Clinical trials: Usual Care
Obesity, Morbid, Ventilator-Induced Lung Injury
Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon
This is a research study to determine if identifying an optimal level of positive end-expiratory pressure (PEEP) targeted specifically to individualized patient characteristics will shorten the time on the ventilator.
- Conditions
- Obesity, Morbid, Ventilator-Induced Lung Injury, Respiratory Failure
- Trial name
- PROP OPEN (NCT03951064)
- Testing
- Esophageal balloon, Intervention Spontaneous Breathing Trial (SBT) and Extubation, Control Spontaneous Breathing Trial and Extubation
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
Pregnancy
Outpatient Foley Catheter Compared to Usual Inpatient Care for Labor Induction
Induction of labor, or causing labor to start before it otherwise starts spontaneously, is sometimes necessary as pregnancy progresses to ensure the safety of both mother and infant.
- Trial name
- NCT02546193
- Testing
- Foley catheter, Misoprostol
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Diabetes Type 2
Evaluation of a Closed-loop Insulin Delivery System at Home With Tailored Home Care Services in Poorly Controlled Type 2 Diabetes Patients (T2D)
Closed-loop insulin delivery system has the potential to improve the condition of many poorly controlled insulin-treated Type 2 Diabetes (T2D) patients.
- Trial name
- CLOSEAP+ (NCT04233229)
- Testing
- t:slim X2 with Control-IQ, home healthcare services, usual care for daily insulin treatment
- Where
- 10 sites in France
- Volunteers
- 43 people
- Sponsor
- Air Liquide Santé International
Hemophilia A
Study Evaluating Safety Of Patients Switching To ReFacto AF In Usual Care Settings
The study will be investigating safety in patients who switch to ReFacto AF from ReFacto and other Factor VIII products.
- Trial name
- NCT00884390
- Testing
- moroctocog alfa (AF-CC) (ReFacto AF), Laboratory tests
- Where
- 74 sites in Austria, Belgium and 12 more
- Volunteers
- 208 people
- Sponsor
- Pfizer
Diffuse Apneic Oxygenation
EmergeNcy Department Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation
To determine the impact, if any the application of oxygen during the apnea period of rapid sequence intubation has on patients being intubated in the emergency department.
- Trial name
- ENDAO (NCT02737917)
- Testing
- Oxygen, Standard of care
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- New York City Health and Hospitals Corporation
Depression in Adolescence
Evaluation of MoodRing on Improving the Quality of Depression Management in Adolescents
The MoodRing intervention is a mobile application for adolescents, parents, and an accompanying web-based clinician portal which enables adolescents to monitor their mood through the use of passively collected smartphone data.
- Trial name
- TECH-E (NCT05376358)
- Testing
- MoodRing App, Usual Care
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Ana Radovic
Musculoskeletal Pain, Mental Health Issue
Work And Vocational advicE Study - Effectiveness of Adding a Brief Vocational Support Intervention to Usual Primary Care
Maintaining the population's fitness for work is a priority for the UK Government. People with poor health often struggle at work and take sick leave. Work brings financial, social and health benefits.
- Conditions
- Musculoskeletal Pain, Mental Health Issue, Mental Health Disorder, Other Physical Health Condition
- Trial name
- WAVE (NCT04543097)
- Testing
- Vocational Support
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Keele University
Hypertension, Hypercholesterolemia
Caduet vs Usual Care in Subjects With Hypertension and Additional Risk Factors
To investigate whether a Caduet based treatment strategy might result in greater reduction in total cardiovascular risk as compared to usual care in subjects with hypertension and additional risk factors.
- Trial name
- CRUCIAL (NCT00407537)
- Testing
- Amlodipine besylate/atorvastatin calcium single pill combination
- Where
- 125 sites in Costa Rica, Croatia and 18 more
- Volunteers
- 1,531 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis
Structured Mobile Technology Based Lifestyle Program vs Usual Care for Patients With Non-alcoholic Fatty Liver Disease
This study will look at physical activity and nutrition in patients with non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).
- Trial name
- NCT03839082
- Testing
- Usual Care then FitBit, FitBit then Usual Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Michigan
Hemophilia A
Study Evaluating Refacto For Pharmacovigilance
The purpose of this study is to investigate the effectiveness and safety of treatment with ReFacto under conditions of routine therapy. Furthermore a continuous benefit/risk assessment will be done.
- Trial name
- NCT00195442
- Testing
- Moroctocog alfa
- Where
- 26 sites in Austria, Germany
- Volunteers
- 288 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Type 2 Diabetes Mellitus, Cardiovascular Disease
Efficacy and Safety in Patients With Type 2 Diabetes Mellitus and Cardiovascular Disease
This study is carried out to assess whether dapagliflozin improves glycemic control, decreases fasting plasma glucose levels, body weight and blood pressure when added to patient's existing medications and how it compares with…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Disease, Inadequate Glycaemic Control
- Trial name
- NCT01042977
- Testing
- Dapagliflozin
- Where
- 135 sites in United States, Argentina and 8 more
- Volunteers
- 964 people
- Sponsor
- AstraZeneca
Gestational Diabetes Mellitus
Randomized Translational Study to Examine the Effects of Shared Care in Management of Gestational Diabetes
Research question (s)/hypothesis: 1. . The effectiveness of the shared care management of gestational diabetes mellitus; 2. . The cost-effectiveness of the shared care management; 3. . Its sustainability
- Trial name
- NCT01565564
- Testing
- Shared glycaemic control care within the local three-tier's antenatal care network
- Where
- China
- Volunteers
- 948 people
- Sponsor
- Tianjin Women and Children's Health Center
Hypertension
Ambulatory vs Office BP Management Usual Care for Diagnosing and Managing Hypertension: A Pilot Study
The purpose of this study is to compare the effectiveness of ambulatory blood pressure monitoring to usual care (blood pressure measurement in the office) in diagnosing and managing hypertension.
- Trial name
- NCT02121041
- Testing
- Amlodipine, Chlorthalidone, Losartan
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Anthony J Viera, MD, MPH
Smoking
A Pilot Randomized Controlled Trial of Financial Incentives, Text Messaging, and Usual Care for Homeless Smokers
The QUIT (Quitting with Usual Care, Incentives, and Technology) Smoking Study is a 3-arm pilot randomized controlled trial that will test the effect of 2 different experimental smoking cessation interventions relative to a…
- Trial name
- QUIT (NCT02565381)
- Testing
- Transdermal nicotine patch, In-person smoking cessation counseling, Contingent financial rewards for smoking abstinence
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Massachusetts General Hospital
Psoriasis
Observational Study Evaluating Etanercept (Enbrel®) In Subjects With Plaque-Type Psoriasis In Usual Care Settings
This prospective observational cohort study will assess the average duration of the drug free interval between etanercept treatment cycles in usual care settings in Germany.
- Trial name
- NCT00708708
- Testing
- etanercept (Enbrel®)
- Where
- Germany
- Volunteers
- 926 people
- Sponsor
- Pfizer
HEMOPHILIA B
Safety and Efficacy of Benefix in Patients With Hemophilia B in Usual Care Settings in China
The purpose of this post-approval study is to evaluate the safety and efficacy of Benefix in subjects with hemophilia B in usual care settings in China.
- Trial name
- NCT02336178
- Testing
- Benefix
- Where
- 16 sites in China
- Volunteers
- 70 people
- Sponsor
- Pfizer
HPV Vaccines
Effectiveness of SMS (Short Message Service) Text Messaging in Increasing Adherence to Gardasil
Human papillomavirus (HPV) is the most common sexually transmitted disease among adolescent females in the United States. Our primary objective is to determine if Short Message Service (SMS) text message reminders increase…
- Trial name
- CHAT (NCT01276184)
- Testing
- SMS Text Message
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Advance Care Planning
Integrated Multidisciplinary Patient and Family Advance Care Planning Trial
The purpose of this study is to compare ways to engage sick patients and their family members in Advance Care Planning (ACP) discussions.
- Trial name
- IMPACT (NCT03609658)
- Testing
- Nurse Navigator Pathway, Usual Care
- Where
- 9 sites in United States
- Volunteers
- 146 people
- Sponsor
- Wake Forest University Health Sciences
Trapeziometacarpal Arthritis
The Effect of Review of a Decision Aid Prior to the Appointment on Decisional Conflict Compared to Usual Care in the Treatment of Trapeziometacarpal (TMC) Arthritis
The investigators plan a prospective randomized controlled study that compares whether the use of a decision aid results in different scores on variables reflective of the decision-making process, behavior, health outcomes…
- Trial name
- NCT03181724
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Obesity, Type2 Diabetes
Cardiovascular Outcomes in Bariatric Surgery Patients With Type 2 Diabetes
The objective of the analysis was to evaluate the relationship between bariatric surgery and cardiovascular outcomes in obese patients with type 2 diabetes.
- Conditions
- Obesity, Type2 Diabetes, Bariatric Surgery Candidate
- Trial name
- NCT03955952
- Testing
- Bariatric Surgery
- Where
- United States
- Volunteers
- 91,700 people
- Sponsor
- The Cleveland Clinic