Clinical trials: Short-chain Fatty Acids
Obesity, Diabetes
Gut Microbiota, Short Chain Fatty Acids, and Adiposity Across The Epidemiological Transition
The objective of this study is to define associations between gut microbiota, SCFAs and obesity in populations spanning the epidemiologic transition, and explore mechanisms by which these factors may independently and…
- Trial name
- NCT03378765
- Testing
- Diet and physical activity monitoring
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Loyola University
Satiety Hormones, Short-chain Fatty Acids
The Impact of Short-Chain Fatty Acids on Gut Hormone Release After Delivery in the Small and Large Intestine of Healthy Volunteers
The goal of this crossover study is to evaluate the impact of short-chain fatty acids (SCFA) on the gut hormone release after administration in the small intestine or colon in healthy participants.
- Conditions
- Satiety Hormones, Short-chain Fatty Acids, Satiety and Appetite, Intestinal Absorption
- Trial name
- Histine (NCT06686888)
- Testing
- SCFA, microcristalline cellulose
- Where
- Belgium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Inflammation, Stress
Mapping the Effect of (neuro)inflammation on Stress Sensitivity in the Brain of Healthy Men
The goal of this interventional study is to determine the effects of inflammation on stress responses in the brain of healthy men.
- Conditions
- Inflammation, Stress, Healthy Volunteer
- Trial name
- INFLAMES (NCT06620679)
- Testing
- Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Kidney Diseases
LONGitudinal Multi-omics Phenotyping of KIDney Function Alteration
This is a longitudinal observation of kidney function, immune system and gut microbiota before and 24 weeks after a live kidney transplantation conducted in donor and recipient pairs living in the same household.
- Trial name
- NCT05570929
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Eating Disorders in Adolescence, Eating Disorders in Children
A Study of the Intestinal Microbiota in Children and Adolescents With Eating Disorders. A Perspective From Psychoneuroimmunology
The goal of this observational study is to learn if behavioral and psychological factors are associated with the intestinal microbiota composition and function in children and adolescents with eating disorders (ED).
- Trial name
- PSYNIGED (NCT07066033)
- Where
- 2 sites in Spain
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Esther Nova
Healthy, Gastrointestinal Discomfort
Effects of an Encapsulated Calcium Butyrate Dietary Supplement on Gut Health
The primary objective of this single-arm pilot study is to investigate the effects of an encapsulated calcium butyrate dietary supplement on gastrointestinal (GI) health outcomes in healthy adults, including GI symptom severity…
- Trial name
- NCT06397482
- Testing
- Encapsulated Calcium Butyrate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kemin Foods LC
Diet Habit
Chestnut Consumption on Modulation of Gut Microbiota and Metabolic Parameters
The chestnut tree (Castanea sativa Mill.) is a species widely cultivated in Portugal, which is a major producer of chestnuts. Nuts are nutritionally interesting, not only because of their content of vitamins, minerals, and…
- Trial name
- CULTIVAR (NCT05705960)
- Testing
- Chestnut
- Where
- Portugal
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Aerobic Endurance, Metabolism
Effect of Short-chain Fatty Acids on Aerobic Endurance
Randomized, double-blind, placebo-controlled crossover study designed to determine the effects of increasing colonic short-chain fatty acid (SCFA) content on aerobic endurance in healthy adults, and to identify underpinning…
- Trial name
- NCT06054607
- Testing
- High-amylose maize starch+acetate/butyrate, Low-amylose maize starch
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Dietary Fiber
Fiber Fermentation, and Short Chain Fatty Acid Kinetics and Utilization Inside the Gut and Systemic Circulation
Nowadays there is a strong interest in optimising human health through manipulation of non-digestible carbohydrates (NDC). NDC can be used as substrates by gut microbiota, which results in NDC degradation, production of…
- Trial name
- NCT04499183
- Testing
- fructo- and galacto-oligosaccharides
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Diet Habit
Arbutus Berry - Intervention Study to Evaluate the Modulation of Intestinal Microbiota and Metabolic Parameters
The tree that produces the arbutus berry, the strawberry tree, scientific name Arbutus unedo L., belongs to the family of Ericaceae.
- Trial name
- F4F (NCT05810922)
- Testing
- arbutus berry
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Child Development
Soy Exposure on Bone Development and Gut Microbiota
In this project, the investigators aim to investigate the effects of soy consumption at early life on the development of gut microbiota and bone growth.
- Trial name
- NCT05213780
- Testing
- No intervention is involved
- Where
- Hong Kong
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Psoriasis
INulin-type Fructans-induced Gut Microbiota Modulation Impact on GUT-SKIN Axis Parameters in Psoriasis
There is increasing evidence of a strong, bidirectional correlation between the gut and the skin, that associates gastrointestinal health with skin homeostasis and allostasis.
- Trial name
- INGUTSKIN (NCT05971992)
- Testing
- Chicory-derived inulin-type β-fructans, Maltodextrin
- Where
- 2 sites in Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Polish Academy of Sciences
Healthy
Towards a Food Ingredient Clinically Proven to Benefit Gut Health: Novel RG-I Variants
The aim of this study is to determine, quantify and understand the potential prebiotic effects of RG-I variants via microbiota modulation. The anti-inflammatory potential effects of these variants will also be investigated.
- Trial name
- NUTRIGUT (NCT06081972)
- Testing
- Maltodextrin, Chicory RG-I, Carrot RG-I
- Where
- Sweden
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Chronic Obstructive Pulmonary Disease, Aging
Fiber Metabolism in Chronic Obstructive Pulmonary Disease
The impact of fiber intake on short chain fatty acid (SCFA) metabolism has not been studied in subjects suffering from COPD. The purpose of this study is to compare changes in SCFA metabolism after inulin vs.
- Trial name
- NCT04459156
- Testing
- Fiber Inulin
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Exercised Induced Asthma, Asthma
The Effects of Prebiotics on Gut Bacterial Parameters, Immune Function & Exercise-Induced Airway Inflammation.
The current study aims to explore the role of prebiotic supplementation in adults with and without Asthma/Exercise-Induced Bronchoconstriction (A/EIB).
- Trial name
- NCT02872675
- Testing
- HOST-DM059, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Amyotrophic Lateral Sclerosis
Longitudinal Evaluation of Short-Chain Fatty Acid Profiles During the Natural Disease Course and a Mediterranean Diet Intervention in Amyotrophic Lateral Sclerosis Patients
This observational study explored the connection between the gut microbiota and the brain in patients with amyotrophic lateral sclerosis (ALS), specifically the modulation of short-chain fatty acids during disease progression and…
- Trial name
- IMPACT-ALS (NCT07178067)
- Testing
- Mediterranean diet
- Where
- Romania
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Healthy
Human Auto-ethanol Formation and Acetate Signaling
The HotFacets study is a randomized, controlled, cross-over meal study that investigates the acute effects of alcohol consumption on short-chain fatty acids dynamics, energy metabolism, and biomarkers.
- Trial name
- HotFacets (NCT05130619)
- Testing
- Ethanol
- Where
- 2 sites in Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cardiometabolic Risk, Abdominal Obesity
Characterization of Gut Microbiota Composition and Activity After a Daily Supplementation of 4.5 g/Day of ChitinGlucan Fibre During 3 Weeks in At-cardiometabolic Risk Volunteers
The aim of this study is to demonstrate the beneficial effects on gut microbiota composition and activity of the diary intake of insoluble fiber (extract from Aspergillus Niger) for three weeks.
- Trial name
- FITACHITIN (NCT03773900)
- Testing
- Kiotransine (chitin-glucan from aspergillus niger)
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Metabolic Syndrome
ButCoIns GUTS: - Gut Immunological Effects of Resistant Starch and Arabinoxylans in Subjects With Metabolic Syndrome
Dietary fibers including resistent starch, RS, and arabinoxylans, AX, have been shown to have anti-inflammatory effects and to change the composition of the faecal micro flora in the colon.
- Trial name
- NCT01618526
- Testing
- Western Style Diet, Healthy Carbohydrate Diet
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Overweight and Obesity
Gastrointestinal And Metabolic Effects From a Prebiotic, Lifting, and Aerobic iNtervention
This study aims to determine the independent and combined effects of prebiotic fiber supplementation and exercise on the gut microbiome and human health.
- Trial name
- GAMEPLAN (NCT05207488)
- Testing
- Fructooligosaccharides (FOS), Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign