Clinical trials: Sham-controlled
Stress Reaction, Stress Related Disorder
Research on the Effects of Combined Neurostimulation Protocols on Stress
The study examines the effects of the combined use of two different non-invasive brain stimulation (NIBS) techniques targeting the DLPFC on stress reactivity and recovery.
- Conditions
- Stress Reaction, Stress Related Disorder, Major Depressive Disorder
- Trial name
- NCT03722095
- Testing
- active tDCS, iTBS
- Where
- Belgium
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Ghent
Cognition, Healthy Volunteers
Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Cognition, Dual-Task Performance, and Interoceptive Accuracy
This study aims to determine the simultaneous effects of transcutaneous auricular vagus nerve stimulation (taVNS) at two frequencies (30 Hz and 100 Hz) compared to sham stimulation on cognitive functions, dual-task performance…
- Trial name
- NCT07897175
- Testing
- taVNS 30 Hz, taVNS 100 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Toros University
Nociceptive Pain
Cervical/Thoracic Neuromodulation and Nociceptive Processing
Several studies have demonstrated that direct currents delivered through the skin at the level of the low-thoracic spinal cord can influence spinal cord function.
- Trial name
- MICROVOLT2 (NCT06367777)
- Testing
- cervical a-tsDCS, thoracic a-tsDCS
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Healthy Volunteers (HV)
Electrical Nerve Stimulation During Sleep for Memory Consolidation
The purpose of this study is to investigate the effects of transcutaneous electrical nerve stimulation (eTNS) applied during sleep on memory consolidation and brain-body physiological coupling.
- Trial name
- NCT07658274
- Testing
- 120 Hz Transcutaneous Electrical Nerve Stimulation, 2 Hz Transcutaneous Electrical Nerve Stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xidian University
Auricular Stimulation
Mastoid taVNS-fMRI
The purpose of this study is to explore whether stimulating different outer parts of the ear using a non-invasive form of ear stimulation called transcutaneous auricular vagus nerve stimulation (taVNS) will create different brain…
- Trial name
- NCT06518356
- Testing
- Transcutaneous Auricular Neurostimulation (tAN)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Hypertension
Blood Pressure and Cardiac Autonomic Adaptations to Isometric Exercise Training
A randomized, sham-controlled intervention measuring the effects of isometric exercise training (IET) on blood pressure and cardiac autonomics.
- Trial name
- NCT05025202
- Testing
- Isometric exercise training
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Canterbury Christ Church University
Irritable Bowel Syndrome With Constipation
Electro-acupuncture for Irritable Bowel Syndrome With Constipation
The aim of the clinical trial is to evaluate the efficacy and safety of electro-acupuncture for irritable bowel syndrome with constipation (IBS-C) patients.
- Trial name
- NCT06219707
- Testing
- Acupuncture needles
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Aging, Inflammation
Boosting Exercise cApaCity With autOnomic Neuromodulation
Background: Exercise performance is a key predictor for healthy ageing. Laboratory and clinical data have shown strength of a nerve called the vagus nerve, which is lost during age-related disease processes, determines exercise…
- Conditions
- Aging, Inflammation, Cardiovascular Diseases
- Trial name
- BEACON (NCT05619107)
- Testing
- Active Transauricular nerve stimulation
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Binge Eating, Obesity
The Effects of Repetitive Transcranial Magnetic Stimulation in Obese People With BED
The presence of binge eating (BE) is a core feature of bulimic syndromes. Binge eating disorder (BED) is a new category in DSM-5 highly associated with higher body mass index (BMI).
- Trial name
- NCT02180984
- Testing
- TMS
- Where
- Brazil
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Cocaine Use, Cocaine Dependence
Effect of rTMS on Neurotrophines Levels in CUD
Brief Summary: Background: Cocaine use disorders (CUD) is a multifactoral disease, involving several brain areas. One of the most investigated is the Dorsolateral Prefrontal Cortex (DLPFC) involved in impulsiveness control.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Abuse, Neurotropism
- Trial name
- BDNFcoca (NCT05824221)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Fat Burn
rPMS and Radiofrequency for Abdominal Toning and Reduction of Subcutaneous Fat
This study will evaluate the clinical efficacy and safety of a simultaneous treatment by high power magnet and radiofrequency energy for toning of abdomen and reduction of subcutaneous fat.
- Trial name
- NCT04587986
- Testing
- BTL-899
- Where
- 3 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Knee Osteoarthritis
Evaluation of NMES Therapy for Pain Relief Associated With Knee Osteoarthritis
A roll-over study of the current CM-2019 trial to assess the same preplanned outcomes of CM-2019 at 14 weeks.
- Trial name
- NCT04367597
- Testing
- Home-based Neuromuscular Electrical Stimulation (NMES) therapy
- Where
- 5 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- CyMedica Orthopedics, Inc
Vagus Nerve Stimulation, Autonomic Nervous System
Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters
This randomized, sham-controlled, crossover study investigates the acute autonomic effects of transcutaneous cervical vagus nerve stimulation (tcVNS) applied at five different frequencies (0 Hz/sham, 10 Hz, 25 Hz, 50 Hz, 100 Hz)…
- Conditions
- Vagus Nerve Stimulation, Autonomic Nervous System, Heart Rate, Blood Pressure
- Trial name
- AVNS-DRC (NCT07274332)
- Testing
- Pulsetto FIT™ - tcVNS 10 Hz, Pulsetto FIT™ - tcVNS 25 Hz, Pulsetto FIT™ - tcVNS 50 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
tDCS, Golf Specific Performance
Wearable tDCS and Acute Golf Shot Performance
Transcranial direct current stimulation (tDCS) has been investigated as an ergogenic aid for two decades, but most sport evidence comes from laboratory stimulators operated by experimenters.
- Conditions
- tDCS, Golf Specific Performance, Athletic Performance Enhancement, Healthy Volunteer
- Trial name
- NCT07839910
- Testing
- Wearable transcranial direct current stimulation (Halo Sport 2)
- Where
- China
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Sport
Alopecia
"iRestore" Light Therapy Apparatus
Current effective therapies of pattern hiar loss are topical minoxidil and oral finasteride. Finasteride is an inhibitor of type 2 5α-reductase and will cause hypospadias in male infant if taken or touched by pregnant woman.
- Trial name
- NCT03331003
- Testing
- low level light therapy, non-LLLT wavelength group
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sleep, Fatigue
The Effect of Acupressure on the Sleep Quality and Fatigue
This research aims to determine the effect of acupressure applied to nurses actively working in internal clinics on sleep quality and fatigue during the COVID-19 pandemic process.
- Trial name
- NCT04923061
- Testing
- Acupressure
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mersin University
Healthy Volunteers (HV), Transcranial Photobiomodulation
Frequency-Dependent Effects of Transcranial Photobiomodulation With Same Peak Irradiance on Cortical Excitability and Fine Motor Performance
This study investigates the frequency-dependent neuromodulatory effects of transcranial photobiomodulation (tPBM) over the primary motor cortex (M1) on cortical excitability and fine motor performance in healthy young adults.
- Conditions
- Healthy Volunteers (HV), Transcranial Photobiomodulation, Cortical Excitability
- Trial name
- NCT07752602
- Testing
- Transcranial Photobiomodulation
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Upper Extremity Function, Motor Performance
Placebo Effect of Immediate Kinesio Taping on Upper Extremity Performance in Healthy Adults
This study investigates whether Kinesio Taping has immediate effects on upper extremity performance in healthy adults and whether these effects may be influenced by placebo mechanisms.
- Conditions
- Upper Extremity Function, Motor Performance, Healthy Volunteers, Perceived Function
- Trial name
- KT-PLACEBO (NCT07515183)
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istinye University
Clinical Study - RCT
Paraspinal Stimulation in Treating MPS
To test the hypothesis that the effect of either multiple deep intramuscular stimulation therapy [(DIMMST: trigger point deep dry needling (TrP-DDN) is combined with paraspinal deep intramuscular stimulation (PDIMS) and needle…
- Trial name
- DIMMST (NCT01708343)
- Testing
- DIMMST
- Where
- 3 sites in Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Healty Volunteers
Acute Effects of Thoracolumbar Fascia Myofascial Release on Cortical Activity
This study will examine the immediate (acute) effects of a single myofascial release technique applied to the thoracolumbar fascia on brain activity in healthy young adults aged 18-25.
- Trial name
- MFR-EEG (NCT07728617)
- Testing
- Thoracolumbar Fascia Myofascial Release (Pilat MIF Crossed-Hands Technique)
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Hitit University