Clinical trials: Predictive Biomarkers
Extensive-stage Small Cell Lung Cancer (ES-SCLC)
Small Extracellular Vesicle miRNAs as Predictive Biomarkers for Immunochemotherapy Efficacy in Extensive-stage Small Cell Lung Cancer
This study aims to investigate the clinical value of small extracellular vesicle (sEV) miRNAs as predictive biomarkers for immunochemotherapy efficacy in extensive-stage small cell lung cancer (ES-SCLC).
- Trial name
- NCT07070011
- Testing
- EC/EP + ICIs
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Shanghai Chest Hospital of Shanghai Jiao Tong University
Major Depressive Disorder
Optimize and Predict Antidepressant Efficacy for Patient With MDD Using Multi-omics Analysis and AI-predictive Tool
OPADE is a non-profit, observational, multicenter, open-label study aimed at defining personalized treatment for Major Depressive Disorder (MDD).
- Trial name
- OPADE (NCT06550037)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Alessio Fasano
Colorectal Cancer
Peripheral Blood Monocytes as Predictive Marker for Colorectal Cancer Diagnosis: A Comparative Study of a Stool Based Versus Blood Based Screening Test
In this prospective study, the main goal is to evaluate the strength of Monomark -a monocyte-based transcriptomic test combined to a mathematical model- in patients with a positive FIT test.
- Trial name
- MonoFIT+ (NCT03462992)
- Testing
- MonoMark
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- DNAlytics
Covid19
Vital Sensor Monitors for CV19 Detection
This study will monitor physical bio-markers such as heart rate, respiratory rate, and temperature to detect potential COVID-19 infections.
- Trial name
- NCT04635787
- Testing
- ANNE One
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Northwestern University
Infertility
Study to Estimate Seedchrony's Predictive Capacity in the Success of Embryo Implantation.
In Vitro Fertilization (IVF) success is below 40%, with Embryo Transfer the leading cause of IVF failure. This clinical investigation aims to evaluate if the levels of an intrauterine biomarker dissolved in the uterine fluid…
- Trial name
- Seedchrony02 (NCT06259084)
- Testing
- Seedchrony
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Manina Medtech
Lung Neoplasms
Sputum Cytometry Analysis in Lung Cancer Screening After Professional Asbestos Exposure
Workers exposed to asbestos are at high risk of lung cancer. Medical follow-up of this population relies on repeated CT-scans which are more accurate for detection of peripheral lesions, and expose to X-rays and to risk of…
- Trial name
- AMORCE-CBP (NCT01687647)
- Testing
- low-dose CT-scan AND induced sputum sample AND blood test
- Where
- 3 sites in France
- Volunteers
- 463 people
- Sponsor
- University Hospital, Caen
Asthma
Evaluation of the Response to Monoclonal Antibody Therapy in Severe Asthma: Research of Predictive Biomarkers in Exhaled Air
This study evaluates the change in the composition of Volatil Organic Compounds (VOC) in patients treated by monoclonal antibody for severe asthma.
- Trial name
- Zina-VOC (NCT03988790)
- Testing
- VOC analysis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hopital Foch
Kidney Transplant, Renal Transplant Failure
Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
The purpose of this study is to assess a new test to detect antibodies which may form following kidney transplant. These antibodies can be difficult to detect as they do not cause any symptoms but can lead to kidney damage.
- Conditions
- Kidney Transplant, Renal Transplant Failure, Kidney Transplant Rejection, Frailty
- Trial name
- HLA-AB (NCT06025240)
- Testing
- cf-DNA, Immunological Events following renal transplant in older age, Determining Predictive Models for Post-transplant HLA-specific Antibody Formation
- Where
- United Kingdom
- Volunteers
- 282 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Brain Tumor, Glioma, Malignant
Prospective Evaluation of AI R&D Tool in Adult Glioma and Other Primary Brain Tumours (PEAR-GLIO)
Pear Bio has developed a 3D microtumor assay and computer vision pipeline through which the response of an individual patient's tumor to different anti-cancer regimens can be tested simultaneously ex vivo.
- Conditions
- Brain Tumor, Glioma, Malignant, Ependymoma, Oligodendroglioma
- Trial name
- PEAR-GLIO (NCT06038760)
- Testing
- Resection
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Ourotech, Inc.
Metastatic Melanoma, Skin Cancer
Immunotherapy Efficacy and PD-L1 as a Predictive Biomarker in Metastatic Melanoma in Slovenia
The purpose of this study is to evaluate the efficacy of immunotherapy in the first-line treatment of metastatic melanoma in Slovenia and to investigate the association between PD-L1 expression and treatment response.
- Trial name
- MAK (NCT07422779)
- Testing
- Pembrolizumab, Nivolumab, Ipilimumab
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- Institute of Oncology Ljubljana
Allografts, Oral cGVHD
The Oral cGVHD as a Predictive Factor of Graft Versus Leukaemia Effect in Patients Who Received an Allograft
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the standard treatment for many malignant blood disorders. Its effectiveness is based on the graft-versus-leukemia (GVL) effect, which is intrinsically linked to…
- Trial name
- NCT07271498
- Testing
- Evaluation of oral cGVHD
- Where
- France
- Volunteers
- 93 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
DENV Without Warning Signs, DENV with Warning Signs
Innovative Multidisciplinary Strategies for Combating Severe Dengue
The goal of this observational study is to identify biomarkers and host factors associated with dengue severity in patients from dengue-endemic regions.
- Conditions
- DENV Without Warning Signs, DENV with Warning Signs, Severe Dengue, Healthy Controls Group - Age and Sex-matched
- Trial name
- COMBAT (NCT06751836)
- Testing
- Infection and no infection
- Where
- 2 sites in Guatemala, India
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Skin Microbiome, Graft Versus Host Disease
The Skin Microbiome in Graft Versus Host Disease
Based on the evidence on the impact of the intestinal microbiome on the Graft Versus Host Disease (GVHD) after allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT), it is hypothesized that the skin-microbiome may play a…
- Conditions
- Skin Microbiome, Graft Versus Host Disease, Graft Versus Host Disease in Skin
- Trial name
- NCT04231500
- Testing
- Skin swabs, Skin punch biopsies, additional blood sampling
- Where
- Switzerland
- Volunteers
- 74 people
- Sponsor
- University Hospital, Basel, Switzerland
Cancer, Breast, Triple Negative Breast Cancer
VISION: Triple Negative Breast Cancer Sample and Clinical Data Acquisition Study
Background: Despite improvements in the treatment of Triple Negative Breast Cancer (TNBC), the cancer returns in half of the women and shockingly 40% are dead within 5 years of their initial cancer diagnosis.
- Conditions
- Cancer, Breast, Triple Negative Breast Cancer, Early-stage Breast Cancer
- Trial name
- NCT06409221
- Testing
- Non-interventional study, Observational only
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Concr
Atherosclerosis, Restenosis
Blood Endothelium Progenitor Cells and Dendritic Cells as Predictive Biomarkers of In-stent Restenosis
clinically relevant in stent restenosis occurs in 5-10% of the non-diabetic patients treated with a coronary bare metal stent. Recent research has identified endothelial progenitor cells as well as dendritic cells as components…
- Trial name
- NCT00493597
- Where
- Belgium
- Volunteers
- 124 people
- Sponsor
- University Hospital, Antwerp
Sleep-Disordered Breathing, Sleep Architecture
Validation of Belun Ring Gen3 Deep Learning Algorithms With Subxiphoid Body Sensor
Hypothesis: BR's Gen3 DL algorithms, combined with its subxiphoid body sensor, can accurately diagnose OSA, categorize its severity, identify REM OSA and supine OSA, and detect central sleep apnea (CSA).
- Conditions
- Sleep-Disordered Breathing, Sleep Architecture, Arrhythmia
- Trial name
- NCT06255613
- Testing
- Belun Ring, Belun Cor
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- Belun Technology Company Limited
CNS Lymphoma
CLIMB: CNS Lymphoma Imaging and Molecular Biomarkers Study
A prospective imaging and translational tissue study in CNS lymphoma to enable further disease characterisation and the development of potential predictive and prognostic biomarkers.
- Trial name
- CLIMB (NCT05828628)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Mycosis Fungoides, Sezary Syndrome
Predictive and Prognostic Biomarkers in Patients With Mycosis Fungoides and Sézary Syndrome.
A translational study for identification of prognostic and treatment-predictive biomarkers in Mycosis fungoides and Sézary syndrome.
- Trial name
- BIO-MUSE (NCT04904146)
- Testing
- Blood tests and testing of analysis of the lymphoma microenvironment in skin, skin barrier and skin microbiology profile.
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lund University Hospital
Multiple Sclerosis, Magnetic Resonance Spectroscopy
MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis
The transition from relapsing-remitting multiple sclerosis to secondarily progressive multiple sclerosis (SPMS) is difficult to identify.
- Trial name
- NCT05491031
- Testing
- magnetic resonance spectroscopy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Premature Rupture of Membrane
Preterm Premature Rupture of Fetal Membranes: Cervical Ultrasound and Biological Markers to Diagnose Prematurity (RECHOBIOL)
Our main hypothesis is to consider that the detection of biomarkers on admission combined with the length of the cervix would improve the prediction of the latency period in case of preterm premature rupture of membranes (pPROM).
- Trial name
- RECHOBIOL (NCT04237142)
- Testing
- Vaginal secretions collection, Blood sample
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Clermont-Ferrand