Clinical trials: Premature Retinopathy
Retinopathy of Prematurity, Newborns
A Study to Collect Data on the Use of Eylea in Babies Born Too Early Who Have a Condition of the Eye Where Blood Vessels Grow Abnormally in the Retina (Retinopathy of Prematurity)
This is an observational study to collect data from Japanese babies with retinopathy of prematurity (ROP) who will be treated with Eylea.
- Conditions
- Retinopathy of Prematurity, Newborns, Infants
- Trial name
- NCT05705258
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- Japan
- Volunteers
- 75 people
- Sponsor
- Bayer
Retinopathy of Prematurity
Skin and Serum Carotenoids in Preterm Infants Fed on a Formula Supplemented With Carotenoids
The primary objectives of this study are to compare the serum and skin concentrations of beta-carotene, lutein, and lycopene in preterm infants fed preterm formulas with mixed carotenoids to serum concentrations in preterm…
- Trial name
- NCT00872664
- Testing
- carotenoids
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Utah
Retinopathy of Prematurity
Peripheral Avascular Retina in Retinopathy of Prematurity
Retinopathy of prematurity (ROP) is a widely known retinal vascular disorder in preterm infants and a leading cause of visual disability or blindness in children.
- Trial name
- NCT06044181
- Testing
- Diode laser photocoagulation.
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Assiut University
Neonatal Pain, Retinopathy of Prematurity (ROP)
Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants
The goal of this clinical trial is to learn whether intranasal fentanyl (a pain medicine given as a nasal spray) can reduce pain and is safe to use during routine eye examinations for retinopathy of prematurity (ROP) in preterm…
- Conditions
- Neonatal Pain, Retinopathy of Prematurity (ROP), Pain Management, Infant, Premature
- Trial name
- FIREFLY (NCT07112430)
- Testing
- Fentanyl Citrate (Intranasal)
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Marsha Campbell-Yeo
Retinopathy of Prematurity
Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity
Extremely premature infants are at risk of developing a potentially blinding eye disease, called retinopathy of prematurity (ROP).
- Trial name
- RoProp (NCT03083431)
- Testing
- Propranolol
- Where
- 3 sites in Germany, Switzerland and 1 more
- Volunteers
- 276 people
- Sponsor
- University of Zurich
Apnea of Prematurity, Retinopathy of Prematurity
Use of Sucrose to Relieve Pain During Eye Exams in Infants
The purpose of this study is to see if an oral sucrose solution can comfort premature infants during their necessary eye exams. The investigators believe that the use of this solution prior to the eye exams will lead to a…
- Conditions
- Apnea of Prematurity, Retinopathy of Prematurity, Pain
- Trial name
- NCT00161694
- Testing
- sucrose solution
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Weill Medical College of Cornell University
Retinopathy of Prematurity
Changes in Vital Signs and Pupil Diameter Related to Pharmacologic Mydriasis in Premature Infants: A Randomized Double Blind Clinical Study
Retinopathy of prematurity (ROP) is one of the common anatomic causes of blindness among Filipinos, accounting for 47.7% of the cases.
- Trial name
- NCT04838665
- Testing
- 0.5% cyclopentolate and 2.5% phenylephrine, 0.5% tropicamide + 0.5% phenylephrine, 0.5% tropicamide + 0.5% phenylephrine with a cotton wick
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of the Philippines
Retinopathy of Prematurity
Iron and Retinopathy of Prematurity (ROP)
The purpose of this study is to determine whether increased transferrin saturation in plasma (that reflects iron overload and/or low transferrin) is an independent risk factor for ROP development and severity.
- Trial name
- Fer-ROP (NCT05133999)
- Testing
- Plasma determination of iron, transferrin and ferritin, Fundus Examination by wide field digital imaging camera (PanocamTM camera)
- Where
- 3 sites in France
- Volunteers
- 175 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Retinopathy of Prematurity
Effect of Vitamin E for Prevention of Retinopathy of Prematurity: A Randomized Clinical Trial.
The retinopathy of prematurity (ROP) is a public health problem, the main causes of ROP are prematurity, use of oxygen, malnutrition and oxidative stress.
- Trial name
- NCT03274596
- Testing
- Vitamin E
- Volunteers
- 90 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Anemia, Neonatal, Intracranial Hemorrhages
Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates
The purpose of this study is to test the safety and effectiveness of a whole own (autologous) umbilical cord blood transfusion in the first 5 days after birth if the baby is born premature <34 weeks and developed anemia of…
- Conditions
- Anemia, Neonatal, Intracranial Hemorrhages, Necrotizing Enterocolitis, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT02050971
- Testing
- Umbilical Cord Blood Infusion, Intravenous Infusion of Peripheral Blood or its Components
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Retinopathy of Prematurity
Study to Assess the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Compared to Laser Photocoagulation in Patients With Retinopathy of Prematurity
The primary objective of the study is to assess the efficacy of aflibercept compared to laser in patients diagnosed with retinopathy of prematurity (ROP).
- Trial name
- BUTTERFLEYE (NCT04101721)
- Testing
- aflibercept, laser photocoagulation
- Where
- 52 sites in United States, Bulgaria and 11 more
- Volunteers
- 127 people
- Sponsor
- Regeneron Pharmaceuticals
Retinopathy of Prematurity (ROP)
Safety, PK and PD of FLQ-101 in Premature Neonates
The purpose of this study is to evaluate safety and efficacy outcomes following exposure to FLQ-101.
- Trial name
- tROPhy-1 (NCT07093255)
- Testing
- FLQ-101
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- FELIQS INC.
Retinopathy of Prematurity, ROP
Automated Screening Device to Detect MTMROP
The purpose of the study is to evaluate the i-ROP DL system for autonomous ROP screening. To demonstrate the sensitivity and specificity of the i-ROP DL system on images obtained by healthcare providers in the neonatal intensive…
- Trial name
- NCT06517836
- Testing
- iROP DL
- Where
- United States
- Volunteers
- 1,284 people, healthy volunteers welcome
- Sponsor
- Siloam Vision
Infant, Premature, Diseases
Serum Vascular Endothelial Growth Factor in Infants With Intravitreal Ranibizumab
To determine the serum concentrations of ranibizumab and vascular endothelial growth factor (VEGF) in infants with retinopathy of prematurity (ROP) who received intravitreal ranibizumab
- Trial name
- NCT03115255
- Testing
- intravitreal ranibizumab
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Retinopathy of Prematurity (ROP), Intraventricular Hemorrhage
Safety and Efficacy Outcomes Following Previously Administered Short-Term Treatment With SHP607 in Extremely Premature Infants
The purpose of this study is to evaluate long-term safety and efficacy outcomes following previously administered short-term exposure to SHP607, as compared to a standard neonatal care group.
- Conditions
- Retinopathy of Prematurity (ROP), Intraventricular Hemorrhage, Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
- Trial name
- NCT04506619
- Testing
- No Intervention
- Where
- 8 sites in United States, Italy and 1 more
- Volunteers
- 26 people
- Sponsor
- Oak Hill Bio Ltd
Retinopathy of Prematurity
The Early Treatment for Retinopathy of Prematurity Study (ETROP)
The goal of the Early Treatment for Retinopathy of Prematurity Study (ETROP) is to test the hypothesis that earlier treatment in carefully selected cases will result in an overall better visual outcome than treatment at the…
- Trial name
- NCT00027222
- Testing
- retinal ablation
- Where
- 26 sites in United States
- Sponsor
- National Eye Institute (NEI)
Retinopathy of Prematurity
WINROP Algorithm Validation for Retinopathy Screening in a Cohort of Premature Infants
When a child was born too early, it is more likely to develop an alteration of its visual function than in the case of term birth.
- Trial name
- WINROP (NCT03347799)
- Volunteers
- 570 people
- Sponsor
- Central Hospital, Nancy, France
Preterm
Hemodynamic Response to Pain During Retinopathy Of Prematurity Screening
Study of cerebral hemodynamic changes in preterm infant and the effect of topical anesthetic eye drops ( benoxinate hydrochloride 0.4% ) on PIPP score and cerebral hemodynamic changes during fundus examination in neonates with…
- Trial name
- NCT05666362
- Testing
- benoxinate hydrochloride 0.4% group, saline 0.9% .
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Alexandria University
Retinopathy of Prematurity
Fasudil Eye Drop in Retinopathy Of Prematurity(ROP)
Eligible eyes are randomly assigned into two groups. Group A receive Fasudil eye drops (concentration 0.5 percent) twice daily. Group B, receive artificial tears drop with the same frequency.
- Trial name
- NCT04191954
- Testing
- Fasudil eye drops (concentration 0.5 percent), receive artificial tears drop
- Where
- Iran
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Retinopathy of Prematurity
Clinical and Genetic Analysis of ROP
Retinopathy of Prematurity (ROP) is a vascular disease affecting the retinas (back of the eye) of low birth weight infants. Although it can be treated effectively if diagnosed early, it continues to be a leading cause of…
- Trial name
- (ROP) (NCT04420156)
- Testing
- No intervention administered.
- Where
- 5 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University