Clinical trials: Pathophysiology
Brain Diseases, Memory Disorders
Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation
The goal of this clinical trial is to investigate the impact of low intensity focused ultrasound pulsation (LIFUP) to two different brain regions, the amygdala and entorhinal cortex, in older adults.
- Conditions
- Brain Diseases, Memory Disorders, Learning Disabilities, Cognitive Impairment
- Trial name
- LIFUPMEMEMOT (NCT03717922)
- Testing
- Low Intensity Focused Ultrasound Pulsation to Amygdala, Low Intensity Focused Ultrasound Pulsation to Entorhinal Cortex
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Geriatric Diseases
Thyroid Dysfunction in Elderly
Thyroid dysfunction in elderly
- Trial name
- Thyroid dysfun (NCT07606560)
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Assiut University
Arrhythmias, Cardiac, Atrioventricular Block
ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing
The goal of this observational study is to evaluate the clinical characteristics of patients undergoing permanent cardiac pacing and to compare procedural efficacy and safety of different implantation approaches in the clinical…
- Conditions
- Arrhythmias, Cardiac, Atrioventricular Block, Reduced Systolic Function, Atrial Fibrillation
- Trial name
- TREEBEARD (NCT06324682)
- Testing
- Cardiac pacing - Conventional RV pacing, Cardiac pacing - Conduction System Pacing, Cardiac pacing - Cardiac resynchronization therapy (pacing - CRTP - or defibrillation - CRTD)
- Where
- 31 sites in Italy
- Volunteers
- 8,400 people
- Sponsor
- University Hospital of Ferrara
Hemodialysis, Thrombolytic Therapy
Comparison of Standard Versus High Dose Urokinase for Dysfunctional Tunneled Dialysis Catheters in Haemodialysis Patients: A Randomized Controlled Trial
Tunneled dialysis catheters (TDCs) remain a frequent form of vascular access for patients undergoing long-term haemodialysis (HD).
- Conditions
- Hemodialysis, Thrombolytic Therapy, Dialysis Access Dysfunction, Randomised Controlled Trial
- Trial name
- SHUT (NCT06802679)
- Testing
- Urokinase
- Where
- Singapore
- Volunteers
- 44 people
- Sponsor
- National Healthcare Group, Singapore
Rectal Cancer, Rectum Neoplasm
Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Trial
Study Purpose: This study aims to understand how pelvic floor rehabilitation (PFR) after low anterior resection (LAR) surgery for rectal cancer affects bowel control and quality of life compared to usual care.
- Conditions
- Rectal Cancer, Rectum Neoplasm, Rectal Neoplasms, Rectal Adenocarcinoma
- Trial name
- PERECARE (NCT06524362)
- Testing
- Pelvic Floor Physiotherapy (PFR), Conventional group
- Where
- India
- Volunteers
- 77 people
- Sponsor
- GEM Hospital & Research Center
Malignant Neoplasm, Unspecified Adult Solid Tumor, Protocol Specific
Imatinib Mesylate in Treating Patients With Advanced Cancer and Kidney Failure
Phase I trial to determine the dose of imatinib mesylate that is most effective with the least amount of toxic side effects in treating patients who have advanced cancer and kidney failure.
- Trial name
- NCT00026169
- Testing
- imatinib mesylate, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- National Cancer Institute (NCI)
Impotence
Study the Safety and Effectiveness of Tadalafil in Men With Diabetes Who Have Problems Getting and Keeping an Erection
Study to evaluate the safety and effectiveness of 2.5 mg and 5 mg tadalafil when taken by men with diabetes mellitus who have problems getting and maintaining an erection.
- Trial name
- NCT00547183
- Testing
- tadalafil
- Where
- Germany
- Volunteers
- 298 people
- Sponsor
- Eli Lilly and Company
Stroke, Upper Extremity Dysfunction
Exoskeleton-assisted Upper Limb Rehabilitation After Stroke
In recent studies, it has been observed that robotic devices make a positive contribution to motor recovery and the activities of daily living.
- Trial name
- NCT04353622
- Testing
- Exoskeleton robot for upper extremity, Conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Marmara University
Gastrointestinal Dysfunction
Gastric Emptying Validation Pilot Study (MRI Val)
The primary aim of this study is to assess (in healthy volunteers) the rate at which a glucose drink leaves the stomach by sequential magnetic resonance imaging (MRI) of the stomach contents using a 0.5 tesla upright MRI scanner…
- Trial name
- MRIVal (NCT05765123)
- Testing
- Oral glucose tolerance test
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Heart Failure, Heart Failure, Systolic
COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart Failure
The purpose of this study was to determine the effect of sacubitril/valsartan (LCZ696) vs. Enalapril on improvement in erectile function and ability in male patients with chronic heart failure with reduced ejection fraction and…
- Conditions
- Heart Failure, Heart Failure, Systolic, Erectile Dysfunction
- Trial name
- CONFIDENCE-HF (NCT03917459)
- Testing
- LCZ696, Enalapril
- Where
- 13 sites in Germany
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Failure, Chronic, Cognitive Dysfunction
Emotion and Cognitive Function and Brain Imaging Change in HD Patients
1. Observe the influence of entering hemodialysis treatment on the emotional and cognitive functions of ESRD patients. 2. Observe the influence of entering hemodialysis treatment on the brain structure imaging of ESRD patients.
- Conditions
- Kidney Failure, Chronic, Cognitive Dysfunction, Magnetic Resonance Imaging
- Trial name
- NCT05137470
- Testing
- This is an observational study
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Friendship Hospital
Esophageal Dysfunction, Pylorus Dysfunction
Normal Values for Esophageal and Pyloric Impedance Planimetry Under General Anesthesia (NormaFLIP)
Impedance planimetry using Endoscopic Functional Lumen Imaging Probe (EndoFLIP) device is a promising diagnostic tool to assess esophageal, esophago-gastric junction and pylorus function.
- Trial name
- NormaFLIP (NCT02905669)
- Testing
- EndoFLIP
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Mild Cognitive Impairment, Older People
Effects of Cognitive Stimulation in Older People With Mild Cognitive Impairment
Mild cognitive impairment is becoming one of the most common cynical manifestations that affect older people. That is why there is a need to investigate non-pharmacological interventions that help to improve or maintain this…
- Trial name
- NCT04663256
- Testing
- Cognitive stimulation group
- Where
- Spain
- Volunteers
- 85 people
- Sponsor
- University of Jaén
Mild Cognitive Impairment
Vildagliptin in Older Adults With Diabetes and Mild Cognitive Impairment
This study investigates the effect of vildagliptin, an inhibitor of the enzyme DPP-4, on the cognitive functioning of elderly diabetic patients with mild cognitive impairment (MCI) documented at mini mental state examination…
- Trial name
- NCT03819127
- Testing
- Vildagliptin 50 MG Oral Tablet, Metformin Pill
- Volunteers
- 60 people
- Sponsor
- University of Catania
Stroke, Cognitive Impairment
The Treatment Effectiveness of Combined tDCs and Neurofeedback (NF) for Patients With Cognitive Deficits After Stroke
This is a double blinded, randomized control trial with a pretest-posttest control and interventional groups design. Both the assessor and participants are blinded to all assessments and evaluations.
- Trial name
- NCT03093142
- Testing
- tDCS & neurofeedback, neurofeedback
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Kowloon Hospital, Hong Kong
Alzheimer Disease
Memory Impairment Study (Mild Cognitive Impairment Study)
The National Institute on Aging (NIA) is launching a nationwide treatment study targeting individuals with mild cognitive impairment (MCI), a condition characterized by a memory deficit, but not dementia.
- Trial name
- NCT00000173
- Testing
- Donepezil, Vitamin E
- Where
- 72 sites in United States, Canada
- Sponsor
- National Institute on Aging (NIA)
MCI, SCD
Effects and Mechanism of the Fully Immersive Virtual Reality Cognitive Training Based on Leisure Activities
The aim of this study is to identify the effects of the immersive leisure-based VR cognitive training, and compare the intervention effects for elderly with MCI and SCD.
- Trial name
- NCT05682469
- Testing
- VR cognitive training, Traditional cognitive training
- Volunteers
- 275 people
- Sponsor
- Chang Gung Memorial Hospital
Right Bundle-Branch Block
Adaptive Cardiac Resynchronization Therapy in Patients With RBBB
This study will address whether acute adaptive RV pacing in sinus rhythm patients with severe LV systolic dysfunction and RBBB is superior to no ventricular pacing, and is as effective as echocardiographically optimized…
- Trial name
- NCT05936294
- Testing
- Optimization of CRT Device
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Henry Ford Health System
Liver Transplantation (LT), Early Allograft Dysfunction
New Biomarkers for Organ Viability Assessment During Hypothermic Machine Perfusion in Liver Transplantation: the Role of Extemporaneous Histological Examination.
Liver transplantation is a life-saving treatment for patients with severe liver disease. Because of the shortage of donor organs, transplant centers increasingly use donor livers that may be more vulnerable to injury and…
- Conditions
- Liver Transplantation (LT), Early Allograft Dysfunction, Primary Non-function, Ischemia-Reperfusion Injury
- Trial name
- LOVE (NCT07674394)
- Testing
- Hypothermic Oxygenated Machine Perfusion (HOPE/D-HOPE)
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Cognitive Impairment, Mild, Depressive Symptoms
Brain Stimulation and Enhancing Cognition in Older Adults
The aim of the current research is to evaluate the efficacy of a combination of Mindfulness-Based Stress Reduction (MBSR) and transcranial direct current stimulation (tDCS) to improve cognitive function in individuals with…
- Conditions
- Cognitive Impairment, Mild, Depressive Symptoms, Anxiety
- Trial name
- NCT03653351
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Washington University School of Medicine
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