Clinical trials: Non Union Fracture
Distal Femur Fracture
Carbo-fix Lateral Plate Devices and Standard Plate-Nail Constructs in Distal Femur Fractures
The purpose of this randomized clinical trial is to decrease non-union rates in distal femur fracture fixation. Carbo-fix lateral femur plate and standard intramedullary nail-plate constructs have been shown to have lower…
- Trial name
- NCT07280169
- Testing
- Carbo-fix Lateral Plate Device, Standard Plate-Nail Construct
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Missouri-Columbia
Scaphoid Fracture Non Union
Arthroscopic Scaphoid Grafting Versus Open Grafting in Scaphoid Non Union
the investigators compare the arthroscopic grafting technique with the traditional open technique in th treatment of scaphoid non union as regards the union rate, time to union and functional outcomes to provide the best…
- Trial name
- NCT07320404
- Testing
- Arthroscopic grafting and k wires fixation, open scaphoid grafting with K wires fixation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Non-union of Fractures
Autologous Stem Cell Therapy for Fracture Non-union Healing
Do mesenchymal stem cells accelerate new bone formation in persistent non-unions.
- Trial name
- NCT02177565
- Testing
- carrier plus in vitro expanded autologous BMSCs
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Infected Non Union and Delayed Union in Fractures of Both Long and Short Bones
Hardware Preservation in Management of Infected Non United or Delayed United Fractures of Long or Short Bones by Debridement and Local Calcium Sulfate Loaded by Antibiotics
Diagnosis of infection based on elevated serum markers of infection (ESR, CRP), discharging sinus, preoperative radiographs suggestive of bone infection and radiological findings .
- Trial name
- NCT05231148
- Testing
- local debridement and local calcium sulfate loaded by antibiotics
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sohag University
Non-union Diaphysary Tibial Fractures
A Prospective Randomized Controlled Trial on the Use of Bone Morphogenetic 7 (BMP-7) (OP-1®) and Demineralized Bone Matrix in Tibial Non-union
The researchers propose a prospective, randomised partially-blinded study to investigate the clinical and radiological outcome, effect on quality of life and socio-economic impact of non-union of diaphysary tibial fractures…
- Trial name
- NCT00551941
- Testing
- BMP-7 in adjunct to fresh frozen allograft, allograft together with DBM
- Where
- 2 sites in Belgium
- Volunteers
- 2 people
- Sponsor
- University Hospital, Ghent
Fracture Non Union, Infection
Antibiotic Loaded Calcium Sulfate RCT
This is a multi-centered, prospective, randomized controlled trial comparing current standard of care for defect management to placement of antibiotic loaded Stimulan as a bone void filler in patients undergoing treatment of…
- Trial name
- NCT03875963
- Testing
- Antibiotic loaded bone filler
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Rib Fracture, Flail Chest
Clinical Study of the U-Plate Fracture Repair System to Treat Rib Fractures
The purpose of this study is to gather information about a device used to help fix broken ribs. Hypothesis: Rib fracture repair with the U-plate system is clinically durable and safe for the indications of flail chest repair…
- Trial name
- NCT00556543
- Testing
- U-plate fracture repair system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Pseudarthrosis, Ununited Fracture
Tuebingen Register of Union Failure After Fractures of the Upper and Lower Extremities
TRUFFLE is a register of clinical patient data of failed bone healing and bone non-union after fracture. All patients suffering from a long bone delayed or non-union after fracture and undergoing revision surgery are registered…
- Trial name
- TRUFFLE (NCT06098157)
- Where
- Germany
- Volunteers
- 850 people
- Sponsor
- Department of Trauma and Reconstructive Surgery at Eberhard Karls University Tuebingen, BG Klinik Tu
Nonunion of Fracture [Pseudarthrosis], Site Unspecified
Validation of Laboratory Test for Predicting Bone Tissue Regeneration
The aim of the study is to determine whether the evaluation of pro-osteogenic activity of autologous serum may predict the effectiveness of platelet gel in regenerating bone tissue in patients with nonunions of long bones.
- Trial name
- Rebone-test (NCT01362413)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Tibial Fractures
Pulsed Electromagnetic Field (PEMF) Stimulation for Tibia Fractures
Fractures of the tibial shaft (diaphysis) are some of the most common long bone fractures. They most frequently occur in males less than 40 years of age.
- Trial name
- NCT00127725
- Testing
- Pulsed electromagnetic field stimulation
- Where
- 5 sites in Australia
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Sydney South West Area Health Service
Treatment Adherence and Compliance
Customized Polyamide Prosthesis. for Mid Shaft Clavicle Fracture
Herein we describe the management of a patient who presented with progressive brachial plexopathy following the initial nonoperative management of a mid shaft clavicular fracture by using 3 D customized polyamide prosthesis.
- Trial name
- NCT05261308
- Testing
- new prosthesis
- Where
- 2 sites in Egypt
- Volunteers
- 1 people
- Sponsor
- Cairo University
Infections, Infected Wound
PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics.
- Conditions
- Infections, Infected Wound, Nonunion of Fracture, Injury Leg
- Trial name
- POvIV2 (NCT05699174)
- Testing
- Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
- Where
- 13 sites in United States
- Volunteers
- 250 people
- Sponsor
- Major Extremity Trauma Research Consortium
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Pseudoarthrosis of Bone, Pseudarthrosis
Treatment of Nonunion Fractures With Mesenchymal Stromal Cells (MSCs)
The goal of this study is to evaluate the bone regeneration capacity of BM-MSC (Bone marrow mesenchymal stromal cells), in patients with nonunion.
- Conditions
- Pseudoarthrosis of Bone, Pseudarthrosis, Non Union Fracture, Nonunion Bone Fracture
- Trial name
- MSC (NCT06103396)
- Testing
- Transplantation of autologous MSCs in nonunion fracture, Transplantation of allogeneic MSCs in nonunion fracture
- Where
- Venezuela
- Volunteers
- 30 people
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Lateral Malleolus Fractures
Double Compression Screw Fixation for Symptomatic Non-union of Lateral Malleolar Ankle Fractures
The aim of this prospective clinical trial study is to evaluate the clinical and radiological outcomes of treating non-union of the lateral malleolar ankle fractures by double compression screw fixation technique.
- Trial name
- NCT07539922
- Testing
- Double Compression Screw Fixation for Symptomatic Non-union of Lateral Malleolar Ankle Fractures
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Sohag University
Congenital Pseudarthrosis of Tibia
A Study to Assess How Effective and Safe NVD003 is for Treating Patients With Congenital Pseudarthrosis of the Tibia.
The purpose of this study is to assess the efficacy and safety of NVD003 in pediatric participants with unilateral Congenital Pseudarthrosis of the Tibia (CPT) compared with iliac crest bone graft (ICBG) at 12 months post graft…
- Trial name
- NCT07112443
- Testing
- NVD003, Iliac Crest Bone Graft
- Where
- 7 sites in United States, Belgium and 2 more
- Volunteers
- 12 people
- Sponsor
- Novadip Biosciences
Congenital Pseudarthrosis of Tibia
NVD-003 in the Treatment of Congenital Pseudarthrosis of the Tibia
A single arm, multi-country, multi-center study in pediatric patients, suffering from congenital pseudarthrosis of the tibia (CPT), treated during the primary surgical intervention with NVD-003, an autologous 3D scaffold free…
- Trial name
- NCT05693558
- Testing
- NVD-003, an autologous 3D scaffold free osteogenic graft
- Where
- 2 sites in United States, Belgium
- Volunteers
- 4 people
- Sponsor
- Novadip Biosciences
Osteoarthritis, Traumatic Arthritis
Actis Total Hip System 2 Year Follow-up
Two-year (2 year) information regarding the performance of the commercially available Actis™ Total Hip System in order to obtain and evaluate the clinical outcomes on a series of cementless primary total hip arthroplasty (THA)…
- Conditions
- Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Congenital Hip Dysplasia
- Trial name
- Actis14014 (NCT02783274)
- Testing
- Actis Total Hip System
- Where
- 9 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- DePuy Orthopaedics
Orthopedic
Long-term Surgical Outcomes of Scaphoid Proximal Pole Fracture Nonunion
The treatment for scaphoid proximal pole nonunion remains challenging due to the poor vascularity in the proximal pole fragment, associated SL injury and the technique of fixation.
- Trial name
- NCT03701269
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Non Union Fracture
A Comparative Study of 2 Doses of BM Autologous H-MSC+Biomaterial vs Iliac Crest AutoGraft for Bone Healing in Non-Union
ORTHOUNION is a multi-centre, open, comparative, randomized, clinical trial with three parallel arms that aims to compare the efficacy of three treatments to enhance bone healing in patients with long bone non-union.
- Trial name
- ORTHOUNION (NCT03325504)
- Testing
- Cultured Mesenchymal Stem Cells, Autologous iliac crest graft
- Where
- 19 sites in France, Germany and 2 more
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Madrid