Clinical trials: Stroke, Chronic
Stroke, Deficit in Manual Activities
Improving Bi-manual Activities in Stroke Patients With Application of Neuro-stimulation
Noninvasive brain stimulations (NIBS) will be used in healthy volunteers and in chronic stroke patients to improve bimanual activities and motor learning.
- Trial name
- NCT02308852
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Chronic Dysphagia, Multiple Sclerosis
A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia
This study will compare an implant with the technique of sensory training to determine which method may improve the ability to swallow and reduce the risk of choking.
- Conditions
- Chronic Dysphagia, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT00376506
- Testing
- Neurostimulation device for dysphagia, External vibrotactile device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Injuries, Spinal Cord, CVA (Cerebrovascular Accident)
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.
- Conditions
- Injuries, Spinal Cord, CVA (Cerebrovascular Accident), Traumatic Brain Injury, MS (Multiple Sclerosis)
- Trial name
- NCT04530955
- Testing
- Prometra II Programmable Pump - Flowonix Medical
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Culicchia Neurological Clinic
Stroke, Gait, Hemiplegic
Validity of a Belt Mounted Accelerometer to Assess Walking Measures in Patients With Chronic Stroke
The aim of this study is to validate the G-walk for several gait parameters, tested against a gold standard three dimensional camera system.
- Trial name
- NCT04288960
- Testing
- Gwalk accelerometer walking trials
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Winchester
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Severe Stroke, Acute Stroke
Stroke Rehabilitation With Exoskeleton-assisted Gait.
Gait recovery is one of the main goals of post-stroke rehabilitation where robotic-assisted practice has shown positive outcomes. However, literature lacks of clinical studies on exoskeleton-supported gait rehabilitation.
- Conditions
- Severe Stroke, Acute Stroke, Chronic Stroke, Cerebrovascular Disorders
- Trial name
- EKSOGAIT (NCT03395717)
- Testing
- Exoskeleton-Assisted Gait Training
- Where
- 4 sites in Italy
- Volunteers
- 162 people
- Sponsor
- IRCCS San Raffaele Roma
Stroke
Effects of Combined Treatment by Botulinum Toxin and Lokomat® on Walking Ability in Chronic Stroke
75% patients in the chronic phase of a stroke keep walking disabilities. Focal spasticity in the paretic lower limb frequently causes these walking disabilities, and the gold standard treatment is intramuscular injection of…
- Trial name
- Lokomat (NCT03659266)
- Testing
- Robotic walking rehabilitation by Lokomat®, Conventional walking rehabilitation
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Kidney Disease, Diabetes (DM)
Moxie Self-Management and Education Support Program
Health education and self-management support are key facilitators of health behaviours. Moxie is a mixed media, self-management, education and support program for Albertans living with cardiovascular-related chronic conditions.
- Conditions
- Chronic Kidney Disease, Diabetes (DM), Heart Disease, Stroke
- Trial name
- NCT07280325
- Testing
- Moxie SMES Letters, Facilitated Relay Letter
- Volunteers
- 9,000 people
- Sponsor
- University of Calgary
Traumatic Brain Injury
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy
This study aims to determine the safety of HB-adMSC infusion and treatment effects of HB-adMSC infusion on brain structure, neurocognitive/functional outcomes, and neuroinflammation after subacute and chronic neurological injury…
- Trial name
- NCT04063215
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hope Biosciences LLC
Stroke, Spasticity, Muscle
Effects of PNF and Static Stretching on Architecture and Viscoelastic Properties of Hemiplegic Elbow
The patients who were diagnosed with stroke in governmental/university/private hospitals, and who needed rehabilitation because of the increased flexor tone in the elbow joint, decreased range of motion and/or decreased function…
- Trial name
- NCT05626790
- Testing
- Exercise, PNF Stretching, Prolonged Stretching
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istanbul University - Cerrahpasa
Stroke
Therapeutic Exercise Program of Physiotherapy Using Telerehabilitation on Chronic Phase Stroke Patients
Stroke is the main cause of physical disability in adults in Catalonia. Despite this, there is a lack of evidence on physiotherapy interventions during the chronic phase of the pathology.
- Trial name
- NCT06944197
- Testing
- Standard Care Guidance Group, Home-Based Therapeutic Exercise - Document Group, Home-Based Therapeutic Exercise - Telerehabilitation Group
- Volunteers
- 75 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Stroke Gait Rehabilitation
The Effect of Blood Flow Restriction Training on Gait Performance on Forty Chronic Stroke Patients Evaluated by STEADYs Gait Assessment.
The goal of this observational study is to learn about the effects of blood flow restriction on gait performance on stroke patients.
- Trial name
- BFRT (NCT07575620)
- Testing
- Blood flow restriction training, Resistance Exercises for lower limb affected
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Proprioceptive Disorders, Balance; Distorted
Targeted Ankle Proprioceptive Training Improves Balance, Gait, and Functional Mobility in Chronic Stroke Survivors
Stroke is a leading cause of long-term disability, with balance and gait deficits affecting >80% of survivors and increasing fall risk.
- Conditions
- Proprioceptive Disorders, Balance; Distorted, Stroke Sequelae
- Trial name
- NCT07420608
- Testing
- Gait training
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- Iqra National University
Hemianopsia
Therapeutic Effects of Transcranial Alternative Current Stimulation (tACS) in Chronic Post Stroke Hemianopia
Background: The most common visual field deficit after retro-chiasmatic lesions is homonymous hemianopia (HH), defined as the impossibility of seeing the contralesional visual hemisphere without ocular injury.
- Trial name
- HEMIANOTACS (NCT04043689)
- Testing
- tACS (transcranial Alternate Current Stimulation)
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke
Paired Associative Stimulation in Stroke
Stroke is the third most common cause of death in the United States after heart disease and cancer, and the leading cause of long-term disability.
- Trial name
- NCT02586597
- Testing
- Transcranial magnetic stimulation & median nerve stimulation
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Chronic Ischemic Stroke
A Safety and Tolerability Study of Human Forebrain Neural Progenitor Cells Injection (hNPC01) in Subjects With Chronic Ischemic Stroke
The principal aims of the clinical investigation involve assessing the safety profile and MTD of human forebrain neural progenitor cells (hNPC01) administered at escalated doses via single-dose intracerebral injection to subjects…
- Trial name
- NCT06299033
- Testing
- hNPC01
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Hopstem Biotechnology Inc.
Post Stroke, Post-Traumatic Headache
Aerobic Exercise and Transcranial Low Laser Therapy in Patients With Central Nervous System Injury
Objective of this protocol will be to evaluate the parameters related to the function of the musculoskeletal and cardiorespiratory system, through a rehabilitation and training program for people with acquired central nervous…
- Conditions
- Post Stroke, Post-Traumatic Headache, Spinal Injuries, Cerebral Palsy, Spastic
- Trial name
- NCT03751306
- Testing
- Transcranial Photobiomodulation, Cardiorespiratory Rehabilitation
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Universidade do Vale do Paraíba
COPD, Congestive Heart Failure
Use of Non Invasive Hemodynamic Cardiovascular Monitoring to Evaluate Emergency Department Patients
This study is an observational prospective pilot trial that utilizes finger cuff non invasive hemodynamic monitoring (NexfinHD Monitor) to assess 4 different groups (CHF/COPD, Trauma, Sepsis, Stroke) of patients on arrival to the…
- Conditions
- COPD, Congestive Heart Failure, Trauma, Sepsis
- Trial name
- NCT00851214
- Testing
- NexfinHD Monitor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Stroke Sequelae, Gait Disorders, Neurologic
Efficacy of Trans-spinal Magnetic Stimulation on Functional Mobility in Chronic Stroke Patients
The goal of this clinical trial is to learn if trans-spinal magnetic stimulation works to treat gait disorders in chronic stroke adults. It will also learn about the safety of trans-spinal magnetic stimulation.
- Conditions
- Stroke Sequelae, Gait Disorders, Neurologic, Stroke
- Trial name
- NCT06593184
- Testing
- Trans-spinal magnetic stimulation
- Where
- 3 sites in Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Pernambuco
Cerebrovascular Accident
Task-Oriented Aerobic Exercise Training in Chronic Stroke Patients
The study is designed to investigate (1) the effects of task-oriented aerobic exercise training on cardiorespiratory fitness, cerebral blood flow, oxygenation, functional performance, and physical activity in patients with…
- Trial name
- NCT00931671
- Testing
- Exercise training
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
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