Clinical trials: Revascularization
Stroke
Gadolinium-Enhanced Extracranial MRA Prior to Mechanical Thrombectomy Is Not Associated With an Improved Procedure Speed
The objective was to assess if performing a pre-intervention gadolinium-enhanced extracranial magnetic resonance angiogram (MRA) in addition to intracranial vascular imaging was associated with improved thrombectomy time metrics.
- Trial name
- NCT03971552
- Testing
- gadolinium-enhanced extracranial magnetic resonance angiogram
- Volunteers
- 912 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Intermittent Claudication
Person-centered Follow up and Health Promotion Program After Revascularization for Intermittent Claudication
The overall aim of the study is to evaluate a nurse-led intervention (person-centered follow up and health promotion) program in comparison to standard follow up for patients treated with surgical or endovascular…
- Trial name
- FASTIC (NCT03283358)
- Testing
- Person-centered follow up
- Where
- 2 sites in Sweden
- Volunteers
- 213 people
- Sponsor
- Karolinska Institutet
Coronary Artery Diseases
BIOTRONIK - BIOFLOW-III Registry French Satellite
For the majority of Coronary Artery Disease (CAD) treatment with Percutaneous Transluminal Coronary Angioplasty (PTCA) provides high initial procedure success.
- Trial name
- NCT02273648
- Testing
- Drug Eluting Stent (DES)
- Where
- 50 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Biotronik France
Peripheral Arterial Disease
Outcomes of Rivaroxaban and Aspirin in PAD After Endovascular Revascularization
Assessing the outcomes of using Rivaroxaban plus Aspirin in patients with Lower Extremity Peripheral Arterial Disease after Endovascular Revascularization
- Trial name
- NCT05308030
- Testing
- Rivaroxaban and Aspirin
- Volunteers
- 100 people
- Sponsor
- Assiut University
Chronic Coronary Syndrome, Myocardial Ischemia
Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome
We will establish a cohort of 570 symptomatic chronic coronary syndrome patients undergoing 15O-water PET and assess their symptoms through repeated questionnaires.
- Conditions
- Chronic Coronary Syndrome, Myocardial Ischemia, Stable Angina, Coronary Artery Disease
- Trial name
- PERFORM-CCS (NCT05865600)
- Testing
- Optimization of guideline-directed medical therapy, Immediate referral for invasive coronary angiography, 3-months delayed referral for invasive coronary angiography
- Where
- Denmark
- Volunteers
- 570 people
- Sponsor
- Gødstrup Hospital
Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI
FFR Driven Complete Revascularization Versus Usual Care in NSTEMI Patients and Multivessel Disease
To compare FFR guided complete revascularization during the index procedure with usual care in non-STEMI patients with multivessel disease.
- Conditions
- Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI, Fractional Flow Reserve, Myocardial, Myocardial Revascularization
- Trial name
- SLIM (NCT03562572)
- Testing
- Ischemia driven revascularization, Usual care group
- Where
- 9 sites in Czechia, Hungary and 1 more
- Volunteers
- 476 people
- Sponsor
- Zuyderland Medisch Centrum
Coronary Disease, Percutaneous Coronary Intervention
Fractional Flow Reserve and Instantaneous Free-wave Ratio Revascularization Strategies in Women
A real world study to evaluate outcomes in women based on guideline identified fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) cutoffs for ischemia (ischemia defined as FFR ≤ 0.80 and iFR ≤ 0.89).
- Conditions
- Coronary Disease, Percutaneous Coronary Intervention, Exercise Test, Myocardial Perfusion Imaging
- Trial name
- FiRST (NCT04599192)
- Testing
- No study intervention
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Yale University
Pulp Necroses
Revascularization of Immature Anterior Necrotic Teeth
The object of this study is to compare the effect of Calcium Hydroxide and Di-antibiotic paste as intracanal disinfectants in the 1st visit of revascularization of necrotic immature permanent anterior teeth.
- Trial name
- NCT03504332
- Testing
- intracanal disinfection in revascularization
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cairo University
Heart Failure With Reduced Ejection Fraction, Ischemic Cardiomyopathy
Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction
Randomized trial to compare clinical outcomes between revascularization versus medical treatment alone in patients with ischemic cardiomyopathy and left ventricular dysfunction.
- Trial name
- RESTORE-PCI (NCT05828719)
- Testing
- Percutaneous coronary intervention
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Samsung Medical Center
Peripheral Arterial Disease, Diabetes Mellitus
The Impact of Diabetes on REvascularization
The presence of foot symptoms at rest or tissue necrosis in patients with peripheral artery disease is a medical urgency and represents a state of critical limb ischemia (CLI) where the risk of amputation, in the absence of…
- Trial name
- TIDE (NCT03085524)
- Testing
- Platelet function testing, Vascular ultrasonography
- Where
- 43 sites in United States, Canada and 1 more
- Volunteers
- 215 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 2 With Acute Coronary Syndrom
Predictors of Coronary Revascularization Outcomes in Type 2 Diabetic Patients With Acute Coronary Syndrome
To explore the metabolic outcomes of PCI versus CABG in diabetic patients presented by ACS. To verify the diagnostic and prognostic value of speckle tracking echocardiography in early detection of MACE after ACS in diabetic…
- Trial name
- NCT04354740
- Testing
- with percutaneous coronary intervention (PCI) are with new-generation drug-eluting stents (DES)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Erectile Dysfunction, Coronary Artery Disease
Erectile and Ejaculatory Function Following Coronary Revascularization
This observational, cross-sectional study aims to compare erectile and ejaculatory function between men with a history of coronary revascularization and men without known coronary artery disease.
- Conditions
- Erectile Dysfunction, Coronary Artery Disease, Ejaculation Disorders
- Trial name
- NCT07878260
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Coronary Artery Disease, Myocardial Revascularization
Nursing Intervention for Adaptation After Myocardial Revascularization
Introduction: Myocardial revascularization is an essential procedure for patients with cardiovascular disease. Its recovery in the outpatient setting involves significant challenges for both the patient and the caregiver.
- Conditions
- Coronary Artery Disease, Myocardial Revascularization, Postoperative Recovery After Cardiac Surgery, Nursing Care
- Trial name
- ADAPT-CABG (NCT07576569)
- Testing
- Nursing Intervention Program, Usual Care
- Where
- Colombia
- Volunteers
- 40 people
- Sponsor
- Universidad de la Sabana
Coronary Disease
Comparison Between 2 Bilateral Internal Thoracic Artery Coronary Artery Bypass Grafting Configurations
Bilateral internal thoracic arteries (BITA) demonstrated superiority over other grafts to the left coronary system in terms of patency and survival benefit.
- Trial name
- NCT01666366
- Testing
- Coronary artery bypass grafting
- Where
- Belgium
- Volunteers
- 304 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Visceral Artery Aneurysm, Mesenteric Artery Ischemia
European Multicentre Study of Long-term Results Following Visceral Arteries Revascularization: the E-VisAR Study
Visceral arteries pathologies are a broad-spectrum of conditions with an extremely low incidence, estimated at 9.2% and 6.2% per 100,000 inhabitants for chronic and acute mesenteric ischemia, respectively, and 0.01-0.2% for…
- Conditions
- Visceral Artery Aneurysm, Mesenteric Artery Ischemia, Renal Artery Aneurysm, Renal Artery Stenosis
- Trial name
- E-VisAR (NCT06913530)
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Myocardial Infarction
Evaluation of a Strategy Guided by Imaging Versus Systematic Coronary Angiography in Elderly Patients With Ischemia
The WHO predicts that cardiovascular morbi-mortality will increase by 120-137% within 20 years due to the aging population. Myocardial infarction without ST segment elevation (NSTEMI) is the most common form of infarction.
- Trial name
- EVAOLD (NCT03289728)
- Testing
- Stress single photon emission CT (SPECT) or Stress ultrasound with dobutamine (DSE), Cornorary angioplasty
- Where
- 2 sites in France
- Volunteers
- 588 people
- Sponsor
- University Hospital, Grenoble
Coronary Artery Disease, Coronary Artery Disease Progression
Disease Characteristics of R-CAD
The present case-control study is designed to investigate the disease characteristics of rapidly progressive coronary artery disease (R-CAD) by comparing the demographics, clinical features, lab results, imaging findings, and…
- Conditions
- Coronary Artery Disease, Coronary Artery Disease Progression, Coronary Stenosis, Coronary Restenosis
- Trial name
- NCT07239921
- Testing
- Protocol-defined Examinations and Evaluations
- Volunteers
- 52 people
- Sponsor
- Peking Union Medical College Hospital
Angina Pectoris
Angiogenesis in Women With Angina Pectoris Who Are Not Candidates for Revascularization
The purpose of this study is to determine whether a one-time intracoronary infusion of Ad5FGF-4 is effective in reducing the time to onset myocardial ischemia as measured by exercise treadmill testing and improving myocardial…
- Trial name
- AWARE (NCT00438867)
- Testing
- Ad5FGF-4
- Where
- 47 sites in United States
- Volunteers
- 300 people
- Sponsor
- Cardium Therapeutics
Peripheral Artery Disease
Contrast Ultrasound Assessment of Perfusion Changes After Peripheral Artery Revascularization
This study represents an important step to validate the use of contrast-enhanced ultrasound (CEU) as a clinical research tool that can be used as a biologic readout of new therapies for Peripheral Artery Disease (PAD), and as a…
- Trial name
- NCT02877563
- Testing
- Contrast ultrasound perfusion imaging of the limb
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Critical Limb Ischemia, Extracellular Matrix Alteration
Matrix Metalloproteinases in Patients With Critical Limb Ischemia Undergoing Surgical Revascularization
In the present study the investigators will evaluate MMPs. serum levels variations in patients affected by critical limb ischemia, before and after lower limb surgical revascularization through venous or prosthetic bypass.
- Conditions
- Critical Limb Ischemia, Extracellular Matrix Alteration, Peripheral Revascularisation
- Trial name
- ROMAMETA (NCT02388867)
- Testing
- Polytetrafluoroethylene (PTFE) bypass grafting., Autogenous vein bypass grafting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro