Clinical trials: Septic
Severe Sepsis, Septic Shock
Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections
In this study the investigators aim to test if C-reactive protein (CRP)or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht severe sepsis and septic shock.
- Trial name
- NCT00934011
- Testing
- C-reactive protein guided antibiotic therapy, Procalcitonin guided antibiotic therapy
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Federal University of Minas Gerais
Septic Cardiomyopathy, Septic Shock
The Preventive Effect of Shenfu Injection on Myocardial Dysfunction in Sepsis
This study focuses on improving heart function in patients with life-threatening blood infections (septic shock). When the body fights severe infections, the heart sometimes struggles to pump blood effectively, which can lead to…
- Trial name
- SHIELD Trail (NCT06898723)
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 440 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Toxic-Shock Syndrome, Sepsis
Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial
Toxic Shock Syndrome (TSS) a severe condition with high morbidity and mortality results from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen toxins are the main causative agents.
- Trial name
- NCT02971670
- Testing
- rTSST-1 Variant Candidate Vaccine
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Biomedizinische Forschungs gmbH
Septic Shock
Adjuvant Therapy With CytoSorb in Refractory Septic Shock
This prospective randomized single center study investigates to what extent the removal of elevated cytokine levels by hemoadsorption has a positive effect on the treatment of patients in septic shock by stabilizing the…
- Trial name
- ACYSS (NCT04013269)
- Testing
- CytoSorb-Therapy
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Healthy Subjects
A Study in Healthy Subjects to Assess the Safety and Tolerability of a 120-hour Continuous Infusion of M6229
This is a Phase I, single-center, randomized, single-blind, placebo-controlled study in healthy subjects assessing the safety, tolerability and pharmacokinetic profile of three different dose levels of M6229 when administered…
- Trial name
- NCT07285603
- Testing
- M6229
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Matisse Pharmaceuticals
Septic Shock
Fluid Responseveness in Sepsis and Its Correlation to CVP
Introduction Aim of the work Patients and methods Type of study Exclusion criteria Statistical analysis Research ethics Reference
- Trial name
- NCT05612529
- Testing
- US , Echocardiography
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Septic Shock
Methylene Blue as a Third-line Vasopressor in Septic Shock
A randomized, prospective study comparing ProvayBlue® to standard care with multiple sympathomimetic vasopressors.
- Trial name
- NCT04089072
- Testing
- Methylene Blue, Phenylephrine
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Carilion Clinic
Septic Shock
Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock
This study evaluates if improvement of renal resistive index when mean arterial pressure increase (at 65 mmHg to 85 mmHg) in early phase of septic shock is predictive of better renal survival.
- Trial name
- SEPSIR (NCT04281277)
- Testing
- increase of mean arterial pressure at 80-85 mmHg., increase of mean arterial pressure at 65-70 mmHg.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Angers
Septic Shock
Microcirculation After MAP Increase in Septic Shock Patients With Previous Hypertension
The optimal levels of mean arterial pressure that must be achieved in septic shock are subject of debate. Studies tried to correlate blood pressure increase in patients with septic shock with microcirculation.
- Trial name
- NCT02519699
- Testing
- norepinephrine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
ARDS, Septic Shock
Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation
to evaluate the effect of use of bronchoscopy in the course of sepsis, weaning from the ventilator, duration of ICU stays and mortality rate in septic patients with ARDS due to VAP.
- Trial name
- NCT06072222
- Testing
- Meropenem, bronchoscopy, ventilator
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- King Abdul Aziz Specialist Hospital
Sepsis, Septic Shock
Health Related Quality of Life After Intensive Care for Sepsis, a National Cohort Study.
The study aims to map the health-related quality of life (HRQoL) after intensive care for Sepsis with the hypothesis that it will be lower than that in the general population.
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe
- Trial name
- NCT06368336
- Volunteers
- 210,484 people
- Sponsor
- Uppsala University Hospital
Septic Shock
Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock
Preliminary studies show that giving a "cocktail" of intravenous vitamin C, vitamin B1, and steroids to critically ill patients with septic shock may dramatically improve mortality in those patients.
- Trial name
- NCT03828929
- Testing
- Vitamin C, Normal saline
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Septic Shock
Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock
Despite best therapy efforts, sepsis and septic shock are associated with mortality rates of up to 40%. This clinical trial will determine the benefit of exogenous Angiotensin II versus norepinephrine (conventional care)…
- Trial name
- MANTRA (NCT06746753)
- Testing
- Angiotensin II, Norepinephrine
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Wake Forest University Health Sciences
Sepsis, Mechanical Ventilation
Clinical Study of Esketamine in Patients With Sepsis Undergoing Invasive Mechanical Ventilation
Sepsis is a syndrome of acute organ dysfunction resulting from dysregulated host responses to infection, often leading to severe complications such as acute lung injury and ARDS.
- Trial name
- NCT07556172
- Testing
- Esketamine, Remifentanil
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Septic Shock
Comparison of Manual PAOP and Automatic PAOP (Smart Wedge)
The pulmonary artery catheter (Swan-Ganz) is a standard tool in intensive care for measuring and monitoring the pulmonary artery occlusion pressure (PAOP).
- Trial name
- SMART-PAPO (NCT07703592)
- Testing
- Swan-Ganz IQ™, Smart Wedge
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Sepsis, Septic Shock
Adrenomedullin and Outcome in Severe Sepsis and Septic Shock
The aim of this prospective study is to assess the prognostic value of bioactive plasma adrenomedullin (ADM) in 600 patients with severe sepsis or septic shock in an international multicenter study and to validate the findings…
- Trial name
- AdrenOSS (NCT02393781)
- Where
- 24 sites in Belgium, France and 3 more
- Volunteers
- 596 people
- Sponsor
- Sphingotec GmbH
Septic Shock
Anisodamine Critically Ill SeptIc Shock
Anisodamine has been widely used in China for its pharmacological effect on improving microcirculation during shock. It has been reported that anisodamine is effective in reducing mortality rate in children with meningitis.
- Trial name
- ACIdoSIS (NCT02442440)
- Testing
- anisodamine
- Where
- 15 sites in China
- Volunteers
- 355 people
- Sponsor
- Jinhua Central Hospital
Esketamine, Sepsis
Immunoinflammatory Regulation of Esketamine in Septic Patients
Studies have shown that excessive systemic inflammatory response and concomitant immunosuppression are the main cause of early death in patients with sepsis.
- Conditions
- Esketamine, Sepsis, Inflammatory Response, Immunosuppression
- Trial name
- NCT04843982
- Testing
- Esketamine hydrochloride
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Septic Shock, Multiple Organ Failure
Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical Study
Septic shock is defined as a subset of sepsis with severe metabolism alterations, leading to organ failure. Septic shock is associated with a high mortality, around 40% according to the SEPSIS 3 definition.
- Trial name
- MEFDASE (NCT04288635)
- Testing
- Whole blood samples
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Angers
Sepsis, Disseminated Intravascular Coagulation
An Observational Study to Learn About the Occurrence of Disseminated Intravascular Coagulation Among Adults With Sepsis in Japan
This is an observational study in which data already collected from people with sepsis (blood poisoning) and/or disseminated intravascular coagulation (DIC) are studied.
- Trial name
- NCT06373159
- Testing
- No study intervention
- Where
- Japan
- Volunteers
- 5,740 people
- Sponsor
- Bayer
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