Clinical trials: Obesity, Severe
Morbid Obesity, Diabetes
Single-Anastomosis Duodeno-Ileal Bypass With Sleeve Gastrectomy (SADI-S) for the Treatment of Morbid Obesity and Its Metabolic Complications
Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy is a modified and simplified duodenal switch. It is performed on morbid obese patients and severe T2DM patients with obesity, and a proper weight loss is expected as…
- Trial name
- SADI-S 250 (NCT01463904)
- Testing
- SADI-S 250
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hospital San Carlos, Madrid
Morbid Obesity
Lifestyleintervention for the Treatment of Severe Obesity
The overall purpose of this project is to study the acute, short- (≤ 1 year) and long- (> 1 year) term effects on body composition and psychological health after a 10 to 14-weeks comprehensive lifestyle modification program for…
- Trial name
- NCT01675713
- Testing
- Intensive lifestyle intervention
- Where
- Norway
- Volunteers
- 149 people
- Sponsor
- Norwegian School of Sport Sciences
Non-alcoholic Fatty Liver Disease, Morbid Obesity
Ursodeoxycholic Acid in Bariatric Surgery
In an open-label trial, 20 otherwise healthy morbidly obese patients scheduled for bariatric surgery will be administered 20 mg/kg/day ursodeoxycholic acid for three weeks until the day before surgery.
- Trial name
- NCT01548079
- Testing
- Ursodeoxycholic Acid (UDCA)
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Obesity
Influence of Plantago Major on Mineral Metabolism and Selected Biochemical Parameters in Obese Women
Effect of oral supplementation with Plantago major on cardiometabolic risk factors and mineral content and lifestyle in obese women: double-blind, randomized clinical trial.
- Trial name
- Plantago (NCT03439540)
- Testing
- Plantago major
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Postoperative Pain
Anterior Abdominal Blocks for Postoperative Pain Control in Obese Patients
The purpose of this study is to compare between two surgical techniques for anterior abdominal wall blocks in obese patients Undergoing Major Gynecological Surgery: Surgical Transversus Abdominis Plane [TAP] block versus Rectus…
- Trial name
- NCT03732027
- Testing
- Surgical Transversus Abdominis Plane Block, Surgical Rectus Sheath Block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Hypothermia, Morbid Obesity
The Efficacy of External Warming During Laparoscopic Bariatric Surgery
External warming is routinely used in general surgery to offset the deleterious effects of hypothermia. It entails deployment of a disposable, external heating blanket attached to a regulated hot-air pump.
- Conditions
- Hypothermia, Morbid Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03429205
- Testing
- No external heating used during surgery, External heating blanket used during surgery
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Severe Obesity
Mazdutide as Adjuvant Therapy Following Sleeve Gastrectomy in Severe Obesity
The SMART study is a 96-week, multicenter, randomized, double-blind, placebo-controlled superiority clinical trial. A total of 256 severe obesity patients are randomized 1:1 to either receive the bariatric surgery plus GCG/GLP-1…
- Trial name
- SMART (NCT07135141)
- Testing
- Sleeve gastrectomy plus early mazdutide initiation
- Where
- 14 sites in China
- Volunteers
- 256 people
- Sponsor
- Beijing Friendship Hospital
Postpartum Hemorrhage
In-vitro Myometrial Contractility After Oxytocin Pre-exposure in Women With Advanced Maternal Age and Morbid Obesity
Women with advanced maternal age and morbid obesity, have a higher incidence of labor induction/ augmentation and cesarean section (CS), and are at a greater risk for postpartum hemorrhage (PPH).
- Trial name
- NCT01865669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Severe Obesity
Bypass Equipoise Sleeve Trial (BEST)
This is nationwide registry-based randomised clinical multicenter trial in which patients will be randomised to gastric bypass (RYGB) or sleeve gastrectomy (SG).
- Trial name
- BEST (NCT02767505)
- Testing
- gastric bypass, Sleeve gastrectomy
- Where
- 21 sites in Norway, Sweden
- Volunteers
- 1,752 people
- Sponsor
- Göteborg University
Anesthesia, Intubation;Difficult
Awake Nasal Fiber-optic Intubation of Severely Obese Patients in Lateral Position
Airway management in severely obese patients remains a challenging issue for anesthetists and may lead to life-threatening situations.
- Conditions
- Anesthesia, Intubation;Difficult, Intubation; Difficult or Failed, Anesthesia Intubation Complication
- Trial name
- NCT04779528
- Testing
- Fiberoptic intubation in supine position., Fiberoptic intubation in lateral position.
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Obesity & Overweight
The Effects of Sleeve Gastrectomy on Fractalkine
Fractalkine (CX3CL1) is a unique chemokine involved in leukocyte adhesion, migration, and obesity-associated adipose tissue inflammation.
- Trial name
- CX3CL1 (NCT07655739)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Mehmet Buğra Bozan
Morbid Obesity, Bariatric Surgery Candidate
Determinants of the Long-Term Success of Bariatric Surgery
The management of obesity is based on a multidisciplinary approach and justifies the use of surgery in patients with the most severe forms.
- Trial name
- PRECOS (NCT03517072)
- Where
- 4 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Lille
Patients After Metabolic-bariatric Surgery, Obesity, Morbid
Adipositas Care & Health Therapy
ACHT - Adipositas Care and Health Therapy - is a structured, digitally-supported, cross-sectoral and close to home program developed for the postoperative care of patients following obesity surgery.
- Trial name
- ACHT (NCT04768127)
- Testing
- early aftercare, mid-term to late aftercare
- Where
- 7 sites in Germany
- Volunteers
- 586 people
- Sponsor
- Wuerzburg University Hospital
Morbid Obesity
Bariatric Embolization of Arteries for the Treatment of Obesity
The purpose of this study is evaluate the safety and effectiveness of bariatric embolization as a minimally-invasive image-guided procedure for morbid obesity.
- Trial name
- BEAT Obesity (NCT02165124)
- Testing
- Artificial Embolization Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Morbid Obesity, Pulmonary Embolism
Laparoscopic Bariatric Surgery: Two Regimens of Venous Thromboprophylaxis: Prospective Randomized Study
Obese patients undergoing bariatric surgery warrant VTE prophylaxis because they are at high risk for developing a fatal pulmonary embolism or postthrombotic syndrome.
- Trial name
- NCT02128178
- Testing
- Enoxaparin 40 mg 2 hours before arm, Enoxaparin 40 mg 12 hours before arm
- Where
- Egypt
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal
Late Gestational Diabetes Mellitus Diagnosis in Obese Women
In the current work, we aim to perform a prospective study that will investigate the relationship between maternal obesity (BMI >30 kg/m2) and morbid obesity (BMI >35 kg/m2) with a late GDM diagnosis (>32 weeks), with an emphasis…
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal, Dystocia, Shoulder, Neonatal Jaundice
- Trial name
- NCT05510518
- Testing
- oral glucose tolerance test (OGTT)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Western Galilee Hospital-Nahariya
Morbid Obesity
Long Term Effects of Weight Loss on Post-prandial Gut Hormone Responses and Meal Induced Thermogenesis
A study to examine post-prandial gut-hormone secretion, meal-induced thermogenesis, fasting plasma metabolomic/lipidomic and cardiovascular indices among surgically managed obese individuals in the long term compared to…
- Trial name
- NCT04170010
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- National and Kapodistrian University of Athens
Morbid Obesity
Efficacy and Mechanism Study of Bariatric Surgery to Treat Moderate to Severe Obesity in Han Chinese Population
This is a long-term follow-up and interventional study in individuals who have been diagnosed with moderate to severe obesity with or without diabetes.
- Trial name
- NCT02653430
- Testing
- Sleeve gastrectomy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Psychotic Disorder, Obesity
Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study
This study is a feasibility study of a multi-component intervention to enhance healthy living among young people with psychotic disorders, specifically targeting smoking and weight.
- Conditions
- Psychotic Disorder, Obesity, Behavior, Addictive
- Trial name
- NCT00350311
- Testing
- nicotine transdermal patch/lozenge
- Where
- 4 sites in Australia
- Volunteers
- 43 people
- Sponsor
- The University of New South Wales
Fat Consumption, Inflammatory Markers
Preoperative Dietary Fat Consumption and Baseline Inflammatory Markers
This single-center, prospective pilot study will examine dietary fat consumption and its relationship with inflammatory markers before surgery and the incidence of perioperative neurocognitive disorders in older surgical…
- Trial name
- D&D (NCT07442981)
- Testing
- Inflammatory markers test in blood prior to surgery, Inflammatory markers test in CSF (cerebrospinal fluid), MOCA test
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Ohio State University