Clinical trials: Vaginal Surgery
Vaginal Surgery, Laparoscopic Surgery
Improved Intra-operative Safety From Optimal Selection of Anti-slip Surface
To identify the best surface to minimize the risk of intra-operative slipping when placed in Trendelenburg position. The outcomes of interest are to minimize the amount of movement from predefined anatomic landmarks and maximize…
- Trial name
- NCT03573557
- Testing
- Pink Pad, Bean Bag, Gel Pad
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Case Comprehensive Cancer Center
Bacterial Vaginoses
A Randomized Controlled Trial of Treatment of Bacterial Vaginosis
This is a double-blinded, placebo controlled, multi-center randomized trial of 482 pregnant women who are diagnosed with Bacterial Vaginosis (BV) in the late 3rd trimester (>34 weeks).
- Trial name
- NCT04578015
- Testing
- Metronidazole
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Ohio State University
Pelvic Organ Prolapse Vaginal Surgery, Platelet Rich Plasma Injection
The Effects of Platelet Rich Plasma Adjuvant to Type I/III Collagen Ratio, Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Pelvic Organ Prolapse Repair
The goal of this clinical trial is to analyze the effect of Platelet Rich Plasma (PRP) Adjuvant To Type I/III Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair.
- Trial name
- POP PRP MMP (NCT07150442)
- Testing
- POP surgery and PRP injection
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Andalas University
Prolapse, Vaginal Vault
Transvaginal Mesh vs. Laparoscopic Colposacropexy- Study
The main objective of the study is to compare subjective efficacy of trans vaginal mesh and laparoscopic colposakropexy (CSP) in women with an apical prolapse.
- Trial name
- TVM vs LCSP (NCT04478747)
- Testing
- TVM, Colposacropexy
- Where
- Finland
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Pelvic Organ Prolapse, Perioperative/Postoperative Complications
Preoperative Gabapentin vs Placebo for Vaginal Prolapse Surgery
This study will recruit women scheduled to undergo vaginal apical suspension surgery (either uterosacral ligament suspension or sacrospinous ligament fixation) with or without other prolapse or anti-incontinence procedures.
- Trial name
- NCT05658887
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Joseph Kowalski
Vaginal Prolapse
Surgical Outcomes of Vaginal Prolapse Repair With Elevate
The purpose of this study is to evaluate outcomes in patients having vaginal prolapse repair with the Elevate prolapse repair kit and compare these outcomes to patients who had a repair with Prolift. .
- Trial name
- NCT01190618
- Where
- United States
- Volunteers
- 417 people
- Sponsor
- Larry Sirls
Obese, Surgery
Does BMI Influence Pain Follow vNOTE Surgery
Overweight and obesity are increasing dramatically worldwide and contribute substantially to the burden of morbidity and mortality.
- Conditions
- Obese, Surgery, Pain, Postoperative
- Trial name
- BMIVNOTES (NCT05230407)
- Testing
- Visual analog scale (VAS) assesment of pain
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Pelvic Organ Prolapse, Surgery
Comparison of Two Apical Repair Methods in Women Undergoing Repairs for Prolapse
To date no study has determined prospectively which technique is superior to prevent recurrent Pelvic Organ Prolapse (POP) after vaginal hysterectomy- a major unmet clinical need.
- Conditions
- Pelvic Organ Prolapse, Surgery, Quality of Life, Complication
- Trial name
- NCT03113513
- Testing
- fixation of the vaginal apex
- Where
- Austria
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Pelvic Organ Prolapse
Tranexamic Acid in Vaginal Reconstructive Surgery
Tranexamic acid (TXA) has been demonstrated to reduce blood loss in trauma, orthopedic, cardiac, and plastic surgeries in numerous well-designed and adequately powered studies.
- Trial name
- TEXAS (NCT06419075)
- Testing
- Tranexamic acid, Vasopressin, NaCl 0.9%
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Uterovaginal Prolapse
Study of Uterine Prolapse Procedures - Randomized Trial
The primary purpose of this randomized clinical trial is to compare the effectiveness and safety of two transvaginal apical suspension strategies for uterovaginal prolapse: a mesh augmented hysteropexy versus vaginal hysterectomy…
- Trial name
- SUPeR (NCT01802281)
- Testing
- Uterosacral ligament suspension, Uphold® LITE
- Where
- 8 sites in United States
- Volunteers
- 183 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Tubal Sterilization
Vaginal Natural Orifice Trans-luminal Endoscopic Surgery Salpingectomy for Tubal Sterilization: Clinical Outcomes and Learning Curve Analysis
The evolution from classical open surgery to laparoscopic surgery has led to a significant reduction of morbidity and mortality.
- Trial name
- NCT05581654
- Testing
- Salpingectomy
- Where
- 4 sites in Belgium
- Volunteers
- 240 people
- Sponsor
- Jani Jacques
Surgical Site Infection, Vaginal Surgery
Vaginal Prep Solutions to Reduce Bacteria Colony Counts in Patients Having a Vaginal Surgery
This is a randomized trial comparing the effectiveness of 4 vaginal prep solutions (betadine, baby shampoo, TechniCare and Peridex) on reducing bacterial colony counts during surgery preparation.
- Trial name
- NCT03854370
- Testing
- Betadine, Peridex, TechniCare
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Wright State University
Endometrial Adenocarcinoma, Endometrial Cancer
Comparison of Sentinel Lymph Node Applications in Endometrial Cancer Cases Performed With Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) and Conventional Laparoscopy
Endometrial cancer is a common cancer in women, and surgery is usually the first step in treatment. During surgery, doctors often check nearby lymph nodes to see if the cancer has spread.
- Trial name
- V-COSMOS (NCT07583329)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Cukurova University
Vaginoscopy
Simplification of Vaginoscopic Surgery Using a Self-retaining External Vulvar Sheet (Darwish Sheet)
Vaginoscopic examination is usually difficult due to continuous leakage of the distension medium from the introitus. This study aims to assess the effectiveness and success of performing diagnostic or operative vaginoscopic…
- Trial name
- Darwish sheet (NCT04387123)
- Testing
- Vaginoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Woman's Health University Hospital, Egypt
Stress Urinary Incontinence, Vaginal Hysterectomy
Vaginal Prolapse Surgery Accompanied by Mid Urethral Sling Versus no Sling for Reduction of Postoperative Incontinence
Prevalence of pelvic organ prolapsed is high in Nepal. After prolapse surgery many patients are affected with incontinence. Incontinence has physical, social and mental effect to the individual.
- Conditions
- Stress Urinary Incontinence, Vaginal Hysterectomy, Quality of Life
- Trial name
- NCT04251923
- Testing
- Retro pubic sling
- Volunteers
- 56 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Pelvic Organ Prolapse
Comparison of V-NOTES and Laparoscopic Mesh-Free Sacrocolpopexy Techniques
This study aims to compare the surgical outcomes, safety profiles, and patient satisfaction between two minimally invasive techniques for pelvic organ prolapse repair: Vaginal Natural Orifice Transluminal Endoscopic Surgery…
- Trial name
- vnotes (NCT07082023)
- Testing
- V-NOTES Mesh-Free Sacrocolpopexy, Laparoscopic Mesh-Free Sacrocolpopexy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Havva Betül Bacak
Post Operative Pain
Patient Satisfaction and Pain Control Following Reconstructive Vaginal Surgery
The investigators hypothesize that patient controlled analgesia (PCA) provides superior pain relief and patient satisfaction when compared to scheduled intravenous analgesia following vaginal reconstructive surgery.
- Trial name
- NCT01442818
- Testing
- Dilaudid PCA, Dilaudid IV Scheduled
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- TriHealth Inc.
Same Day Discharge, Pelvic Organ Prolapse
Same Day Discharge Following Pelvic Reconstructive Surgery
This is a prospective cross-sectional study in which patients undergoing major pelvic reconstructive surgery with total vaginal hysterectomy will be recruited and enrolled.
- Conditions
- Same Day Discharge, Pelvic Organ Prolapse, Total Vaginal Hysterectomy
- Trial name
- NCT04804826
- Testing
- Pelvic Reconstructive Surgery
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- TriHealth Inc.
HPV, Cervical Cancer
Multimodality Treatments of HPV-related Lesions of the Female Genital Tract
Cervical cancer is one of the most preventable types of cancer, as it develops over an extended period, and its causative agent is well-known.
- Conditions
- HPV, Cervical Cancer, Cervix Lesion, Vagina Disease
- Trial name
- NCT05938192
- Testing
- vaccination
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano