Clinical trials: Retinal Disorders
Epiretinal Membrane, Macular Hole
Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
The aim of this study is to test the efficacy of the combination of dye Lutein, Zeaxanthin and brilliant blue to stain the internal limiting membrane as well as the epiretinal membranes during the Vitrectomy surgery.
- Conditions
- Epiretinal Membrane, Macular Hole, Proliferative Diabetic Retinopathy
- Trial name
- NCT01627977
- Testing
- Dye of Lutein, Zeaxanthin and Brilliant Blue
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
Central Serous Chorioretinopathy
High-dose Antioxidants for Central Serous Chorioretinopathy
Central serous chorioretinopathy (CSC) is the serous neurosensory detachment that usually involves the macular area. It is common in patients between 30-50 years old and effects male more often than female with the ratio of 5-10.
- Trial name
- NCT00963131
- Testing
- antioxidants tablets
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Prince of Songkla University
Radiation Retinopathy
Steroids for Early Treatment of Radiation Retinopathy
Radiation retinopathy is a known complication of ocular radiation therapy. To date there is no known effective treatment. In addition to their anti-vascular endothelial growth factor (VEGF) properties, corticosteroids decrease…
- Trial name
- NCT03238157
- Testing
- Fluocinolone Acetonide (FA) implant
- Where
- United States
- Sponsor
- The Cleveland Clinic
Macular Degeneration, Central Visual Impairment
Scotoma Perimetry Oculomotor Training
The proposed research is relevant to public health because a greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has potential to benefit millions of individuals…
- Trial name
- SPOT (NCT05456581)
- Testing
- 'Scotoma awareness' Training, Control Training
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Alabama at Birmingham
Sickle Cell Disease
Spectralis HRA+OCT Imaging of the Retina With Autofluorescence in Sickle Cell Disease
To determine the retinal and choroidal thickness in patients with sickle cell disease compared to age, race matched population without sickle cell disease to allow a better understanding of the clinical manifestations of sickle…
- Trial name
- NCT01123369
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Bronchopulmonary Dysplasia
OCTA Evaluation of Retinal Vascularization in Preterm Infants With or Without Bronchopulmonary Dysplasia
Retinal vascularization in humans develops between the 16th and 36th weeks of amenorrhea, in a centrifugal pattern starting from the optic disc.
- Trial name
- OCTA_BRO (NCT07586683)
- Testing
- OCT Angiography
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Epiretinal Membrane, Age Related Macular Degeneration
Intravitreal Anti-VEGF in Exudative AMD With Epiretinal Membranes
Study designed to evaluate the effect of significant ERM on the visual and anatomic outcomes of intravitreal anti-VEGF therapy for eAMD.
- Trial name
- NCT01846351
- Volunteers
- 16 people
- Sponsor
- New England Retina Associates
Diabetic Retinopathy
Medico-economic Comparison Between Treatment with Panretinal Photocoagulation by Laser in 1 Session Versus 4 Sessions in Diabetic Retinopathy
Despite the fact that the efficacy of a single session of multispot laser has been demonstrated in the treatment of patients with diabetic retinopathy as compared with four sessions of single-spot laser, the management of…
- Trial name
- LIGHT (NCT03242031)
- Testing
- monospot panretinal photocoagulation, multispot panretinal photocoagulation
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cognitive Change
Yoga Training and Retinal Vasculature With Parkinson's Disease
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function in persons with Parkinson's disease.
- Trial name
- NCT06194227
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional Yoga
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Miami
X-Linked Retinitis Pigmentosa
Natural History of the Progression of X-Linked Retinitis Pigmentosa
The objective of the study is to gain a better understanding of disease progression over time in participants with X-linked retinitis pigmentosa (XLRP).
- Trial name
- XOLARIS (NCT04926129)
- Testing
- Other: Assessments
- Where
- 22 sites in United States, Canada and 5 more
- Volunteers
- 201 people
- Sponsor
- NightstaRx Ltd, a Biogen Company
Retinopathy of Prematurity
The Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP)
To evaluate the effect of ambient light reduction on the incidence of retinopathy of prematurity (ROP).
- Trial name
- NCT00000156
- Testing
- Goggles, Ambient Light Reduction
- Where
- 3 sites in United States
- Sponsor
- National Eye Institute (NEI)
Stargardt Disease, Stargardt Disease 1
Prescreening Study to Identify Potential Stargardt Participants for ACDN-01 Clinical Trials (STARPATH)
This is an observational prescreening study. Individuals who are eligible for prescreening will undergo testing procedures that may be used to determine eligibility in ACDN-01 clinical trials.
- Conditions
- Stargardt Disease, Stargardt Disease 1, Cone Rod Dystrophy, Juvenile Macular Degeneration
- Trial name
- NCT06445322
- Testing
- Prescreening Assessments
- Where
- 9 sites in United States
- Volunteers
- 50 people
- Sponsor
- Ascidian Therapeutics, Inc
Macular Degeneration, Age-Related Macular Degeneration
Development of a Device to Measure Dark Adaptation
Age Related Macular Disease (AMD) is easily the leading cause of blindness in older people in developed countries. It affects between 30 and 50 million individuals worldwide, with around 30% of the over 65's showing early signs…
- Trial name
- NCT02090751
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Ovarian Cancer
- Trial name
- NCT00003173
- Testing
- filgrastim, thiotepa, autologous bone marrow transplantation
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Retinovascular Disease
Intravitreal Avastin Versus Intravitreal Avastin and Triamcinolone in Central Retinal Vein Occlusion(CRVO)
In this study we intend to evaluate and compare the outcomes of intravitreal avastin versus avastin and triamcinolone on improving the visual acuity and macular edema and late complications of CRVO like NVI and NVG.
- Trial name
- NCT00370630
- Testing
- Avastin (Bevacizumab) and triamcinolone
- Where
- Iran
- Volunteers
- 15 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Macular Edema
Efficacy and Safety of VEGF Trap Eye in Diabetic Macular Edema (DME) With Central Involvement
To determine the efficacy of intravitreally (IVT) administered VEGF Trap-Eye on the best-corrected visual acuity (BCVA) assessed by the early treatment diabetic retinopathy study (ETDRS) chart in subjects with diabetic macular…
- Trial name
- VIVID EAST (NCT01783886)
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321), Macular Laser Photocoagulation
- Where
- 25 sites in China, Hong Kong and 2 more
- Volunteers
- 381 people
- Sponsor
- Bayer
Rhegmatogenous Retinal Detachment
Corneal Endothelial Cell Loss After Pneumatic Retinopexy for the Repair of Primary Rhegmatogenous Retinal Detachment
There are multiple ways to treat retinal detachment, the aim of this study is to compare the amount of corneal endothelial cell loss after pneumatic retinopexy in comparison to vitrectomy.
- Trial name
- NCT02185469
- Testing
- Pneumatic retinopexy, vitrectomy, sulfur hexafluoride (SF6)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cytomegalovirus Retinitis, HIV Infections
An Open Study of Foscarnet Treatment First Episode CMV-Retinitis in AIDS Patients
To evaluate the safety and efficacy of foscarnet induction therapy for treatment of AIDS patients experiencing their first episode of cytomegalovirus (CMV) retinitis.
- Trial name
- NCT00002039
- Testing
- Foscarnet sodium
- Where
- United States
- Sponsor
- Astra USA
Diabetic Retinopathy, Type 1 Diabetes
Effect of Omega-3 Fatty Acids on Eye Blood Vessels in Type 1 Diabetes
This double-blind, placebo-controlled randomized clinical trial evaluates the effects of omega-3 fatty acid supplementation on retinal vascular structure and function in children and adolescents with type 1 diabetes.
- Conditions
- Diabetic Retinopathy, Type 1 Diabetes, Omega 3 Fatty Acids
- Trial name
- O3RETINA (NCT07255326)
- Testing
- Omega 3 Fish Oil supplements
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- University of Faisalabad
Open-Angle Glaucoma
Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma
Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow may have distinctive patterns in medically well-controlled open-angle glaucoma patients.
- Trial name
- IOPMG (NCT00481208)
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
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