Clinical trials: Nitrates
Tooth Sensitivity
Different Concentrations of Potassium Nitrate in In-office Tooth Bleaching Sensitivity
The aim of this randomized, double-blind controlled clinical study was to evaluate the absolute risk and intensity of sensitivity to dental bleaching in adults on the application of two different gels based on potassium nitrate…
- Trial name
- NCT03323372
- Testing
- 3% potassium nitrate and 0.25% sodium fluoride, 5% potassium nitrate and 2% sodium fluoride
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Amazonas
Dietary Habits, Nitrates
Effects of Beet Juice and Diet in Female Rowers
The purpose of this study is to determine the effects of nitrate-rich beetroot juice supplementation on exercise performance in female rowers when accounting for habitual vegetable nitrate consumption.
- Conditions
- Dietary Habits, Nitrates, Exercise
- Trial name
- NCT06045845
- Testing
- Beet Juice
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Beetroot Juice, Caffeine
Acute Effects of Beetroot Juice and Caffeine Co-ingestion on Lower-limb Strength and Muscular Endurance in Females
The aim of this study is to evaluate the acute effects of beetroot juice and caffeine, consumed individually or in combination, on lower-limb strength and muscular endurance in physically active women.
- Conditions
- Beetroot Juice, Caffeine, Placebo, Beetroot Juice with Caffeine Co-ingestion
- Trial name
- NCT06758323
- Testing
- Beetroot juice combined with caffeine (COM)
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Jose Manuel Jurado Castro
No Dental Disease, Non-smoking
Effects of Daily Nitrate Consumption on Oral Bacteria Composition, Blood Pressure and Vascular Function
Diseases of the heart and blood vessels, including raised blood pressure, are one of the leading causes of death worldwide. Higher intakes of dietary nitrate, found abundantly in root vegetables such as beetroot, have been shown…
- Trial name
- REBOC2 (NCT03784742)
- Testing
- Nitrate rich beetroot juice
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Reading
Nitric Oxide, Insulin Sensitivity
Nutritional Supplementation and Insulin Sensitivity
Type 2 diabetes mellitus (T2DM) is a progressive disease and early intervention and prevention strategies are therefore very important. An important early hallmark in the development of T2DM is insulin resistance.
- Conditions
- Nitric Oxide, Insulin Sensitivity, Vascular Function, L-arginine
- Trial name
- NCT04239482
- Testing
- L-arginine + Nitrate / Nitrite
- Where
- Netherlands
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Aging
Exploring the Effect of Inorganic Nitrates on the Human Microvascular Physiology - a Pilot Study.
We conducted a randomised, placebo-controlled, double blind, cross-over, trial to examine the short-term effect of concentrated beetroot juice on vascular outcomes in a young (18-35 years) and older group (55-75 years).
- Trial name
- ENIH-MPS (NCT04276766)
- Testing
- Crossover intervention
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Burn
Study of the Treatment of Burn Wounds With Antimicrobial Topical Soaks
Determine effectiveness of various antimicrobial solutions on burn wounds (infections, wound healing, length of hospital stay).
- Trial name
- Soaks (NCT00675922)
- Testing
- Sulfamylon 5% and Silver Nitrate Soaks
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Non ST Segment Elevation Acute Coronary Syndrome, Contrast Induced Nephropathy
Supplementation With Beetroot Juice to Prevent Contrast Associated Nephropathy During Hospitalization for Acute Coronary Syndrome Without ST Elevation
The goal of this study is to compare the possible beneficial effect of beetroot juice supplementation versus the usual management during hospitalization to prevent contrast-induced nephropathy after cardiac catheterizations.
- Trial name
- RENACS (NCT06695429)
- Testing
- Beetroot juice
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Hospital General Universitario Santa Lucia
Malnutrition
Vegans Health Status and Exposure to Pesticides and Nitrate
This research concerns nutritional and toxicological health risk evaluation among long-term vegans. Research focus is in cumulative exposure to pesticides.
- Trial name
- NCT02288546
- Where
- Finland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Functional Dyspepsia, Gastro Esophageal Reflux
Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting
The purpose of this prospective cohort study is to compare upper GI symptoms and endoscopy findings in Canada with Japan and Iran, and correlate this with the upper GI microbiome.
- Conditions
- Functional Dyspepsia, Gastro Esophageal Reflux, Peptic Ulcer, Normal Control
- Trial name
- NCT03868267
- Where
- 3 sites in Canada, Iran and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Hamilton Health Sciences Corporation
Nitric Oxide, Oral Microbiome
Nitrate Mouth Rinse and the Oral Microbiome
The study is aimed to determine if changes to the oral microbiome occur after the use of a nitrate rich mouth rinse. Participants with be asked to use either a controlled (water) mouthrinse once daily for 2 weeks while…
- Trial name
- NCT06588049
- Testing
- Beet Root, Water
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Dalhousie University
Nasopharyngeal Carcinoma
Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients
The purpose of this study is to evaluate whether dietary nitrate supplementation could improve the salivary flow for nasopharyngeal carcinoma patients receiving concurrent chemo-radiation therapy.
- Trial name
- NCT02854410
- Testing
- Sodium nitrate, sodium chloride
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Heart Failure With Normal Ejection Fraction
Treatment of HFpEF With Nitrate Supplement
The objective of this project is to determine if Neo40, a nitric oxide generating lozenge, when consumed twice daily by subjects with HFpEF, will increase exercise tolerance, decrease symptoms and improve quality of life for…
- Trial name
- NCT03289481
- Testing
- Active lozenge
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- MaineHealth
Coronary Artery Disease
Pilot Study of Organic Nitrates on Endothelial Function in CAD Patients
Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54).
- Trial name
- ONEEF (NCT01030367)
- Testing
- PETN, ISDN
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Julius-Maximilians University
Fluorosis, Dental, Non-Fluoride Enamel Opacities
Treatment of Hypersensitivity Using Diode Laser and Desensitising Agent on Fluorosed and Non-fluorosed Teeth
The present study was designed as a randomised controlled clinical trial which was unicenter, double-blinded, parallel designed study, according to the Consolidated Standards of Reporting Trials (CONSORT) criteria, 2010.
- Conditions
- Fluorosis, Dental, Non-Fluoride Enamel Opacities, Dentin Sensitivity
- Trial name
- NCT03237793
- Testing
- Fluorosed Group, Non Flourosed Group
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Vital Pulp Therapies, Pulpotomy
Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars
The purpose of this RCT is to compare the clinical/radiographic outcomes of Potassium nitrate in polycarboxylate cement and MTA as pulpotomy biomaterials used for asymptomatic vital primary lower second molar and this will help…
- Conditions
- Vital Pulp Therapies, Pulpotomy, Pulp Disease, Dental, Pulpotomies Primary Teeth
- Trial name
- NCT06871709
- Testing
- Potassium Nitrate in Polycarboxylate cement, MTA-Anglus
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Umbilical Granuloma
Double Ligation and Topical Silver Nitrate
To study and compare the efficacy and safety of Double Ligation and Topical Silver Nitrate Solution while treating children with Umbilical Granulomas
- Trial name
- RCT (NCT04248101)
- Testing
- Double Ligation, Topical Silver Nitrate
- Volunteers
- 176 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Chronic Stable Angina Pectoris
Acute Episodes in Chronic Stable Angina: Assessment of the Use of the Coronary Vasodilator Propatyl Nitrate.
This is an open, self-paired study of 200 patients with heart failure who have a diagnosis of chronic stable angina pectoris, who will be treated for 30 days with propatyl nitrate (10mg) .
- Trial name
- NCT02315976
- Testing
- Propatyl Nitrate
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Fundação Educacional Serra dos Órgãos
Acute Nitrate Ingestion on Athletic Performance
Acute Nitrate Supplementation in Cyclists
Six days of dietary nitrate (NO3-) supplementation in the form of beetroot juice (~0.5 L•d-1; 5.1-11.2 mmol NO3- •d-1) has been purported to reduce pulmonary oxygen uptake (VO2) during submaximal exercise and increase tolerance…
- Trial name
- NCT01384968
- Testing
- beetroot juice
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Tympanic Membrane Perforation
Effectiveness of Silver Nitrate Cauterization vs Conservative Management in Tympanic Membrane Perforation Closure
The objective of this study is to evaluate the effectiveness of 50% silver nitrate chemical cauterization compared to conservative management (spontaneous healing) in closing small, dry tympanic membrane perforations.
- Trial name
- NCT07833670
- Testing
- 50% Silver Nitrate Cauterization
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Muhammad Ali Javed