Clinical trials: Perfusion
Obesity, Insulin Resistance
Effects of Intermittent Fasting on Insulin Resistance, Cardiac Metabolism, and Cerebral Perfusion
The overall purpose of the study is to investigate whether three weeks of intermittent fasting (alternate-day fasting, (ADF)) result in a more pronounced "metabolic shift" towards the use of ketone bodies than three weeks of…
- Trial name
- NCT05181267
- Testing
- Intermittent fasting
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Neuropsychiatric Systemic Lupus Erythematosus
Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus
The purpose of this study is to determine if three functional Magnetic Resonance brain imaging techniques: Magnetic Resonance Spectroscopy(MRS),Magnetic Resonance perfusion, and Diffusion Tensor Imaging(DTI) can detect brain…
- Trial name
- NCT00730002
- Testing
- Magnetic Resonance Angiography (MRA), Magnetic resonance imaging, MRA
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Pressure Distribution, Military Litters
NATO Litter: Fluid Immersion System (FIS) Versus Traditional Mattress for Pressure Dispersion
The purpose of this study is to measure peak skin interface pressures and the total area of the body exposed to skin interface pressure above 30 mm Hg at different areas of the body in the supine position on two different support…
- Conditions
- Pressure Distribution, Military Litters, Peak Pressure Index, Total Surface Area
- Trial name
- NCT03483623
- Testing
- NATO WELP combination, NATO FIS combination, RAVEN WELP combination
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Coronary Artery Disease
CO2 as a Stress Agent for Perfusion Imaging
Myocardial perfusion imaging (MPI) is a nuclear scan using a radioisotope to see blood flow to the muscles of the heart when the heart is at rest and when it is under stress.
- Trial name
- CO2 STRESS (NCT02043535)
- Testing
- Delivery of precise levels of carbon dioxide with the RA-MR™ Virtual Sequential Gas Delivery System., Delivery of rubidium radioisotope (Rb-82) using the automated pump/elution system
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Endothelial Dysfunction, Myocardial Perfusion Abnormalities
Cardiac Magnetic Resonance Imaging for Detecting Endothelial Dysfunction
The goal of this research study is to demonstrate that Cardiac Perfusion MRI with Vasomotor Stress may serve as a non-invasive and less risky imaging technique for detecting non-obstructive perfusion deficits and/or abnormalities…
- Conditions
- Endothelial Dysfunction, Myocardial Perfusion Abnormalities, Cardiac MRI Perfusion With Vasomotor Stress, Diabetes
- Trial name
- NCT00808535
- Testing
- Cardiac Perfusion MRI w Vasomotor Stress
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alzheimer Disease, Dementia, Vascular
Cerebral Vascular Reserve in Small Vessel Disease and Alzheimers Disease
Alzheimers disease and cerebral small vessel disease have a considerably overlap in patients and have common risk factors. The diseases are difficult to separate in individual patients and we hypothesize that a reduced cerebral…
- Trial name
- NCT05443308
- Testing
- Cerebral [15O]H2O PET before and after diamox infusion
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Ocular Physiology, Microcirculation
Role of Adenosine in the Control of Choroidal Blood Flow During Changes in Ocular Perfusion Pressure.
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. For a long time it had been assumed that the choroid is a strictly passive vascular bed, which shows no autoregulation.
- Trial name
- NCT00712764
- Testing
- Adenosine
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Bleeding
Assessment of Limb Perfusion During Junctional Tourniquet
The goal of this study is to use contrast enhanced ultrasound to determine the degree to which flow is reduced during application of a junctional tourniquet (JT).
- Trial name
- NCT02092415
- Testing
- Application of a Junctional Tourniquet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Healthy Volunteer, Coronary Arterial Disease
Ultralow Dose PET Imaging of 18F-flurpiridaz
The goal of this clinical trial is to evaluate an investigational ultralow dose positron emission tomography (PET) imaging technique for known or suspected coronary artery disease (for detecting myocardial ischemia or infarction)…
- Conditions
- Healthy Volunteer, Coronary Arterial Disease, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT07284576
- Testing
- 18F-flurpiridaz
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
Spontaneous Coronary Artery Dissection
A Study of SCAD Using Stress Contrast Echocardiography
This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.
- Trial name
- NCT07178509
- Testing
- Stress Echocardiography with Contrast
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Heart Disease
Distribution of Rubidium-82, Nitrogen-13 Ammonia, and Fluorine-18 Fluorodeoxyglucose in Normal Volunteers
Establish the normal distributions of Rb-82, N-13 ammonia, and F-18 FDG (radioactive tracers) in the heart using PET imaging. These tracers would be eventually used in evaluating the hearts of patients with heart disease.
- Trial name
- NCT01433705
- Testing
- Rb-82 Pet scans, F-18 FDG Pet scans, N-13 ammonia Pet scans
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anesthesia
Clonidine Added Lidocaine in Intraocular Pressure and Hemodynamics Ocular in Sub-Tenon's and Peribulbar Anesthesia
Regional anesthesia in orbit can reduce ocular blood flow, increase in intraocular pressure (IOP) or the pharmacological action of local anesthetics.
- Trial name
- NCT02733757
- Testing
- Clonidine
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Healthy
Comparison of Extended Release Tacrolimus (Advagraf) and Cyclosporine A Microemulsion on Renal Function in Healthy Volunteers
The purpose of this study is to compare the effects of steady state tacrolimus vs. cyclosporine on renal pharmacodynamics in healthy volunteers.
- Trial name
- NCT00818194
- Testing
- extended release tacrolimus, cyclosporine A microemulsion
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Dyspepsia
Mast Cells in Acid-induced Intestinal Permeability
This is a randomized, double-blind, cross-over study in healthy volunteers. In the first part, the duodenum of the participants will be perfused with acid or saline, during which intragastric pressure will be monitored to assess…
- Trial name
- NCT02664051
- Testing
- Nalcrom
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Limb Threatening Ischemia
Multimodal Noninvasive Assessment of Peripheral Circulation in Chronic Limb-threatening Ischemia
Assessment of a novel diagnostic method for screening and diagnosing chronic limb-threatening ischemia (CLTI). Using hyperspectral and thermal imaging, the perfusion and oxygenation in the lower limbs will be studied in healthy…
- Trial name
- NCT05786001
- Where
- Finland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tampere University
Lower Urinary Tract Symptoms
Bladder Wall Blood Perfusion Pattern and Sexual Dysfunction in Female Patients With Lower Urinary Tract Symptoms, and the Association of That Perfusion Pattern and Therapeutic Efficacy of Antimuscarincs for Female Overactive Bladder Syndrome.
Overactive bladder syndrome (OAB) affects around 17 % of female population. However, the etiology of OAB is complicated and unclear in many aspects.
- Trial name
- NCT01282840
- Testing
- Tolterodine SR
- Where
- Taiwan
- Volunteers
- 676 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Pressure Ulcer
Peripheral Perfusion and Oxygenation in Areas of Risk of Skin Integrity Impairment Exposed to Pressure Patterns.
Objectives: 1. To analyze the changes in peripheral tissue oxygenation in tissues subjected to different pressure regimes in healthy humans. 2.
- Trial name
- POTER-DIC (NCT02736838)
- Testing
- tcpO2, Laser Doppler
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Kawasaki Disease, Heart Disease
Real Time Myocardial Contrast Echocardiography and Dobutamine Stress Perfusion Magnetic Resonance Imaging
The present study is designed to: 1. investigate the safety and efficacy of Real time myocardial echocardiography (RT-MCE) in adolescents and adults ages 12-50 with congenital and acquired congenital heart disease 2.
- Trial name
- ECHOBIKE (NCT00861848)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Myocardial Ischemia
Quantitative Myocardial Perfusion Reserve by Cardiovascular Magnetic Resonance
The purpose of this study is to validate a full-automated post-processing software for quantitative perfusion of the myocardium with magnetic resonance imaging.
- Trial name
- NCT02723747
- Testing
- myocardial perfusion with magnetic resonance imaging
- Where
- Sweden
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet