Clinical trials: Preventive Medicine
Cancer
Promoting Organizational Capacity to Implement Cancer Control Programs Among Latino Churches
This research study aims to develop an organizational-level intervention to enable communities to adopt, adapt, implement and sustain evidence-based interventions (EBIs) to address cancer disparities among Latinos.
- Trial name
- CRUZA (NCT01740219)
- Testing
- Capacity Enhancement, Standard Dissemination
- Where
- 3 sites in United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Non-steroidal Anti-inflammatory Drug Adverse Reaction
Research for Prevention and Treatment of NSAIDs Related Gastrointestinal Side Effects
We aim to evaluate the protective effects of eradication of HP and continue using Geranylgeranylacetone (GGA) on NSAIDs related gastroenterological lesions.
- Trial name
- NCT01547559
- Testing
- part1:teprenone, part1:EAC-T, part1:EA-EMC-T
- Where
- 2 sites in China
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Healthy
Impact of a Physical Activity Intervention on Cardiometabolic Health, Mental Health, and Lifestyle Factors.
The first objective of this study is to compare cardiometabolic and mental health across the four interregion Meuse-rhine (IMR).
- Trial name
- IMR-BZ (NCT07237893)
- Testing
- Smartwatches with progressive step targets
- Where
- 4 sites in Belgium, Germany and 1 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Liege
HIV Infections, HIV Seronegativity
A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of 100 mcg of Env 2-3 in MF59
To evaluate the safety and immune response of 100 mcg Env 2-3 antigen administered on days 0, 30, 180, and 365. Preliminary immunologic data from protocol VEU 005B show evidence of the development of functional antibodies in the…
- Trial name
- NCT00000632
- Testing
- Env 2-3
- Where
- 3 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
BRCA1 Mutation, Breast Cancer
Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation
This phase III trial compares denosumab to placebo for the prevention of breast cancer in women with a BRCA1 germline mutation. A germline mutation is an inherited gene change which, in the BRCA1 gene, is associated with an…
- Conditions
- BRCA1 Mutation, Breast Cancer, Breast Diseases, Breast Neoplasms
- Trial name
- BRCA-P (NCT04711109)
- Testing
- Denosumab, Quality-of-Life Assessment
- Where
- 47 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Atherosclerosis
Long-term Impact Evaluation of a Worksite-based Lifestyle Intervention to Reduce Cardiovascular Risk in Office Workers
The main objective of TANSNIP-PESA is to determine in a population of asymptomatic bank employees with high and low imaging defined cardiovascular disease (CVD) risk the effectiveness of a comprehensive 3-year worksite-based…
- Trial name
- TANSNIP-PESA (NCT02561065)
- Testing
- Lifestyle intervention
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Malaria
Comparison of Three Drug Combinations for Intermittent Treatment of Malaria in Children
Intermittent preventive treatment (IPT) offers a way of preventing malaria infection without compromising the development of malaria immunity or encouraging drug resistance.
- Trial name
- NCT00561899
- Testing
- SP, amodiaquine, piperaquine, dihdroartemisinin, intermittent preventive treatment, Du-Cotecxin
- Where
- The Gambia
- Volunteers
- 1,295 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections, HIV Seronegativity
A Phase I Clinical Trial to Evaluate: Part A. The Safety of MTP-PE/MF59 Adjuvant Emulsion. Part B. The Safety and Immunogenicity of Env 2-3, a Yeast Derived Recombinant Envelope Protein of Human Immunodeficiency Virus-1, in Combination With MTP-PE/MF59
To evaluate the safety of a fixed antigen dose with an increasing dose of adjuvant (MTP-PE/MF59, a substance to enhance the immune response to vaccine) in volunteers. To evaluate local and systemic reactions (Part A).
- Trial name
- NCT00000972
- Testing
- MTP-PE/MF59, Env 2-3
- Where
- 3 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sleep Disturbances, Depression
Neurobiological Investigations of Mindfulness, Depression and Sleep Disturbances in Medical Staffs and Community Elders
The research team proposes a multi-year study with the first year focusing on the developmental phase. In this initial phase, we aim to recruit 40 participants (including healthcare staff and older adults) from Shuang-Ho Hospital…
- Trial name
- NIMDS (NCT07179172)
- Testing
- Mindfulness-Based Stress Reduction (MBSR) 8-Week Program
- Where
- Taiwan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Vulvar Health, Vulvar Self-Examination
Health Belief Model-Based Vulvar Self-Examination Education
This randomized controlled trial was conducted to evaluate the effectiveness of a Health Belief Model-based Vulvar Self-Examination (VSE) education program on women's health beliefs, vulvar health awareness, and vulvar…
- Conditions
- Vulvar Health, Vulvar Self-Examination, Women's Health, Health Belief Model
- Trial name
- NCT07621315
- Testing
- Self-Examination of the Vulva Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Preventive Medicine, HIV Infections
Retention in PrEP Care for African American MSM in Mississippi
Innovative and novel HIV prevention interventions are urgently needed for African American (AA) young men who have sex with men (YMSM) in the South, and in Mississippi in particular.
- Trial name
- NCT03256435
- Testing
- RAMP PrEP initiation, adherence, and retention intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Brown University
Healthy
The Role of L-arginine in the Endothelial Dysfunction
Acute cardiac and vascular events, like heart attack and sudden cardiac death manifest a clear surge in the early morning hours around the time of waking, so that their peak onset is between 6AM and 11AM.
- Trial name
- NCT00583388
- Testing
- L-arginine, Ultrasound
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Preleukemia, Myelodysplastic Neoplasm
Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS
This is a single-arm pilot study of the feasibility and safety of metformin in patients with clonal cytopenia of undetermined significance (CCUS) or lower-risk myelodysplastic neoplasms (LR-MDS).
- Conditions
- Preleukemia, Myelodysplastic Neoplasm, Cytopenia, Preleukemic Anemia
- Trial name
- NCT04741945
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kirsten Grønbæk
Malaria, Falciparum, Anemia
The Community Effectiveness of IPTi in Southern Tanzania
The safety and efficacy of Intermittent Preventive Treatment for malaria and anaemia control in Infants (IPTi) have already been documented in Southern Tanzania, affording an opportunity to gain operational experience in…
- Trial name
- NCT00152204
- Testing
- Sulfadoxine-pyrimethamine used for IPTi, IPTi
- Where
- Tanzania
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Preterm Delivery, Preterm Contractions
The Impact of Bryophyllum on Preterm Delivery
The purpose of this study is whether Bryophyllum is more effective and has less side effects than traditional labor inhibitors in preventing preterm delivery.
- Conditions
- Preterm Delivery, Preterm Contractions, Cervical Shortening
- Trial name
- NCT00163579
- Testing
- Bryophyllum
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Depression, Healthy
Bone Loss in Premenopausal Women With Depression
The purpose of this study is to determine whether women with major depression lose bone mass at a faster rate than women without depression.
- Conditions
- Depression, Healthy, Osteopenia, Osteoporosis
- Trial name
- NCT00006180
- Testing
- Alendronate
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Well-Being, Lifestyle, Healthy
An Exploratory Feasibility Study
This study explores the feasibility of ContextWell, a well-being education programme that combines an online webinar with an AI-powered behavioural nudging system.
- Conditions
- Well-Being, Lifestyle, Healthy, Young Adult, Behavior and Behavior Mechanisms
- Trial name
- Contextwell (NCT07009964)
- Testing
- ContextWell Educational Programme
- Where
- Ireland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University College Dublin
HIV Infections
A Phase I Safety and Immunogenicity Trial of HIV-1 gp120 C4-V3 Hybrid Polyvalent Peptide Immunogen Mixed in Mineral Oil Containing Mannose Mono-Oleate (IFA)
To evaluate the safety of HIV-1 gp120 C4-V3 hybrid polyvalent peptide immunogen (C4-V3 peptides) formulated in mineral oil containing mannose mono-oleate (IFA) in HIV-1 uninfected volunteers.
- Trial name
- NCT00000886
- Testing
- HIV-1 C4-V3 Polyvalent Peptide Vaccine
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Preventive Medicine, Health Promotion
Development of Health Management Model for Chinese Medical Preventive Medicine
The purpose of this project is to design a health management model of TCM preventive medicine that meets the need of healthy or suboptimal healthy people.
- Trial name
- NCT03640169
- Testing
- Health management of TCM preventive medicine
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Poverty, Income
addressInG iNcome securITy in Primary carE
Social processes that impact the health of individuals have been labeled the social determinants of health (SDOH). These are "the conditions in which people are born, grow, live, work and age.
- Conditions
- Poverty, Income, Social Determinants of Health
- Trial name
- IGNITE (NCT02459184)
- Testing
- Income Security Health Promotion
- Where
- Canada
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto