Clinical trials: Replacement
Total Knee Replacement Closure, Wound Closure
A Comparative Study of Incision Closure Methods for Total Knee Replacement
The aim of the study is to compare incision closure techniques for total knee replacement using a combination of state-of-the-art sutures with tissue adhesives or staples in an effort to identify the best approach with respect to…
- Trial name
- NCT01088074
- Testing
- Histoacryl Tissue Adhesive, Dermabond, Staples
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Foundation for Southwest Orthopedic Research
Smoking Cessation
Interventions for Smoking Among Persons in Recovery
Examine the efficacy of a stepped-care smoking cessation intervention for current and former smokers in chemical dependency treatment programs.
- Trial name
- INSPIRE (NCT00714896)
- Testing
- Stepped-Care, Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth
To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.
This study will compare commercially available, commonly used mouth rinses (0.12% chlorhexidine (CHX) vs. Ethylenediaminetetraacetic acid (EDTA)) for immediate post-operative and daily antiseptic use after tooth extraction and…
- Trial name
- NCT07191262
- Testing
- 0.12% CHX and Essential Oil mouthrinse, 2.6% EDTA and 0.2% EDTA mouth rinse
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Degenerative Joint Disease, Osteoarthritis
Comparison of Clinical Outcomes and Performance of Total Knee Replacement Patients Before and After Surgery
This study is to determine the relevancy of clinical scales for outcome measures as compared to flexion angle and other gait measures.
- Conditions
- Degenerative Joint Disease, Osteoarthritis, Knee Injury, Trauma, Connective Tissue Disorder
- Trial name
- TKR (NCT01379118)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Obesity, Diet Modification
Efficacy of Balanced Nutrition Meal Replacement Along With a Caloric Restriction on Body Weight Control
The present study was designed to evaluate the impact of a nutritionally balanced conventional meal replacement diet with caloric restriction (intervention for 8 weeks) in Taiwanese obese subjects.
- Conditions
- Obesity, Diet Modification, Nutrient; Excess
- Trial name
- nutrition (NCT03642925)
- Testing
- Meal replacement diet
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Arthroplasty, Replacement, Hip
Assessing the Wear Rates of the ADM/MDM Hips Using 3D X-ray Analysis
A common complication post hip replacement is hip dislocation or hip instability which can lead to the hip implants being revised.
- Trial name
- NCT04019925
- Testing
- ADM/MDM hip
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Total Knee Arthroplasty, Total Knee Replacement
ALknee Follow-up Study of the Cementless ATTUNE Rotating Platform and the Cementless LCS Rotating Platform Knee System
The cementless ATTUNETM Rotating Platform Knee system was compared in a single-blind, randomized RSA trial to its predecessor, the LCS rotating platform Knee System.
- Conditions
- Total Knee Arthroplasty, Total Knee Replacement, Knee Osteoarthritis
- Trial name
- NCT05623215
- Testing
- Radiographs of the knee for radiostereometric analysis (RSA)
- Where
- Netherlands
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Spaarne Gasthuis
Tobacco Use Cessation
Improving Varenicline Adherence and Outcomes in Homeless Smokers
the purpose of the study is to see if varenicline in combination with motivational counseling helps homeless cigarette smokers quit smoking.
- Trial name
- NCT00786149
- Testing
- Varenicline plus Motivational Interviewing counseling, Varenicline without counseling
- Where
- United States
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Knee Osteoarthritis
Persona MC vs Attune Total Knee Replacement Study
This study aims to compare clinical and functional outcomes of a cohort of patients that have undergone a medial congruent TKR to a similar cohort of patients that have undergone a conventional TKR and a cohort of control…
- Trial name
- PERTUNE (NCT03580772)
- Testing
- Persona TKR, Attune TKR
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Knee Arthroplasty
The PATH Study to Promote Physical Activity After Knee Replacement
The purpose of this study is to examine the feasibility and preliminary efficacy of a physical therapist led physical activity intervention for knee replacement patients within an outpatient physical therapy facility.
- Trial name
- NCT03768206
- Testing
- Standard Physical Therapy, Physical therapist discuss aerobic physical activity, Physical activity session
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Postoperative Pain
Sacral Canal Block for Hip Replacement the Efficacy and Safety of Controlled Intraoperative Hypotension
To observe the efficacy and safety of sacral canal block in controlled blood pressure reduction during hip replacement in the elderly, and to provide a better option for controlled blood pressure reduction during clinical hip…
- Trial name
- NCT07064434
- Testing
- Sacral canal block combined with general anesthesia, Simple general anesthesia
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Replacement of Supralaryngeal Airway
Evaluation of Supralaryngeal Airway Removal During Initial Resuscitation of the Trauma Patient
In the trauma setting, if a patient has arrived in the trauma bay with an ETC/King LT-D in place, it has traditionally been immediately exchanged out for an ETT upon arrival.
- Trial name
- NCT00585598
- Testing
- replacing supralaryngeal airway with ET tube
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Surgical Education, Operating Room Nursing
Digital Gamification vs. Traditional Training for Hip Replacement Instrument Table Setup (ORNurse)
This randomized controlled trial aims to compare the effectiveness of a digital gamification-based training method and a traditional training method on instrument table layout skills in total hip replacement surgery.
- Conditions
- Surgical Education, Operating Room Nursing, Educational Technology
- Trial name
- ORNurse (NCT07194148)
- Testing
- Gamified Digital Education (ORNurse: Steril Setup 1.0), Traditional Training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- DERYA ESENKAYA
Dental Implant
The Accuracy of s-CAIS Compared With c-LIS
To compare the static computer-aided implant surgery (s-CAIS) and conventional laboratory-guided implant surgery (c-LIS) in terms of accuracy for single tooth replacement in posterior areas.
- Trial name
- NCT05361226
- Testing
- Accuracy measurement
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Patients With Ischemic or Idiopathic Dilated Cardiomyopathy
Multihormonal Deficiencies and miRNA Profile in Chronic Heart Failure: Effects of Combined Hormonal Replacement Therapy
The results from this study will be useful to gain detailed information on the correlation related to pathophysiological aspects between endocrine system and clinical status of patients with heart failure, and to identify factors…
- Trial name
- NCT05769387
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
Arthroplasty, Replacement, Hip
Longjohn Amgen Study - Effect of Denosumab...
The overall objective of the proposed study is to quantify bone loss around non-cemented total hip replacement femoral and acetabular components using DEXA analysis in patients receiving Prolia (denosumab) in the first year of…
- Trial name
- EDRPBLFHR (NCT02444585)
- Testing
- Denosumab
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Transcatheter Aortic Valve Replacement
Monitored Anesthesia Care vs. General Anesthesia for Transcatheter Aortic Valve Replacement
This study is being done to evaluate the impact that monitored anesthetic care (MAC) versus general endotracheal anesthesia (GETA) has on hospital length of stay, rate of ICU admission, and procedural mortality for patients…
- Trial name
- NCT04107038
- Testing
- General Endotracheal Anesthesia, Monitored anesthesia care
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Knee Replacement
Biomechanical Assessment of a High Congruency Knee Bearing
The aim of the project is to compare the biomechanics of three different bearing designs used in total knee replacement (TKR) implants.
- Trial name
- NCT02422251
- Testing
- Mobile high congruency bearing (Columbus), Fixed high congruency bearing (Columbus)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Menopause
Pharmacokinetics and Pharmacodynamics of 3 Dosages of Estriol After Continuous Vaginal Administration for 21 Days
This clinical trial evaluated the pharmacokinetics and pharmacodynamics of estriol in healthy post-menopausal women after the application of one vaginal ring containing one of three different dosages of estriol (100 mg (Test 1)…
- Trial name
- NCT03363997
- Testing
- Estriol 0.125 mg/day, Estriol 0.250 mg/day, Estriol 0.500 mg/day
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Osteoarthritis, Pain
Safety of Non-delayed Weight Bearing After Total Hip Replacement With Non-Cemented Fiber Metal Taper Stem
The purpose of this study is to determine if full weight bearing following total hip replacement can speed recovery when the hip replacement in the long bone of the leg is not cemented into the bone.
- Trial name
- NCT00179088
- Testing
- Patient may be able to put weight on the operated leg
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center