Clinical trials: Pain, Chronic Disease
Pain, Chronic, Pain, Joint
Subjective Observational Study of Patients Using Transdermal Cream Medication And/Or Transdermal Patches With Or Without Oral Non-Narcotic Medications
purpose of this study is to evaluate the level of pain perceived by patients using a transdermal cream and/or transdermal patch with or without an oral medication as a pain management solution.
- Conditions
- Pain, Chronic, Pain, Joint, Pain Syndrome
- Trial name
- NCT03768011
- Testing
- transdermal cream and or patch
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Data Collection Analysis Business Management
Migraines
Quantitative Sensory Testing and Occipital Nerve Stimulator
The primary aim of this study is to assess the reversibility of a range of psychophysical markers of pain processing in patients with chronic migraine or cluster headache before and after ONS insertion and comparing to patients…
- Trial name
- NCT06022848
- Testing
- occipital nerve stimulator
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Fibromyalgia, Irritable Bowel Syndrome
Clinical Study on Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain
The project investigates on the role of pain avoidance, comorbidity and stress response for the development of chronic somatic and visceral pain.
- Trial name
- NCT00222209
- Testing
- Experimental heat pain model
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Knee Osteoarthritis
Clinial Application of Park et al.(The Knee 27 (2020) 1577-1584)'s Study
The goal of this study was to perform pulsed radiofrequency ablation with a modified target suggested in the cadaver study by Park et al.
- Trial name
- NCT05202847
- Testing
- pulsed radiofrequency ablation to modifined points group, pulsed radiofrequency ablation to conventional points group
- Sponsor
- Gangnam Severance Hospital
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
Clinical Evaluation of the Efficacy and Safety of a Medical Device in the Form of Rectal Suppositories (Prospidol®) for the Treatment of Symptoms Associated With Chronic Prostatitis/Chronic Pelvic Pain Syndrome.
The goal of this clinical trial is to evaluate whether a medical device is effective and safe in treating chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in adult men.
- Trial name
- NCT07685847
- Testing
- Prospidol suppository
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- S&R Farmaceutici S.p.A.
Chronic Low Back Pain, Degenerative Disc Disease
Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms
Opioids are frequently prescribed for chronic low back pain (CLBP). Psychiatric illness, such as high levels of depression and anxiety symptoms, is a common co-occurrence in chronic pain patients (and is termed comorbid negative…
- Conditions
- Chronic Low Back Pain, Degenerative Disc Disease, Depression, Anxiety
- Trial name
- NCT01502644
- Testing
- Oxycodone, Morphine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Brigham and Women's Hospital
Chronic Tendinopathy
Percutaneous Needle Tenotomy (PNT) Versus Platelet Rich Plasma (PRP) With PNT in the Treatment of Chronic Tendinosis
Tendinopathy is a clinical syndrome of chronic pain and tendon degeneration that impairs a person's ability to perform daily activities and recreation.
- Trial name
- NCT01833598
- Testing
- PNT + PRP, PNT alone
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Chronic Orofacial Pain, Temporomandibular Disorder (TMD)
Orofacial Pain Self-management: Personality Moderation Effect
The objective of this clinical trial is to study the effect of self-management on pain perception in patients with chronic orofacial pain and temporomandibular disorders (TMD) comparing it with the conventional treatment proposed…
- Conditions
- Chronic Orofacial Pain, Temporomandibular Disorder (TMD), Temporomandibular Disorders (TMD), Temporomandibular Dysfunction (TMD)
- Trial name
- NCT06932406
- Testing
- Self-management intervention, Clinical Practice Guideline Intervention
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Migraine Disorders
Occipital Nerve Stimulation (ONS) for Migraine: OPTIMISE
The primary objective of this study is to evaluate the safety and efficacy of occipital nerve stimulation (ONS) using the Boston Scientific Corporation (BSC) Precision™ System in the management of intractable chronic migraine…
- Trial name
- OPTIMISE (NCT01775735)
- Testing
- Occipital nerve stimulator
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- Boston Scientific Corporation
Neuropathic Pain
Infusion Treatments of Chronic Peripheral Neuropathic Pain
This study aimed to evaluate and compare the efficacy of ketamine and lidocaine infusion in patients with chronic peripheral neuropathic pain.
- Trial name
- NCT06297915
- Testing
- Ketamine, Lidocain
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Hacettepe University
Chronic Pain, Major Depressive Disorder
The Internet Therapy for Depression Trial
The objective of this trial is to collect data on the feasibility, acceptability, and preliminary effectiveness of internet delivered Cognitive Beaviour Therapy (iCBT) and Acceptance and Commitment Therapy (iACT) interventions…
- Trial name
- INTEREST (NCT04009135)
- Testing
- internet delivered cognitive behavioural therapy (iCBT), online delivered acceptance and commitment therapy (iACT), Attention Control (AC)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Memorial University of Newfoundland
Temporomandibular Disorders (TMDs)
Diagnostic Study Accuracy of Jaw Motion Analyzer(JMA) Versus Research Diagnostic Criteria(RDC/TMD) and Magnetic Resonance Imaging(MRI) for Temporomandibular Disorders Among Patients With Chronic Orofacial Pain.
The goal of this diagnostic accuracy study is to determine the diagnostic accuracy of jaw motion analyzer(JMA) in terms of sensitivity and specificity with target cut of points used by valid reference standards which will be the…
- Trial name
- NCT07486609
- Testing
- The Jaw Motion Analyzer (JMA, Zebris, Germany) as the index test, Research Diagnostic Criteria for Temporomandibular Disoders, Magnetic Resonance Imaging
- Where
- Egypt
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cairo University
Running-related Injuries, Medial Tibial Stress Syndrome
Machine Learning-Based Risk Identification and Precision Exercise for Common Running Injuries
This study aims to identify biomechanical risk factors associated with common running-related injuries in recreational runners using machine learning analysis.
- Conditions
- Running-related Injuries, Medial Tibial Stress Syndrome, Patellofemoral Pain, PFP, Chronic Achilles Tendinopathy
- Trial name
- NCT07689916
- Testing
- Multidimensional Precision Intervention, Precision Exercise Intervention
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Zeyi Zhang
Endometriosis-related Pain
Transcutaneous Electrical Nerve Stimulation for Endometriosis-related Chronic Pain
The study evaluates the effect of TENS (transcutaneous electrical nerve stimulation) as add-on treatment compared with conventional analgesic treatment in patients with endometriosis-related chronic pain.
- Trial name
- NCT05152264
- Testing
- Transcutaneous electrical nerve stimulation (TENS), Conventional analgesic treatment
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Göteborg University
Chronic Pain
Intra-Articular 0.5 % Lidocaine Injection for Osteoarthritis
In this study, investigators compared the efficacy of intra-articular 0.5% lidocaine and saline injection on pain, stiffness and physical function in patients with osteoarthritis.
- Trial name
- NCT02632565
- Testing
- Lidocaine, Saline
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- H. Evren Eker
Temporomandibular Joint Disorders
Comparison of the Effect of Pain Neuroscience Education Combined With Physiotherapy, and Physiotherapy Alone in Temporomandibular Disorders
This research study aims to evaluate the effectiveness of Pain Neuroscience Education (PNE) when it is added to a physiotherapy program for people experiencing chronic temporomandibular disorders (TMD).
- Trial name
- NCT07147764
- Testing
- Physiotherapy, Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ainaz Shahedi
Pain, Chronic Disease
Modulation of Central Hypersensitivity in Chronic Musculoskeletal Pain by Intravenous Tropisetron
Chronic pain is associated with hypersensitivity of the central nervous system. The drug under investigation (tropisetron) has been shown in animal studies to attenuate central hypersensitivity.
- Trial name
- NCT00889499
- Testing
- Tropisetron 2 mg, Tropisetron 5mg
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Low Back Pain (CLBP)
Modifying Lumbar Flexion Pain Thresholds in Chronic LBP Using Virtual Reality and Visual-Proprioceptive Manipulation
This study investigates the potential to modify movement-evoked pain in individuals with chronic low back pain (LBP) by manipulating visual proprioceptive feedback through virtual reality (VR).
- Trial name
- CLEVER-BODY (NCT06750887)
- Testing
- Normal condition, Understated condition, OVERSTATED CONDITION
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Cardenal Herrera University
Opioid Use Disorder, Opioid Misuse
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
The present study seeks to examine the implementation process of culturally tailoring screening and brief intervention for both chronic pain and opioid misuse/opioid use disorder in three American Indian and Alaska Native (AI/AN)…
- Conditions
- Opioid Use Disorder, Opioid Misuse, Chronic Pain
- Trial name
- OPTIC (NCT06565416)
- Testing
- Implementation Strategies
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- University of New Mexico
Neuropathic Pain, Thoracotomy
Sensory Perception After Thoracotomy
The study will investigate characteristics of chronic pain after thoracotomy
- Conditions
- Neuropathic Pain, Thoracotomy, Chronic Pain
- Trial name
- NCT00910949
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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