Clinical trials: Refractive Surgery, open to volunteers
Myopia, High Myopia
Clinical Results of Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia
Small Incision Lenticule Extraction (SMILE) was introduced in 2011 using the VISUMAX femtosecond laser (Carl Zeiss Meditec, Jena, Germany). It is designed for correction of myopia and myopic astigmatism.
- Trial name
- NCT04110067
- Testing
- Small Incision Lenticule Extraction (SMILE) with Visumax (Carl Zeiss Meditec, Jena)
- Where
- Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Suphi Taneri
Cataract, Refractive Errors
Strengthening Community- to- Hospital Eye Care Pathways From Boko Eye Care Center in Rural Assam
This operational research project aims to strengthen continuity of eye care delivery between community screening and hospital-based treatment in rural Assam by redesigning referral pathways from the Boko Eye Care Center (ECC) to…
- Trial name
- NCT07333248
- Testing
- Experimental: Integrated Referral and Engagement Model
- Where
- India
- Volunteers
- 2,000 people
- Sponsor
- Seva Canada Society
Visual Correction, Refractive Surgery
Outcomes of Cataract & Refractive Procedures
The primary objective of the database is to retrospectively analyse the visual and refractive outcomes of cataract and refractive procedures in order to continuously assess outcomes and also compare outcomes between the different…
- Conditions
- Visual Correction, Refractive Surgery, Cataract Surgery
- Trial name
- NCT07481487
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Vision Care Collective Limited
Correction Vision Surgery, Cataract Surgery
Clinical Outcomes of Bilateral Clareon Vivity in Post-Refractive Patients
Millions of people have undergone laser vision correction surgery and are motivated to continue with spectacle independence as they develop presbyopia (gradual loss of your eyes' ability to focus on nearby objects)and cataract.
- Trial name
- NCT06924944
- Testing
- cataract surgery
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Utah Eye Centers
Myopia, Astigmatism
SMILE Surgery in One Eye Compared to Ray Tracing-guided LASIK Surgery in the Fellow Eye
Participants will undergo LASIK surgery in one eye using ray tracing guided technology in one eye and LASIK surgery in the other eye using wavefront guided technology.
- Trial name
- NCT07721714
- Testing
- Ray tracing guided LASIK surgery
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Stanford University
Presbyopia Correction, Astigmatism
A Planned Study at Multiple Sites is Being Done to Compare the Results of Two Types of Trifocal Toric Intraocular Lenses Used in Cataract Surgery
To evaluate the clinical outcomes and patient satisfaction of two commercially available trifocal toric intraocular lenses Primary Objective: To compare the distance-corrected intermediate visual acuity between the two trifocal…
- Conditions
- Presbyopia Correction, Astigmatism, Cataract
- Trial name
- NCT07232615
- Testing
- Optiflex TRIO Intraocular Lens, AcrySof® IQ PanOptix®
- Where
- 6 sites in Germany, India and 1 more
- Volunteers
- 138 people
- Sponsor
- Biotech Healthcare Holding Gmbh
Astigmatism
Arcuate Incisions With Light Adjustable Lens for Astigmatism Correction in Lens Surgery
This study aims to evaluate the safety and effectiveness of femtosecond laser arcuate corneal relaxing incisions (AK) combined with Light Adjustable Lens (LAL) implantation for correcting pre-existing corneal astigmatism in…
- Trial name
- NCT07140653
- Testing
- Femto arcs, Light Adjustable Lens (LAL)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Center For Sight
Cataract, Fuchs Endothelial Corneal Dystrophy
Partial Range Of Field IOLs in DMEK-Enabled Procedures
Study Overview This study aims to evaluate the visual outcomes, quality of vision, and patient satisfaction after receiving an extended range PRoF intraocular lens (IOL) during triple Descemet Membrane Endothelial Keratoplasty…
- Trial name
- PROFIDE (NCT07441616)
- Testing
- combined cataract and lamellar endothelial keratoplasty
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Keratoconus, Refractive Surgery
AI-Orchestrated Workflow Versus Consultant Ophthalmologist for Refractive Surgery and Keratoconus Diagnosis (AEYE Trial)
Background and Rationale: Laser vision correction procedures, such as LASIK (Laser-Assisted In Situ Keratomileusis), PRK (Photorefractive Keratectomy), and SMILE (Small Incision Lenticule Extraction), are highly effective but…
- Conditions
- Keratoconus, Refractive Surgery, Machine Learning, Artifical Intelligence
- Trial name
- AEYE (NCT07096232)
- Testing
- Multi-Agent AI Diagnostic Workflow (AEYE)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Hazem Yassin Clinics
Cataract
Clinical Evaluation of Extended Depth-of-focus Intraocular Lens in Refractive Cataract Surgery: a Randomized Controlled Trial
The goal of this clinical trial is to compare the clinical outcomes of two extended depth-of-focus intraocular lens after cataract surgery. The randomized controlled trail will enroll 90 participants.
- Trial name
- NCT06658119
- Testing
- cataract surgery
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Myopia
Comparison of Myopic Small Incision Lenticule Extraction (SMILE) With VISUMAX 500 Versus VISUMAX 800 Platforms
Small incision lenticule extraction (SMILE) procedure is a well-known procedure for the correction of myopia. The purpose of this research study is to compare the two SMILE procedures with different laser platforms (VISUMAX 500…
- Trial name
- NCT07505264
- Testing
- SMILE surgery with Visumax 500, SMILE surgery with Visumax 800
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Singapore Eye Research Institute
Refractive Surgery
CONTOURA vs WFO Ablation PRK & LASIK
This is a prospective randomized contralateral double-masked study. Each patient will be randomized as to which eye undergoes wave-front optimized (WFO) vs.
- Trial name
- NCT05037370
- Testing
- Wave-Front Optimized (WFO) ablation vs Topography-guided (TG) ablation
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Tomography
UNITY DX Cornea Study
The purpose of this study is to validate the clinical measurement performance of an investigational biometer. Subjects will undergo multiple measurements of the eye, and the agreement, repeatability, and reproducibility of…
- Trial name
- NCT07768735
- Testing
- UNITY DX, ANTERION
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Myopia, Refractive Ametropia
The Impact of 'A Miss Is as Good as a Mile': Is Compensation Necessary for Minimal Ocular Deviation in Myopic Laser Surgery?
The goal of this clinical trial is to evaluate the effect of intraoperative kappa-angle compensation on postoperative visual quality in patients undergoing small incision lenticule extraction (SMILE) using the VisuMax 800…
- Trial name
- NCT07512115
- Testing
- Apply compensation to the Kappa angle., Apply no compensation to the Kappa angle
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Recruitment of Participants
Study of the Correlation Between Preoperative Precise Biometrics, Spatial Assessment and Postoperative Visual Quality in Cataract Patients
This study summarizes the experience of precision treatment and postoperative management of various types of cataract, and intend to further improve the quality of Clinical Cataract diagnosis and treatment.
- Trial name
- NCT04833491
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pseudoexfoliation Syndrome, Cataract
Corneal Biomechanics and Surgically Induced Astigmatism in Pseudoexfoliation Syndrome
This prospective study aims to evaluate the influence of corneal biomechanical properties on surgically induced astigmatism following standard phacoemulsification cataract surgery in patients with pseudoexfoliation syndrome…
- Conditions
- Pseudoexfoliation Syndrome, Cataract, Astigmatism
- Trial name
- NCT07722247
- Testing
- phacoemulsification cataract surgery
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- Kata Culina
Pediatric Cataract, IOL Implantation
Myopia Progression Control Using Atropine 0.05% After Pediatric Cataract Surgery And Intraocular Lens Implantation Surgery
Myopic shift remains a debilitating and unpredictable adverse event following pediatric cataract surgery. While research exploring peripheral myopic defocus for post-cataract surgery myopia prevention shows promising results, the…
- Conditions
- Pediatric Cataract, IOL Implantation, Myopia Progression
- Trial name
- NCT07364370
- Testing
- Atropine Eye drops
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Cataract (Post-operative Cataract Surgery Follow-up), Refraction Error
Can Tailored Surgical Incisions Reduce Refractive Error and Dependence on Glasses After Cataract Surgery?
Astigmatism is a common cause of continued dependence on glasses after cataract surgery and may lead to patient dissatisfaction with surgical outcomes.
- Trial name
- AST-2 (NCT07623317)
- Testing
- Adapted clear corneal incisions
- Volunteers
- 100 people
- Sponsor
- Linkoeping University
Ophthalmology
Optimizing the Ocular Surface With Systane COMPLETE Pre- and Post-operatively in Patients With Dry Eye Planning for Cataract Surgery: An Extension Study of Optimizing the Ocular Surface With Systane COMPLETE in Patients With Dry Eye Planning for Cataract Surgery
Compare the corneal astigmatism data before and after the use of Systane COMPLETE to evaluate its impact on predicting changes in postoperative residual astigmatism, as well as the effects of using or not using Systane COMPLETE…
- Trial name
- NCT06886373
- Testing
- Systane Complete
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- National Taiwan University Hospital
Myopia, Astigmatism
A Three-Phase Contralateral Comparison of Ray-Tracing Guided LASIK Versus Three Other Refractive Surgery Platforms to Correct Myopia or Myopia With Astigmatism
This purpose of this study is to compare a new form of LASIK called Ray Tracing Guided LASIK to 3 other forms of corneal refractive surgery: 1. KLEx (KeratoLenticule Extraction) using the Zeiss Visumax 800 Laser, 2.
- Trial name
- NCT07201298
- Testing
- Ray-Tracing Guided LASIK, Keratorefractive Lenticule Extraction (KLEx), WaveFront Optimized LASIK
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hoopes Vision