Clinical trials: Sham-controlled
Trigger Points
Effect of Thoracic Manipulation on Latent Trigger Point
The aim of this study is to investigate the effect of one session thoracic manipulation on pressure pain threshold and rhomboid muscle strength in healthy individuals with latent trigger point.
- Trial name
- NCT05554887
- Testing
- Thrust manipulation
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Atopic Dermatitis
Antipruritic Effect of Acupuncture in Patients With Atopic Dermatitis
Introduction: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease inducing poor quality of life. Its conventional treatments often cause unsatisfactory relief and adverse effects in long-term application.
- Trial name
- NCT02844452
- Testing
- Acupuncture
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kyunghee University
Cognitive Dysfunction ( MMSE < 24 )
Effects of tDCS on Cognitive Function in Older Adults With Subjective Cognitive Decline: Randomized Sham-Controlled Trial
This randomized, double-blind, sham-controlled clinical trial evaluates the effects of transcranial direct current stimulation (tDCS) using the Sooma Oy device on cognitive function in older adults with Subjective Cognitive…
- Trial name
- TDCSCOGSCDTRIA (NCT07531888)
- Testing
- Transcranial Direct Current Stimulation
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Autónoma del Estado de Hidalgo
Healthy
Pilot Study for the Effects of Transcranial Magnetic Stimulation on the Brain Using an Electronic Medical Device
This study is a randomized, double-blind, and sham-controlled trial to examine the effects of transcranial magnetic stimulation on the brain of health individuals.
- Trial name
- NCT02932085
- Testing
- Neurostar TMS Therapy System, NeuroStar XPLOR System
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Aging
Brain Stimulation and Cognitive Training in Healthy Older Adults
The aim of this study is to investigate whether a tDCS-accompanied intensive cognitive training of working memory leads to performance improvement in healthy older individuals.
- Trial name
- TrainStim (NCT03838211)
- Testing
- Anodal tDCS, Intensive cognitive training
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Impacted Third Molar Tooth
Effects of Photobiomodulation Conditioning in Impacted Third Molars
The removal of third molars should be considered to avoid problems such as cysts and other complications. Surgical intervention with the manipulation of oral tissues has the undesirable postoperative effects of pain, trismus…
- Trial name
- NCT05344222
- Testing
- Infrared LED, Similar device - Infrared ED
- Where
- Brazil
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Healthy Adults
Trancranial Pulse Stimulation on Anterior Insula Cortex and Dorsal Anterior Cingulate Cortex
Transcranial pulse stimulation (TPS) is a newly developed non-invasive brain stimulation (NIBS) technique from Austria \& Germany with highly promising applicability in neuropsychiatric disorders.
- Trial name
- NCT06635161
- Testing
- Trancranial pulse stimulation (without a stand-off device), Transcranial pulse stimulation (with Neurology stand-off device)
- Where
- Hong Kong
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Healthy Control Subjects
Impact of Spaced iTBS on Plasticity in the Motor Cortex
The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using intermittent theta-burst stimulation (iTBS) on brain plasticity in healthy, right-handed individuals aged 18 to 50 years.
- Trial name
- STEP-MC (NCT06735794)
- Testing
- Compressed iTBS, Spaced iTBS
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation
Accelerated Transcranial Magnetic Stimulation in Treatment-Resistant Depressed Patients
Depression is the leading cause of disability worldwide and around 800,000 suicides occur each year. According to the World Health Organization, major depressive disorder (MDD) is expected to be the leading cause of the global…
- Conditions
- Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation, Accelerated Protocol, Sham-controlled
- Trial name
- NCT06783361
- Testing
- Transcranial Magnetic Stimulation with figure-eight coil
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Vagus Nerve Stimulation, Autonomic Nervous System
Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters
This randomized, sham-controlled, crossover study investigates the acute autonomic effects of transcutaneous cervical vagus nerve stimulation (tcVNS) applied at five different frequencies (0 Hz/sham, 10 Hz, 25 Hz, 50 Hz, 100 Hz)…
- Conditions
- Vagus Nerve Stimulation, Autonomic Nervous System, Heart Rate, Blood Pressure
- Trial name
- AVNS-DRC (NCT07274332)
- Testing
- Pulsetto FIT™ - tcVNS 10 Hz, Pulsetto FIT™ - tcVNS 25 Hz, Pulsetto FIT™ - tcVNS 50 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Diaphragm, Respiratory Muscles
Ultrasound Evaluation of Changes in Diaphragm Induced by Osteopathic Manipulative Techniques
A wide number of osteopathic techniques focusing on diaphragm have been proposed but, although systematically and efficiently used, there is a general lack of evidences able to clarify how and to which extent osteopathic…
- Conditions
- Diaphragm, Respiratory Muscles, Osteopathic Medicine, Ultrasonography
- Trial name
- NCT02801058
- Testing
- Osteopathic manipulative treatment
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Scarlata, Simone, M.D.
Sham-controlled, Healthy Adult Participants
Stimulation Evaluation for Neuromodulation Sensory Effects
The goal of this clinical trial is to learn how healthy adults experience low-level electrical stimulation delivered through the study device. This study is not intended to treat a medical condition.
- Conditions
- Sham-controlled, Healthy Adult Participants, Electric Stimulation
- Trial name
- SENSE (NCT07777991)
- Testing
- Intersectional Short-Pulse (ISP) Stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Adraxe Corp.
Functional Neurological Disorder, Motor Symptoms
Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)
This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.
- Trial name
- TMS-VNS (NCT07710677)
- Testing
- Vagial Nerve Stimulation (VNS) active stimulation
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Chronic Rhinitis
RhinAer Procedure for Treatment of Chronic Rhinitis Study
The purpose of this study is to compare the RhinAer procedure with radiofrequency (RF) energy to sham procedure for treatment of chronic rhinitis.
- Trial name
- RHINTRAC (NCT04533438)
- Testing
- RhinAer Stylus
- Where
- 13 sites in United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Aerin Medical
Experimental Dental Pain
Mechanisms of Acupuncture Analgesia on Experimental Dental Pain - A Psychophysical Study (Phase1)
The investigators will assess the effects of manual acupuncture on experimental dental pain in 36 healthy subjects by means of subjective pain intensity ratings and pain-specific autonomic nervous system (ANS) reactions.
- Trial name
- MAC-DENT1 (NCT02589418)
- Testing
- Acupuncture, No Acupuncture
- Where
- 2 sites in Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cerebral Palsy
Task-oriented Game Therapy Using Enhances Functions in Children With Cerebral Palsy.
Cerebral Palsy is an umbrella definition that refers to a disorder that occurs after a problem affecting a person's brain functions and has symptoms such as sensory, motor and mental deficits.
- Trial name
- NCT06071182
- Testing
- Task-oriented Fruit ninja game
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Erzurum Technical University
Aging, Inflammation
Boosting Exercise cApaCity With autOnomic Neuromodulation
Background: Exercise performance is a key predictor for healthy ageing. Laboratory and clinical data have shown strength of a nerve called the vagus nerve, which is lost during age-related disease processes, determines exercise…
- Conditions
- Aging, Inflammation, Cardiovascular Diseases
- Trial name
- BEACON (NCT05619107)
- Testing
- Active Transauricular nerve stimulation
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Insomnia, Sleep
Vestibular Nerve Stimulation to Improve Sleep
A randomized, double blind sham controlled clinical trial to evaluate the efficacy of vestibular nerve stimulation (VeNS) compared to a sham control a as a means of improving sleep as measured by ISI scores and EEG recordings The…
- Conditions
- Insomnia, Sleep, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT04219566
- Testing
- VeNS
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Neurovalens Ltd.
Sleep, Fatigue
The Effect of Acupressure on the Sleep Quality and Fatigue
This research aims to determine the effect of acupressure applied to nurses actively working in internal clinics on sleep quality and fatigue during the COVID-19 pandemic process.
- Trial name
- NCT04923061
- Testing
- Acupressure
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mersin University