Clinical trials: Noninvasive
Healthy, Hypoxia
SpO2 Accuracy of Noninvasive Disposable Pulse Oximeter Sensor
The purpose of this clinical study is to validate the SpO2 accuracy of the Stryker Sustainability Solutions pulse oximetry sensors during non-motion conditions over the range of 70-100% SaO2 as compared to arterial blood samples…
- Trial name
- NCT05245526
- Testing
- STRYKER SUSTAINABILITY SOLUTIONS PULSE OXIMETERS
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Stryker Sustainability Solutions
Pregnancy Related
Cell- Based Noninvasive Prenatal Testing (NIPT): Single Cell Prenatal Diagnosis (SCPD)
The purpose of the overall study is to develop improved methods for recovery of fetal cells from the mother's blood in order to develop a clinically useful form of cell-based, diagnostic, noninvasive prenatal testing (NIPT).
- Trial name
- NIPT & SCPD (NCT05076734)
- Testing
- Redraw for analysis of blood samples from healthy pregnant women
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Luna Genetics
Healthy, Anemia
Noninvasive Hemoglobin Repeatability and Reproducibility in a Blood Donation Setting
The primary objective of this clinical investigation is to report on the repeatability and reproducibility of SpHb measurements from Rad-67 devices and DCI Mini sensors used to screen prospective blood donors at a donation center.
- Trial name
- NCT04490863
- Testing
- Rad-67 Pulse oximeter & DCI Mini sensor
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Healthy
Comparison of Noninvasive Hemoglobin Disposable Sensors
In this study, the concentration of hemoglobin within the subject's blood will be reduced in a controlled manner by administering fluids intravenously.
- Trial name
- NCT03125031
- Testing
- Rainbow adhesive adult/pediatric sensor, Rainbow adhesive adult/neonatal sensor
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Healthy
Non-invasive Measurement of Glucose with Advanced Spectroscopy Techniques and Machine Learning Models
Primary aim of this pilot study is to provide evidence for a non-invasive, continuous, and transcutaneous measurement method to determine blood glucose levels robustly and accurately.
- Trial name
- NCT06406075
- Testing
- Lab demo 1.0
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Liom Health AG
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Study of Electrical Impedance Myography (EIM) in ALS
This trial is studying Electrical Impedance Myography (EIM) for measuring muscle health. The trial is studying people with Amyotrophic Lateral Sclerosis (ALS), other neuromuscular diseases, and healthy volunteers to see if the…
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Charcot-Marie-Tooth Disease, Multiple Sclerosis
- Trial name
- NCT02011204
- Testing
- Electrical impedance myography (EIM)
- Where
- 6 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Skulpt, Inc.
Rhesus D Genotype
A Noninvasive Test for Fetal RHD Genotype
The objective of this study is to evaluate the performance of Sequenom's noninvasive test for fetal RHD genotype. The test uses MALDI-TOF mass spectrometry to detect DNA.
- Trial name
- NAFTnet RHD (NCT00871195)
- Where
- 13 sites in United States, Canada
- Volunteers
- 520 people
- Sponsor
- Sequenom, Inc.
Intracranial Hypertension
Comparison of the Non-invasive ICP HeadSense Monitor vs Lumbar CSF Pressure Measurement
In current practice patients with a suspected increase of intracranial pressure (ICP) will undergo a lumbar puncture with measurement of cerebral spinal fluid (CSF) pressure (as a marker for ICP).
- Trial name
- NCT02773901
- Testing
- HS-1000
- Where
- 3 sites in Denmark, Germany and 1 more
- Volunteers
- 60 people
- Sponsor
- HeadSense Medical
Chronic Obstructive Pulmonary Disease
A40 Expiratory Flow Limitation Registry
This prospective observational multicenter registry study will include adults greater than 40 years old, diagnosed with chronic obstructive pulmonary disease, requiring home noninvasive ventilation as part of standard medical…
- Trial name
- NCT04419428
- Testing
- BiPAP A40 Expiratory Flow Limitation (EFL)
- Where
- United Kingdom
- Sponsor
- Philips Clinical & Medical Affairs Global
Surgery
Validation of Noninvasive Hemoglobin, Comparison of PVI to Standard Methods, and Validation of Clinical Efficacy of ORI
The study goal is to establish the correlation of hemoglobin values determined by the noninvasive pulse oximetry-determined hemoglobin (SpHb) system with hemoglobin as measured by other validated devices.
- Trial name
- NCT02841397
- Testing
- Masimo Pulse CO-Oximeter
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Masimo Corporation
Coronary Allograft Vasculopathy (CAV)
Magnetocardiography as a Noninvasive Diagnostic Strategy for Identifying Coronary Allograft Vasculopathy
Purpose: To show early feasibility of magnetocardiography (MCG) to identify coronary Cardiac positron emission tomography (PET) is the preferred non-invasive tests to assess for CAV and incorporation of quantitative myocardial…
- Trial name
- M-CAV (NCT05751915)
- Testing
- CardioFlux
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Genetesis Inc.
Down Syndrome, Aneuploidy
Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies
To collect samples for the purpose of developing and optimizing an in vitro noninvasive prenatal diagnostic (NIPD) test. The NIPD test employs circulating cell free (ccff) DNA extracted from whole blood samples collected from…
- Trial name
- CHARMM-AP (NCT01052688)
- Testing
- Maternal blood draw of 30 to 50ml
- Where
- 10 sites in United States
- Volunteers
- 150 people
- Sponsor
- Sequenom, Inc.
Hypotension of Hemodialysis
Early Warning of Intradialytic Hypotension in Hemodialysis Patients
In this study, the investigators will monitor patients undergoing hemodialysis treatment with a non-invasive wearable PPG-based device.
- Trial name
- NCT04680039
- Testing
- Continuous monitoring
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Biobeat Technologies Ltd.
Infertility
Eeva™ System Study: Noninvasive Recording and Visualization of Individual Embryos Cultured to Blastocyst Stage
The purpose of this study is to demonstrate that the Eeva System may be used to identify embryos on Day 2 that are most likely to form blastocysts.
- Trial name
- Eeva (NCT01369446)
- Testing
- Eeva System Study
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Progyny, Inc.
Healthy, Hypertension
Validation of Noninvasive Blood Pressure Device
This is a prospective, nonrandomized multi-center study for the investigation of noninvasive sphygmomanometers. The purpose of the study is to validate the clinical performance of the Masimo noninvasive blood pressure device…
- Conditions
- Healthy, Hypertension, Hypotension
- Trial name
- NCT04676152
- Testing
- Masimo Noninvasive Blood Pressure Device
- Where
- 2 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Heart Failure, Dyspnea
Correlation Research Study: IQ2, NcIQ and IQ101
The new NcIQ thoracic impedance monitor is based on the predicate device, the IQ101. The new model uses the same 3-dimensional signal averaging as the original device, but also include second radio frequency signal to permit the…
- Conditions
- Heart Failure, Dyspnea, Hypertension, Pacemaker
- Trial name
- NMT-CT (NCT00491777)
- Testing
- Noninvasive Hemodynamic Patient Monitor
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Noninvasive Medical Technologies, Inc.
Cardiogenic Shock, Acute Myocardial Infarction
Clinical Evaluation of NIRSense Tissue Oximetry Sensor Monitoring to Early Detect Cardiogenic Shock
This is a prospective, single-center, observational pilot study of the investigational NIRSense Tissue Oximetry Sensor System (Envello Core), a noninvasive wearable sensor patch that uses near-infrared spectroscopy (NIRS) and…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Acute Decompensated Heart Failure
- Trial name
- NCT07825363
- Testing
- NIRSense Tissue Oximetry Sensor System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NIRSense Inc.
Healthy, Hypoxia
SpO2 Accuracy of Noninvasive Pulse Oximeter Sensor With Motion Conditions
The purpose of this clinical study is to validate the SpO2 accuracy of the Stryker Sustainability Solutions pulse oximetry sensors during motion conditions over the range of 70 -100% SaO2 as compared to arterial blood samples…
- Trial name
- NCT06149416
- Testing
- Experimental Masimo RD SET SpO2 Adhesive Sensors
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Stryker Sustainability Solutions
Restless Legs Syndrome
Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome During Opioid Medication Reduction
Prospective open-label single-arm feasibility study assessing the tolerability of opioid medication reduction in conjunction with noninvasive peripheral nerve stimulation (NPNS) for patients taking prescription opioids to treat…
- Trial name
- NCT04698343
- Testing
- Noninvasive Peripheral Nerve Stimulation (NPNS)
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Noctrix Health, Inc.
Intracranial Pressure Increase
Non-invasive Diagnostic for Assessing Elevated Intracranial Pressure
The study is a prospective, multi-center, non-randomized, open label observational study. The objective of this study is to compare the accuracy of the EyeBOX to a clinical diagnosis of abnormal ICP as determined by an external…
- Trial name
- NCT03418753
- Testing
- EyeBOX for ICP
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Oculogica, Inc.