Clinical trials: Placenta
First Trimester Pregnancy, Fetal Heart Activity Absent
Markers of Oxidative Stress in a Early Week Miscarriage: Ischemia of Modified Albumin
The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage.This study was undertaken to…
- Conditions
- First Trimester Pregnancy, Fetal Heart Activity Absent, Absence of Fetal Pole on Ultrasonographic Examination.
- Trial name
- IMA (NCT01988740)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Malaria in Pregnancy
Follow-up of Immunological Pattern and Pregnancy Outcomes in Women Previously Received Placental Malaria Vaccine
Study Population: Participants of the previous PRIMVAC vaccine trial and women aged 18 to 35 years Sample Size: 90 Study duration: 21 months Subject duration: 12 months if pregnancy doesn't occurred.
- Trial name
- PRIMVACLongT (NCT05426187)
- Where
- Burkina Faso
- Volunteers
- 90 people
- Sponsor
- Groupe de Recherche Action en Sante
Smoking, Tobacco, Placenta Diseases
Effects of Smoking on Placenta and Lactation
Maternal smoking during pregnancy although it is known to be associated with fetal growth restriction, it's effect on postpartum breastfeeding is not yet clear.
- Conditions
- Smoking, Tobacco, Placenta Diseases, Breastfeeding, Fetal Conditions
- Trial name
- NCT06456645
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Pre-Eclampsia
Role of ASpirin in Placental and Maternal Endothelial Cell Regulation IN Pre-eclampsia
Endothelial dysfunction and defective placental vascularization are hypothesized to be significant causes of preeclampsia. In preeclampsia, due to vascular endothelial dysfunction, vasoconstriction and platelet activation can…
- Trial name
- ASPERIN (NCT03893630)
- Testing
- Acetylsalicylic Acid 81 mg, Acetylsalicylic Acid 162 mg, Control
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- John O'Brien, MD
Covid19
COVID-19 and Pregnancy: Placental and Immunological Impacts
The aim of this study is to compare placental pathologies in patients with COVID 19 infection at the time of childbirth or a history of COVID 19 during pregnancy versus control patients
- Trial name
- MaterCov (NCT04726111)
- Testing
- Specimens specific for the study
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Hopital Foch
Epidermolysis Bullosa Dystrophica
Study of the Blood and Skin Immunological Profile of Patients With Recessive Dystrophic Epidermolysis Bullosa: in Vivo Analysis and the Impact of Placental Stem Cells in Vitro
Patients with recessive dystrophic epidermolysis bullosa (RDEB) suffer from acute and chronic post-bullous wounds along with impaired skin healing.
- Trial name
- ISTRADEB (NCT06177353)
- Testing
- Sampling
- Where
- 2 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnant Women
Evaluation of Placenta Maturity by the Sonographic Textures
The aim of this study is to evaluate placenta maturity by the sonographic textures.The evaluation of placenta maturity by the sonographic textures is related to anticipative pregnancy and actual pregnancy .
- Trial name
- NCT01255930
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taipei Medical University WanFang Hospital
Chorioamnionitis, Puerperal Endometritis
Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term
The aims of this study are to determine whether antibiotics administered routinely in women presenting with premature rupture of membranes later than the 37+0 weeks of gestation can alter the rate of maternal and neonatal…
- Conditions
- Chorioamnionitis, Puerperal Endometritis, Neonatal Early Onset Sepsis, Neonatal Meningitis
- Trial name
- NCT01633294
- Testing
- Ampicillin + gentamicin
- Where
- Portugal
- Volunteers
- 161 people
- Sponsor
- Hospital de Santa Maria, Portugal
Placenta Accreta With Bladder Invasion
Bladder Conservative Surgery in r Abnormally Invasive Placenta With Bladder Invasion
Placental borders and mapping by ultrasonography and Doppler ultrasonography (placental mapping) preop. And verified intraoperatively .
- Trial name
- NCT04263753
- Testing
- Bladder conservative surgery in placenta accretta
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Preeclampsia (PE), Intrauterine Growth Restriction (IUGR)
Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)
In pregnancies with placental insufficiency, the only available treatment is close monitoring to determine the point at which the risks of preterm birth for the baby are lower than the risks of continuing the pregnancy.
- Conditions
- Preeclampsia (PE), Intrauterine Growth Restriction (IUGR), Placental Insufficiency
- Trial name
- STATIN-PRE (NCT07098975)
- Testing
- Pravastatin 40 mg
- Where
- 2 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Placental Abruption, Placenta Diseases
Study on Retroplacental Hematomas in Finistère
Cases with placental abruption will be identified by interrogation of two databases of Brest University Hospital between January 2013 and December 2018. First trimester PAPPA and bhCG levels will be recorded.
- Trial name
- HEMOPLACENTA (NCT04168606)
- Where
- France
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Placenta Accreta
Galectin-3 and Placenta Accreta
Galectins are a family of carbohydrate-binding proteins that have a high affinity to galactosides, its protein portion is located in the nucleus and the cytoplasm with its carbohydrate recognition domain which has high ability to…
- Trial name
- NCT04573452
- Testing
- Galectin-3, Placental Galactin-3
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Assiut University
Pregnancy Complications, Pre-Eclampsia
Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Pregnancy increases the risk of thrombosis. Placenta-mediated diseases are a risk factor for cardiovascular pathologies and can lead to maternal-fetal morbidity and mortality.
- Conditions
- Pregnancy Complications, Pre-Eclampsia, Growth Retardation, Intrauterine
- Trial name
- GROSSAUTOP-2 (NCT06779916)
- Testing
- Blood test, Urine test
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Placenta; Implantation
MRI Screening of Placenta Adhesion Abnormalities
Placenta Adhesion Abnormalities (PAA) are the consequence of an excessive invasion of the placenta within the myometrium. PAA are related to severe maternal pregnancy outcomes, especially in case of incidental discovery during…
- Trial name
- DIANE (NCT04328532)
- Testing
- MRI
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Central Hospital, Nancy, France
Incisional Hernia
A Prospective, Double-Blinded, Randomized Controlled Trial of dHACM for Incisional Hernia Prophylaxis
Currently, no standard of care exists to prevent incisional hernias (IH). This study will compare how frequently IH develop in standard abdominal closures vs. abdominal closures with dHACM added.
- Trial name
- NO-HERNIA (NCT04417140)
- Testing
- dHACM (AmnioWrap)
- Where
- United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Scar Niche, Myometrial Remodeling
Postplacental Copper Intrauterine Device Versus Postpartum Progesterone-only Pills on Uterine Niche Formation
The purpose of the study is to determine whether immediate postplacental copper T380A intrauterine device insertion increases uterine-niche incidence compared with postpartum progestin-only pills after primary cesarean section .
- Conditions
- Scar Niche, Myometrial Remodeling, Contraceptive Device; Complications, Cesarean Section Complications
- Trial name
- T380A (NCT07264933)
- Testing
- Primary Cesarean Section, immediate postplacental insertion of a copper T380A intrauterine device, progesterone-only pills
- Where
- Egypt
- Volunteers
- 750 people
- Sponsor
- Benha University
Placenta Accreta
Ligation of Anterior Internal Iliac Artery With Conservative Management of Partial or Focal Placenta Accreta Spectrum
The patients will be divided into 2 groups: Group (A) - Study group: Cases managed by lower segment resection with ligation of the anterior division of the internal iliac artery Group (B) - Control group: Cases managed by lower…
- Trial name
- NCT05471102
- Testing
- Study group: lower segment resection with ligation of the anterior division of the internal iliac artery, Control group: lower segment resection without ligation of the anterior division of the internal iliac artery
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pregnancy Related, Substance Use
The Impact of Opioid and Cannabis Exposure on Fetal Growth
Individually, both opioid and cannabis exposure during pregnancy are associated with changes in fetal growth. The extent to which opioid and cannabis exposure affect fetal growth is unknown.
- Conditions
- Pregnancy Related, Substance Use, Fetal Growth Retardation, Placenta Diseases
- Trial name
- IMPACT (NCT05899101)
- Where
- 5 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr. Laura Gaudet
Placenta Accreta
Placenta Accreta Spectrum Management: Uterine Preservation Using JSICA Technique - Retrospective Cross-Sectional Study
The goal of this study is to present the Jakarta Surgical Uterine Conservation (JSICA) technique and its perioperative outcomes in Placenta Accreta Spectrum patients.
- Trial name
- NCT05871645
- Testing
- Jakarta Surgical Uterine Conservation (JSICA) Technique, Standard Hysterectomy
- Where
- Indonesia
- Volunteers
- 323 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Vitamin D Deficiency
Vitamin D Deficiency and Placental Calcification in Low-risk Obstetric Population - Are They Related?
Maternal vitamin D deficiency has been suggested to influence fetal and neonatal health. The role of placenta in vitamin D regulation is known but alteration of Vitamin D levels at placental pathologies is unknown.
- Trial name
- NCT02190396
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital