Clinical trials: Randomized-controlled Trial
Meningococcal Vaccine
A Trial to Describe the Immunogenicity and Safety of 2 Doses of Bivalent rLP2086 (Trumenba) and a Pentavalent Meningococcal Vaccine in Healthy Subjects >=10 to <26 Years of Age.
This study is examining safety and immunogenicity of 2 doses of Trumenba administered on a 0-,6- month schedule. This trial is also studying safety and immunogenicity of a meningococcal pentavalent vaccine.
- Trial name
- NCT03135834
- Testing
- MenABCWY, Saline, rLP2086
- Where
- 75 sites in United States, Czechia and 2 more
- Volunteers
- 1,610 people, healthy volunteers welcome
- Sponsor
- Pfizer
Furcation Defects
PRF+1% MF for Class II Mandibular Furcation Defects
The aim of the present trial is to evaluate the efficacy of PRF with 1% MF in treatment of mandibular class II furcation defects and its comparison to PRF and access therapy alone.
- Trial name
- NCT03207698
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with Platelet rich fibrin (PRF)+1% Metformin (Drug) in gel form
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Intervention Studies, ASA Physical Status I
Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications: 1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite 2. Calcium Silicate 3.
- Conditions
- Intervention Studies, ASA Physical Status I, Intracanal Medication, Periapical Abscess
- Trial name
- RCT (NCT07641933)
- Testing
- Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Primary Dysmenorrhea
Yoga Effects in Primary Dysmenorrhea
The goal of this clinical trial was to assess whether a yoga-based exercise program could improve aerobic endurance, sleep quality, and reduce menstrual symptoms and pain in young women aged 18-25 with primary dysmenorrhea.
- Trial name
- NCT07020338
- Testing
- Yoga Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Acute Pain, Anxiety
Effects of Complementary Therapies Delivered Via Mobile Technologies
The purpose of this study is to determine the effects of complementary therapies delivered via mobile technologies have a therapeutic effect on surgical patients' anxiety, pain, and self-efficacy in healing reports before…
- Conditions
- Acute Pain, Anxiety, Self Efficacy
- Trial name
- NCT02236455
- Testing
- Audio Relaxation Technique, Medical Music Intervention, Nature Therapy without Music
- Where
- Iceland
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of San Francisco
Mitochondrial Biogenesis, Inflammation
EFFECTS OF PYRROLOQUINOLINE QUINONE (PQQ) SUPPLEMENTATION ON NON-ENDURANCE TRAINED ATHLETES
The aim of this study was to investigate the effects of six weeks of PQQ supplementation in non-endurance-trained individuals on: 1. physiological and metabolic response during a FATmax-VO₂peak exercise test 2.
- Trial name
- NCT07148726
- Testing
- Pyrrole Quinoline Quinone (PQQ)
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Padova
Sedentary Lifestyle, Cardiometabolic Risk
Effects of Aerobic and Resistance Exercise on Cardiovascular Biomarkers in Sedentary Women
This randomized controlled trial investigated the effects of aerobic and resistance exercise on cardiovascular and inflammatory biomarkers in sedentary young women.
- Trial name
- NCT07457047
- Testing
- Aerobic Exercise Training, Resistance Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Scars
Ablative 10600 nm Fractional Laser Therapy for the Treatment of Scars
Rationale: Scars can be highly disfiguring and may result in functional impairment and psychosocial problems. Recently, fractional laser therapy (FLT) has been introduced as a promising novel treatment modality for scars.
- Trial name
- NCT01358838
- Testing
- ablative 10600 nm fractional laser therapy
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Well-Being, Psychological, Laughter Yoga
Laughter Yoga in Midwifery Students
The aim of this study is to examine the effect of laughter yoga on well-being and psychological adjustment in first-year midwifery students and to evaluate its potential contributions in the context of adaptation to the…
- Trial name
- NCT07212348
- Testing
- Laughter Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Agri Ibrahim Cecen University
Quality of Life (QOL), Anxiety
Testing the Efficacy of the "Syd" App on Improving Quality of Life and Mental Health Among University Students in the Kingdom of Saudi Arabia
The goal of this clinical trial is to learn if using the "See Yourself Differently" (syd) app can help improve quality of life and mental health for university students in Saudi Arabia.
- Conditions
- Quality of Life (QOL), Anxiety, Stress, Affect (Mental Function)
- Trial name
- NCT06979778
- Testing
- See Yourself Differently (syd) mobile app
- Where
- Saudi Arabia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- iamYiam Limited
Pregnancy Related, Infant Development
BabyQ's: Randomized Controlled Trial of Health Messaging in Pregnancy and Infancy
This randomized controlled intervention evaluates the effect of a mobile health behavioral intervention to test messages to reduce sugar-sweetened beverage intake during pregnancy and infancy.
- Trial name
- NCT04238585
- Testing
- Mobile messaging
- Where
- United States
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pancreas Neoplasm Malignant Resectable
Laparoscopic Versus Open Distal Pancreatectomy for Pancreatic Cancer: a Multicenter Randomized Controlled Trial
When pancreatic cancer of the body and tail is diagnosed, a distal pancreatectomy is planned. This operation can be performed with open surgery, or with laparoscopic surgery.
- Trial name
- NCT03957135
- Testing
- Laparoscopic distal pancreatectomy, open distal pancreatectomy
- Where
- South Korea
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Portal Hypertension, Chronic Liver Disease
EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement
This study will directly compare the endoscopic ultrasound guided approach to obtain adequate liver biopsies and portal pressure gradient measurements to the current standard of care which uses the transjugular approach.
- Conditions
- Portal Hypertension, Chronic Liver Disease, Cirrhosis
- Trial name
- NCT05118308
- Testing
- Transjugular hepatic venous pressure gradient measurement with liver biopsy, Endoscopic ultrasound portal pressure gradient measurement with liver biopsy
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Contracture of Muscle, Thigh, Muscle Rigidity
Differents Intensities of Passive Stretching on ROM, Neuromuscular and Performance in Soccer Players: A Blinded RCT
Intensity is a "qualitative" variable of a muscle stretching protocol, which is very little studied due to its inherent characteristic of the individual being stretched.
- Conditions
- Contracture of Muscle, Thigh, Muscle Rigidity, Strain of Hamstring Muscle (Disorder)
- Trial name
- NCT03150563
- Testing
- Passive static stretch
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Endodontic Inflammation
Comparison Between the Vibringe and the Conventional Needle
The Vibringe is the first endodontic sonic irrigation system that enables delivery and activation of the irrigation solution in the root canal, in only one step.
- Trial name
- NCT03551587
- Testing
- Vibringe
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acupuncture Therapy
Using Omics Technology to Explore the Mechanism of Acupuncture Treatment of Different Acupoints of Knee Osteoarthritis
In recent years, commonly used Omics techniques, including genomics, proteomics, metabolomics, have been applied in the studies on the mechanism of acupuncture effect.
- Trial name
- NCT04733352
- Testing
- acupuncture
- Where
- 2 sites in Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Critical Illness, Stress
Effects of a Psycho-cognitive Nursing Intervention on Patients' Outcomes in Critical Illness
The purpose of this study is to investigate whether a psycho-cognitive nursing intervention including relaxation, guided imagery, touch and music listening can improve the clinical and psychological outcome of critically ill…
- Conditions
- Critical Illness, Stress, Inflammatory Response
- Trial name
- NCT02423252
- Testing
- Massage, Relaxation, Guided imagery and music listening., No Intervention
- Where
- Cyprus
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr Elizabeth Papathanassoglou
Low Back Pain, Pelvic Pain
Virtual Reality to Improve Low-back Pain and Pelvic Pain During Pregnancy
A large percentage of women suffer low back and pelvic pain both during and after pregnancy. There are several factors to which these complaints are attributed, even affecting their daily lives.
- Trial name
- NCT05571358
- Testing
- Virtual Reality (Nature Trek)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Perinatal Anxiety, Perinatal Depression
Evaluating Overcoming Anxiety in Pregnancy and Postpartum as an Online Self-Directed Program
The pregnancy and postpartum periods can be joyous times in life; however, they can also be filled with challenging physical, emotional, and lifestyle changes.
- Trial name
- NCT04844138
- Testing
- Overcoming Anxiety in Pregnancy and Postpartum Online Self-Directed Program
- Where
- Canada
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Anxiety, Evidence-based Practice
The Effect of Music on Anxiety and Caregiver Burden in Family Caregivers of Patients With Lung Cancer
This randomized controlled trial evaluated the effects of a 7-day self-selected music intervention on caregiver burden and anxiety among first-degree family caregivers of patients with lung cancer.
- Conditions
- Anxiety, Evidence-based Practice, Caregiver Burden, Nursing
- Trial name
- NCT07847138
- Testing
- Music intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
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