
- Trial name
- NCT05452421
- Testing
- Isotonic carbohydrate beetroot juice drink, Beetroot juice drink
- Where
- Singapore
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
HIV/AIDS
People Living With HIV/AIDS, Nitrate, Endotelial Function, Arterial Stiffness and Skeletal Muscle Oxygenation
Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality.
- Trial name
- NCT03485248
- Testing
- Beetroot Juice
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Exercise Nutritional Physiology
Influence of Dietary Nitrate on Time Trial Performance in Swiss Paracycling Athletes
The aim of this study is to investigate wether beetroot juice or sodium nitrate enhances time trial performance in Swiss paracycling athletes compared to the ingestion of a placebo supplement.
- Trial name
- nitrate_TT (NCT02454049)
- Testing
- beetroot juice, sodium nitrate, water
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
High Blood Pressure, Flow Mediated Dilation
Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure
It is hypothesized that the daily supplementation of a nitrate-rich, two-ounce fruit and vegetable energy supplement (Isagenix International LLC) by healthy young adults with a would increase circulating nitrates and improve…
- Trial name
- NCT03486145
- Testing
- fruit and vegetable juice supplement
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Dentin Hypersensitivity
Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste
Assess the clinical efficacy of 5% Potassium Nitrate Toothpaste (Colgate-Palmolive Company, New York, NY, USA) on providing dentinal hypersensitivity relief (tactile and air blast) in comparison to Colgate Cavity Protection…
- Trial name
- NCT06956599
- Testing
- test toothpaste, Control toothpaste
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Other Abnormal Granulation Tissue Nos
Granulation Tissue Treatment: Silver Nitrate vs Kenalog vs Washcloth Abrasion
Granulation tissue, or excess tissue, forms around gastrostomy tube sites and is a common problem seen in the pediatric surgery population.
- Trial name
- NCT02519738
- Testing
- Silver Nitrate, Kenalog (Triamcinolone), Washcloth Abrasion
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoporosis
The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis
Osteoporosis or "thinning of the bones" affects in 1 in 4 Canadian women and 1 in 8 Canadian men. Moreover, while the rates of osteoporosis among Canadians are stabilizing, worldwide the number of people afflicted with…
- Trial name
- NCT00252421
- Testing
- Nitroglycerin ointment 15 mg/day daily for 24 month
- Where
- Canada
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dietary Supplement, Placebo
Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults
Beetroot juice supplementation has shown the capacity for provoking different physiological effects (e.g. vasodilation and muscle contraction increments).
- Trial name
- BEET_ELDERLY (NCT05337527)
- Testing
- beetroot juice
- Where
- Spain
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Obese Individuals, Central Adiposity
Post-exercise Blood Pressure With Inorganic Nitrate
This study is examining whether acute inorganic nitrate supplementation in the form of beetroot juice, paired with an acute bout of exercise, affects blood pressure and what is the magnitude of the difference compared to exercise…
- Trial name
- BEET-DOWN (NCT07869472)
- Testing
- Beetroot Juice - Active + Exercise, Beetroot Juice - Active + No exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Health Risk Behaviors
Nitrate INFORMER Water Study
Nitrate is a controversial component of vegetables, meat, and drinking water. The now well-established benefits of nitrate, through the enterosalivary nitrate-nitrite-nitric oxide (NO) pathway, on cardiovascular risk factors and…
- Trial name
- NCT05710341
- Testing
- Water with added nitrate, Water without added nitrate
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Edith Cowan University
Health Risk Behaviors
Nitrate INFORMER Nitrosamine Study
Nitrate is a controversial component of vegetables, meat, and drinking water. The now well-established benefits of nitrate, through the enterosalivary nitrate-nitrite-nitric oxide (NO) pathway, on cardiovascular risk factors and…
- Trial name
- NCT05045807
- Testing
- Meat with added nitrate, Meat with added nitrate plus vegetables
- Where
- Australia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Edith Cowan University
Exercise Performance
Effects of Beetroot Juice and Caffeinated Coffee on Exercise Performance in Recreationally Active Men
The goal of this clinical trial was to evaluate how acute intake of beetroot juice, caffeinated coffee, and their combination affected aerobic and anaerobic exercise performance in healthy recreationally active men.
- Trial name
- NCT07797062
- Testing
- Beetroot juice, Caffeinated Turkish Coffee, Water
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Metabolic Disease, Obesity
Determination of the Independent Effects of Beetroot Juice Components, Dietary Nitrate and Antioxidants, on Exercise Tolerance and Health Benefits in Individuals With Obesity
The purpose of this study is to assess the effects of acute beetroot juice supplementation on exercise performance and cardiometabolic health in obese individuals with secondary cardiometabolic complications.
- Conditions
- Metabolic Disease, Obesity, Exercise
- Trial name
- BEETIT (NCT03545009)
- Testing
- Sodium Nitrate, Beetroot Juice no Nitrate, Beetroot Juice
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Tooth Sensitivity
Different Concentrations of Potassium Nitrate in In-office Tooth Bleaching Sensitivity
The aim of this randomized, double-blind controlled clinical study was to evaluate the absolute risk and intensity of sensitivity to dental bleaching in adults on the application of two different gels based on potassium nitrate…
- Trial name
- NCT03323372
- Testing
- 3% potassium nitrate and 0.25% sodium fluoride, 5% potassium nitrate and 2% sodium fluoride
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Amazonas