Clinical trials: Respiratory Inflammation
Asthma, HIV
Adiposity and Airway Inflammation in HIV-Associated Airway Disease
The goals of this study are to 1) examine the relationships among inflammation, obesity, and asthma in people with HIV and 2) to test if special subtypes of cells or markers are present in the blood and lungs of people with HIV…
- Conditions
- Asthma, HIV, Adiposity
- Trial name
- SHOP (NCT02975258)
- Testing
- Blood draw, Questionnaires, Spirometry
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Pittsburgh
CKD (Chronic Kidney Disease) Stage 5D, Uremia; Chronic
Studies on Adsorption International Learning Initiative Global
Use of sorption technologies in patients undergoing maintenance hemodialysis with inflammatory syndrome and clinical manifestations of uremia
- Conditions
- CKD (Chronic Kidney Disease) Stage 5D, Uremia; Chronic, Uremic; Toxemia, Inflammation Chronic
- Trial name
- SAILING (NCT07123909)
- Testing
- Patients will undergo a combined hemodialysis and hemosorption procedure. The study cartridge for hemosorption by Jafron HA130 contains the original adsorbing material.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Botkin Hospital
Severe Asthma
The Inflammatory Profile of Exacerbations in Patients With Severe Asthma Receiving Tezepelumab: The TezEx Study
Tezepelumab is a treatment that is approved by NICE (National Institute for Health and Care Excellence, https://www.nice.org.uk/) for patients with severe asthma, that remains poorly controlled despite high dose inhaled…
- Trial name
- TezEx (NCT06666504)
- Testing
- Prospective Data Analysis
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cough Variant Asthma
Observation of Cough Variant Asthma Treated in Combination of Chanqin Granules.
This single-center, randomized, double-blind, placebo-controlled trial was undertaken at an outpatient clinic in Shuguang Hospital. Newly diagnosed cough variant asthma adult patients with the T.C.M.
- Trial name
- NCT03319043
- Testing
- Chanqin granules
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Allergic Rhinitis
Nasal Budesonide Efficacy on Nasal FeNO in Children With Allergic Rhinitis
In clinical trials for treatment of allergic rhinitis a significant reduction of the total symptom score compared to baseline has been demonstrated by using nasal budesonide.Previous results in adults show that the assessment and…
- Trial name
- NCT02409563
- Testing
- Budesonide nasal spray (100 mcg bid), Budesonide nasal spray (50 mcg bid
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Inflammation, Work Related Illnesses
Airway Inflammatory Profile Among Cleaning Workers From Different Workplaces
There are consistent evidences through epidemiologic studies in different places, reinforced by occupational asthma records studies, that cleaning workers have a high risk in developing asthma.
- Conditions
- Inflammation, Work Related Illnesses, Symptoms and Signs, Asthma, Occupational
- Trial name
- NCT03311048
- Testing
- Nasal swab, Questionnaires
- Where
- Brazil
- Volunteers
- 167 people
- Sponsor
- University of Sao Paulo
Asthma
Markers of Airway Inflammation in BAL Fluid From Children With Asthma
The study compares the biochemical markers in bronchoalveolar lavage samples from asthmatic children to those markers found in non-asthmatic children with other respiratory diseases.
- Trial name
- NCT00838552
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- National Jewish Health
Asthma, Inflammation
Pathogenesis and Genetics of Environmental Asthma Ozone Study
The goals of the research are designed to accomplish genetic association studies of candidate genes in healthy normal individuals exposed to 0.2 ppm for 2.25 hours with intermittent exercise in order to search for associations…
- Trial name
- NCT00574158
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Heart Failure, Pulmonary Disease, Chronic Obstructive
Pulmonary Function, Chronic Obstructive Pulmonary Disease (COPD) Prevalence, and Systemic Inflammation in Chronic Heart Failure With or Without COPD
The aim of the present study is: 1. To investigate pulmonary function abnormalities (restriction, obstruction, diffusion impairment, mixed pulmonary defects) in patients with chronic heart failure (CHF) and to determine which of…
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Inflammation
- Trial name
- NCT01429376
- Testing
- Pulmonary function tests, Blood tests, Questionnaires
- Where
- 2 sites in Netherlands
- Volunteers
- 234 people
- Sponsor
- Rijnstate Hospital
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Sepsis, Septic Shock
Pharmacokinetics of XueBiJing in Patients With Sepsis
Pharmacokinetics and disposition of XueBiJing compounds in patients with sepsis
- Conditions
- Sepsis, Septic Shock, Community Acquired Pneumonia
- Trial name
- NCT03475732
- Testing
- XueBiJing injection
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Southeast University, China
Statin, Airway Disease
Adjunctive Role of Statin Therapy on Airway Inflammation and Clinical Consequences of Chronic Obstructive Pulmonary Disease
This study aimed to evaluate the impact of statin therapy on the clinical consequences, as well as airway inflammation and radiological features, in severe chronic obstructive pulmonary cases.
- Conditions
- Statin, Airway Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT07549932
- Testing
- Statin, placepo intervention
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mohamed Salah El-Sayed
COVID-19
Immune Biomarkers of Outcome From COVID-19
A new virus to humans, first identified in December 2019, is causing a global pandemic with over 1 million infections and many thousands of deaths.
- Trial name
- IBOC (NCT04436484)
- Testing
- Peripheral blood sampling
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University Hospital Plymouth NHS Trust
Chronic Obstructive Pulmonary Disease
INvestigating COPD Outcomes, Genomics and Neutrophilic Inflammation With Tiotropium and Olodaterol
This protocol describes a randomised controlled trial to test the hypothesis that 6 months of treatment with tiotropium and olodaterol will result in a reduction in bacterial load, an improvement in neutrophilic inflammation and…
- Trial name
- INCOGNITO (NCT03152149)
- Testing
- Tiotropium & olodaterol, fluticasone furoate & vilanterol
- Where
- 4 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Dundee
COPD
A Safety, Tolerability and Efficacy Study in Chronic Obstructive Pulmonary Disease (COPD) Patients With QBM076.
This was a 2 Part study. Part 1 was a safety and tolerability study in GOLD I-III COPD patients. Part 2 was an efficacy study in GOLD I-III COPD patients.
- Trial name
- NCT01972776
- Testing
- QBM076
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 48 people
- Sponsor
- Novartis Pharmaceuticals
COVID-19, Respiratory Failure
Compartmental Inflammation in Mechanically Ventilated Patients With COVID-19
The aim of the present study is to examine the inflammatory response in the pulmonary compartment and blood of critically ill patients admitted to the ICU with COVID-19.
- Trial name
- COV2ICU-DK (NCT04354584)
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
COVID, Corona Virus Infection
Intensive Care Associated Complications and Outcome of Acute Respiratory Distress Syndrome Due to COVID-19
COVID-19 patients with a severely symptomatic progression with development of an Acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 need prolonged intensive care treatment involving pharmacological immobilization…
- Conditions
- COVID, Corona Virus Infection, Sars-CoV2
- Trial name
- NCT04397172
- Testing
- Study Arm
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Lung Diseases
Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.
The INSPIRE CHILD-study is a clinical research project focused on understanding lung diseases in children. The study aims to explore how the presence of certain bacteria, immune responses, and inflammatory markers in the lungs…
- Trial name
- INSPIRE CHILD (NCT06746077)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aarhus University Hospital
Critical Illness, Hemodynamic Instability
Complications Related to Transpulmonary Thermodilution
The transpulmonary thermodilution is commonly used in patients with acute circulatory failure in the intensive care unit and for monitoring surgical patients at high risk.
- Conditions
- Critical Illness, Hemodynamic Instability, Septic Shock, Acute Respiratory Distress Syndrome
- Trial name
- COTRADIL (NCT04319965)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Bicetre Hospital
Asthma
Elite Sport and Development of Asthma
International studies have shown that elite athletes have a high prevalence of respiratory symptoms and asthma as compared to normal subjects.
- Trial name
- NCT00262587
- Testing
- Seretide
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
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