Clinical trials: Vaping
Vaping Cessation
Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation
This research focuses on maximizing the chances of successfully quitting vaping. A large, pragmatic community-based clinical trial is planned in New Zealand to build on existing evidence from previous vaping and smoking cessation…
- Trial name
- EQUIT3 (NCT06832098)
- Testing
- Nicotine patches plus nicotine mouth spray, Nicotine Tapering Plan
- Where
- New Zealand
- Volunteers
- 774 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
While the prevalence of smoking in the United States general population has declined over the past 50 years, there has been little to no decline among people with mental health conditions.
- Trial name
- NCT04090879
- Testing
- Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Brown University
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Prevalence of smoking among individuals with opioid use disorder (OUD) is six-fold that of the general US adult population. The mortality rate of opioid-dependent smokers is four times that of opioid-dependent nonsmokers, and…
- Trial name
- NCT04092101
- Testing
- Cigarettes with varying nicotine content, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Tobacco Dependence
Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers
The overall goal of this project is to understand the likely health effects of cigarette smokers switching to a Standardized Research Electronic Cigarette (SREC) and to assess the role of nicotine delivery on switching and…
- Trial name
- NCT03625986
- Testing
- Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Smoking, Electronic Cigarette Use
Dual Use Approach Bias Training for Nicotine Addiction
The present project will evaluate the initial efficacy of approach bias retraining among dual combustible cigarette (CC) and electronic cigarette (ECIG) users.
- Conditions
- Tobacco Smoking, Electronic Cigarette Use, Substance Use
- Trial name
- NCT05306158
- Testing
- CC+ECIG Condition, CC Condition
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Houston
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Despite marked reductions in cigarette smoking in the general population, smoking among economically disadvantaged women has increased.
- Trial name
- NCT04092387
- Testing
- Varying the nicotine content of cigarettes, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Vaping, Cessation, Tobacco
Text Message Quit Vaping Intervention for Adolescents
This research study, conducted by Truth Initiative, will help us learn how text messaging can help adolescents between 13 and 17 years of age quit vaping.
- Trial name
- NCT04919590
- Testing
- This is Quitting, Assessment only control, Waitlist control
- Where
- United States
- Volunteers
- 1,681 people, healthy volunteers welcome
- Sponsor
- Truth Initiative
E-Cig Use
Quit Nicotine: E-Cig Cessation Intervention
The purpose of this study is to find out if a new intervention helps teenagers who vape nicotine quit vaping. The program involves two parts: giving rewards (also called contingency management [CM]) and online video counseling…
- Trial name
- NCT04898075
- Testing
- Remote Contingency Management (CM) for nicotine abstinence, Control
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Cigarette Smoking
E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services
This randomized controlled trial evaluated the feasibility and potential efficacy of 1) e-cigarette switching (EC) or 2) e-cigarette switching + financial incentives for combustible cigarette cessation (EC+FI)
- Trial name
- EXCHANGE (NCT03743532)
- Testing
- E-cigarette Switching, Financial Incentives
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Electronic Cigarette Use
Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)
This study aims to better understand how e-cigarettes (ECIG) nicotine flux impacts several behavioral economic measures of abuse liability.
- Trial name
- NCT04332926
- Testing
- Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Vaping Cessation
Pilot Study of a Smartphone-Based Vaping Cessation Program
Prospective, open label, single center clinical study enrolling up to 100 participants to evaluate the effect of the Pivot vaping cessation program.
- Trial name
- NCT05642598
- Testing
- Pivot for Vape
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Pivot Health Technologies Inc.
Acute Lung Injury, Pulmonary Injury
Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung Injury
This is an observational - data and specimen collection study. There have been increasing reports of vaping-induced lung injury, including severe lung injury and rare cases of death.
- Conditions
- Acute Lung Injury, Pulmonary Injury, Electronic Cigarette Use, Electronic Cigarette Related Lung Injury
- Trial name
- ENDALI (NCT05316727)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cigarette Smoking, Addiction
Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder
Patients in addiction treatment have exceptionally higher rate of cigarette smoking and very low quit rates compared to the general population.
- Conditions
- Cigarette Smoking, Addiction, E Cig Use
- Trial name
- NCT04063267
- Testing
- E cigarettes, Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Smoking Cessation
Cytisine and E-cigarettes With Supportive Text-messaging for Smoking Cessation (Cess@Tion)
This research focuses on maximizing the benefits of proven smoking cessation interventions to support people who smoke to quit, as part of the strategy to help New Zealand become smoke-free.
- Trial name
- Cess@Tion (NCT05311085)
- Testing
- Cytisine, Nicotine delivered via an e-cigarette, Cytisine plus nicotine delivered via an e-cigarette
- Where
- New Zealand
- Volunteers
- 807 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Smoking, Smoking Cessation
Preference-based Tools for Smoking Cessation Among Disadvantaged Smokers, a Pragmatic Randomised Controlled Trial
Objective: Our study aims to evaluate the effectiveness of the "STOP" (Sevrage Tabagique à l'aide d'Outils dédiés selon la Préférence: Smoking Cessation using preference-based tools) intervention, a preference-based smoking…
- Trial name
- STOP (NCT04654585)
- Testing
- The STOP intervention, Standard Care
- Where
- 15 sites in France
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Société de Formation Thérapeutique du Généraliste - Recherche
E Cig Use
Young Adult EC Use and Respiratory Outcomes
E-cigarette (EC) use continues to increase among youth, and EC may be detrimental to youth respiratory health. Public health officials and the Food and Drug Administration (FDA) can now regulate ECs.
- Trial name
- NCT04395274
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Obesity, Smoking Cessation
Trial for Harm Reduction With Incentives & Vaping E-cigarettes
The purpose of this study is to provide preliminary information on the effect of electronic nicotine delivery systems (ENDS) provisions and contingent incentives (CI) on smoking in individuals with overweight/obesity who smoke…
- Trial name
- THRIVE (NCT06111053)
- Testing
- ENDS, CI, No ENDS
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Brown University
Adolescent Behavior, Tobacco Use
Media Literacy for High School Tobacco Prevention
This research project will explore the feasibility and acceptability of a web-based media literacy tobacco prevention program. The project will be conducted with 9th or 10th graders in two high schools in Pittsburgh, Pennsylvania.
- Conditions
- Adolescent Behavior, Tobacco Use, E-Cig Use
- Trial name
- NCT05120466
- Testing
- AD IT UP media literacy intervention, Usual health education curriculum
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Nicotine, E-liquid Flavors
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes
The goal of this application is to test whether menthol and fruit flavors impact e-cigarette use through dissociable mechanisms and exert their effects differentially across nicotine doses.
- Trial name
- NCT04038515
- Testing
- Nicotine 0 mg/mL, Nicotine 6 mg/mL, Nicotine 12 mg/mL
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence, E-Cig Use
Research and Innovation to Stop E-cigarette/Vaping in Young Adults
The aim of this study is to test intervention components to help young adults quit vaping. A 2x2 factorial design will be used where all participants receive quitline-delivered behavioral phone counseling, and components to be…
- Trial name
- (RISE) (NCT04974580)
- Testing
- Nicotine patch, Phone Counseling, Digital Coaching
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Ohio State University