Clinical trials: Spontaneously Breathing
Respiratory Distress Syndrome, Surfactant Administration by Aerosolization
Does The Surfactant Administration by Aerosolization Effective?
The present study was designed to evaluate, in premature babies with RDS breathing spontaneously, the efficacy of combined treatment with nasal continuous positive airway pressure (CPAP) and aerosolized surfactant.
- Trial name
- NCT02825953
- Testing
- surfactant, nasal continuous positive airway pressure, non-invasive intermittent positive-pressure ventilation
- Volunteers
- 75 people
- Sponsor
- nihat demir
Child
Pediatric Diaphragm Thickness Trial
The evaluation of diaphragm function in ventilated patients is not easy. One option is to use esophageal pressure (Pes) measurements but recently, diaphragmatic ultrasound has proven itself as a useful tool in this setting.
- Trial name
- PeDia (NCT04882553)
- Testing
- Diaphragmatic echography, Measurement of esophageal pressure, Registration of respiratory mechanics
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University Hospital, Antwerp
Hypovolemia
Arterial Pressure Derived Dynamic Parameters to Detect Preload Responsiveness in Spontaneously Breathing Patients
The management of septic shock patients includes the infusion of fluids, however fluids may be deleterious if the patient does not respond by increasing cardiac output.
- Trial name
- NCT06480942
- Testing
- Detection of preload responders by a PLR test
- Where
- France
- Volunteers
- 39 people
- Sponsor
- CHU de Reims
Transcervical Resection of Endometrium, Transcervical Resection of Fibroids
Comparing Two Types of Sedation to Gynaecological Patients
The primary endpoint is to investigate the difference in pain between patients who receive deep sedation with spontaneous breathing versus patients who receive general anesthesia.
- Conditions
- Transcervical Resection of Endometrium, Transcervical Resection of Fibroids, Transcervical Resection of Polyp
- Trial name
- NCT01412632
- Testing
- Remifentanil, propofol and citanest
- Where
- Denmark
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypovolemia, Surgery
Focused Assessed Echocardiography to Predict Fluid Responsiveness
The aims of the study are: 1. To evaluate the feasibility of echocardiography monitoring in postoperative unit; 2. To assess diagnostic value of different focussed echocardiography parameters to define fluid responsiveness for…
- Conditions
- Hypovolemia, Surgery, Hypotension
- Trial name
- fluidres (NCT03044405)
- Testing
- Fluid challenge, Focused transthoracic echocardiography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Coronavirus Infection, Oxygen Deficiency
Prone Positioning in Spontaneously Breathing Nonintubated Covid-19 Patient: a Pilot Study
The prone position consists of placing the patient on his or her stomach with the head on the side, during sessions lasting several hours a day and could help spontaneous ventilate the patient.
- Trial name
- ProCov (NCT04344106)
- Testing
- Prone positioning
- Where
- France
- Volunteers
- 25 people
- Sponsor
- ELHARRAR Xavier
Anesthesia
The Effect of Pressure Support Ventilation on Spontaneous Breathing in Anesthetized Subjects
The aim of this prospective study is to determine the effect of pressure support ventilation (PSV) on minute alveolar ventilation (MAV) and end-tidal carbon dioxide (ETCO2) in anesthetized spontaneously breathing subjects by…
- Trial name
- NCT02385305
- Testing
- Pressure support ventilation by anesthesia machine (Apollo, Dräger)
- Sponsor
- Massachusetts General Hospital
ICU Patients, Intubation
Pulmonary and Ventilatory Effects of Trigger Modulation in Intubated ICU
Pressure support ventilation allows intubated ICU patients to breathe spontaneously. Among specific settings, the adjustment of the trigger value (or threshold for triggering the ventilator) has not been explored to date.
- Conditions
- ICU Patients, Intubation, Spontaneously Breathing, Pulmonary Function
- Trial name
- Trigger (NCT04041817)
- Testing
- Trigger setting of pressure support ventilation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Covid-19 Infection
Awake Pronation for Covid-19 Treatment
Observational studies have shown that prone position (PP) in spontaneously breathing patients, may improve oxygenation in individuals with Acute Respiratory Failure (ARF), due to Covid-19 infection.
- Trial name
- NCT04667286
- Testing
- Prone Position (PP)
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Infiltration, Extravasation
Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Spontaneously Breathing Adult Volunteers
Vascular access in patients carries a significant risk of accidental extravasation of intravenous (IV) fluids and medications with the potential for tissue injury.
- Trial name
- NCT01458873
- Testing
- sodium bicarbonate 4.2%, diluted sodium bicarbonate 2.1%, normal saline
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Anesthesia
Comparison of Minimal Fresh Gas Requirements of Baby EAR and Jackson Rees Anesthetic Circuit
The investigators invented the baby enclosed afferent reservoir anesthesia circuit (Baby EAR) which could be used safely in children between 5 and 20 kg, using a fresh gas flow of 2.5 and 3 L/min in the spontaneous breathing and…
- Trial name
- NCT02167269
- Testing
- Baby EAR
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Khon Kaen University
Respiratory Failure
Humidity Therapy for Spontaneously Breathing Tracheostomy Patients
The goal of the study is to compare the safety and efficacy of molecular water and bland aerosol therapy (particulate water) in providing adequate humidity to the inspired gas of spontaneously breathing tracheostomy patients.
- Trial name
- NCT02686489
- Testing
- Heated humidification, Cool bland aerosol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rush University Medical Center
Fluid Responsiveness
Fluid Responsiveness in Spontaneously Ventilating Patient
The purpose of this study is to find out if non-invasive dynamic parameters can predict fluid responsiveness in spontaneous breathing patients.
- Trial name
- NCT04574011
- Testing
- Passive leg raising
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Intensive Care Unit Syndrome, Muscle Weakness
Effect of Critical Patients Mobilization on Respiratory and Peripheral Muscle Strength and Functional Capacity.
To analyze changes on respiratory muscle strength, peripheral and functional capacity of critically ill patients with clinical and surgical etiology, breathing spontaneously and bedridden, within 48 hours of admission to the…
- Trial name
- NCT02919085
- Testing
- Early ambulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal de Pernambuco
Healthy
Evaluation of Breathing Effort in Spontaneously Breathing Subjects
The aim of the research project is to evaluate the breathing effort using the Work of Breathing (WoB) and Pressure-Time Product (PTP) parameters, depending on the increasing flow resistance.
- Trial name
- NCT04051645
- Testing
- Breathing through a system with adjustable flow resistance
- Where
- Czechia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Acute Respiratory Failure, Pediatric Respiratory Distress Syndrome
Closed-loop Synchronization Versus Conventional Synchronization
A prior research indicated that asynchrony between the patient and ventilator occurred in 33 percent of 19,175 breaths, and was seen in every patient.
- Trial name
- CHESTSIPP (NCT05731024)
- Testing
- close-loop synchronization controller with SPONT mode, Conventional synchronization settings with SPONT mode
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Respiratory Failure, Ventilatory Failure
Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19 Infection
This study uses the AirGo band to monitor changes in tidal ventilation in spontaneously breathing patients with COVID-19 associated respiratory failure.
- Conditions
- Respiratory Failure, Ventilatory Failure, COVID-19, Pneumonia
- Trial name
- NCT04356443
- Testing
- AirGo Respiratory Monitor
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Premature Birth
Prophylactic DR-CPAP on Late Preterm Infants Born by C-section: an RCT
A Pragmatic Randomized Controlled Pilot Trial to Evaluate the Impact of Early Prophylactic Continuous Positive Airway Pressure with or without Supplemental Oxygen in Spontaneously Breathing Late Preterm Newborn Infants Born by…
- Trial name
- PLANT (NCT05204719)
- Testing
- Prophylactic Delivery Room Continuous Positive Airway Pressure
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Idiopathic Pulmonary Fibrosis
Inspiratory Effort and Respiratory Mechanics in Spontaneously Breathing Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis: a Matched Control Study
Idiopathic pulmonary fibrosis is a life-threatening lung disease characterized by progressive deterioration of lung function and a median survival time of 3-5 years from diagnosis.
- Trial name
- IERATIC (NCT05313672)
- Volunteers
- 20 people
- Sponsor
- Roberto Tonelli
Respiratory Distress Syndrome
Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients
Study to test the hypothesis that aerosolized Infasurf can decrease the need for intubation and instillation of liquid surfactant to the airway.
- Trial name
- NCT03058666
- Testing
- Aerosolized Calfactant, Solarys
- Where
- 22 sites in United States
- Volunteers
- 477 people
- Sponsor
- ONY