Clinical trials: Skin Closure, active
Scar
Disposable Noninvasive Skin Closure for Promoting Postoperative Wound Healing and Preventing Surgical Skin Scarring
The purpose of this study is to evaluate the efficacy and safety of a disposable noninvasive skin closure device in promoting postoperative wound healing and reducing surgical scar formation.
- Trial name
- NCT07849010
- Testing
- Disposable Noninvasive Skin Closure Device (Shanghai Zhizhong Medical Technology Co., Ltd. Catalog No.: 240430PFF)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Peking University Third Hospital
Leg Ulcers, Leg Ulcers Venous
Vacuum Compression Therapy and Tissue Oxygenation in Chronic Leg Ulcers
Chronic lower limb ulcers, particularly those of venous etiology, are difficult-to-heal wounds that severely affect patients' quality of life. Adequate tissue oxygenation is essential for wound healing.
- Trial name
- NCT07901517
- Testing
- Vacuum Compression Therapy (VCT), Standard Wound Care
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- BTL Industries Ltd.
Allergic Contact Dermatitis, Osteoarthritis, Hip
Rate of Allergic Contact Dermatitis and Cosmetic Outcomes
The patients from the Department of Orthopaedics Center for Joint Replacement will be asked to participate in the study. These patients will be randomized to one of three wound closure products, Sylke adhesive dressing, Exofin…
- Conditions
- Allergic Contact Dermatitis, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT06957444
- Testing
- Sylke Adhesive Dressing, Exofin Skin Glue, Suture Strip Plus
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- West Virginia University
Wound Closure, Wound Care
Safety Study of Microlyte DualGuard
The primary purpose of this research is to evaluate the safety and effectiveness of Microlyte® DualGuard wound dressing in the healing of partial thickness donor site wounds, also known as skin graft donor sites.
- Trial name
- SAGGA (NCT07695688)
- Testing
- Microlyte DualGuard, Allevyn Foam (Standard of Care Control)
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Imbed Biosciences
Cesarean Delivery
Post-Operative Cesarean Section Cosmesis
Given the high numbers of cesarean deliveries being performed today, there has been interest in optimizing surgical techniques. Several recent reviews have summarized the evidence for various steps of cesarean delivery, but…
- Trial name
- NCT06412978
- Testing
- absorbable subcuticular polyglycolic acid staples (INSORB), subcuticular, polyglecaprone suture (Monocryl)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Surgical Wound, Wound Heal
Influence of Sun Protection and Linear Repair of Cutaneous Surgical Defects
The purpose of this study is to determine the potential influence of sun protection on the aesthetic outcome of post-surgical scars following the reconstruction of Mohs micrographic surgery defects via linear repair.
- Conditions
- Surgical Wound, Wound Heal, Wound of Skin, Scar
- Trial name
- NCT05074238
- Testing
- Zinc containing suncreen
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Cesarean Section, Surgical Site Infection
Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions
This study is evaluating whether Steri-Strips® provide additional benefits when used after cesarean section (C-section) surgery.
- Conditions
- Cesarean Section, Surgical Site Infection, Wound Dehiscence, Seroma
- Trial name
- STRIP-CS (NCT07686913)
- Testing
- Steri-Strip™ Skin Closures, Standard Cesarean Wound Closure
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- Riverside University Health System Medical Center
Compare Cosmetic Outcomes of Subcuticular Skin Closure Using Polypropylene and Polyglactin
Polypropylene Versus Polyglactin in Upper Limb Subcuticular Skin Closure
Polypropylene versus Polyglactin in Upper Limb Subcuticular Skin Closure
- Trial name
- NCT07582679
- Testing
- Upper limb wounds subcuticular skin closure with Polypropylene, Upper limb wounds subcuticular skin closure with Polyglactin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Shebin El-Kom Teaching Hospital
Surgical Site Infection
Subcutaneous Lavage in Cesarean Section
The goal of this clinical trial is to learn if antiseptic washing prior to skin closure during cesarean section reduces rates of surgical site infection.
- Trial name
- NCT06454227
- Testing
- Subcutaneous washing, no subcutaneous washing
- Where
- Israel
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Epidermolysis Bullosa (EB)
Efficacy and Safety Study to Evaluate SD-101 in Epidermolysis Bullosa
The upcoming trial is for EB patients is a topically applied whole-body treatment of patients with either Simplex, RDEB or Junctional (nH) ages 1 month to 12 years old at study entry.
- Trial name
- NCT07482787
- Testing
- SD-101 Dermal Cream (6%), Vehicle (SD-101 0%)
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Paradigm Therapeutics
Diabetic Foot Ulcer
Evaluation of Combinational Use of Negative Pressure Wound Therapy (NPWT) for Diabetic Foot Wounds
Singapore has one of the world's highest diabetes-related lower limb amputation rates in the world. Between 2008 - 2017, 4724/5306 (89.0%) of all major amputations and 6656/7227 (92.1%) of all toe/ray amputations performed in…
- Trial name
- NCT06832787
- Testing
- Negative Pressure Wound Therapy, Kerecis, Delayed primary closure with local flap
- Where
- 2 sites in Singapore
- Volunteers
- 75 people
- Sponsor
- Singapore General Hospital
Oral Cancer, Oral Cavity Cancer
Radial Forearm Donor Site Closure
The radial forearm free flap (RFFF) is widely used in head and neck reconstruction. Its thinness, pliability, pedicle length, and vessel size are particularly suited for oropharyngeal and oral cavity reconstruction.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Donor Site Complication
- Trial name
- NCT05740033
- Testing
- Split-Thickness Skin Graft for Radial Forearm Donor Site Closure, Hatchet Flap for Radial Forearm Donor Site Closure
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Diabetic Foot Ulcer (DFU), Ulcer
Evaluating Autologous Platelet-Rich Fibrin Plasma for Chronic Diabetic Foot Ulcers
To prospectively evaluate the safety and efficacy of an Autologous Platelet-Rich Fibrin Plasma system when applied in conjunction with Standard of Care for management of chronic Diabetic Foot Ulcers.
- Conditions
- Diabetic Foot Ulcer (DFU), Ulcer, Wound Closure, Wound Management
- Trial name
- NCT07840378
- Testing
- PRFM, Standard of Care (SoC)
- Volunteers
- 55 people
- Sponsor
- Tiger Biosciences, LLC.
Diabetic Foot Ulcers (DFUs), Diabetic Foot
Miro3D Wound Matrix for Treatment of Diabetic Foot Ulcers
This study is designed to evaluate whether the Miro3D Wound Matrix, when used in addition to standard of care, improves healing outcomes in patients with chronic diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcers (DFUs), Diabetic Foot, Chronic Wounds
- Trial name
- FOCUS 3D (NCT07632001)
- Testing
- Miro3D Wound Matrix, Standard of Care
- Where
- 14 sites in United States
- Volunteers
- 180 people
- Sponsor
- Reprise Biomedical, Inc.
Carpal Tunnel Syndrome, Median Nerve Entrapment
An Absorbable Suture Versus a Non-absorbable Suture in Carpal Tunnel Release, a Randomized Controlled Trial
The study compares two widely used treatments in closing the wound after open carpal tunnel release surgery: absorbable and non-absorbable sutures.
- Trial name
- SUPER (NCT05503719)
- Testing
- Surgical wound closed with an absorbable suture, Surgical wound closed with a non-absorbable suture
- Where
- Finland
- Volunteers
- 116 people
- Sponsor
- Kuopio University Hospital
Hidradenitis Suppurativa (HS)
Pelashield™ PainGuard™ vs Restrata® in HS Surgery
Hidradenitis Suppurativa (HS) is a long-lasting skin condition that causes painful lumps and infections. In severe cases, patients need surgery to remove the affected skin.
- Trial name
- NCT07316192
- Testing
- Pelashield Painguard
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rutgers, The State University of New Jersey
Venous Leg, Venous Leg Ulcer (VLU)
Evaluating the Durability of Closure for Venous Leg Ulcers
The goal of this observational study is to determine the durability of closure for venous leg ulcer subjects that achieved closure in the THOR trial.
- Conditions
- Venous Leg, Venous Leg Ulcer (VLU), Venous Leg Ulcer, Venous Ulcer
- Trial name
- THORSDOTTIR (NCT06697925)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Kerecis Ltd.
Pregnancy
Absorbable Staples Versus Conventional Skin Closure in Women Undergoing Cesarean Delivery
Despite the high numbers of cesareans being performed, scientific evidence behind which surgical techniques are best remains uncertain.
- Trial name
- NCT07167199
- Testing
- Subcuticular monocryl suture, Subcuticular absorbable staple using Insorb device
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- Inova Health Care Services
Pressure Sore
NPWTi on Closure of Chronic Pressure Sores
The primary objective of this study is to assess the effectiveness of the Negative Pressure Wound Therapy system with instillation therapy (NPWTi) on closure of chronic pressure sores.
- Trial name
- NCT05598398
- Testing
- V.A.C.Ulta™ Negative Pressure Wound Therapy System, Standard of Care (Wet-to-dry dressings)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Northwestern University
Pressure Ulcer (PU), Pressure Ulcers, Bedsores, Decubitus Ulcer
Effectiveness and Costs of Pressure Ulcer Treatment and the Quality of Life of Patients With Pressure Ulcers Receiving Home-Based and Institutional Care
A study aimed at comparing the effectiveness of treatment, costs, and quality of life of patients with pressure ulcers in home care and institutional care.
- Conditions
- Pressure Ulcer (PU), Pressure Ulcers, Bedsores, Decubitus Ulcer, Quality of Life, INSTITUTIONAL CARE
- Trial name
- NCT07763106
- Testing
- residential home care treatment, long-term care treatment
- Where
- 3 sites in Poland
- Volunteers
- 80 people
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice